PREDECT posters for the meeting of 12-‐14 October 2014 in Riga # Thematic Author Title The use of triple cultures to characterize the mechanism of the molecular crosstalk between tumor, stromal and monocytic cells Impact of the tumor microenvironment on 3D breast cancer microtissues Androgen dependency of prostate cancer 2D/3D co-‐culture models Single-‐cell based segmentation of 3D confocal image stacks of fluorescent 3D tumor spheroids Establishing 2D prostate cancer co-‐cultivation systems to study tumor-‐stroma interactions Recapitulation of NSCLC microenvironment in stirred-‐tank culture systems Characterization of a novel cell model to study the influence of tumor microenvironment on breast cancer progression Organisation Bayer Pharma Janssen Name Albin Rudisch, Wolfgang Sommergruber Kristin Stock Suzana Vidic Janssen Michael Barbier Weizmann Institute Yan Stein iBET Vitor E. Santo iBET Marta Estrada 1 3D Boehringer Ingelheim 2 3 3D 3D 4 3D 5 3D 6 3D 7 3D 8 3D A Variety of 3D and 3D Co-‐Culture Settings for VCAP cells VTT 9 in vivo Erasmus MC Matthias Nees, Malin Åkerfelt, Ville Härmä Petra van Duijn 10 in vivo EPFL Georgios Sflomos 11 in vivo AstraZeneca Emma Davies 12 in vivo Roche Lena Vockentanz 13 in vivo University of Helsinki Elsa Marques 14 in vivo Erasmus MC Matthijs Moll 15 in vivo Erasmus MC Matthijs Moll 16 in vivo Oncotest Eva Oswald 17 Tissue Slice Biomedicum Genomics Oy Hanna Ala-‐Hongisto, Pauliina Munne 18 Tissue Slice AstraZeneca Emma Davies 19 20 Tissue Slice Tissue Slice Erasmus MC University of Helsinki Wytske van Weerden Katja Närhi 21 Tissue Slice Stuttgart IKP Meng Dong 22 23 WP2 WP4 Development of GEMM derived in vitro and in vivo models for prostate cancer An improved pre-‐clinical model for ER_ positive breast cancer reveals tissue structure/microenvironemt as critical determinant of hormone sensitivity Establishment of a transplantable GEMM mammary tumour model Development of Breast Cancer PDX Models by Intraductal and Intra-‐mammary Fat Pad Transplantation Deconstructing Myc and Myc;Lkb1fl/fl breast cancer model: syngrafts and hormone therapy in ex vivo cultures. Androgen metabolism in tissue slice cultures of patients with castration-‐resistant prostate cancer (CRPC) Endocrine-‐humanized in vitro and in vivo models for the progression of castration resistant prostate cancer (CRPC) Co-‐culture in vivo: orthotopic growing lung cancer cells mono-‐and co-‐culture in NOG mice Primary Human Breast Tumour Explant Platform for Integrated Profiling and Target Validation Induction of HIF1a influences estrogen receptor expression in ex-‐vivo culture of tumour tissue Manipulating the PI3K/AKT pathway in ex vivo prostate cancer tissue slices Ex vivo culture of Kras-‐driven murine pulmonary cancer Further optimization of lung tumor tissue slice cultivation plans and preliminary results Relevance of the VCaP in vivo model for castration-‐resistant prostate cancer Interactive PCA plot tool for PREDECT data visualization Orion University of Tartu 24 WP4 Image analysis for PREDECT: current status and future directions University of Helsinki Elina Mattila Tauno Metsalu Anne Grote, Riku Turkki, Yinhai Wang
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