Amir Darakhshan Pelvic Floor Disorders

Pelvic Floor Disorders
Amir Darakhshan MD FRCS (Gen Surg)
Consultant Colorectal and General Surgeon
What is Pelvic Floor Disorder
• Surgical perspective
“ symptoms of RED, FI or prolapse
on the background of PF failure ”
What is Pelvic Floor Disorder
• Pelvic Floor Failure = Structural
– Perineal descent
– Rectocoele, enterocoele, cystocoele, poor bladder neck
support
– Uterine, vaginal vault prolapse
• Rectal Evacuatory Difficulties (RED)
– ODS, RI, rectocoele, anismus, poor effort
• Incontinence
– FI, UI
• Dysmotility
– Constipation, diarrhoea, IBS
Stress MRI
What is Pelvic Floor Disorder
• Pelvic Floor Failure
– Perineal descent
– Rectocoele, enterocoele, cystocoele, poor bladder neck
support
– Uterine, vaginal vault prolapse
• Rectal Evacuatory Difficulties (RED)
– ODS( descent, RI, rectocoele), anismus, poor effort
• Incontinence
– FI, UI
• Dysmotility
– Constipation, diarrhoea, IBS
What is Pelvic Floor Disorder
• Pelvic Floor Failure
– Perineal descent
– Rectocoele, enterocoele, cystocoele, poor bladder neck
support
– Uterine, vaginal vault prolapse
• Rectal Evacuatory Difficulties (RED)
– ODS, RI, rectocoele, anismus, poor effort
• Incontinence
– FI (urge, passive), UI
• Dysmotility
– Constipation, diarrhoea, IBS
What is Pelvic Floor Disorder
• Pelvic Floor Failure
– Perineal descent
– Rectocoele, enterocoele, cystocoele, poor bladder neck
support
– Uterine, vaginal vault prolapse
• Rectal Evacuatory Difficulties (RED)
– ODS, RI, rectocoele, anismus, poor effort
• Incontinence
– FI (urge, passive), UI
• Dysmotility
– Constipation, diarrhoea, IBS
Patient Assessment -1
• History and examination
• Are symptoms primarily
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pan –enteric/colonic dysmotility
RED
Incontinence (+/- urinary)
All of above
Patient Assessment -2
• Bowel habit
• constipation, abdo distension/pain, nausea
• straining, perineal support, digitation, prolapse,
fragmented defaecation, difficulty wiping
• Obstetric
• number, 2nd stage labour, forceps, tears
• Urinary symptoms
Patient Assessment -3
• Investigations
– U&Es, TFT, Ca2+
– Colonic transit marker study, colonoscopy
– EAUS, Total Pelvic Floor US
– Anorectal physiology
– Video proctography
– Stress MRI
– Urodynamic studies (urogynaecology)
Transit Marker Study
Anatomy
EAUS
Transverse perineii
External sphincter
Internal sphincter
Video Proctogram
Sacrum
Small
bowel
Rectum
Femur
Stress MRI - Straining
Multi-compartment failure
RED
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Poor propulsive effort
Perineal descent
Rectocoele
Rectal mucosal Intussusception
Rectal prolapse
Anismus
Rectocoele
Rectal
intussusception
Rectocoele
FI - Normal Anus
• Diarrhoea
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Infection
Inflammatory Bowel
Small Bowel Resection
Tumours
Entero-enteric fistula
• Rectum
– Reduced Sensation
– Reduced Capacity
• Fibrosis
• Radiotherapy
• Resection, Proctitis
– Tumour
– Poor emptying
• Faecal impaction
• ODS
• Poor technique
FI – Abnormal Anus
• Passive
– Reduced resting
tone
– IAS atrophy
– Neurologic
Dysfunction
• Urge
– Trauma
– Obstetric anal injury
– Iatrogenic
• Stretch
• Fistula
• Haemorrhoidectomy
– Impalement
– Military
EAUS
External sphincter
Internal sphincter
Management of RED
Non-operative
• Diet, fluid intake optimisation
– Soft, bulky stool
• Exercise
• Biofeedback
– Correct toilet technique
– Perineal/vaginal splinting
– Pelvic floor exercises, balloon
expulsion
Management of FI
Non operative
• Diet fluid intake optimisation
• Medication
– Loperamide, codeine, colestyramine
– Suppostories, Enemas
– Anal plug
– Biofeedback
– Rectal irrigation: Peristeen, Qufora
Biofeedback
Balloon expulsion
Biofeedback
Anal Plug
Rectal Irrigation
Management of RED
Operative
• Rectocoele repair
• Rectopexy
– Ventral mesh
– Posterior
• STARR
Rectocoele repair
Rectocoele repair
Rectocoele repair
Rectal Intussusception
Lindsey et al
Oxford Rectal Prolapse
Grade
Rectal Prolapse
Surgical options
• Abdominal
– Effective
– Low recurrence rates
– Better improvement
in FI
– Anterior/posterior
– Open or lap
– Constipation
• Perineal
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Frail/elderly
Avoid laparotomy/GA
High recurrence
Higher FI
Low morbidity
Lower constipation
Rectopexy
Results Post Rectopexy
• Improvement in continence 80-90%
• Severe post-op constipation 50%
– “denervation inertia”
– Kinking of rectosigmoid
– Resection?
• Recurrence <5% at 5 years
• (c/f perineal procedure 18-30%)
Results Ventral Rectopexy
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Lead point of intussusception = anterior
No postero-lat mobilisation
Resolution of constipation 80%
Avoids worsening of constipation
– supports denervation inertia
– refutes kinking
• Long term function unclear
– Decreases at 12 months
STARR for ODS
STARR
Management of FI
Operative
• Restore anatomy
– Anterior sphincter repair +/- perineum
repair
– Correct prolapse/intussusception
• Rectopexy, intra-anal Delormes, STARR
– Repair rectocoele
• Transvaginal, STARR
– Bulking agents
• IAS defect, keyhole deformity
STARR - Outcome
• Improvement ODS and structure in >90% of
patients
• European STARR registry
– 2,224 patients, 12-month follow-up
– significant improvement
• obstructive defaecation score (15.8 vs. 5.8, P<0.001)
• symptom severity score (15.1 vs. 3.6, P<0.001)
• quality of life
Jayne DG et al. Stapled transanal rectal resection for obstructed defecation syndrome: one
year results of the European STARR Registry. Dis Colon Rectum 2009 July;52(7):1205-12.
STARR - Complications
• Overall - 36%
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Urgency
Bleeding
Sepsis
Staple line complications
Incontinence
Pain
rectal necrosis
rectovaginal fistula
20%
5%
4.4%
3.5%
%
<2%
<1%
<1%
Management of FI
Operative
• Restore anal function
– Artificial Anal Sphincter, Graciloplasty
• Neuromodulation
– SNS, PTNS
Anterior
Anal Sphincter Repair
Anterior
Anal Sphincter Repair - 2
Sacral Nerve Stimulation
SNS
• Minimally invasive
• Urinary incontinence
– FI/Constipation
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Implantable electrode
Electrical stimulation sacral nerve
Neuromodulation
Sub-threshold stimulation
Sacral Nerve Stimulation
• 2 stage
– Temporary/trial
– Bowel diary
– Improvement
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50-75% fully continent
>75% pts incontinence episodes halved
Improved ability to defer defaecation
Increased bowel movements
Reduced abdominal pain and bloating
SNS Permanent
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If temporary SNS successful
Fully implantable
Tined/barbed leads
IPG
Stimulation parameters
Hand-held patient controller
Sacral Nerve Stimulation
Injectable Bulking Agents
• For passive soiling/FI
– Into intersphincteric space/IAS
– Biomaterials
• PTQ
• carbon-coated beads (Durasphere(R)
• dextranomer in stabilised hyaluronic acid
(NASHA Dx)
• The Gatekeeper(™) prosthesis: solid
polyacrylonitrile cylinder
Injectable Bulking Agents
Outcomes
• Improved continence scores at 6 months
• <50% maintained improvement at 12
months
• Better results with >2 sites injected
• May require repeat treatment
• SE: Pain mainly, infection
Restore anal function