Behavioral state determines cell-type specific gamma-band

Behavioral state-dependent cell-type specific gammaband synchronization in V1 of the awake mouse
Network Level: Local Field Potential
Cellular Level: Action Potentials
PV+
Attention,
Running
(in mice)
- Low membrane
resistance
- Fast membrane
time constant
Quiet
wakefulness
Sleep
Buszaki and Draguhn, 2004
Amanda Casale, PhD
Salk Institute for Biological Studies
Callaway Lab
Do the membrane properties
of PV+ and Pyr cells allow them
to become selectively active
during different behavioral states?
Sudhof, 2008
Pyr
- High membrane
resistance
- Slow membrane
time constant
Network Level: LFP power increases in high and decreases
in low frequencies during running
Local Field Potential
Stationary
Periodogram
Low frequency
Delta
200 ms
Running
High frequency
Gamma
Cellular Level: Spontaneous firing rates increase in
PV+ and putative pyramidal cells during running
Percent Change in Firing Rate
(Running vs Stationary)
PV+
Putative Pyr
Sudhof, 2008
*
*
*
PV+
Putative Pyr
*p < 0.05 Wilcoxon Signed Rank
Network and Cellular Level: PV+ cell spiking has
increased gamma-band synchronization during running
Putative Pyr
Pairwise Phase Consistency
PV+
Stationary
Running
Frequency (Hz)
Stationary
Running
Frequency (Hz)

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