www.melisacanada.com The first and only metal hypersensitivity test in Canada. More sensitive and reliable than traditional ‘patch test’ 1 • Optimized lymphocyte transformation test (LTT) • Type IV hypersensitivity test • Stimulation Index (SI) greater than 3 provides a positive result Convenient and easy for patients Over 20 years of research and experience in Europe and USA May be covered by third party plans Available at Rocky Mountain Analytical Exposure to metals in some individuals may provoke a hypersensitivity reaction and result in health problems. Risk of metal exposure in symptomatic patients: 2 80 70 60 [%] 50 40 30 20 10 0 Ni Cd Au Pd HgCI Mo Be TiO2 Pb Frequency and distribution of metal reactivity in 700 symptomatic patients. Pt List of conditions that may be associated with metal hypersensitivity Metal hypersensitivity Systemic The metals in the middle of the periodic table are called transition metals which are unstable and bind to enzymes and cell proteins. • Dental restorations include metals such as titanium, nickel, gold and mercury • Orthopedic implants use aluminum, chromium, cobalt, molybdenum and others • Jewellry, cosmetics, IUDs are other sources of metals Local • Autoimmune disorders • Systemic dermatitis • Dry mouth • Chronic Fatigue Syndrome (CFS) • Multiple Sclerosis • Oral lichen planus • Fibromyalgia (FM) • Arthritis • Burning Mouth Syndrome • CNS disturbances • Headaches • Eczema • Depression • Acne Removal of allergic metals can result in remarkable clinical improvement1 In genetically susceptible people, this binding of metals would activate the immune system and may lead to hypersensitivity and autoimmunity. Comparison of metal hypersensitivity in Comparison of Metal Hypersensitivity in patients with and without Fibromyalgia (FM).3 patients with and without FM . 3 40 35 Comparison of metal sensitivities in symptomatic vs. asymptomatic patients. 2 25 18 12 8 10 5 Symptomatic Patients (n=700) 60 21 20 15 General Population 70 Controls (n=277) 30 [%] 80 FM Patients (n=39) 36 10 8 4 0 Aluminum Cadmium Lead Nickel 50 [%] Comparison of nickel hypersensitivity in patients Comparison of Metal Hypersensitivity in with and without Chronic patients with and without CFS. Fatigue Syndrome (CFS).4 40 2 30 CFS Patient (n=50) 60 20 52 Controls (n=73) 50 10 36 40 0 Nickel Cadmium [%] 30 24 19 20 14 9 10 0 Female Male All Selecting the right metals panel Panel Typical User 1- Mercury & Amalgam MERCURY Dental & AMALGAM 2- Implants 3- Comprehensive IMPLANTS Orthopaedic COMPREHENSIVE Autoimmune, AUTO IMMUNE Dental, Fertility DENTAL FERTILITY Aluminum Beryllium Cadmium Calcium titanate Chromium Cobalt Copper Ethylmercury Gold Indium Inorganic Mercury Iridium Lead Manganese Methylmercury Molybdenum Nickel Niobium Palladium Phenyl mercury Platinum Silver Thimerosal Tin Titanium dioxide Titanium Sulphate Vanadium Zirconia * Ask for pricing References 1. Stejskal V, Hudecek R, Stejskal J, Sterzl I. Diagnosis and treatment of metal-induced side-effects. Neuro Endocrinol Lett 2006; 27 (Suppl 1): 7-16 2. Valentine-Thon, E. Muller,K. et al. LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Neuro Endocrinol Lett 2006; 27(Suppl 1):17-24. 3. Shanklin, D., Stevens, V, Hall, M., and Smalley, D. Enviromental immunogens and T-cell-mediated responses in fibromyalgia; evidence for immune dysregulation and determinants of granuloma formation. Experimental and Molecular Pathology 2000; 69:102-118. 4. Marcusson, J., Lindh, G., and Evengard, B. Chronic fatigue syndrome and nickel allergy. Contact Dermatitis 2007; 40(5):269-272. www.melisacanada.com www.melisacanada.com Rocky Mountain Analytical Changing lives, one test at a time www.rmalab.com MEL.DA.01