Current IBiS and IGP Course Offerings Course # Title Type Instructor Course QUARTER Description IGP 405 Cell Biology CORE - Cell Biology Mitchell / Kosak Winter Structure and function of cells and their organelles. Morphological, molecular, and physiological approaches to solving cell-biological problems. IGP 442 Microbiology Core - Cell Biology Satchell Spring Structure and function, taxonomy and replication of infectious agents. Host-parasite interactions and microbial diseases. Prerequisites: IGP 405, IGP 410, and IGP 401 or equivalent. IBIS 406 Cell Biology CORE - Cell Biology Horvath Spring Biology of cell organelles including translocation of proteins through membranes, protein secretion, organelle inheritance during mitosis, membrane trafficking etc. IGP 410 Molecular Biology & Genetics CORE - Molecular Biology Klumpp Fall IGP 426 Signal Transduction and Molecular Pharmacology CORE - Molecular Biology Watterson Winter This course introduces regulatory pathways and molecular themes employed in signal transduction and their modulation by pharmacological agents. The molecular basis of diverse diseases and existing therapies for them engage the various pathways that will be covered in the course. IGP 435 Receptors and Signaling Mechanisms CORE - Molecular Biology Stern, Kiyokawa Spring Integrated discussion of different superfamilies of signaling receptors and their effectors. Pathways discussed include G-protein linked, growth factors and cytokines, nuclear receptors and transcription factors. IGP 475 Virology CORE - Molecular Biology Longnecker Spring Mechanisms of genome replication, control of gene expression, and protein functions are analyzed in RNA and DNA viruses. IBIS 402 Eukaryotic Molecular Biology CORE - Molecular Biology Morimoto Fall Genome and gene structure and organization; transcription and its control, aspects of signaling and developmental control of gene expression; RNA processing, translation and their regulation; DNA replication and its control; molecular analysis of disease; applications of molecular biology in biotechnology. IGP 440 Immunology Core - Systems-level Biology Fang Winter IGP 450 Tumor Cell Biology Core - Systems-level Biology Cheng, C. Spring IGP 466 Structural Basis of Signal Transduction Core - Systems-level Biology Freymann Spring IBIS 404 Principles and Methods of Animal Development CORE - Systems-level Carthew Biology IGP 401 Biochemistry CORE - Biophysics Prakriya / He IGP 465 Macromolecular Structure and Function CORE - Biophysics Freymann Winter IBIS 401 Molecular Biophysics CORE - Biophysics Mondragón Spring Winter Fall Topics in molecular biology and the mechanisms of gene and cellular regulation. Prerequisites: Past or simultaneous enrollment in IGP 401 or equivalent. An integrated view of contemporary immunology: antigens, antibodies, humoral and cell-mediated immune responses, cellular interactions, and regulation of immune responses. Basic aspects of the neoplastic phenotype, including morphologic, biochemical, genetic, cytogenetic, and other features; regulation of cell proliferation and differentiation; basic concepts in molecular mechanisms of chemical, viral, and radiation carcinogenesis; solid tumor growth, progression, and metastasis; tumor immunology. The structural and thermodynamic basis by which protein- protein or protein-nucleic acid interactions mediate signal transduction. Signaling pathways used to explore how the structural biological mechanisms underlying these pathways can be experimentally determined and understood. Offered every other year, on even years Major concepts of embryogenesis in model animals; axis formation; cell-to-cell signaling; tissue patterning; stem cells. Emphasis on experimental principles. Structures and properties of proteins, nucleic acids, and polymers, complex and simple carbohydrates, and lipids; thermodynamic principles applied to biologic systems; molecules; structural correlates and functional expressions. Selected topics in the structure and function of proteins and nucleic acids; conformational studies of GTP binding proteins and kinases, enzyme mechanisms and active site ligands, structural basis of protein DNA interaction, catalytic RNA. Offered every other year, on odd years Protein and nucleic acids structure; forces that determine macromolecular structure; transport and diffusion; macromolecular assemblies; molecular machines and single molecule studies; x-ray crystallography; electron microscopy and image reconstruction; nuclear magnetic resonance; spectroscopy Current IBiS and IGP Course Offerings General principles of drug action at the molecular level. Topics: receptor theory, drug metabolism, pharmacokinetics, drug discovery, pharmacology of various important classes of therapeutic agents. Offered every other year, on odd years IGP 420 Molecular Basis of Drug Action Core - Quantitative Biology Silinsky IBIS 410 Quantitative Biology CORE - Quantitative Biology Marko IGP 430 Genetics CORE - Genetics Urbanek Winter IBIS 403 The Human Proteome CORE - Genetics Kelleher Winter IGP 403 Advanced Immunology ELECTIVE Bryce IGP 422 Introduction to Translational Research ELECTIVE Schnaper Su 12 IGP 425 Topics in Drug Discovery ELECTIVE Watterson Fall IGP 433 Advanced Microbial Pathogenesis ELECTIVE Seifert Winter IGP 456 Topics in Developmental Biology ELECTIVE Kluppel Fall IGP 462 Eukaryotic Molecular Biology ELECTIVE Thimmappaya Fall Structure and expression of genetic information in eukaryotic organisms, emphasizing chromosome structure and replication, genomic organization, nuclear events involved in RNA synthesis, and transcriptional and translational control mechanisms. Prerequisites: IGP 410 or equivalent. IGP 480 Molecular Mechanisms of Carcinogenesis ELECTIVE Green Fall Current literature relating experimental approaches and recent discoveries in the fields of cell biology, virology, and molecular genetics to mechanisms of carcinogenesis. Advanced level. IGP 495 Science and Society ELECTIVE Hockberger R. Miller Winter Exploration of the foundations of modern science and discussion of how these ideas impact social issues in the biomedical sciences (creationism, abortion, euthanasia, eugenics, cryogenics, replacement therapies, animal rights). IBIS 408 Fundamentals of Macromolecular Crystallography and NMR ELECTIVE Radhakrishnan F12 Principles and practical applications of macromolecular crystallography and NMR in contemporary structural biology research. For advanced grad students; usually offered every other year IBIS 409 Biophysical Methods for Macromolecular Analysis Fall Principles and practical applications of biophysical methods in contemporary biological research, with an emphasis on understanding macromolecular structure and function. The techniques that will be covered include fluorescence spectroscopy (FRET and anisotropy), circular dichroism, analytical ultracentrifugation, surface plasmon resonance, single molecule techniques (optical tweezers and AFM), electron microscopy and mass spectrometry. For advanced grad students; usually offered every other year IBIS 417 IBIS 455 IGP 494 IBIS 423 Cell and Structural Biology of Alzheimer’s Disease Scientific Writing & Speaking Colloquium on Integrity in Biomedical Research Ethics in Biological Research Winter Fall Fall ELECTIVE Radhakrishnan ELECTIVE Klein Spring ELECTIVE Sontheimer Brickner Winter Required - RCR training Anderson RCR Klos Dehring Quantitative nature of a modern molecular understanding of basis of biology and the proper analysis of data. The course will have two parts, first an introduction to statistics and data analysis, and second an introduction to biophysics. Genetics of prokaryotic and eukaryotic organisms; gene regulation and variation; chromosome structure and behavior; linkage and recombination; quantitative and population genetics; biochemical and developmental genetics; and manipulation of genes in organisms, including humans. Contemporary mass spectrometry; 2-D gels; quantitative and functional proteomics; analysis of post-translational modifications;, transcript profiling; strategies and technologies for genome mapping and sequencing; the human genome; polymorphisms, SNPs and genome translocations in cancer. Paper reading and discussions on selected topics in Immunology This course is intended to introduce the basic life sciences graduate student to the thought processes involved in human disease research by providing an overview of disease processes, how they are treated, and how basic biological science is used to develop those treatments. Key precedents and contemporary topics in drug discovery research in academia and industry. Principles of drug design and action, pharmacogenetics, macromolecular target identification and characterization, bioassays and animal models of disease, study design and information management. Properties of microorganisms important in the pathogenesis genesis of infectious diseases. Emphasis on molecular aspects of virulence as they relate to host-parasite interactions. This class examines, through short lectures but primarily paper discussions, the different ways in which disrupted developmental signaling leads to birth defects. We will examine the normal and abnormal developments of multiple tissue. Seminar concerning the molecular biology of Alzheimer's disease. Fall Education in the responsible conduct of research and the applied ethics area of bioethics. Spring Education in the responsible conduct of research and the applied ethics area of bioethics.
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