PROGRAM

2nd International ALA and Porphyrin Symposium (IAPS2)
~PROGRAM~
Date: November 15-16, 2014
Location: Lecture Hall, 1st Building, The Institute of Medical Science, The University of Tokyo
November 15, 2014
9:45-10:15
10:15-10:45
Registration
Opening Remarks and Presentation Ceremony
Naohide Yamashita (Chairperson of IAPS2, Institute of Medical Science, Univ. of Tokyo)
Khalil Bin Ebrahim Hassan (Ambassador Extraordinary and Plenipotentiary, Bahrain to
Japan)
10:45-11:30
Opening Lecture (Chair: Kenzabro Tani)
Perspectives of Translational Research to develop Innovative Medicine in Asia
-Past, Present and FutureKen-ichi Arai, MD, PhD (Prof. Emeritus, Univ. of Tokyo, Founding President, A-IMBN,
Founder & Chairman, SBI Biotech Co. Ltd)
11:30-13:00
Lunch
Symposium 1: Translational Research in Middle East and International Cooperation
(Chair: Naohide Yamashita)
13:00-13:15
S1-1
An urgent question in medical field and a feeling of hope for strengthening of relations with
Japan in Bahrain
Mohammed A. Al-Awadhi (Kingdom of Bahrain Ministry of Health)
13:15-13:30
S1-2
R&D system and the present situation of clinical trial using ALA in Bahrain
Abdulla Darwish (Bahrain Defence Force)
13:30-13:45
S1-3
Mission and Activities of MEJ
Kenji Wada (Medical Excellence Japan)
13:45-14:00
S1-4
Internationalization of Japanese Clinical Trials
Toshiyoshi Tominaga (Pharmaceuticals Medical Devices Agency, Japan)
Symposium 2: ALA-mediated Photodynamic Diagnosis
(Chair: Taro Shuin)
14:00-14:30
S2-1
Invited Lecture
The First reported Experience in the GCC countries on the use of the new 5-ALA capsules
in the detection of Bladder Cancer
Ziad Al-Naieb (Arabian Gulf University - Bahrain)
14:30-15:00
S2-2
Aminolevulinic acid-mediated photodynamic diagnosis as a novel medical strategy for
urological malignancies
1
1
2
2
Keiji Inoue , Hideo Fukuhara , Atsushi Kurabayashi , Mutsuo Furihata , Taro Shuin
1
1
2
( Department of Urology, Department of Pathology, Kochi Medical School)
15:00-15:30
S2-3
Evaluation
of
a
New
Endoscopic
Fluorescence
Imaging
Modality
Using
Oral
5-Aminolevulinic Acid for Colorectal Tumors
Eriko So (National Cancer Center)
15:30-16:00
Coffee Break
16:00-16:30
Plenary Lecture 1 (Chair: Mamoru Nango)
Inspired by Hemoglobin: Polymer-Conjugated Porphyrins as a Super Oxygen Carrier
Hiroyuki Nishide (Waseda Univ.)
16:30-17:00
Plenary Lecture 2 (Chair: Tohru Tanaka)
Introduction of Nanoparticles generated by Porphyrin-Lipid
Eugene Satoshi Takagi (Bio-Xcelerator K.K)
17:00-17:30
Presidental Lecture (Chair: Ichiro Okura)
The glycemic effect of 5-ALA in humans
Naohide Yamashita (Chairperson of IAPS2, Institute of Medical Science, Univ. of Tokyo)
18:00-20:00
Banquet (TOMY Hall)
November 16, 2014
9:00-9:15
Registration
Symposium 3: Novelty and Challenge in ALA Research
(Chair: Hiroshi Itoh, Daru Lu)
9:15-9:45
S3-1
5-Aminolevulinic acid improves physical performance and glucose tolerance of sarcopenic
mice through activation of muscle mitochondrial biogenesis
Hiroshi Itoh, Chikako Fujii, Kazutoshi Miyashita (Dep. of Internal Medicine, School of
Medicine, Keio University)
9:45-10:15
S3-2
Invited Lecture
Preventive and Theraputic Effects of 5-ALA plus SFC on HFD Wistar Rats
Fangfang Zhou, Hongyan Chen, Daru Lu (School of Life Sciences, Fudan University, China)
10:15-10:45
S3-3
5-Aminolevulinic acid suppresses visceral fat accumulation in obese rats with a high-fat diet
1
1
2
2
3
Yasuhiro Kido , Yasuhiro Shimamura , Izumi Horinouchi , Yoshiya Izumi , Kyoko Tsuchiya ,
4
1
1
1
Setsuko Miyanari , Yukiko Kobayashi , Masashi Kuwahata ( Graduate School of Life and
2
3
Environmental Sciences, Kyoto Prefectural University, Biomaterial in Tokyo Co. Ltd., SBI
4
Pharmaceuticals Co. Ltd., COSMO OIL Co. Ltd.)
10:45-11:15
S3-4
5-ALA administration ameliorates insulin-resistance but mitochondrial dysfunction in
5-aminolevulinate synthase 1 (ALAS1) gene-targeted heterozygous mice
1
1
1
1
Osamu Nakajima , Shinichi Saitoh , Takekazu Nohara , Nobuyuki Shirasawa , Hiroshi
1
2
2
2
1
Nakano , Kiwamu Takahashi , Tohru Tanaka , Motowo Nakajima ( Yamagata University
2
School of Medicine, Japan, SBI Pharmaceuticals Co., Ltd., Japan)
11:15-11:45
S3-5
The effect of 5-aminolevulinic acid combined with ferrous iron on obesity and diabetes
1
1
1
2
2
Takeshi Hara , Urara Ota , Hitoshi Nakagawa , Emi Tsuru , Masayuki Tsuda , Atsuko
1
1
1
1
1
1
Kamiya , Yasushi Kuroda , Yuya Kitajima , Shin Watanabe , Aya Koda , Masahiro Ishizuka ,
3
3
1
1
1
Keiji Inoue , Taro Shuin , Motowo Nakajima , Tohru Tanaka ( SBI Pharmaceuticals Co.,
2
Ltd., Institute for Laboratory Animal Research, Kochi Medical School, Kochi University,
3
Department of Urology, Kochi, Medical School, Kochi University)
11:45-13:00
Lunch
Symposium 4: New Wave Research on Photodynamic Therapy
(Chair: Sadao Kaneko, Herbert Stepp)
13:00-13:30
S4-1
Invited Lecture
ALA for stereotactic interstitial PDT of malignant glioma
Herbert Stepp (Laser-Forschungslabor, LIFE Center, University Hospital of Munich,
Germany)
13:30-14:00
S4-2
Stereotactic Interstitial PDT using Photofrin® for brain tumors
Sadao Kaneko (Kashiwaba Neurosurgical Hospital)
14:00-14:30
S4-3
Photodynamic Therapy using 5-Aminolevulinic Acid for Cervical Cancer
～From basic research to clinical trials～
Mika Mizuno (Department of Obstetrics and Gynecology, Nagoya University Graduate
School of Medicine)
14:30-15:00
S4-4
Ionizing irradiation with 5-aminolevulinic acid (ALA)-induced protoporphyrin IX：Evaluation
of delayed intracellular production of reactive oxygen species (ROS) in glioma cells in vitro
1
1
2
1
1
Junkoh Yamamoto , Takehiro Kitagawa , Tohru Tanaka , Kunihiro Ueta , Daisuke Akiba ,
1
Yoshiteru Nakano , Shigeru Nishizawa
1
1
( Department of Neurosurgery, University of
2
Occupational and Environmental Health, SBI Pharmaceuticals CO., Ltd., Tokyo, Japan)
15:00-15:30
S4-5
Invited Lecture
Apoptosis of THP-1 Macrophages Induced by Sonodynamic Therapy Using a New
Sonosensitizer Hydroxyl Acetylated Curcumin after ALA
1
1
1
1
Liming Yang , Longbin Zheng , Xuesong Li , Jiayuan Kou , Ye Tian
1,2
1
( Department of
Pathophysiology, Harbin Medical University, Harbin, Heilongjiang, China,
2
Division of
Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang,
China)
15:30-16:00
Coffee Break
Symposium 5: General presentations (held in JAPANESE)
(Chair: Keiji Inoue, Motowo Nakajima, Shun-ichiro Ogura)
16:00-16:15
S5-1
Artificial Photosynthesis System Based on the Water-Soluble Porphyrins
Yutaka Amao (Advanced Research Institute for Natural Science and Technology, and
Research Centre for Artificial Photosynthesis, Osaka City University and Precursory
Research for Embryonic Science and Technology (PRESTO), Japan Science and
Technology Agency)
16:15-16:30
S5-2
Fluorescence ability of various intra-cranial neoplasms in 5-ALA PDD: relationship among
their fluorescence appearance, spectral radiance, and cell viability
Yoshinaga Kajimoto, Ryokichi Yagi, Naoki Omura, Takahiro Fujishiro, Takashi Yoneda,
Shinji Kawabata, Toshihiko Kuroiwa (Department of neurosurgery, Osaka Medical College)
16:30-16:45
S5-3
ABCG2 inhibitor enhance the therapeutic effect of ALA-PDT against glioma stem cell
1
1
1
1
Naoki Omura , Yoshinaga Kajimoto , Takahiro Fujishiro , Naosuke Nonoguchi , Seigo
1
2,3
4
Kimura , Ichiro Nakano , Toshihisa Ishikawa , Toshihiko Kuroiwa
Neurosurgery, Osaka Medical College,
2
1
1
( Department of
Department of Neurological Surgery,
3
James
4
Comprehensive Cancer, NGO Personalized Medicine & Healthcare)
16:45-17:00
S5-4
Porphyrin Derivatives Mediated Sonodynamic Therapy on Malignant Glioma Cells in Vitro
1
2
1
1
Shogo Endo , Nobuki Kudo , Shigeru Yamaguchi , Hiroyuki Kobayashi , Shunsuke
1
1
1
Terasaka , Kiyohiro Houkin ( Department of Neurosurgery, Graduate School of Medicine,
2
and Laboratory of Biological Engineering, Graduate School of Information Science and
Technology, Hokkaido University)
17:00-17:15
S5-5
5-aminolevulinic acid-based photodymanic diagnosis for prostate
cancer: Mapping of
red-fluorescent loci in human prostate calls
1
1
2
2
Hideo Fukuhara , Keiji Inoue , Atsushi Kurabayashi , Mutsuo Furihata , Taro Shuin
1
1
2
( Department of Urology, Department of Pathology, Kochi Medical School)
17:15-17:30
S5-6
Intraoperative dynamic imaging assisted surgery using photodynamic diagnosis and
indocyanine green fluorescence
1
2
2
2
Tsutomu Namikawa , Hideo Fukuhara , Keiji Inoue , Taro Shuin , Kazuhiro Hanazaki
1
1
2
( Department of Surgery, Department of Urology, Kochi Medical School)
17:30-17:45
S5-7
Mechanism of 5-aminolevulinic acid -mediated photodynamic therapy for prostate cancer
1
2
2
2
Atsushi Kurabayashi , Hideo Fukuhara , Keiji Inoue , Taro Shuin , Mutsuo Furihata
1
1
2
( Department of Pathology, Department of Urology, Kochi Medical School)
17:45-18:00
S5-8
5-aminolevulinic acid (5-ALA) induced Photodynamic diagnosis of lymph node metastasis in
colorectal cancer
Kyoichi Harada, Yasutoshi Murayama, Yosuke Kamada, Masumi Nishimura, Yutaka Kondo,
Tomoya Hatakeyama, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Shuhei Komatsu,
Atsushi Shiozaki, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Daisuke Ichikawa,
Hitoshi Fujiwara, Kazuma Okamoto, Chouhei Sakakura, and Eigo Otsuji (Department of
Digestive Surgery, Kyoto Prefectural University of Medicine)
18:00-18:15
S5-9
PDD mediated 5-ALA for peritoneal metastasis due to advanced gastric cancer and our
attempt to conduct new Investigator initiated trial in Japan
Hisashi Hara, Tsuyoshi Takahashi, Takahiko Nishigaki, Miyazaki Yasuhiro, Tomoki Makino,
Yukinori Kurokawa, Makoto Yamasaki, Hiroshi Miyata, Shuji Takiguchi, Masaki Mori,
Yuichiro Doki (Graduate School of Medicine, Department of gastroenterological surgery,
Osaka University)
18:15-18:30
S5-10
Sonochemical internalization using 5-aminolevulinic acid enhances the cytotoxic effect of
bleomycin
1
2
3
3
4
Tomohiro Osaki , Yoshihiro Uto , Masahiro Ishizuka , Toru Tanaka , Nobuyasu Yamanaka ,
4
1
1
1
1
Tsukasa Kurahashi , Kazuo Azuma , Yusuke Murahata , Takeshi Tsuka , Norihiko Ito ,
1
1
1
Tomohiro Imagawa , Yoshiharu Okamoto ( Department of Veterinary Clinical Medicine,
2
School of Veterinary Medicine, Tottori University, Department of Life System, Institute of
Technology and Science, Graduate School, The University of Tokushima,
4
Pharmaceuticals Co., Ltd., ITO Physiotherapy & Rehabilitation)
18:30
Closing Remark
3
SBI

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