Lithium and the brain David Cousins MRC Clinician Scientist Institute of Neuroscience Newcastle University RCPsych International Congress 2014 This is lithium… Locating lithium… Questions… Lithium compartments by time Hillert et al Neuroscience Letters 2012 Locating lithium… Fundamentals of MRS Fundamentals of MRS Fundamentals of MRS 1H MRS spectrum Multinuclear MRS Rudimentary 7Li MRS Renshaw and Wicklund Biological Psychiatry 1988 Rudimentary 7Li MRS Renshaw and Wicklund Biological Psychiatry 1988 Rudimentary 7Li MRS Renshaw and Wicklund Biological Psychiatry 1988 Rapid, quantitative 7Li MRS Smith et al 2012 Rapid, quantitative 7Li MRS Smith et al 2012 Rapid, quantitative 7Li MRS Smith, Cousins and Blamire, MRM 2012 Lithium MRS as an image Soares et al 2000 Lithium MRS as an image Soares et al 2000 Lithium 3D chemical shift imaging Lithium imaging in the brain of patients with bipolar disorder at 4 tesla Lee et al MRM 2012 Lithium 3D chemical shift imaging Lithium imaging in the brain of patients with bipolar disorder at 4 tesla Lee et al MRM 2012 Lithium 3D chemical shift imaging Lithium imaging in the brain of patients with bipolar disorder at 4 tesla Lee et al MRM 2012 True imaging True lithium imaging True lithium imaging 5 mM 10 mM 100 mM 25 mM 50 mM Scan duration 50 s True lithium imaging Potential advances Potential advances Steady-state free precession Incomplete dephasing T2 adds to T1 signal Short TE 7Li T2 measurement Port et al Journal of MRI 2013 Port et al Journal of MRI 2013 Short TE 7Li T2 and response Port et al Journal of MRI 2013 BRITISH ASSOCIATION FOR PSYCHOPHARMACOLOGY 40th Anniversary Online CPD Resource Summer Meeting Schizophrenia Substance misuse including comorbidity Bipolar disorder Perinatal disorders ADHD focussing on adults Depression Anxiety disorders Sleep Old Age Child and Adolescent (coming soon) 20 ̶̶̶ 23 July 2014 Cambridge www.bap.org.uk
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