MEETING VENUE Dear Colleagues, The pursuit of translational medicine is the conversion of scientific discovery into health improvement, one of the priority of biomedical science in 21st century. The main goal of this meeting is to bring together clinicians, research scientists and industry partners for discussing the medical advances from the laboratory to the clinic. For this reasons, The Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) is pleased to invite you to attend the “3rd Conference on translational medicine on pathogenesis and therapy of immune-mediated diseases” to be held at Humanitas Congress Center in Milan (Italy) from September 29th until October 1st, 2014. This third edition of the workshop has a particular focus on inflammation and innate immunity responses that, as first lines of defense in several models of human diseases, play a key roles in the pathogenesis of cancer, autoimmune diseases, inflammatory bowel disorders and viral infections. Indeed, the elucidation of host’s inflammatory responses within the innate immune compartment is a required experimental step for the development of novel and alternative therapeutic strategies to cure these diseases. As occurred in the two past editions of this workshop, you will experience a high quality scientific program with the presence of word renowned national and international speakers that will discuss the latest advances in their fields. The meeting will be opened by a lecture given by Jules Hoffmann (awarded with the Nobel Prize for Medicine in 2011) and will be closed by another lecture delivered by Robert Gallo. We have also scheduled a satellite symposium on Next Generation Sequencing and Transcriptome, a current hot topic in the field of molecular immunology. Moreover, there will be two lunchonseminars dedicated to the role of the pathologist in translational immunology and to the novel therapeutic approaches with cancer stem cells. Finally, the current state of the art in the field of biomedical research in Italy and the funding opportunities available for young scientists will be discussed in a round table with expert in the fields and grant officers from both public and private funding agencies. Intensive social and interactive programs (happy hours, coffee breaks, poster sections with open bar, round table, scientific exchanges with pioneers in the fields of translational immunology, etc) are thought to enforce scientific networks for young scientists. The detailed program is available on our web site. The meeting is supported by University of Milan, the European Federation of Immunological Societis (EFIS), Society for Leukocyte Biology (SLB), Associazione Italiana per la Ricerca Sul Cancro (AIRC) and Humanitas Research Hospital. Several travel awards from SIICA, SLB, AIRC and EFIS are available for young scientists below 40 years old. We invite you to actively participate to our meeting by submitting abstracts that will contribute to improve the level of our scientific program and advance our knowledge in the field. Hoping to see you in Milan HUMANITAS CONGRESS CENTRE Via Manzoni, 113 - Rozzano - Milan SCIENTIFIC SECRETARIAT Marco Cassatella | University of Verona, Italy Carmelo Carlo Stella | University of Milan, Humanitas Research Hospital, Milan, Italy Silvio Danese | Humanitas Research Hospital, Milan, Italy Marco Gattorno | Institute Giannina Gaslini, Genova, Italy Pietro Invernizzi | Humanitas Research Hospital, Milan, Italy Massimo Locati | University of Milan, Humanitas Research Hospital, Milan, Italy Enrico Lugli | Humanitas Research Hospital, Milan, Italy Luis Montaner | Wistar Institute, Philadelphia, PA, USA Antonino Spinelli | Humanitas Research Hospital, Milan, Italy Anna Villa | National Research Council, Humanitas Research Hospital, Milan, Italy ORGANIZING SECRETARIAT MATERIA PRIMA T. 03631848776 - F. 03631920301 www.materia1a.it - [email protected] www.translationalimmunology.it TRAVEL AWARDS 4 SIICA travel awards of € 500 for young SIICA members - under 40 years old 4 AIRC travel awards of € 500 for young scientist - under 40 years old 1 JLB travel award of $ 1.000 for the best presentation that will be invited to be published on the journal following a peer-review Workshop SIICA Italian Society of Immunology Clinical Immunology and Allergology Milan | SEPTEMBER 29th - 30th, OCTOBER 1st - 2014 www.translationalimmunology.it 3RD CONFERENCE of translational medicine on pathogenesis and therapy of immune-mediated diseases A meeting aimed to enhance synergic interactions between scientists and physicians working in the field of clinical and experimental immunology Focus on inflammation EFIS travel awards for young scientist - under 40 years old CHAIRMAN OF THE MEETING Domenico Mavilio University of Milan Humanitas Research Hospital, Milan, Italy DEADLINES Chairman of the meeting JUNE 15th, 2014 Deadline for abstract submission and registration with discounted rate JULY 15th, 2014 Confirmation of abstract acceptance for both poster and oral presentation In collaboration with MONDAY, SEPTEMBER 29th 2014 Early Afternoon SATELLITE SYMPOSIA ON NEXT GENERATION SEQUENCING AND TRANSCRIPTOME Supported by Illumina and Charles River Speakers: - Dave Delano, Senior Product Manager Illumina, San Diego, CA, USA Illumina solutions for trascriptomics - Yann Herault, IGBMC, Inserm, Strasbourg, France Mouse phenogenomics to evaluate transcriptome-driven hypothesis - Enzo Medico, Candiolo Cancer Institute and University of Torino, Italy Analysis of tumor-stroma interactions by species-specific transcriptional profiling of patient-derived xenografts - Raffaele Calogero, University of Torino, Italy Circulating non-coding RNA as Biomarker in Human Diseases Open and Welcome Ceremony Domenico Mavilio, Humanitas Research Hospital and University of Milan, Milan Italy OPENING LECTURE Chairman: Alberto Mantovani, Humanitas Research Hospital and University of Milan, Milan Italy Speaker: Jules Hoffmann, University of Strasbourg, France, Nobel Prize for Medicine in 2011 Toll Like Receptors and Innate Immune responses Welcome Reception and Italian Happy Hours for all participants TUESDAY, SEPTEMBER 30th 2014 WEDNESDAY, OCTOBER 1st 2014 Morning Session IMMUNITY, AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES Chairmen: Marco Gattorno, Istituto Giannina Gaslini, Genova, Italy Pietro Invernizzi, Humanitas Research Hospital, Milan Italy Speakers: - David Adams, University of Birmingham, UK Primary Sclerosing Cholangitis: an autoimmune disease driven by the gut - Ansgar W. Lohse, University Medical Center, Hamburg, Germany Pathogenesis of autoimmune hepatitis: too little or too much T reg activity? - David Jones, Newcastle University, U.K. Autoimmune liver diseases - Primary Biliary Cirrhosis - Dan Kastner, NHGRI/NIH, Bethesda, MD, USA Autoinflammatory diseases - Anna Rubartelli, IRCCS, San Martino Hospital, Genova, Italy The critical role of stress in IL-1β and regulatory cytokine production by healthy and NLRP3-mutated monocytes - Richard Siegel, NIAIMS, NIH, Bethesda, MD, USA Autoinflammatory diseases - Dirk Foell, University Hospital Muenster. Germany Autoinflammatory diseases and Rheumatoid Arthritis Four short talks (10 minutes) selected from submitted abstracts Morning Session INNATE IMMUNITY AND TUMOR IMMUNOLOGY Chairmen: Massimo Locati, Humanitas Research Hospital and University of Milan, Milan Italy Carmelo Carlo Stella, Humanitas Research Hospital and University of Milan, Milan Italy Speakers: - Adrian Hayday, King’s College, London, UK A new (and optimistic) perspective on the suppression of Tumour-Infiltrating Lymphocytes - Jo Van Ginderachter, VIB, Gent, Belgium Macrophage and dendritic cell heterogeneity in the tumor microenvironment - Vincenzo Bronte, University of Verona, Italy Myeloid suppressor cells and inflammation-driven tumors - Haribabu Bodduluri, University of Lousville, KY, USA Leukocyte networks in tumors - Ralf Küppers, University of Duisburg-Essen, Germany The role of the microenvironment in lymphoma pathogenesis - Constantine Mitsiades, Dana-Farber Cancer Institute, Boston, USA Host immune response in multiple myeloma - Dirk Foell, University Hospital Muenster. Germany Autoinflammatory diseases and Rheumatoid Arthritis Four short talks (10 minutes) selected from submitted abstracts LUNCHONSEMINAR: ROLE OF THE PATHOLOGIST IN PROJECTS OF TRANSLATIONAL IMMUNOLOGY Suported by Space Speaker: Claudio Doglioni, Istituto San Raffaele, Milan, Italy LUNCHONSEMINAR: CANCER STEM CELLS: MOLECULAR IDENTITY AND CLINICAL SIGNIFICANCE Suported by Dompè Speaker: Piero Dalerba, Stanford School of Medicine, Standford, CA, USA Afternoon Session INNATE IMMUNITY AND VIRUSES Chairmen: Luis Montaner, Wistar Institute, Philadelphia, PA, USA Enrico Lugli, Humanitas Research Hospital, Milan, Italy Speakers: - Marco Colonna, Washington University, St. Louis, MO, USA ΝΚ cells/Dendritic Cells and viruses - Michael Malim, Kings College, London, U.K HIV-1 Infection, Type-1 Interferon and Viral Restriction - Daniel Douek, VRC, NIAID/NIH, Bethesda, MD, USA Perturbing Type I Interferon Signaling in Acute SIV Infection - Julie Dechanet-Merville, CNRS, Bordeaux, France Cell stress recognition by CMV-induced gamma-delta T cells Cell stress recognition by CMV-induced gamma-delta T cells - Christian Munz, University of Zurich, Switzerland NK cells and viruses - Luigi Naldini, Istituto San Raffaele and Telethon Insitute, Milan, Italy Lentiviruses and gene therapy - Matteo Iannacone, Istituto San Raffaele, Milan, Italy In vivo imaging of antiviral immune responses in the liver Four short talks (10 minutes) selected from submitted abstracts Afternoon Session INNATE IMMUNITY AND INFLAMMATORY BOWEL DISEASES Chairmen: Silvio Danese, Humanitas Research Hospital, Milan Italy Antonino Spinelli, Humanitas Research Hospital and University of Milan, Milan Italy Speakers: - Stefania Vetrano, Humanitas Research Hospital, Milan, Italy The epithelium in IBD: a break in the wall? - Christoph Becker, Friedrich-Alexander-University, University Medical Center, Erlangen, Germany Is Crohn’s disease an immune defect or an immune excess? - Britta Siegmund, Charité – Universitätsmedizin Berlin Cross-Talk of non-immune cells and immune cells in the regulation of IBD - Nicola Gagliani, Yale University, New Haven, CT, USA The complex role of Th17 and Tr1 cells in the regulation of intestinal homeostasis - Matthieu Allez, University of Paris, France Manipulation of the innate or the adaptive immune system as a novel approach for IBD? Late afternoon ROUND TABLE: ROLE OF PRIVATE CHARITIES AND SOCIETY IN THE SUPPORT TO BIOMEDICAL SCIENCE AND YOUNG SCIENTISTS IN ITALY: THE STATE OF THE ART. Social Dinners with Live Music for all participants, Travel Award Ceremony Four short talks (10 minutes) selected from submitted abstracts CLOSING LECTURE Chairman: Domenico Mavilio, Guido Poli Speaker: Robert Gallo, Institute of Human Virology, University of Maryland, Baltimore, MD USA Pathogenesis of HIV-1 Infection Italian Happy Hours for all participants
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