PUBLICATIONS
A. Peer reviewed
1. Köhl J, Casaretto M, Gier M, Karwath G, Gietz C, Bautsch W, Saunders D, BitterSuermann D. Reevaluation of the C3a active site using short synthetic C3a analogues.
Eur J Immunol 1990; 20:1463-1468. IF: 4,865
2. Suckau D, Köhl J, Karwath G, Schneider K, Casaretto M, Bitter-Suermann D,
Przybylski M. Molecular epitope identification by limited proteolysis of an immobilized
antigen-antibody complex and mass spectrometric peptide mapping. Proc Natl Acad Sci
1990; 87: 9848-9852. IF: 9,380
3. Kretzschmar T, Kahl K, Rech K, Bautsch W, Köhl J, Bitter-Suermann D.
Characterization of the C5a receptor on guinea pig platelets. Immunobiology 1991;
183:418-432. IF: 3,461
4. Kroll B, Emde M, Jeromin A, Penner L, Rechkemmer G, Kretzschmar T, Klos A, Köhl
J, Bautsch W. Functional expression of a human C5a receptor clone in Xenopus oocytes
requires additional RNA. FEBS Lett 1991; 291:208-210. IF: 3,264
5. Kola A, Klos A, Bautsch W, Kretzschmar T, Köhl J. Functional activities of synthetic
anaphylatoxic peptides in widely used biological assays. Clin Exp Immunol 1992;
88:368-372. IF: 2,853
6. Kretzschmar T, Pohl M, Casaretto M, Przewosny M, Bautsch W, Klos A, Saunders D,
Köhl J. Synthetic peptides as antagonists of the anaphylatoxin C3a. Eur J Biochem
1992; 210:185-191. IF: 3,579
7. Bautsch W, Emde M, Kretzschmar T, Köhl J, Suckau D, Bitter-Suermann D. Human
C5a anaphylatoxin:Gene cloning and expression in Eschericha coli. Immunobiology
1992; 185:41-52. IF: 3,461
8. Bautsch W, Kretzschmar T, Stuhmer T, Kola A, Emde M, Köhl J, Klos A, BitterSuermann D. A recombinant hybrid anaphylatoxin with dual C3a/C5a activity. Biochem
J 1992; 288:261-266. IF: 4,371
9. Klos A, Bank S, Gietz C, Bautsch W, Köhl J, Burg M, Kretzschmar T. C3a receptor on
dibutyryl-cAMP-differentiated U937 cells and human neutrophils: the human C3a
receptor characterized by functional responses and 125I-C3a binding. Biochemistry
1992; 31:11274-11282. IF: 3,379
10. Pletschette M, Köhl J, Kuipers J, Schmidt RE. Opportunistic Capnocytophaga
canimorsus infection. Lancet 1992; 339: 308 (Letter). IF: 28,409
11. Kretzschmar T, Jeromin A, Gietz C, Bautsch W, Klos A, Köhl J, Rechkemmer G, Bitter
Suermann D. Chronic myelogenous leukemia-derived basophilic granulocytes express a
functional active receptor for the anaphylatoxin C3a. Eur J Immunol 1993; 23:558-561.
IF: 4,865
12. Köhl J, Lübbers B, Klos A, Bautsch W, Casaretto M. Evaluation of the C-terminal C5a
effector site with short synthetic C5a analog peptides. Eur J Immunol 1993; 23:646-652.
IF: 4,865
13. Hartmann H, Lübbers B, Casaretto M, Bautsch W, Klos A, Köhl J. Rapid quantification
of C3a and C5a using a combination of chromatographic and immunoassay procedures. J
Immunol Methods 1993; 166:35-44. IF: 2,120
14. Federwisch M, Wollmer A, Emde M, Stuhmer T, Melcher T, Klos A, Köhl J, Bautsch
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W. Tryptophan mutants of human C5a anaphylatoxin: a fluorescence anisotropy decay
and energy transfer study. Biophys Chem 1993; 46:237-248. IF: 2,362
15. Klos A, Mätje C, Rheinheimer C, Bautsch W, Köhl J, Burg M. Amino acids 327-350 of
the human C5a-receptor are not essential for [125I] C5a binding in COS cells and signal
transduction in Xenopus oocytes. FEBS Lett 1994; 344:79-82. IF: 2,264
16. Bubeck P, Grötzinger J, Winkler M, Köhl J, Wollmer A, Klos A, Bautsch W. Sitespecific mutagenesis of residues in the human C5a anaphylatoxin which are involved in
possible interaction with the C5a receptor. Eur J Biochem 1994; 219: 897-904. IF: 3,579
17. Weber S, Lottspeich F, Köhl J. An epitope of elongation factor Tu is widely distributed
within the bacterial and archaeal domains. J Bacteriol 1995; 177: 11-19. IF: 3,636
18. Schmidt U, Köhl J, Kawalla G, Hecke F, Regel G. Systemic response of fibrin
degradation products, cytokines, and anaphylatoxins in multitrauma patients early after
injury. In: Kongreßbericht zur 111. Tagung der Deutschen Gesellschaft für Chirurgie
Langenbecks Arch. Chir. 1995 Suppl. II : 128-130. IF: 0,921
19. Köhl J. Nabbing a MAb. ASM News 1995; 61: 181. IF: 0,95
20. Stöve S, Klos A, Bautsch W, Köhl J. Reevaluation of the storage conditions for blood
samples which are used for determination of complement activation. J Immunol Methods
1995; 182: 1-5. IF: 2,120
21. Burg M., Martin U, Rheinheimer C, Köhl J, Bautsch W, Böttger EC, and Klos; A.
Interferon- up-regulates the human C5a-receptor (CD88) in myeloblastic U937-cells
and related cell-lines. J Immunol. 1995; 155: 4419-4426. IF: 6,00
22. Burg M, Raffetseder U, Grove M, Klos A, Köhl J, Bautsch W. G-16 complements the
signal transduction cascade of chemotactic receptors for complement factor C5a (C5a-R)
and N-formylated peptides (fMLF-R) in Xenopus laevis oocytes, FEBS Lett.1995; 377:
426-428. IF: 3,264
23. Raffetseder U, Röper D, Laurence M, Gietz C, Klos A, Grötzinger J, Wollmer A, Boulay
F, Köhl J, Bautsch W. Site-directed mutagenesis of conserved charged residues in the
helical region of the human C5a receptor: Arg206 determines high affinity binding sites
of C5a receptor. Eur J Biochem.1996; 235: 82-90. IF: 3,579
24. Stöve S, Welte T, Wagner T. O. F, Kola A, Klos A, Bautsch W, Köhl J. Circulating
complement proteins in patients with sepsis and SIRS. Clin. Diagn. Lab Immunol 1996;
3: 175-183. IF: 2,511
25. Kola A, Baensch M., Bautsch W, Hennecke M, Klos A, Köhl J. Epitope mapping of a
C5a neutralizing mAb using a combined approach of phage display, synthetic peptides
and site-directed mutagenesis. Immunotechnology 1996; 2: 115-126. IF: 0,000
26. Crass T., Raffetseder U., Martin U., Grove M., Klos A., Köhl J., and Bautsch W.
Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated
U937 cells. Eur J Immunol, 1996, 26: 1944-1950. IF: 4,865
27. Burg M, Martin U, Rheinheimer C, Köhl J, Bautsch W, Klos A. Differential regulation
of the C3a and C5a receptors (CD88) by IFN- and PMA in U937 cells and related
myeloblastic cell lines. J Immunol, 1996, 157: 5574 - 5581. IF: 6,000
28. Stöve S, Hartmann H, Klos A, Bautsch W, Köhl J. Early diagnosis of sepsis by rapid
measurement of C3a/C3 plasma levels. In: Faist E, Baus AE, Schildberg FW, (eds.),
MOF, MODS and SIRS- Concepts, Clinical Correlates and Therapy, Proceedings of the
3rd International Congress on The Immune Consequences of Trauma, Shock and Sepsis:
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Mechanisms and Therapeutic Approaches. Pabst Science Publisher, Lengerich, 1996,
162 -170.
29. Hennecke M, W, Kola A, Klos A, Bautsch W, Köhl J. A selection system to study C5aC5a-receptor interaction: phage display of a novel C5a anaphylatoxin, C5aAla27. Gene,
1997, 184: 263 - 277. IF: 2,578
30. Hartmann K, Henz BM, Krüger-Krasagakes S, Köhl, J, Burger R, Haase I, Lippert U,
Zuberbier T. C3a and C5a stimulate chemotaxis of human mast cells. Blood, 1997, 89:
2863 - 2870. IF: 10,432
31. Bock D, Martin U., Gärtner S., Rheinheimer C., Arseniev L., Barker M., Monk M.N.,
Bautsch W., Köhl J., Klos A. The C-terminus of the hman C5aR (CD 88) is required for
normal ligand-dependent receptor-internalization. Eur J Immunol., 1997, 27: 1522 1529. IF: 4,865
32. Hecke F., Schmidt U., Kola A., Bautsch W., Klos A., Köhl J. Circulating complement
proteins in multiple trauma patients - correlation with injury severity, development of
sepsis, and outcome, Crit Care Med, 1997, 25: 2015 - 2024. IF: 6,594
33. Martin, U., Bock, D., Arseniev, L., Tornetta, M.A., Ames, R., Bautsch, W., Köhl, J.,
Ganser, A., Klos, A. The human C3a receptor is expressed on neutrophils and monocyes,
but not on B or T Lymphocytes. J Exp Med, 1997, 186: 199 - 207. IF: 15,219
34. Vogel, U., Weinberger, A., Frank, R., Müller, A., Köhl, J., Atkinson, J.P., Frosch, M.
Complement factor C3 deposition and serum resistance in isogenic capsule and
lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis. Infect
Immunity, 1997, 65: 4022 - 4029. IF: 3,987
35. Hennecke, M., Otto, A., Baensch, M., Kola., A, Bautsch, W., Klos, A., Köhl, J. A
detailed analysis of the C5a anaphylatoxin effector domain: Selection of C5a phage
libraries on differentiated U937 cells. Eur J Biochemistry, 1998,252: 36 - 44. IF: 3,579
36. Hawlisch, H., Frank, R., Hennecke, M., Baensch, M., Sohns, B., Arseniev, L., Bautsch,
W., Kola, A., Klos, A., Köhl, J. Site-Directed C3a-receptor antibodies from phage
display libraries. J Immunol, 1998, 160: 2947 - 2958. IF: 6,000
37. Baensch M., Frank R., Köhl J. Conservation of the Amino-terminal epitope of
elongation factor Tu in eubacteria and archea. Microbiology, 1998, 144: 2241 - 2246.
IF: 0,705
38. Lüneberg E, Zähringer U, Knirel YA, Steinmann D, Hartmann M, Steinmetz I, Rohde
M, Köhl J, Frosch M. Phase-variable expression of lipopolysaccharide contributes to the
virulence of Legionella pneumophila. J Exp Med, 1998, 188: 49 –60. IF: 15,219
39. Paral D, Sohns, B, Crass T, Grove M, Köhl J, Klos A, Bautsch W. Genomic
organization of the human C3a-receptor (C3aR). Eur J Immunol, 1998, 28: 2417-2423.
IF: 4,865
40. Lienenklaus S, Ames RS, Tornetta MA, Sarau HM, Foley JJ, Crass T, Sohns B,
Raffetseder U, Grove M, Hölzer A, Klos A, Köhl J, Bautsch W. Cutting Edge: Human
C4a anaphylatoxin elicits C3a-receptor mediated effects in guinea pigs but not in man. J
Immunol, 1998, 161: 2089 – 2093. IF: 6,000
41. Kola A., Baensch M., Bautsch W., Klos A., Köhl J. Analysis of the C5a anaphylatoxin
core domain using a C5a phage library selected on differentiated U937 cells. Mol
Immunol, 1999, 36: 145 – 152. IF: 3,555
42. Crass T., Ames R.S., Sarau H.M., Tornetta M.A., Foley J.J., Köhl J., Klos A., Bautsch
W. Chimeric receptors of the human C3a-receptor (C3aR) and C5a-receptor (C5aR;
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CD88). J Biol Chem, 1999, 274: 8367 – 8370. IF: 5,520
43. Heller T., Gessner, J.E., Schmidt R.E., Klos A., Bautsch W., Köhl J. Cutting Edge:
FcRI on macrophages and complement mediate the inflammatory response in immune
complex peritonitis. J Immunol, 1999, 162: 5657-5661. IF: 6,000
44. Settmacher B, Bock D, Saad H, Gärtner S, Rheinheimer C, Köhl J, Bautsch W, Klos A.
Modulation of C3a activity: internalization of the human C3a-receptor and its inhibition
by C5a. J Immunol, 1999, 162: 7409-7416. IF: 6,000
45. Heller T, Hennecke M, Baumann, U., Gessner J.E., Meyer zu Vilsendorf A., Baensch M,
Kola A, Boulay F, Baumann U, Klos A, Bautsch W, Köhl J. Selection of a C5a-receptor
antagonist from phage libraries attenuating the inflammatory responses in immune
complex disease and ischema/reperfusion injury. J Immunol, 1999, 163: 985-994. IF:
6,000
46. Murray I, Köhl J, Cianflone K. Acylation stimulating protein (ASP): structure:function
determinants of cell surface binding and triacylglycerol synthetic activity. Biochem J
1999, 342: 41-48. IF: 4,371
47. Link C., Hawlisch H., Friedrichsen M., Meyer zu Vilsendorf A., Gyleruz S., Nagel E.,
Köhl J. Selection of phage-displayed anti guinea pig C5 and C5a antibodies and their
application in xenotransplantation. Mol Immunol, 1999, 36: 1253 –1247. IF: 3,555
48. Köhl J. Antikörper aus dem Reagenzglas. Die gelben Hefte. Jg. XXXIX, Heft 1, 1999,
22-31.
49. Köhl J. Antibodies from phage display libraries. Biomedical Progress 1999, 12: 65-70.
IF: 1,853
50. Köhl J. and Gessner J.E. On the role of complement and Fc- receptors in the Arthus
reaction. Mol Immunol, 1999, 36: 893-903. IF: 2,076
51. Jannssen U., Bahlmann F., Köhl J., Zwirner J., Haubitz M., Floege J. Activation of the
acute phase response and of complement C3 in patients with IgA-nephropathy. Am. J.
Kidney Dis. 2000, 35:21-28. IF: 4,822
52. Baumann U, Köhl J., Schwerter-Strumpf K., Tschernig T., Schmidt R.E., Gessner J.E.
A codominant role of FcRIII and C5aR in the reverse Arthus reaction. J Immunol 2000,
164: 1065-1070. IF: 6,000
53. Hawlisch H., Meyer zu Vilsendorf A., Nagel E., Bautsch W., Klos A., Köhl J. Guinea
pig C3 specific rabbit single chain Fv antibodies from bone marrow, spleen and blood
derived phage libraries. 2000, J Immunol Methods 236: 117 - 131. IF: 2,120
54. Petering H, Köhl J, Weyergraf A, Kimmig D, Smolarski R, Knapp A, Elsner J.
Characterization of synthetic C3a analog peptides on human eosinophils in comparison
to the native complement component C3a. J Immunol 2000 164: 3783 - 3789. IF: 6,000
55. Templin C., Schröder C., Simon A.R., Laaff G., Köhl J., Chikobava M., Lapin B.,
Steinhoff G., Martin U. Analysis of potential porcine enodgenous retrovirus transmission
to baboon in vitro and in vivo. 2000, Transplant. Proc. 32: 1163-1164. IF: 1,055
56. Simon A.R., Schröder C., Martin U., Chikobava M., Templin C., Laaf G., Köhl J.,
Lapin B., Haverich A., Steinhoff G. An attempt to induce tolerance in a pig-to-primate
transplantation model by infusion of ultrahigh numbers of donor peripheral blood
mononuclear cells: fist promising results. 2000, Transplant. Proc. 32: 1052-1053. IF:
1,055
57. Meyer zu Vilsendorf A., Nagel E., Link C., Jörns A., Köhl J. Prolonged survival of
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guinea pig to rat heart xenografts following complement depletion and B-cell directed
immunosuppression by malonitrylamide. 2000, Transplant. Proc. 32: 864-865. IF: 1,055
58. Selberg O., Martin M., Klos A., Bautsch W., Köhl J. Discrimination of Sepsis and SIRS
by determination of circulating plasma concentrations of procalcitonin, C3a and IL-6.
2000, Crit. Care Med., 28: 2793-2798. IF: 6,594
59. Karp C.L., Gruppe A., Schadt E., Ewart S.L., Keane-More M., Cuomo P.J., Köhl J.,
Wahl L., Kupermann D., Germer S., Aud D., Peltz G., Wills-Karp M. Identification of
complement factor 5 (C5) as a susceptibility locus for experimental allergic asthma.
2000 Nat. Immunol. 3: 221 - 226. IF: 25,113
60. Bautsch W., Hoymann H-G., Zhang Q., Meyer-Wiedenbach I., Raschke u., Ames R.S.,
Sohns B., Meyer zu Vilsendorf A., Klos A., M. Grove, Köhl J., Cutting edge: Guinea
pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic
airway disease: evidence for an involvement of the C3a anaphylatoxin in the
pathogenesis of asthma. 2000 J. Immunol., 165: 5401 –5405. IF: 6,000
61. Meyer zu Vilsendorf A., Nagel E., Link C., Jörns A., Nagel E., Köhl J. Preconditioning
with the prostacyclin analog eprostenol and cobra venom factor prevents reperfusion
injury and hyperacute rejection in discordant liver transplanatation. 2001
Xenotransplantation 8: 41 - 47. IF: 2,288
62. Köhl J. Anaphylatoxins and infectious and non-infectious inflammatory diseases. 2001
Mol. Immunol. 38: 175 -187. IF: 3,555
63. Link C., Meyer zu Vilsendorf A., Köhl J. Analysis of preformed xenoreactive antibodies
in the discordant guinea pig to rat model using a guinea pig fibroblast-like cell line. 2001
Scand. J. Clin. Lab. Invest. 6: 51-55. IF: 1,363
64. Templin C., Schröder C., Simon A.R., Laaff G., Köhl J., Chikobava M., Lapin B.,
Winkler M.E., Wiebe K., Steinhoff G., Martin U. Long-term monitoring of
xenotransplanted baboons: no evidence for pig enodgenous retrovirus transmission. 2001
Transplant. Proc. 33: 692. IF: 1,055
65. Hawlisch H., Müller M., Frank R., Bautsch W., Klos A., Köhl J. Site speficic anti-C3a
receptor specific single chain antibodies selected by differential panning on
nitrocellulose sheets. 2001 Anal. Biochem. 293: 142-145. IF: 3,088
66. Baumann U., Chouchakova N., Gewecke B., Köhl J., Carroll M.C., Schmidt R.E.,
Gessner J.E. Distinct tissue site-specific requirements of mast cells and complement
components C3/C5a receptor in IgG immune complex-induced injury of skin and lung.
2001 J. Immunol. 167: 1022 -1027. IF: 6,000
67. Krug N., Tschernig T., Erpenbeck VJ., Hohlfeld JM., Köhl J. Complement factors C3a
and C5a are increased in bronchoalveolar lavage fluid after segmental allergen
provocation in asthmatics. 2001 Am. J. Respir. Crit. Care Med. 164: 1841-1843. IF:
9,792
68. Mollnes TE., Brekke O-L., Bergseth G., Christiansen D., Fure H., Videm V., Lappegard
KT, Köhl J., Lambris J. Essential role of complement and the C5a receptor in
Escherichia coli induced oxidative burst in a novel lepirudin based human whole blood
model of inflammation. 2002 Blood 100:1869-187. IF: 10,432
69. Baumann U., Shushakova, N., Skokova J., Köhl J, Schmidt. R.E., Gessner, J.E.
Complement and Fc receptors in autoimmune-associated inflammation. 2002 Mod. Asp.
Immunobiol., 2: 269 – 272.
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70. Soruri A., Kiafard Z., Dettmer C., Riggert J., Köhl J., Zwirner J. IL-4 down-regulates
anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxininduced migration in vivo. 2003 J. Immunol. 170: 3306. IF: 6,000
71. De Vries B., Köhl J., Leclerqc W., Wolfs T., Van Bijnen A., Heeringa P., Buurmann W.
Complement factor C5a mediates renal ischemia reperfusion injury independent from
neutrophils. 2003 J. Immunol.170: 3883 - 3889. IF: 6,000
72. Settmacher B., Reinheimer C., Hamacher H., Ames R., Wise A., Jenkinson L., Bock D.,
Schaefer M., Köhl J., Klos A.. Structure-function studies of the C3a-receptor: Cterminal serine and threonine residues which influence receptor internalization and
signaling. 2003 Eur. J. Immunol. 33:920 - 927 IF: 4,865
73. Otto M, Hawlisch H, Monk PN, Müller M, Klos A, Karp CL, Köhl J. C5a mutants are
potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that
determines agonism or antagonism. 2004 J Biol Chem. 279:142-151. IF: 5,520
74. Godau J., Heller Y., Hawlisch H., Trappe M., Howells E., Best J., Zwirner J., Verbeek
J.S., Hogarth PM., Gerard C., van Rooijen N., Klos A., J. Engelbert Gessner, and Köhl
J. C5a initiates the inflammatory cascade in immune complex peritonitis. 2004 J.
Immunol. 173: 3437-3445. IF: 6,000
75. Hawlisch H, Wills-Karp M, Karp CL, Köhl J. The anaphylatoxins bridge innate and
adaptive immune responses in allergic asthma. Mol Immunol. 2004 41:123-131. IF:
3,196
76. Bälder R., Bautsch W., Zwirner J., Köhl J., Hoymann H.G, Glaab T., Erpenbeck V.,
Fuchs B., Krug N., Braun A. Parmacological targeting of anaphylatoxin receptors during
the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway
inflammation. 2005 J. Immunol. 174:783-789. IF: 6,000
77. Wills-Karp M and Köhl J. New Insights into the Role of the Complement Pathway in
Allergy and Asthma. Curr Allergy Asthma Rep. 2005 5:362-369. IF: 2,75
78. Skokowa J, Ali S R, Felda O., Kumar V., Konrad S., Shushakova N., Schmidt R.E.,
Piekorz R., Nürnberg B., Spicher K., Birnbaumer L., Zwirner J., Claassens J.W.C.,
Verbeek J.S., van Rooijen N., Köhl J., and Gessner J.E. Macrophage induce the
Inflammatory response in the pulmonary Arthus Reaction through Gi2 activation that
cotrols C5aR and Fc Receptor cooperation 2005 J. Immunol. 174:3041-3050. IF: 6,000
79. Hawlisch H., Belkaid Y., Bälder R., Hildeman, D., Köhl J.. C5a negatively regulates
Toll-like receptor 4-induced immune responses. 2005 Immunity, 22: 415-426. IF:
20,579
80. Therien AG, Baelder R., Köhl J. Agonist Activity of the Small Molecule C3aR Ligand
SB 290157. 2005 J. Immunol. 174: 7479 – 7480 (letter). IF: 6,000
81. Addis-Lieser A., Köhl J., and Chiaramonte M.G. Opposing regulatory roles of
complement factor 5 in the development of bleomycin-induced pulmonary fibrosis.
2005 J. Immunol. 175:1894-902. IF: 6,000
82. Hillebrandt S, Wasmuth H.E., Weiskirchen R., Hellerbrand C., Keppeler H., Werth A.,
Wilkens G., Geier A., Schirin-Sokhan, Lorenzen J., Köhl J., Gressner A.M., Matern S.,
Lammert F. Complement factor 5 is a genetic risk factor that modifies liver fibrosis in
mice and humans. 2005 Nat. Genetics 37:835-43. IF: 30,259
83. Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles
AA, Shah JS, Köhl J, Belkaid Y, Wills-Karp M. CD4+CD25+ T cells protect against
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experimentally induced asthma and alter pulmonary dendritic cell phenotype and
function. 2005 J. Exp. Med. 202: 1549-1561. IF: 15,219
84. Köhl J., Bälder R., Lewkowich I., Pandey M.K., Hawlisch H., Wang L., Herman N.,
Sproles A., Best J., Zwirner J., Lambris J.D., Whitsett J.D., and Wills-Karp M.. A
regulatory role for the C5a anaphylatoxin on type 2 immunity in asthma. 2006 J. Clin.
Invest. 116: 783-796. IF: 16,559
85. Köhl J. The role of complement in danger sensing and transmission. Immunol. Res.,
2006 34: 157-176. IF: 2,93
86. Köhl J., Drug evaluation: the C5a receptor antagonist PMX-53. Curr. Opin. Mol. Ther.
2006 8:529-38. IF: 3,42
87. Hawlisch H and Köhl J. Complement and Toll-like receptors: key regulators of adaptive
immune responses. Mol Immunol 2006 43:13-21. IF: 4,768
88. Gressner O, Meier U, Hillebrandt S, Wasmuth H, Köhl J, Sauerbruch T, Gressner AM,
Lammert F. Gc-globulin concentrations modify the effect of C5 haplotype on serum
activities of complement factor 5 2007 Clin. Biochem. 40: 771-775. IF: 1,926
89. Jongerius I, Köhl J, Pandey M.K., Ruyken M., van Kessel K.P.M., van Strijp J.A.G.,
Rooijakkers H.M. Staphylococcal complement evasion by various convertase-blocking
molecules. J. Exp. Med. 2007 204:2461-2471. IF: 15,219
90. Köhl J. and Wills-Karp M. Complement regulates inhalation tolerance at the dendritic/T
cell interface. Mol. Immunol. 2007, 44:44-56 IF: 3,742
91. Köhl J and Wills-Karp M. A dual role for complement in allergic asthma. Curr. Op.
Pharmacol., 2007 7:283-289. IF: 5,443
92. Reis ES, Barbuto JAM, Köhl J, Isaac L. Impaired dendritic cell differentiation and
maturation in the absence of C3. Mol. Immunol. 2008, 45: 1952-1962. IF: 3,555
93. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Hoesel LM, Zetoune FS, Cianflone K,
Huber-Lang M, Köhl J., Gerard C., Sarma JV, Ward PA. Functional roles for C5a in
sepsis. 2008 Nat. Medicine, 14:551-557. IF: 27,553
94. Lewis AG, Köhl G, Qing M., Devarajan P, Köhl J. Pharmacological targeting of the C5a
receptor during cold ischemia as a novel therapeutic concept to improve kidney graft
survival. 2008 Clin. Exp. Immunol. 153:177-126. IF: 2,853
95. Khodoun M., Strait R., Orekov T., Hogan S., Debroski H., Köhl J.; Finkelman FD.
Peanuts induce shock by activating complement. 2009 J. Allergy Clin. Immunol. 123:
342-351. IF: 9,773
96. Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Köhl J. Anaphylatoxins in health
and disease. Mol. Immunol. 2009 46:2753-66. IF: 3,202
97. Zhang X., Lewkowich I.P., Köhl G., Clark J.F., Wills-Karp M., Köhl J. A protective
role for C5a in the development of allergic asthma associated with altered levels of B7H1 and B7-DC on plasmacytoid dendritic cells. 2009 J. Immunol. 182: 5123-5130. IF:
6,000
98. Esmann L. Idel C., Sarkar A., Hellberg L., Behnen M., Möller S., van Zandbergen G.,
Klinger M., Köhl J., Bussmeyer T. Phagocytosis of apoptotic cells by neutrophil
granulocytes: diminished proinflammatory neutrophil function. 2010 J Immunol. 184:
391-400. IF: 5,646
99. Weaver DJ, Reis E.S., Pandey M.K., Köhl, G., Harris, N., Gerard C., Köhl, J. C5a
receptor-deficient dendritic cells promote induction of Treg and Th17 cells. 2010. Eur
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J. Immunol. 40: 710-721. IF: 5,179
100. Bestebroer J., Aerts P.C., Rooijakkers S.H., Pandey M.K., Köhl J., van Strijp J.A., de
Haas C.J. Functional basis for complement evasion by staphylococcal superantigen-like
7. 2010. Cell Microbiol. 12: 1506-1516. IF: 5,725
101. Hashimoto M., Hirota K., Yoshitommi H., Maeda S., Teradaira S., Akizuki S., PrietoMartin P., Nomura T., Sakaguchi N., Köhl J., Heymann B., Takahashi M., Fujita T.,
Mimori T., Sakaguchi S. Complement drives Th17 cell differentiation and triggers
autoimmunity. 2010 J. Exp. Med. 207:1135-1143. IF: 15,219
102. Fritsche L.G., Lauer N., Hartmann A., Stippa S., Keilhauer C.N., Oppermann M.,
Pandey M.K., Köhl J., Zipfel P.F., Weber B.H., Skerka C. An imbalance of human
complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for agerelated macular degeneration (AMD). 2010 Hum Mol Genet. 19:4694-4704. IF: 7,386
103. Zhang X, Köhl J. A complex role for complement in allergic asthma. Expert Rev. Clin.
Immunol. 2010 6: 269-77. IF: 5,646
104. Karsten CM and Köhl J. The complement receptor CD46 tips the scales in TH1 selfcontrol. Nat Immunol. 2010 11:775-777. IF: 26,199
105. Zhang X., Schmudde I., Laumonnier Y., Pandey M., Clark J.F., König P., Gerard N.P.,
Gerard C., Wills-Karp M., Köhl J. A critical role for C5L2 in the pathogenesis of
experimental allergic asthma 2010 J. Immunol. 185:6741-6752. IF: 5,646
106. Tsuboi N, Ernandez T, Li X, Nishi H, Cullere X, Mekala D, Köhl J, Lee DM, Mayadas
TN. Human neutrophil FcRIIA regulation by C5aR promotes inflammatory arthritis in
mice. 2011 Arthritis & Rheum. 63:467-478. IF: 7,332
107. Reis S. E., Lange T., Köhl G., Hermann A., Tschukalow A.V., Naujoks J., Born J.,
Köhl J. Sleep and circadian rhythm regulate circulating complement factors and
immunoregulatory properties of C5a. Brain Behav. Immun. 2011 25:1416-1426. IF:
5,061
108. Raby A-C., Holst B., Davies J., Colmont C., Laumonnier Y., Coles B., Shah S., Hall J.,
Topley N., Köhl J., Morgan B.P., Labeta M.O. Toll-like receptor activation enhances
C5a-induced pro-inflammatory responses by negatively modulating the second C5a
receptor C5L2. Eur. J. Immunol. 2011 41:2741-2752. IF: 5,179
109. Laumonnier Y., Schmudde I., Köhl J. The role of complement in the diagnosis and
management of allergic rhinitis and allergic asthma. Curr Allergy Asthma Rep. 2011
11:122-130. IF: 2,75
110. Fusakio M.E., Mohammed J.P., Laumonnier Y., Hoebe K., Köhl J.*, Mattner J*. C5a
regulates NKT and NK cell function in sepsis. J. Immunol. 2011 187:5805-5812.
*denotes equal contribution. IF: 5,646
111. Strait R.T., Hicks W., Barasa N., Mahler A., Khodoun M., Köhl J., Stringer K., Witte
D., Van Rooijen N., Susskind B.M., Finkelman F.D.. MHC class I-specific antibody
binding to nonhematopoietic cells drives complement activation to induce transfusionrelated acute lung injury in mice. 2011 J. Exp. Med. 208:2525-2544. IF: 15,219
112. King B.C., Nowakowska J., Karsten C.M., Garred P., Köhl J., Renström E., Blom
A.M. Thioredoxin-1 and its truncated form, Trx80, have opposing inhibitory and
activating properties for human complement. 2012 J. Immunol. 188:4103-4112. IF:
5,646
113. Oefner C.M., Winkler A., Hess C., Lorenz A.K., Holecska V., Huxdorf M., Stoehr
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A.D., Schoen A-L., Van D.V., Schommartz T., Darcan Y., Blacnhard V., Schmudde I.,
Laumonnier Y., Ströver H.A., Hegazy A.N., Eiglmeier S., Schoen C.T., Mertes
M.M.M., Loddenkemper C., Hamelmann, E., Löhning M., Köhl J., Hutloff A., Berger
M., Wardemann H., Ehlers M. Tolerance induction with T cell-dependent protein
antigens induces regulatory sialylated IgGs. 2012 J. Allergy. Clin. Immunol. 129:16471655. IF: 11,003
114.Kasperkiewicz M, Nimmerjahn F, Wende S, Hirose M, Iwata H, Jonkman MF,
Samavedam U, Gupta Y, Möller S, Rentz E, Hellberg L, Kalies K, Yu X, Schmidt E,
Häsler R, Laskay T, Westermann J, Köhl J, Zillikens D, Ludwig RJ. Genetic
identification and functional validation of FcgRIV as key molecule in autoantibodyinduced tissue injury. 2012 J Pathol. 228:8-19. IF: 6,318
115.Karsten C.M., Pandey M.K., Figge J., Taylor P.R., Rosas M., McDonald J.U., Berger
M., Petzold D., Blacnhard V., Winkler A., Hess C., Reid D.M., Majoul I.V., Strait
R.T., Harris N.L., Köhl G., Nimmerjahn F., Finkelman F.D., Brown G.D., Ehlers M.,
Köhl J. Galactosylated IgG1 links FcRIIB and Dectin-1 to block complementmediated inflammation. 2012 Nat. Med. 18:1401-1406. IF: 28,054
116.Reis S.E., Chen H., Sfyroera G., Monk P.N., Köhl J., Ricklin D., Lambris J.D. C5aRdependent cell activation by physiological concentrations of C5adesArg: insights from
a novel label-free cellular assay. 2012 J. Immunol. 189:4797-4805. IF: 5,646
117.Karsten CM and Köhl J. The immunoglobulin, IgG Fc receptor and complement
triangle in autoimmune diseases. Immunobiology 2012 217: 1067-1079. IF: 3,180
118.LeFriec G., Sheppar D., Whiteman P., Karsten C.M., Shamoun S., Laing A., Bugeon
L., Dallman M.J., Melchionna T., Chillakuri C., Smith R.A., Couzi L., Fremeau-Bacchi
V., Köhl J., Waddingtaon S.N., McDonnell J.M., Handford P.A., Baker A., Lea S.M.,
Kemper C. The CD46-Jagged1 interaction is critical for human TH1. 2012 Nat.
Immunol. 13:1213-1221. IF: 26,199
119.Schmudde I., Ströver, J.A., Vollbrandt T., König P., Karsten C.M., Laumonnier Y.,
Köhl J. C5a receptor signaling in dendritic cells controls the development of
maladaptive Th2 and Th17 immunity in experimental allergic asthma. 2013 Mucosal
Immunol. 6:807-825. IF: 7,537
120.Le Friec G., Köhl J., Kemper C. A complement a day keeps the Fox(p3) away. Nat.
Immunol. 2013 14:110-112. IF: 26,199
121.Ludwig R.J., Kalies K., Köhl J., Schmidt E., Zillikens D. Emerging treatments for
pemphigoid disease. Trends Mol. Med. 2013 19:501-512. IF: 9,571
122.Kemper C. and Köhl J. Novel roles for complement receptors in T cell regulation and
beyond. Mol. Immunol. 2013 56:181-190. IF: 4,185
123.Hess C., Winkler A., Lorenz A.K., Holecska V, Blanchard V., Eiglmeier S., Schoen AL., Stoehr A.D., Petzold D., Schommartz T., Fischer M.M.M., Schoen C.T., Herrmann
A., Köhl J., Madaio M.P., Berger M., Wardemann H., Ehlers M. T cell-independent B
cell activation induces immunosuppressive sialylated IgG antibodies. 2013 J. Clin.
Invest. 123:3788-3796. IF: 13,765
124.Stemerding A.M., Köhl J., Pandey M.K., Kuipers A., Leusen J., Boross P., Nederend
M., Weersink A.Y.L., van de Winkel J.G.J., van Kessel K.P.M., van Strijp J.A.G..
Staphylococcus aureus formyl peptide receptor-like 1 inhbitor (FLIPr) and its
homologue FLIPr-like are potent FcR anagonists that inhibit IgG-mediated effector
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functions. 2013 J. Immunol. 191:353-362. IF: 5,362
125.Asgari E., Le Friec G., Yamamoto, H., Perucha E., Sacks S.S., Köhl J., Cook H.T.,
Kemper C.. C3a modulates IL-1ß secretion in human monocytes by regulating ATP
efflux and seubsequent NLRP3 inflammasome activation. 2013 Blood 122:3473-3481.
IF: 9,775
126.Schmudde I., Laumonnier Y., Köhl J. Anaphylatoxins coordinate innate and adaptive
immune responses in allergic asthma. Semin. Immunol. 2013 25:2-11. IF: 5,926
127.Iwata H., Bieber K., Tiburzy B., Chrobok N., Kalies L., Shimizu A., Leineweber S.,
Ishiko A., Vorobyev A., Zillikens D., Köhl J., Westermann J., Seeger K., Manz R.,
Ludwig R.J.. B cells, dendritic cells, and macrophages are requried to induce an
autoreactive CD4 helper T cell response in experimental epidermolysis bullosa
acquisita. 2013 J. Immunol. 191:2978-2988. IF: 5,362
128.Karsten C.M., Laumonnier Y., Köhl J. Functional analysis of C5a effector responses in
vitro and in vivo. Methods Mol. Biol. 2014 1100:291-304.
129.Chen H., Assmann J.C., Krenz A., Rahman M., Grimm M., Karsten C.M., Köhl J.,
Offermanns S., Wettschurek N., Schwaninger M.. HCA2 mediates the protective effect
of dimethyl fumarate in experimental autoimmune encephalomyelitis. 2014 J. Clin.
Invest. 124:2188-2192. IF: 13,765
130.Schmitz V., Almeida L. N., Svensjö E., Monteiro A.C., Köhl J., Scharfstein J. C5a and
bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma
cruzi infection. 2014 J. Immunol. Sep 3. pii: 1302417. [Epub ahead of print] IF: 5,646
131.Schulze F.S., Beckmann T., Nimmerjahn F., Ishiko A., Collin M., Köhl J., Goletz S.,
Zillikens D., Ludwig R., Schmidt E.. FcRIIB, FcRIII and FcRIV mediate tissue
destruction in experimental bullous pemphigoid. 2014 Am. J. Pathol. 184:2185-2196.
IF: 5,205
132.Strait R.T., Posgai MT, Mahler A., Barasa N., Jacob C.O., Köhl J., Ehlers M, Stringer
K., Shanmukappa SH, Witte D., Hossain M, Khodoun M, Herr AB, Finkelman F.D.
IgG1 protects against renal disease in a mouse model of cryoglobulinemia. 2014 Nature
Nov 2. doi: 10.1038/nature13868. [Epub ahead of print] IF: 42,351
133.Engelke C., Wiese A., Schmudde I., Ender F., Ströver H.A., Vollbrandt T., König P.,
Laumonnier Y., Köhl J.. Distinct roles of the anaphylatoxins C3a and C5a in dendritic
cell-mediated allergic asthma. 2014 J. Immunol Oct 29. pii: 1400080. [Epub ahead of
print]. IF: 5,646
BOOKS:
Book chapters
1.
Bitter-Suermann D, Köhl J. Inflammation-promoting complement fragments. In: Albert
ED, von Boehmer H, Dierich MP, Du Pasquier L, Eichmann K, Gemsa D, Götze O,
Kalden JR, Kaufmann SHE, Kirchner H, Resch K, Riethmüller A, Schimpl A, Sorg C,
Steinmetz M, Wagner H, Zachau HG (eds.), Progress in Immunology Vol. VII Proceedings of the 7th international Congress of Immunolgy. Berlin, Springer-Verlag,
1989, pp. 186-193.
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2.
Dwenger A, Nerlich ML, Pape HC, Schweitzer G, Köhl J, Sturm JA. The effects of
prostaglandin E1 on nonspecific immune components, complement activation, lung
functions, and the hemodynamics of multiple traumatized patients at risk for ARDS. In:
Hartel W (ed.) Chirurgisches Forum f. experim.u.klinische Forschung. Proceedings of
the 108. Tagung der Deutschen Gesellschaft für Chirurgie. Springer Verlag, Heidelberg,
1991, pp.355-358
3. Köhl J. and Bitter-Suermann D. Anaphylatoxins. In: Whaley K, Loos M, Weiler JM
(eds.) Complement in Health and Disease, Kluwer Academic Publishers, Dordrecht,
1993, pp. 299-324.
4. Köhl J. Anaphylatoxins. In: Dodds A, Sim B (eds.) Complement: A Practical
Approach, Oxford University Press, Oxford, 1997, 135 - 163.
5. Bitter-Suermann D, Köhl J. Komplementsystem. In Gemsa D, Kalden JR, Resch K.
(eds.) Immunologie , 4. Auflage, Georg Thieme Verlag, Stuttgart, New York, 1997, 70 86.
6. Hultschig C., Baensch M., Köhl J., Frank R. Mutilplexed affinity sorting and analysis
of libraries on libraries: application to protein design and proteome research. In: Epton
R. (Ed.). Innovation and perspectives in solid phase synthesis & combinatorial libraries,
Mayflower Worldwide Ltd., Birmingham, U.K.. 2000, pp. 7 –10.
7. Wills-Karp M., Köhl J., Karp C.L. Complement factor 5 and asthma. In: Therapeutic
targets for airway inflammation: Ed. Eissa N.T., 9, 2003, New York. Vol 177: 699-713.
8. Hawlisch H., Wills-Karp M., Karp C.L, Köhl J. The complex roles of anaphylatoxins
in allergic asthma and autoimmune diseases. In: Complement in Health and Disease,
Ed. Janos Szebeni, Kluwer Academic Publishers, Boston, 2004 pp. 315-344.
9. Köhl J. Self, Non-Self and Danger: a complementary view. In: |Adv. Exp. Med. Biol.
Kluwer Academic/Plenum Publishers, 2006, 586:71-94.
10. Karsten C.M. and Köhl J. Cross-talk between antibodies, IgG Fc receptors and the
complement system. In: Molecular and cellular mechanisms of antibody activity. Ed.
Falk Nimmerjahn, Springer 2013 pp. 159-187.
11. Lindorfer, M.A., Köhl J., Taylor R.P. Interactions between the complement system and
antibody Fc: linking adaptive and innate immunity. Eds. Margaret E.
Ackermann and Falk Nimmerjahn, Elsevier 2013, pp. 49-74
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June 23-26 CS1 Session A-8:30 LGI 1 2 3 4 5 6 7 8 9 10 11 Class