5-MeO-MiPT

5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
H3C
H3C
O
CH3
N
CH3
N
H
1. GENERAL INFORMATION
IUPAC Name:
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-methylpropan-2-amine
CAS#:
96096-55-8 (base)
Synonyms:
5-methoxy-N-methyl-N-isopropyltryptamine
Source:
DEA Reference Material Collection
Appearance:
White Powder (base)
UVmax (nm):
Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form
Chemical Formula
Molecular Weight
Melting Point ( oC)
Base
C15H22N2O
246
243.7
HCl
C15H22N2O . HCl
282
Not Determined
Latest Revision: 5/27/2014
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5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in deuterium oxide (D2O) containing TSP for 0 ppm
reference and maleic acid as quantitative internal standard.
Instrument:
Parameters:
400 MHz NMR spectrometer
Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1
H NMR: 5-MeO-MiPT; Lot SF1797; D2O; 400 MHz
Maleic acid (ISTD)
HOD
TSP
10
9
8
7
6
5
4
3
2
1
0
1 11
7.5
1
7.0
3
6.5
Latest Revision: 5/27/2014
6.0
5.5
5.0
2
3
3
4.5
4.0
3.5
3.0
Chemical
Shift (ppm)
SWGDRUG.org/monographs.htm
6
2.5
2.0
1.5
1.0
0.5
0
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5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
1
H NMR: 5-MeO-MiPT; Lot SF1797; D2O; 400 MHz
2.0
1.5
1.0
0.5
0
1
1
7.45
7.40
7.5
7.35
1
7.30
7.25
1
7.20
7.15
7.10
7.05
7.00
6.95
0.50
5.0
0.25
2.5
0
0
3
3.900
2
3.875
3.70
3.65
3.60
3.55
3.50
6
3
4
2
0.1
2
1
0
0
0
0.4
0.3
0.2
3
3.35
3.30
3.25
3
3.20
3.15
2.825 2.800
6
1.30 1.25 1.20
Chemical Shift (ppm)
3.2 Gas Chromatography/Mass Spectrometry
Sample Preparation: Dilute analyte ~ 1 mg/mL base extracted into chloroform
Instrument:
Column:
Carrier Gas:
Agilent gas chromatograph operated in split mode with MS detector
DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µm
Helium at 1 mL/min
Temperatures:
Injector: 280oC
MSD transfer line: 280oC
MS Source: 230 oC
MS Quad: 150oC
Latest Revision: 5/27/2014
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5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Oven program:
1) 100oC initial temperature for 1.0 min
2) Ramp to 300 oC at 12 oC/min
3) Hold final temperature for 9.0 min
Split Ratio = 20:1, 1 µL injected
Injection Parameters:
MS Parameters:
Mass scan range: 30-550 amu
Threshold: 100
Tune file: stune.u
Acquisition mode: scan
13.357 min
Retention Time:
6
Intensity [x 10 ]
86
EI Mass Spectrum: 5-MeO-MiPT; Lot H-0413
1.5
200
246
229
215
201
188
160
174
180
220
240
m/z
174
145
160
160
145
130
140
130
120
117
90
103
100
86
90
80
56
44
60
246
103
70
77
41
4
Intensity [x 10 ]
40
70
77
EI+
56
63
41
0.5
117
44
1.0
63
4
3
EI+
40
60
80
Latest Revision: 5/27/2014
100
120
140
160
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180
200
220
229
215
1
201
188
2
240
m/z
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5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument:
Scan Parameters:
FTIR with diamond ATR attachment (1 bounce)
Number of scans: 32
Number of background scans: 32
Resolution: 4 cm-1
Sample gain: 8
Aperture: 150
1624
2609
3037
3095
%Transmittance
FTIR ATR (Diamond, 1 Bounce): 5-MeO-MiPT; Lot SF1797
430
498
862
1065
1205
48
648
696
966
56
552
744
1360
1435
1454
1475
64
1581
2794
2831
2848
2970
72
796
40
2500
Wavenumber (cm-1)
447
525
584
552
615
744
818
430
648
862
696
498
779
914
48
877
56
1500
966
1028
1039
1065
1082
1115
1134
1167
1205
1236
1259
1435
1454
1475
64
2000
1321
1350
1360
1385
1581
72
3000
1497
1624
%Transmittance
3500
796
40
1700
1600
1500
Latest Revision: 5/27/2014
1400
1300
1200
1100
1000
900
SWGDRUG.org/monographs.htm
800
700
Wavenumber (cm-1)
Page 5 of 6
5-MeO-MiPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
4. ADDITIONAL RESOURCES
Spratley, T.K.; Hays, P.A.; Geer, L.C.; Cooper, S.D.; McKibben, T.D. Analytical Profiles for Five
"Designer" Tryptamines. Microgram Journal 2005, 3 (1-2), 54-68.
Wikipedia
http://en.wikipedia.org/wiki/5-MeO-MiPT
Latest Revision: 5/27/2014
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