download full programme here - Haematology Association of Ireland

ANNUAL MEETING PROGRAMME
Friday 17th October 2014
08.00-09.15
09.15
Tea/Coffee/Scones
Opening of the Annual HAI Meeting – Dr Moulod El-Agnaf, President
09.30-11.15
09.30-09.40
10.30-11.10
SESSION 1 - Chairpersons: Dr John Quinn and Prof. Michael O’Dwyer
COMPREHENSIVE FISH TESTING OF SORTED PLASMA CELLS FROM 51 CONSECUTIVE
PATIENTS WITH MYELOMA
Rachel Brodie1, D O'Brien1, S Liptrop1, G Crotty2, K Perera2, D O'Keeffe3, B Hennessy4, P
Browne1, P Hayden1
1
Haematology Department, St. James Hospital , Dublin, 2Haematology Department,
Midlands Regional Hospital, Tullamore, 3Haematology Department, Limerick University
Hospital, Limerick, 4Haematology Department, Waterford Regional Hospital, Waterford
THE PREVALENCE OF CALR MUTATIONS IN A COHORT OF PATIENTS WITH
MYELOPROLIFERATIVE NEOPLASMS
Eduarda Grinsztejn1, 2, MJ Percy3, D McClenaghan3, RJG Cuthbert3, MF McMullin2, 3
1
Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
2
, Queens University of Belfast, Belfast, Northern Ireland
3
Haematology, Belfast City Hospital, Belfast, Northern Ireland
GETTING HOT UNDER THE CALR: INVESTIGATING CALRETICULIN MUTATIONS IN ADULT
AND CHILDHOOD MYELOPROLIFERATIVE NEOPLASMS
Stephen E Langabeer1, K Haslam1, C McMahon2, E Conneally3
1
Cancer Molecular Diagnostics, St. James's Hospital, Dublin, Ireland
2
Department of Haematology, Our Lady's Children's Hospital, Dublin, Ireland
3
Department of Haematology, St. James's Hospital, Dublin, Ireland
IMPORTANCE OF ACHIEVING DIALYSIS-INDEPENDENCE FOR SURVIVAL IN MYELOMAASSOCIATED RENAL FAILURE - A RETROSPECTIVE AUDIT OF MYELOMA PATIENTS WITH
DIALYSIS-DEPENDENT RENAL FAILURE AT PRESENTATION
Suzanne McPherson1, W Azam1, N Nazir1, P Thornton1, P Murphy1, J Sargent1, M Denton2,
C Magee2, P Conlon2, J Quinn1
1
Haematology department, Beaumont Hospital, Beaumont Road, Dublin 9
2
Nephrology department, Beaumont Hospital, Beaumont Road, Dublin 9
P53 EXPRESSION IN PATIENTS WITH MYELODYSPLASTIC SYNDROME AT DIAGNOSIS AND
FOLLOWING TREATMENT WITH AZACITIDINE
N Strahan, Su Wai Maung, M Jeffers, B Maguire, J McHugh, J O'Loughlin, G O'Connor, R
Desmond, H Enright
1
Haematology, Tallaght Hospital, Dublin , Ireland
ACUTE PROMYELOCYTIC LEUKAEMIA – A SINGLE CENTRE REVIEW 2003-2014
Liam Smyth1, S Langabeer2, P Hayden1, C Flynn1, PV Browne1, E Vandenberghe1, 2, L Bacon1,
E Conneally1
1
Department of Haematology, St. James's Hospital, Dublin, Ireland
2
Department of Cancer Molecular Diagnostics, St. James's Hospital, Dublin, Ireland
STATE OF THE ART LECTURE:
11.10-11.40
HAEMATOLOGICAL MALIGNANCIES AND COAGULATION – INSIGHTS AND POTENTIAL
THERAPEUTIC OPPORTUNITIES
Prof. James O’Donnell, Consultant Haematologist, St James’s Hospital, Dublin
TEA/COFFEE/POSTERS AND MEET THE SPONSORS
09.40-09.50
09.50-10.00
10.00-10.10
10.10-10.20
10.20-10.30
1
ANNUAL MEETING PROGRAMME
Friday 17th October 2014
11.40-12.25
12.25-12.45
12.45-13.45
13.45-15.25
13.45-13.55
13.55-14.05
14.05-14.15
14.15-14.25
14.25-14.35
14.35-15.25
15.25-16.00
16.00-17.00
16.00-16.15
STATE OF THE ART LECTURE – Chairpersons: Dr Catherine Flynn & Dr Jeremy Hamilton
ALLOGENEIC STEM CELL TRANSPLANT FOR MYELOFIBROSIS IN THE ERA OF JAK
INHIBITORS
Dr Donal McLornan, Consultant Haematologist, King's College Hospital NHS Foundation
Trust and Guy's and St.Thomas' NHS Foundation Trust, London
Poster Viewing (General Membership)
(SpR Trainers Meeting with Dr Catherine Flynn)
LUNCH
SESSION 3: Chairpersons: Dr Larry Bacon and Dr Brian Hennessy
VON WILLEBRAND FACTOR PLAYS A ROLE IN THE PATHOGENESIS OF EXPERIMENTAL
CEREBRAL MALARIA
Niamh O'Regan1, K Gegenbauer1, O Smyth2, J O'Donnell 1
1
Haemostasis Research Group, Institute of Molecular Medicine, Trinity College,
Dublin, 2Department of Paediatrics, OLHSC, Dublin, Ireland
PROGNOSTIC SIGNIFICANCE OF WT1 AND PRAME GENE EXPRESSION IN BONE MARROW
SAMPLES OF MDS AND AML PATIENTS TREATED WITH AZACYTIDINE
Claire Andrews1, S Moran1, N Harten2, J Quinn1, PD Thornton1,2, P Murphy1
1
Haematology Department, Beaumont Hospital, Dublin 9
2
Haematology Department, Connolly Hospital, Blanchardstown, Dublin 15
BLOOD DONOR COMPLIANCE STUDY, NORTHERN IRELAND TRANSFUSION SERVICE
Kieran G Morris, KA Maguire
1
Transfusion Medicine, Northern Ireland Blood Transfusion Service, Belfast, Northern
Ireland
ANALYSIS OF THE MUTATIONAL SPECTRUM IN AML PATIENTS DETECTED BY THE ION
AMPLISEQ AML GENES RESEARCH PANEL
Jessica Black1, Jill Kilner2, Ken Mills1, Mary Frances McMullan1, Amy Jayne McKnight2, Mark
Catherwood3, 1Blood Cancer Research Group, Centre for Cancer Research and Cell Biology
(CCRCB), Queen’s University Belfast, NI, 2Molecular Genetics, Belfast City Hospital, Belfast,
NI, 3Department of Haematology, Belfast City Hospital, Belfast, NI.
BORTEZOMIB WITH CYCLOPHOSPHAMIDE AND DEXAMETHASONE AS INITIAL
TREATMENT PRIOR AUTOLOGOUS STEM CELL TRANSPLANTATION IN MULTIPLE
MYELOMA IS EFFECTIVE, WELL TOLERATED AND DOES NOT IMPAIR STEM CELL
MOBILISATION– A SINGLE CENTRE EXPERIENCE
Khalid Saeed1, T Meenahan1, C Gibbons1, R Snedker1, M AbdelRahman1, A Hodgson2, A
Hayat1, M Murray1, G Walpole2, J Krawczyk1, M Odwyer1
1
Haematology, University College Hospital, Galway, 2Haematology, Sligo General Hospital
STATE OF THE ART LECTURE – Chairpersons: Dr Helen Enright & Dr Jeremy Sargent
TREATING CLL WITHOUT CHEMOTHERAPY
Dr Patrick Thornton, Consultant Haematologist, Beaumont Hospital, Dublin
TEA/COFFEE/POSTERS AND MEET THE SPONSORS
PRESIDENT’S SYMPOSIUM – Chairpersons: Dr Moulod El-Agnaf & Dr Eibhlin Conneally
N-LINKED GLYCANS WITHIN VON WILLEBRAND FACTOR A1A2A3 DOMAINS MODULATE
VWF CIRCULATORY CLEARANCE VIA MACROPHAGES
Jamie M O' Sullivan1, A Chion1, G Bergsson1, O Rawley1, N O' Regan1, S Keyes1, M Lavin1, T
Brophy1, JS O' Donnell1, 2, 1Haemostasis Research Group, Trinity College Dublin, Institute of
Molecular Medicine St James's Hospital, Dublin 8, 2National Centre for Hereditary
Coagulation Disorders, St James's Hospital, Dublin 8, Ireland
2
ANNUAL MEETING PROGRAMME
Friday 17th October 2014
16.15-16.30
16.30-16.45
16.45-17.00
17.00-17.10
17.10-18.00
USING MINIMAL RESIDUAL DISEASE (MRD) ANALYSIS TO DIRECT FURTHER
THERAPY FOLLOWING FOUR CYCLES OF FLUDARABINE, CYCLOPHOSPHAMIDE
AND RITUXIMAB (FCR): INTERIM ANALYSIS OF THE ICORG 07-01 STUDY
Niamh Appleby1, I Parker2, M Cahill3, G Crotty4, H Enright5, B Hennessy6, A Hodgson7, M
Leahy8, A Hayat9, E Vandenberghe1, 1St. James's Hospital, Dublin 8, 2ICORG, 3Cork University
Hospital, Cork, 4Midlands Regional Hospital, Tullamore, 5AMNCH, Tallaght, Dublin 24,
6
Waterford Regional Hospital, Waterford, 7Sligo General Hospital, Sligo
8
Limerick University Hospital, Limerick, 9Galway University Hospital, Galway
ATRA-INDUCED ACTIVATION OF AUTOPHAGY IS INTEGRAL TO ACUTE PROMYELOCYTIC
LEUKAEMIA CELL DIFFERENTIATION AND IS A POTENTIAL TARGET FOR PHARMACOLOGIC
MODULATION
Nina Orfali1,2, NP Mongan2,3, TR O'Donovan1, MJ Nyhan1, MR Cahill4, LJ Gudas2, SL
McKenna1, 1Cork Cancer Research Centre, University College Cork, Cork, Ireland
2
Department of Pharmacology, Weill Cornell Medical College, New York, USA
3
Faculty of Medicine and Health Science, University of Nottingham, Leicestershire, UK
4
Department of Haematology, Cork University Hospital, Cork, Ireland
TO CHARACTERISE STANDARD LABORATORY COAGULATION PARAMETERS AND PLASMA
THROMBIN GENERATION IN VERY PRETERM INFANTS AND TO INVESTIGATE THEIR
RELATIONSHIP TO CLINICAL OUTCOMES.
Elaine Neary1, N McCallion1, 2, B Kevane3, 4, M Cotter3, K Egan4, I Regan5, F NiAinle3,4
1
Neonatology, Rotunda Hospital, Dublin, 2Paediatrics, Royal College of Surgeons, Dublin,
3
Haematology, Rotunda Hospital, Dublin, 4University College Dublin (UCD) Conway
Institute, School of Medicine an, UCD, Dublin, 5Haematology, Our Lady's Children's
Hospital, Crumlin, Dublin, Ireland
Prof. Shaun McCann – EHA UPDATE
LIAM O’CONNELL LECTURE – Chairpersons: Dr Kieran Morris & Dr Diarmaid O’Donghaile
PATIENT BLOOD MANAGEMENT: THE EVOLUTION OF TRANSFUSION PRACTICE
Darrell Triulzi, Professor of Pathology, Director Division of Transfusion Medicine
University of Pittsburgh, Medical Director, Institute for Transfusion Medicine
18.15-19.30.
20.00
OFFICIAL POSTER VIEWING WITH REFRESHMENTS
EVENING DINNER – CLARION HOTEL, SLIGO
3
ANNUAL MEETING PROGRAMME
SATURDAY 18TH OCTOBER 2014
08.15-09.30
09.30-10.10
09.30-09.35
09.35-09.40
09.40-09.45
09.45-09.50
09.50-09.55
09.55-10.00
10.00-10.05
Tea/Coffee and Registration
SESSION 5 – Chairpersons: Dr Denis O’Keeffe & Dr Vince Jenkins
PATIENT SELF-TESTING OF INR USING U-TELL SOFTWARE, PATIENT EMPOWERMENT
WITHIN A SERVICE TECHNOLOGY FRAMEWORK
Paul F Carlin1, S Graham1, JA Ives3, JA Augusto1, J Wallace4, P Nicholl4, J McKnight3, A Agus5,
R Verghis5, B Clelland4, M McTear4, M El-Agnaf2
1
R&ampD, South Eastern Health and Social Care Trust, Belfast, 2Haematology, South
Eastern Health and Social Care Trust, Belfast, 3OPD, South Eastern Health and Social Care
Trust, Belfast, 4Faculty of Computing & Engineering, University of Ulster, Belfast, 5Statistics,
Northern Ireland Clinica Trials Unit, Belfast, Northern Ireland
SYSTEMIC THERAPY IN ACQUIRED HAEMOPHILIA A - A SINGLE INSTITUTE EXPERIENCE
Sarah Lawless1, P Das2, G Benson1
1
N. Ireland Haemophilia Centre, Belfast City Hospital, Belfast, UK
2
Department of Clinical Oncology, Belfast City Hospital, Belfast, UK
EXPOSURE OF VON WILLEBRAND FACTOR TO SHEAR SIGNIFICANTLY ENHANCES ITS
PROTEOLYSIS BY PLASMIN
Teresa M Brophy1, JS O'Donnell1
1
Haemostasis Research Group, Trinity College Dublin, Dublin, Ireland
INVESTIGATING THE TUMOUR MICROENVIRONMENT IN CHRONIC LYMPHOCYTIC
LEUKAEMIA: A ROLE FOR STAT3
Sarah Brophy1, PV Browne1,2, E Vandenberghe1,2, AM McElligott1
1
The John Durkan Leukaemia Laboratories, Institute of Molecular Medicine, Trinity College,
Dublin, 2Department of Haematology, St James's Hospital, Dublin, Ireland
TREATMENT FREE REMISSION IN CHRONIC MYELOID LEUKAEMIA - A NEW GOAL: IS THIS
POSSIBLE IN IRELAND (ROI)?
Emma M Groarke1, M Leahy1, S Langabeer2, M Ryan3
1
Department of Haematology, University Hospital Limerick, Dooradoyle, Limerick, Ireland
2
Department of Haematology, Waterford Regional Hospital, Waterford, Ireland
3
Cancer Molecular Diagnostics Laboratory, St. James's Hospital, Dublin 8, Ireland
AGE RELATED FACTOR IX CORRECTION IN SYMPTOMATIC FEMALE CARRIERS OF
HAEMOPHILIA B LEYDEN
Michelle Lavin1,2, PV Jenkins1,2, C Keenan1, M Byrne1, NM O'Connell1,2, JS O'Donnell1,2
1
National Centre for Hereditary Coagulation Disorders, St. James's Hospital, Dublin, Ireland
2
Haemostasis Research Group, Institute of Molecular Medicine, Trinity Centre for Health
Sciences, St. James's Hospital, Trinity College Dublin, Ireland
LOW MOLECULAR WEIGHT HEPARIN (LMWH) INHIBITS THROMBIN AND VEGF INDUCED
ENDOTHELIAL PERMEABILITY
Barry Kevane1,2, K Egan2, E Neary3, A Lennon4, F Ní Áinle1,2,4
1
Haematology, Rotunda Hospital, Dublin , Ireland
2
University College Dublin (UCD) Conway Institute, School Of Medicine and Medical
Science, UCD, Dublin, Ireland
3
Neonatology, Rotunda Hospital, Dublin, Ireland
4
Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
4
ANNUAL MEETING PROGRAMME
Saturday 18th October 2014
10.05-10.10
LOW UTILIZATION RATES OF NATIONAL DIRECTED UMBILICAL CORD BLOOD BANK: A
RETROSPECTIVE REVIEW OF COLLECTIONS OVER 17 YEARS (1997-2014)
Sarhar Khan1, A Walsh2, S Shaw3, R Hagan4, C Hickey5, N Gardiner6, J Crowley7, O Smith8, A
9
10
11
O'Marcaigh , D O'Donghaile , D O'Donghaile
1
2
Medical, Irish Blood Transfusion Service, Dublin, Transplant Coordinator, Irish Blood Transfusion
3
4
Service, Dublin, Tissue Bank, Irish Blood Transfusion Service, Dublin, HLA, Irish Blood Transfusion
5
Service, Dublin, HLA, Irish Blood Transfusion Service, Dublin,
6
7
Stem Cell Laboratory, St James's Hospital Dublin, Dublin, HLA, Irish Blood Transfusion Service,
8
9
Dublin, Medical, Our Lady's Children's Hospital, Crumlin, Dublin, Medical, Our Lady's Children's
10
11
Hospital, Crumlin, Dublin, Medical, Irish Blood Transfusion Service, Dublin, Medical, St James
Hospital, Dublin, Ireland
10.10-10.15
10.15-10.20
10.20-10.25
10.25-10.30
10.30-10.35
10.35-11.00
11.00-11.45
11.45-12.30
AN EIGHT COLOUR SINGLE TUBE ASSAY FOR THE SENSITIVE DETECTION OF MINIMAL
RESIDUAL DISEASE IN B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA.
Anita Dowling, S Liptrot, E Vandenberghe
1
Haematology Department, St. James's Hospital,, James's Street, Dublin 8., Ireland
INTERROGATING THE INTERACTION OF METALLIC NANOPARTICLES ON MALIGNANT B
LYMPHOCYTES UNDER STATIC AND SHEAR CONDITIONS
Laura C Kickham1,2,3, A.M McElligott2, A.P Bell3, A Prina-Mello1,3, E Vandenberge2,4, Y
Volkov1,3, P.V Browne2,4, 1Nanomedicine Group, Department of Clinical Medicine, Trinity
College Dublin, Dublin 2, 2The John Durkan Leukaemia Laboratories, Department of Clinical
Medicine, Trinity College Dublin, Dublin 2, 3Centre for Research on Adaptive
Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2, 4Department
of Haematology, St James' Hospital, Dublin 8, Ireland
INTERIM PET/CT SCANNING IN A COHORT OF IRISH PATIENTS WITH HODGKIN
LYMPHOMA DIAGNOSED 2007-2013: VALIDATION OF REPORTING AND PROGNOSTIC
VALUE
Jill Mackarel1, L Smyth4, K Perera4, G Crotty4, H O'Leary5, P Thornton6, M Ryan3, F Jackson3,
E Vandenberghe1, C Johnston2, B Hennessy3
1
Haematology, St. James Hospital, Dublin, 2Radiology, St. James Hospital, Dublin,
3
Haematology, Waterford Regional Hospital, Waterford, 4Haematology, Midlands Regional
Hospital, Tullamore, 5Haematology, University Hospital Limerick, Limerick, 6Haematology,
Connolly Hospital, Blanchardstown, Dublin, Ireland
CHARACTERISTICS, TREATMENT OUTCOMES AND SURVIVAL OF IRISH PATIENTS WITH
CHRONIC MYELOMONOCYTIC LEUKAEMIA
J McHugh, H Enright, Cathie Burke, S Wai Maung, 1Haematology, Tallaght Hospital, Dublin
Awareness of Venous Thromboembolism (VTE) Risk and Attitudes to Prophylaxis among
Ambulatory Cancer Patients.
John Holland1, Murphy CG1, 2, O’ Keeffe J2, Bird BH1, 2.
1. University College Cork, Ireland; 2. Dept of Haematology and Oncology Bon Secours
Hospital, Cork, Ireland
TEA/COFFEE/POSTERS AND MEET THE SPONSORS
STATE OF THE ART LECTURE – Chairpersons: Dr Moulod El-Agnaf and Dr Gerard Crotty
UPDATE ON UPFRONT MANAGEMENT OF MULTIPLE MYELOMA
María-Victoria Mateos, Associate Professor, Haematology, University Hospital of
Salamanca, Spain
STATE OF THE ART LECTURE: Chairperson: Dr Christine Macartney &
Dr Corrina McMahon
MDS IN THE YOUNG - ENTITIES, MECHANISM AND THERAPY
Prof. Dr. Charlotte Niemeyer, Department of Paediatric Haematology & Oncology,
University Hospital, Freiburg
5
ANNUAL MEETING PROGRAMME
Saturday 18th October 2014
12.30-12.55
Annual General Meeting
13.00-14.30
LUNCH AND QUIZ
14.30-15.35
SESSION 7 – Chairpersons: Dr Fionnuala NiAinle & Dr Kevin Ryan
14.30-14.45
FELLOWSHIP UPDATE – Dr Tony McElligott, 2012 Award Winner
14.45-15.30
STATE OF THE ART LECTURE
FIBRINOGEN AND POSTPARTUM HAEMORRHAGE
Prof. Peter Collins, Cardiff University, Wales
15.30
PRIZES AND AWARDS & CLOSE OF MEETING
Sunday 19th OCTOBER, 2014
Time: 09.30-12.30
Education Session for SpRs, Registrars & Trainees in
Haematology
Topic: TBC
6

Download Report