19/11/2014 CURRICULUM VITAE Guy G . ROUSSEAU Present status Professor Emeritus, Department of Biochemistry and Cell Biology, Louvain University Medical School (UCL) and de Duve Institute of Cellular Pathology (ICP), Brussels, Belgium Professional address de Duve Institute, Genetics and Development, LAPD-B1.75.03, 75 Avenue Hippocrate, B-1200 Brussels, Belgium Phone: + 32-2-764 7529 ; Fax: + 32-2-764 7507 E-mail: [email protected] Website: www.deduveinstitute.be/liver_and_pancreas_development.php Private data Belgian, born in Brussels, June 8, 1939 Married, three children Home address: 83A Herlinval, B-6983, Ortho, Belgium Home phone: + 32 (0)84 468256 or 0474 74 24 05 Degrees 1964 M.D. Louvain University Medical School, Summa cum Laude 1966 M.Sc. McGill University (Montreal, Canada), Magna cum Laude 1975 Ph.D. (Agrégé de l'Enseignement Supérieur), Louvain University Medical School Postgraduate experience 1963-1966 Junior Internship and Residency in Internal Medicine, Montreal University Hospitals, and Research Fellow (Prof. J. Genest), Department of Investigative Medicine, McGill University, Montreal, Canada 1966-1970 Research Fellow in Physiology at the University of Louvain (Prof. J. Crabbé) and in Biochemistry at the Free University of Brussels (Prof. H. Chantrenne) 1970-1973 US-PHS Fogarty International Research Fellow (1970-72) and Lecturer in Biochemistry (1972-73), Department of Biochemistry and Biophysics (Prof.G. Tomkins), University of California at San Francisco, USA 1975-2004 Senior Investigator, de Duve Institute of Cellular Pathology (ICP), Brussels Belgium (Invited Professor and Investigator : 2004-2009) 2 Appointments Research Fellow of the FNRS, Belgium (1968-1982 : from "Chargé de Recherches" to "Directeur de Recherches") Head, Hormone and Metabolic Research Unit, UCL-ICP (1981-2004) Professor with tenure at the University of Louvain (1982-2004) Deputy Dean (Secrétaire Académique), Louvain University Medical School (1990-1994) Chairman, Department of Biochemistry and Cell Biology (1994-2000) Member of the « Medical Center », St Luc University Hospital (1996-2004) Main Scientific Interest Control of Eukaryotic Gene Expression by Hormones and by Transcription factors Scientific achievements (about 200 publications and 250 invited conferences) Elucidation of the first molecular steps in corticoid hormone action Steroid structure-activity relationships and development of novel hormone antagonists First demonstration that the thyroid hormone receptor binds to a defined gene region Discovery and cloning of the genes that control the metabolic signal molecule "fructose 2,6bisphosphate", elucidation of their regulation by oncogenes and tumor promoters and rôle in the Warburg Effect (increased glucose consumption by cancer cells) Discovery of HNF-6 and of the Onecut family of tissue-restricted transcription factors Unraveling of new genetic control mechanisms of pancreas and liver development Patents -Animal non humain génétiquement modifié et diabétique PCT/BE99/00108 (inventors: Guy G. Rousseau & Frédéric P. Lemaigre) -Composition pharmaceutique destinée au traitement ou à la prévention du diabète et du cancer PCT/BE99/00112 (inventors: Guy G. Rousseau & Frédéric P. Lemaigre) Science Citation Index (1975- 2005) : 6622 Editorial activities Biochemical Journal, Editorial Board, 1983-1989 Journal of Steroid Biochemistry, Corresponding Editor, 1979-1994 Médecine-Sciences, Scientific Committee, 1985-2005 Referee for scientific journals (e.g. J. Cell Science, Hepatology, Biochem. J., Biochemistry, FEBS Lett., Diabetologia, Mech. Dev., Mol. Cell. Endo., Endocr. Rev., Eur. J. Biochem., J. Mol. Med., Biochim. Biophys. Acta, etc ...) 3 Teaching Faculty of Medicine of UCL : Human Physiology and Endocrine Pharmacology (graduate program) ; Molecular Biology of Hormone Action (postgraduate program) Scientific Prizes Prize SPECIA for the best student at the end of Medical School, 1964 Prize "Jean de MEYER" of the Royal Academy of Sciences (Belgium), 1968 Prize "A. LEMAIRE" of UCL for work on the "Mechanism of action of Steroid Hormones, 1969 Prize "Dr R. REDING" Belgian League against Cancer, 1972 PFIZER Prize for Medical Research, 1975 European MACK FORSTER AWARD for Clinical Investigation, 1982 SMITH-KLINE-BEECHAM Prize, 1989 RIK & NEL WOUTERS Prize for Cancer Research, 1992 (shared with L. Hue) International Prize of Physiology LUCIEN DAUTREBANDE, 1997 (shared with L.Hue) PRIX QUINQUENNAL du Gouvernement Belge (2005) Other activities and honors Francqui Chair at the University of Antwerp (1991) Francqui Chair at the University of Brussels (1997) President of the Scientific Committee for Biochemistry and Molecular Biology of the FNRS (until 2005) Scientific advisor for the FRIA and for the Ministry of Economic Affairs (Belgium) (until 2005) Foreign expert for the INSERM and the CNRS (France); FWF (Austria); BARD (Israël); EOLAS (Ireland); Belgian representative at COST (European Union) InBev-Baillet Latour "Scientific Committee for Medical Research" : Member (2006-2011) ; President (2011-present) Fellow of the Royal Academy of Medicine of Belgium Grand Officier de l'Ordre de la Couronne (Belgium) Translation From English : Biochemistry, by D. Voet and J.G. Voet, Wiley, 3rd ed. 2004 (1560 pages) to French : Biochimie, par D. Voet and J.G. Voet, De Boeck et Larcier, 2ème éd. 2005. November 1, 2014
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