FUENTE: UPTODATE
Clinical manifestations and treatment of Epstein-Barr virus infection
Author
John L Sullivan, MD
Sección Complicaciones de la infección por VEB.
Hemophagocytic lymphohistiocytosis — EBV is one of the recognized
initiating causes of hemophagocytic lymphohistiocytosis (HLH), a
potentially fatal genetic disorder characterized pathologically by
generalized histiocytic proliferation and hemophagocytosis (picture 3)
[23]. Patients with this unusual syndrome present with fever, generalized
lymphadenopathy, hepatosplenomegaly, hepatitis, pancytopenia and
coagulopathy. T cell proliferation is a primary feature of HLH. The
pathogenesis, diagnosis and treatment of this disorder are discussed in
detail elsewhere. (See "Treatment and prognosis of hemophagocytic
lymphohistiocytosis".

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