Jennifer L. Mamrosh 1 1 Baylor Plaza N610, Houston, TX 77030 URL: jennifermamrosh.com E-mail: [email protected] EDUCATION 2005 - 2009 University of Minnesota- Twin Cities, Minneapolis, MN B.S. in Biochemistry; Chemistry minor 2009 - 2014 Baylor College of Medicine, Houston, TX Ph.D. in Biomedical Sciences, Department of Molecular and Cellular Biology Advisor: David D. Moore, Ph.D. Title: A conserved role of nuclear receptor LRH-1/NR5A2 in endoplasmic reticulum stress resolution. (expected) RESEARCH EXPERIENCE 2006 - 2009 Laboratory of Dr. William Engeland, University of Minnesota-Twin Cities As part of an Undergraduate Research Opportunities Program (UROP) grant, I worked to develop a rat model of stress-induced binge eating behavior for our laboratory to pursue as a new research direction for study of stress hormone physiology. Following chronic binge eating behavior, I observed novel changes in hypothalamic stress hormone release which appeared to stimulate further binge eating. Additionally, I engineered a system to allow simultaneous measurement of stress hormone release in combination with Per2- promoter driven luciferase in cultured tissue to better understand the involvement of circadian rhythmicity in endocrine homeostasis. 2008 - 2009 Laboratory of Dr. Gordon Legge, University of Minnesota-Twin Cities I assisted in the development of a spatial nagivation testing protocol and research with human subjects. I also helped develop facial navigation testing software with the goal to improve accessibility for low-vision and blind patients. 2009 - 2014 Laboratory of Dr. David Moore, Baylor College of Medicine The global focus of my thesis research was to define a novel pathway by which nuclear receptor LRH-1/NR5A2 responds to endoplasmic reticulum (ER) stress, as well as to trace evolution of this pathway. Using mouse models, I determined that LRH-1 and downstream pathway components PLK3 and ATF2 are required for ER stress resolution independent of the unfolded protein response and all other known ER stress resolution pathways. Additionally, LRH-1 agonism is beneficial in the context of ER stress and may represent a novel therapeutic approach to diabetes, neurodegenerative diseases, and other human diseases compounded by misfolded proteins. Based on strong metazoan conservation of NR5A nuclear receptors yet evolutionary divergence of most functional roles, I speculated that LRH-1 may be conserved primarily for its role in responding to misfolded protein. Through use of C. elegans, a previously unstudied model organism in our lab group, I determined that the worm LRH-1 homolog was similarly required for ER stress resolution. Aided by the multispecies approach, I also predicted an unexpected role for LRH-1 in atypical ubiquitin conjugation following proteotoxic stress. I am currently working to functionally characterize this previously unreported stress response pathway. HONORS AND AWARDS 2009 Undergraduate Research Opportunities Program (UROP) grant recipient 2010 NIDDK Molecular Endocrinology training grant recipient 2011 Outstanding Poster Award, MCB Graduate Student Symposium, Baylor College of Medicine 2012 Poster Finalist, MCB Graduate Student Symposium, Baylor College of Medicine 2013 1st Place Speaker, MCB Graduate Student Symposium, Baylor College of Medicine 2013 2013 Invited Speaker, FASEB Conference (From Unfolded Proteins in the ER to Disease) 2013 Department nominated speaker at Baylor College of Medicine’s Graduate Research Symposium 2013 Nominee from Baylor College of Medicine for Fred Hutchinson Cancer Research Center ’s Harold M. Weintraub Graduate Student Award 2014 University of Minnesota’s College of Biological Science’s “20 Under 30” 2 Departmental nominee for Deborah K. Martin Achievement Award in Biomedical Sciences, Baylor College of Medicine SERVICE 2010 - 2011 Student Temporary Advisory Committee (STAC) member, MCB Department, Baylor College of Medicine Role: To mentor incoming graduate students 2011 - 2013 Graduate Education Council (GEC) member, MCB Department, Baylor College of Medicine Role: To review and modify required graduate coursework; to recruit and make admission decisions on incoming graduate students 2011 - 2013 Mentor for NIDDK Medical Student Summer Research Program in Diabetes Role: To teach second year medical students (3 in total) basic science research skills and help prepare them to present their research at a national symposium 2012 - 2013 Website creator for David Moore’s lab 2013 2013 Rice Undergraduate Research Symposium (RURS) poster judge, Rice University IT system development volunteer, Baylor College of Medicine Role: To advise on development of a website to monitor and aid students’ progress towards a Ph.D. PUBLICATIONS 2011 Jae Man Lee, Yoon Kwang Lee, Jennifer L. Mamrosh, Scott A. Busby, Patrick R. Griffin, Manish C. Pathak, Eric A. Ortlund, David D. Moore. Antidiabetic Effects of a Novel Agonist Ligand for the Nuclear Receptor LRH-1. Nature. PMID 21614002 2014 Jennifer L. Mamrosh, Jae Man Lee, Martin Wagner, Peter J. Stambrook, Richard J. Whitby, Richard N. Sifers, San-Pin Wu, Ming-Jer Tsai, Francesco J, DeMayo, David D. Moore. Nuclear receptor LRH1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. eLife. PMID 24737860 [in preparation] Jennifer L. Mamrosh, Jane Shin, Juan P. Hernandez, Jessica Sowa, Andrew Follick, Lita Duraine, Hugo J. Bellen, Meng C. Wang, David D. Moore. A conserved role for NR5A nuclear receptors in mobilizing ubiquitin conjugation for protein degradation following proteotoxic stresses. POSTERS AND PRESENTATIONS 3 2011 (Poster) MCB Graduate Student Symposium, Baylor College of Medicine 2012 (Poster) Graduate School Student Symposium, Baylor College of Medicine 2012 (Poster) Keystone Symposia (Nuclear Receptor Matrix: Reloaded), Whistler, BC 2012 (Poster) MCB Graduate Student Symposium, Baylor College of Medicine 2012 (Presentation) MCB Research & Development Series, Baylor College of Medicine 2012 2013 (Poster) Graduate School Student Symposium, Baylor College of Medicine 2013 (Presentation) FASEB Conference (From Unfolded Proteins in the ER to Disease), Saxtons River, VT 2013 (Presentation) NIDDK Molecular Endocrinology Training Grant Symposium, Baylor College of Medicine 2013 (Presentation) Graduate School Student Symposium, Baylor College of Medicine (Presentation) MCB Graduate Student Symposium, Baylor College of Medicine INDEPENDENT LEARNING 2014 Certificate courses offered by Coursera.org: Bioinformatics Methods I, University of Toronto 2014 Bioinformatics Methods II, University of Toronto 2014 Introduction to Mathematical Thinking, Stanford University 2014 Introduction to Interactive Programming in Python, Rice University 2014 Introduction to Mathematical Philosophy, Ludwig Maximilian University of Munich 2014 2014 Introduction to Systems Biology, Icahn School of Medicine at Mount Sinai 2014 Bioinformatics: Life Sciences on Your Computer, Johns Hopkins University 2014 R Programming, Johns Hopkins University Principles of Computing, Rice University
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