For Research Use Only. Not for use in diagnostic procedures. TS-M703-P Page 1 of 2 T-Select PEPTIDE I-Ab/I-Ad OVA helper Peptide ISQAVHAAHAEINEAGR Code No. TS-M703-P Quantity 100 L Concentration 10 mg/mL For Research Use Only. Not for administration to humans, and not for diagnostic or therapeutic use. Peptide Sequence: ISQAVHAAHAEINEAGR (17 aa) Origin: Ovalbumin (OVA), 323-339 aa Please refer to the data sheet of MHC Tetramer reagent which comprises this epitope peptide and b I-A (MBL, PN TS-M710-1) for more details. HLA Restriction: I-Ab, I-Ad I-Ab OVA323-339 Tetramers Molecular Weight: 1,774 Da Purity: ≧98% Formulation: 10 mg/mL peptide solution in DMSO Mouse I-A Alleles Handle using contamination. aseptic b techniques to TS-M710-1 I-A OVA323-339 Tetramer-PE b TS-M710-2 I-A OVA323-339 Tetramer-APC avoid I-A Mouse strains C57BL/-, BXSB/Mp, 129/- Storage Conditions Store at –20°C. Repeated freeze-thaw cycles should be avoided. Background T lymphocytes play a central role in the immune system. Major histocompatibility complex (MHC) is important for T cell recognition of surface antigen. In humans, MHC is also called human leukocyte antigen (HLA). MHCs present epitope peptides derived from both self and non-self protein, and these MHC/peptide complexes are recognized by T cells + via their T-cell receptors (TCRs). In general, CD8 cytotoxic T cells (CTLs) recognize the MHC class + I/peptide complex and CD4 helper T cells recognize MHC class II/peptide complex. Epitope peptides binding to class I molecules typically consist of approximately 8 to 10 consecutive amino acid residues. Meanwhile, epitope peptides binding to class II molecules are not constrained in size and can vary from 11 to 30 amino acids long. T-Select PEPTIDE is a ready-to-use epitope peptide in liquid form and this peptide is used to produce MHC Tetramer reagent. Epitope peptides enable to stimulate CTLs in an antigen-specific manner, and also to induce T-helper immunity. Therefore, T-Select PEPTIDE series are available for T cell stimulation and expansion to examine T cell functions such as cytokine production, expression of cell surface marker, cytotoxic activity, etc. b MHC class II d I-A k I-A S I-A BALB/c, SJL/J DBA/2, C3H/He B10.S B10D2 References for OVA323-339 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) Shimonkevitz R, et al. J Immunol 133: 2067-2074 (1984) Sette A, et al. Nature 328: 395-399 (1987) Buus S, et al. Science 235: 1353-1358 (1987) Valmori D, et al. J Immunol 149: 717-721 (1992) van der Most RG, et al. J Immunol 157: 5543-5554 (1996) Scott CA, et al. Immunity 8: 319-329 (1998) Ossendorp F, et al. J Exp Med 187: 693-702 (1998) Barnden MJ, et al. Immunol Cell Biol 76: 34-40 (1998) de Cerio ALD, et al. Int Immunol 11: 2025-2034 (1999) Robertson JM, et al. J Immunol 164: 4706-4712 (2000) de Cerio ALD, et al. Int Immunol 15: 691-699 (2003) Moon JJ, et al. Immunity 27: 203-213 (2007) Landais E, et al. J Immunol 183: 7949-7957 (2009) Related Products Anti-Mouse TCR (I-Ad/OVA323-339) Antibodies K0221-3 K0221-5 anti-mouse TCR DO11.10 (KJ1.26) PE labeled anti-mouse TCR DO11.10 (KJ1.26) OVA Peptides/Helper Peptides TS-5001-P TS-M703-P TS-M701-P TS-M702-P TS-M704-P TS-M707-P TS-M708-P H-2Kb OVA peptide I-Ab/I-Ad OVA helper peptide I-Ab HBc helper peptide I-Ad Tetanus toxin p30 helper peptide I-Ab MOG peptide I-Ab ESAT-6 peptide I-Ak HEL peptide MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. URL http://ruo.mbl.co.jp e-mail [email protected] TS-M703-P Page 2 of 2 Mouse OVA Tetramers TS-M710-1 TS-M710-2 TS-5001-1C TS-5001-2C TS-M541-1 TS-M541-2 TS-M542-1 TS-M542-2 TS-M543-1 TS-M543-2 b I-A OVA323-339 Tetramer-PE I-Ab OVA323-339 Tetramer-APC H-2Kb OVA Tetramer-SIINFEKL-PE H-2Kb OVA Tetramer-SIINFEKL-APC H-2Kb OVA E1 Tetramer-EIINFEKL-PE H-2Kb OVA E1 Tetramer-EIINFEKL-APC H-2Kb OVA G4 Tetramer-SIIGFEKL-PE H-2Kb OVA G4 Tetramer-SIIGFEKL-APC H-2Kb OVA Q4H7 Tetramer-SIIQFEHL-PE H-2Kb OVA Q4H7 Tetramer-SIIQFEHL-APC Mouse class II Tetramers TS-M710-1 TS-M710-2 TS-M704-1 TS-M705-1 TS-M706-1 TS-M707-1 b I-A I-Ab I-Ab I-Ab I-Ab I-Ab OVA323-339 Tetramer-PE OVA323-339 Tetramer-APC MOG35-55 Tetramer-PE FMLV123-141 Tetramer-PE E52-68 Tetramer-PE ESAT-61-20 Tetramer-PE Pick up Tetramers TS-M501-1 TS-MCD-1 TS-MCD-2 H-2Kb -galactosidase Tetramer-DAPIYTNV-PE Mouse CD1d Tetramer–PE Mouse CD1d Tetramer–APC Kit AM-1005 IMMUNOCYTO Cytotoxity Detection Kit Others D341-4 D271-4 D271-A64 732121 K0222-3 A07704 MTG-001 mouse CD4-FITC (GK1.5) mouse CD8-FITC (KT15) mouse CD8-Alexa Fluor® 647 (KT15) mouse CD16/32 (93) anti-mouse TCR 3DT-52.5 (KJ12.98) 7-AAD Viability Dye Clear Back (Human FcR blocking reagent) T-Select Peptides TS-5002-P TS-M502-P TS-M503-P TS-M505-P TS-M506-P TS-M507-P TS-M508-P TS-M509-P TS-M510-P TS-M511-P TS-M512-P TS-M513-P TS-M514-P TS-M515-P TS-M516-P TS-M517-P TS-M518-P TS-M519-P TS-M520-P H-2Db H-2Db H-2Kd H-2Db H-2Kd H-2Kb H-2Db H-2Kb H-2Ld H-2Ld H-2Db H-2Db H-2Ld H-2Kd H-2Dd H-2Dd H-2Db H-2Ld H-2Kd LCMV gp33 peptide Influenza NP peptide Listeria LLO peptide human gp100 peptide RSV peptide MuLV peptide Influenza NP peptide SeV peptide MCMV IE1 peptide -galactosidase peptide LCMV gp33 (C9M) peptide LCMV NP396 peptide LCMV NP118 peptide malaria peptide HIV P18-I10 peptide BCG MPT51 peptide CEA peptide P815 peptide Influenza HA peptide TS-M521-P TS-M522-P TS-M523-P TS-M524-P TS-M525-P TS-M526-P TS-M527-P TS-M528-P TS-M529-P TS-M530-P TS-M531-P H-2Ld H-2Ld H-2Kb H-2Db H-2Kd H-2Kd H-2Db H-2Db H-2Kb H-2Dk H-2Dk MuLV gp70 peptide HBsAg peptide HSV-1 gB peptide HY Uty peptide EGFP peptide HER2 peptide Influenza NP peptide Influenza PA peptide VSV NP peptide polyomavirus MT peptide HTLV-1 Tax38-46 peptide T-Select Mouse Tetramers TS-5002-1C TS-M502-1 TS-M503-1 TS-M505-1 TS-M506-1 TS-M507-1 TS-M508-1 TS-M509-1 TS-M510-1 TS-M511-1 TS-M512-1 TS-M513-1 TS-M514-1 TS-M515-1 TS-M516-1 TS-M517-1 TS-M518-1 TS-M519-1 TS-M520-1 TS-M521-1 TS-M522-1 TS-M523-1 TS-M524-1 TS-M525-1 TS-M526-1 TS-M527-1 TS-M528-1 TS-M529-1 TS-M530-1 TS-M531-1 H-2Db H-2Db H-2Kd H-2Db H-2Kd H-2Kb H-2Db H-2Kb H-2Ld H-2Ld H-2Db H-2Db H-2Ld H-2Kd H-2Dd H-2Dd H-2Db H-2Ld H-2Kd H-2Ld H-2Ld H-2Kb H-2Db H-2Kd H-2Kd H-2Db H-2Db H-2Kb H-2Dk H-2Dk LCMV gp33 Tetramer-KAVYNFATC-PE Influenza NP Tetramer-ASNENMDTM-PE Listeria LLO Tetramer-GYKDGNEYI-PE human gp100 Tetramer-KVPRNQDWL-PE RSV Tetramer-SYIGSINNI-PE MuLV p15E Tetramer-KSPWFTTL-PE Influenza NP Tetramer-ASNENMETM-PE SeV Tetramer-FAPGNYPAL-PE MCMV IE1 Tetramer-YPHFMPTNL-PE -galactosidase Tetramer-TPHPARIGL-PE LCMV gp33 (C9M) Tetramer-KAVYNFATM-PE LCMV NP396 Tetramer-FQPQNGQFI-PE LCMV NP118 Tetramer-RPQASGVYM-PE malaria Tetramer-SYIPSAEKI-PE HIV P18-I10 Tetramer-RGPGRAFVTI-PE BCG MPT51 Tetramer-GGPHAVYLL-PE CEA Tetramer-EAQNTTYL-PE P815 Tetramer-LPYLGWLVF-PE Influenza HA Tetramer-IYSTVASSL-PE MuLV gp70 Tetramer-SPSYVYHQF-PE HBsAg Tetramer-IPQSLDSWWTSL-PE HSV-1 gB Tetramer-SSIEFARL-PE HY Uty Tetramer-WMHHNMDLI-PE EGFP Tetramer-HYLSTQSAL-PE HER2 Tetramer-TYLPTNASL-PE Influenza NP Tetramer-ASNENMDAM-PE Influenza PA Tetramer-SSLENFRAYV-PE VSV NP Tetramer-RGYVYQGL-PE polyomavirus MT Tetramer-RRLGRTLLL-PE HTLV-1 Tax38-46 Tetramer-ARLHRHALL-PE Please check our web site (http://ruo.mbl.co.jp) for up-to-date information on products and custom MHC Tetramers. 140806-1
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