Conference Venue: Alte Aula der Philipps-Universität „Alte Universität“, Lahntor 3, Marburg Time Schedule: June, 30 2014, 12.20h - 20.00h July, 1st 2014, 08:30h - 14.00h Organizers: PD. Dr. Magdalena Huber / Med. Mikrobiologie Marburg Prof. Dr. Tobias Bopp / Gutenberg Universität Mainz Monday, 30 June 2014 12:20 “Welcome Address” Regulatory T Cells Regulatory T Cell Reg Chair: Jochen Hühn 12:30 MALT1 is an intrinsic regulator of Tregs Anne Brüstle, Ontario Cancer Institute, Toronto 12:50 c-FLIP regulates Treg homeostasis Carlos Plaza Sirvent, HZI Braunschweig (AG Schmitz) 13:10 The Keap1/Nrf2 pathway, a cellular defense mechanisms against oxidative stress, facilitates regulatory T cells Kim Ohl, Forschungslabor Kinderklinik Aachen (AG Tenbrock) 13:30 Alloantigen-specific Tregs and Tolerance Karolina Ebert, Universität Freiburg (AG Tanriver) 13:50 Alloantigen-specific regulatory T cells induced by thymic antigen-presenting cells prolong allograft acceptance and are stable in vivo Garima Garg, HZI Braunschweig (AG Hühn) 14:10 A TCR-regulated negative pathway controls Foxp3 expression by interfering with the activities of STAT5 and Foxo1 Michael Lohoff, Philipps Universität Marburg 14:30 Break Chair: 14:50 Depletion of Foxp3+ regulatory T cells promotes fatal T helper (Th)2 cell development in pulmnary fungal infection Bianca Schulze, Universität Leipzig (AG Alber) 15:10 Protein kinase CK2 enables regulatory T cells to suppress excessive Th2 responses in vivo Alexander Ulges, Universität Mainz (AG Bopp/Schmitt) 15:30 T-bet and IFNγ are despensable for the colitis-inducing potential of CD4+ T cells Jakob Zimmermann, DRFZ Berlin (AG Radbruch) 15:50 Reduced skin carcinogenesis in alpha-melanocyte-stimulating hormone-treated mice is based on the inhibition of myeloid-derived suppressor cell expansion Nadine Sucker, Universität Münster (AG Loser) 16:10 B r e a k – please visit the companies!!!! TH17 CELLS Chair: Ari Waisman 16:50 A crucial role for IκBNS in the Th17 differentiation Ingo Schmitz, Helmholtz Zentrum Braunschweig (AG Schmitz) 17:10 Malt1-dependent Roquin cleavage in CD4+ T cells promotes Th17 differentiation via dereperession of Roquin targets IκBζ and IκBNS Katharina Jeltsch, LMU München (AG Heissmeyer) 17:30 Alternative splicing of FOXP3 controls differentiation of Th17 cells Reiner Mailer, Karolinska Insitut, Schweden 17:50 Epigenetic signature of ex vivo Th17 cells Bi-Huei Yang, Helmholtz Zentrum Braunschweig (AG Hühn) 18:10 Break DETECTION OF HUMAN AUTOREACTIVE CELLS Chair: Christian Becker 18:30 Direct ex vivo characterization of rare autoantigen-specific human CD4+ T cells Stefanie Gamradt, Charité Berlin (AG Scheffold) 18:50 Autoreactive circulating CD8+ T cells in patients suffering from atopic dermatitis show a differentiated phenotype Lennart Rösner, MH Hannover (AG Werfel) 19:10 „Maintenance of regulatory T cell fate“ Alexander Rudensky, University of New York 19:55 “walk to the Castle of Marburg” 20:30 D i n n e r – “Landgrafenschloß Marburg” Tuesday, 1st July 2014 Mechanisms of Autoimmunity Chair: Friederike Berberich-Siebelt 08:30 Th1 and Th17 cells promote crescent formation in Experimental Autoimmune Glomerulonephritis Hans-Willi Mittrücker, Universität Hamburg-Eppendorf 08:50 IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1 Sylvia Heink, TU München (AG Korn) 09:10 Toso: a regulator of inflammation and autoimmunity Dirk Brenner, Ontario Cancer Institute, Toronto 09:30 NFATc1 and NFATc2 deficiency attenuates EAE via distinct mechanisms Lena Dietz, Universität Würzburg (AG Berberich-Siebelt) 09:50 Break Regulation of T cell response Chair: Ingo Schmitz 10:10 The resting Th cell memory of human bone marrow maintains longterm memory for systemic antigens Andreas Radbruch, DRFZ Berlin 10:30 T cell receptor upregulation creates a feedback loop that marks self reactive thymocytes for negative selection Ravindra Sapkota, TU München (AG Buch) 10:50 The impact of dietary proteins on the maintenance of mucosal homeostasis Alexander Visekruna, Philipps Universität Marburg 11:10 Regulation of human immune responses against mucosal antigens by antigen-specific regulatory T cells Petra Bacher, Charité Berlin (AG Scheffold) 11:30 A short splice variant of the tumor suppressor gene CYLD enhances the development of IL-9 Dependent allergic airway disease in mice Sebastian Reuter, Universität Mainz (AG Reuter-Buhl/Stassen) 11:50 The cAMP response element mudulator (CREM) influences the Th2 response in an IL-2 dependent manner Klaus Tenbrock, Kinderklinik Aachen 12:10 Break CD8+ T Cell Activation and memory Chair: Hans-Willi Mittrücker 12:40 Linking functional diversity and TCR affinity in chronic infections Dietmar Zehn, Universität Lausanne, Schweiz 13:00 Deletion of immunodominant epitopes of murine cytomegalovirus favors the expansion of highavidity CD8 T cells specific for subdominant epitopes Rafaela Holtappels, Immunologie, Universität Mainz 13:20 The role of Inhibitor of Apoptosis Proteins (IAPs) for T cell expansion/survival during anit-viral Immunity Peter Aichele, Immunologie, Universität Freiburg 13:40 Characterization of syntaxin 11-deficient mice as a new mouse model for familial hemophagocytic lymphohistiocytosis type-4 (FHL-4) Tamara Kögl, Universität Freiburg (AG Aichele) 14:00 Memory CD8+ T cells reside and rest in contact to IL-7 producing stromal cells in murine bone marrow Özen Sercan Alp, DRFZ Berlin (AG Radbruch) 14:30 Award for „Best Talk“ Spo nso ri ng: Financial Support 1500,00 € Financial Support 1500,00 €
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