Programme

EBMT Severe Aplastic Anaemia
and Infectious Diseases
Working Parties
Bruno Rotoli Memorial
Joint Educational Course
29 Sept – 1 Oct 2014, Naples, Italy
Organisers: S. Cesaro, C. Dufour, A. Risitano
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Welcome address
Dear Colleagues,
On behalf of the EBMT we are very pleased to invite you to a Joint Educational Meeting of the Infectious Diseases
and the Severe Aplastic Anaemia Working Parties. Following the success of the previous Joint Educational Meetings
the program has been designed to cover the main aspects of pathophysiology, diagnosis and therapy of infectious
diseases and of bone marrow failure syndromes. These topics will include the management of bacterial, fungal and
viral infections in the setting of hematopoietic stem cell transplantations and bone marrow failure syndromes, with
specific discussion on the most burning controversies in the field. For bone marrow failure syndromes, the topics
will include the differential diagnosis of different acquired and inherited forms of aplastic anemia, the recent
insights in their treatment, including transplant and non-transplant options and their specific procedures, as well as
long-term outcome and possible complications. A dedicated section will deal with issues specific to inherited bone
marrow failure syndromes; in addition, this year we decided to offer a half-day special spot on Paroxysmal
Nocturnal Hemoglobinuria, focusing on recent insights in its pathophysiology and treatments.
The meeting includes two and half Educational Days: the first will be dedicated to Infectious Diseases and the third
to Aplastic Anemia. In between, the second day will be dedicated to PNH and to the Working Party Business
Meetings, during which relevant ongoing studies and new projects will be discussed. The Business Meetings are
open to any participant who wishes to be informed about, and to participate actively in the Working Parties. In
keeping with the scientific scope of the WPs and with the Educational purpose of the course, the meeting will give
participants the opportunity to discuss and interact with all these experts during the sessions and the social events.
The venue is the Castel dell’Ovo, in the heart of the bay of Naples. This unique setting combines the magnitude of
history with the beauty of the Neapolitan coast. There are a range of hotels and accommodation options located
conveniently for the castle, close to both the sea-front boulevard (the Neapolitan “ramblas”), and the old town
with all its historical attractions (Royal palaces, Royal theater, Plebiscito square) – great places to get a taste of the
real Naples. Registration will include all educational sessions and participation in the Working Party business
meetings (which are in parallel), as well as participation in the social program.
This stimulating scientific program will bring together the world’s leading experts in the field, who are actively
contributing to improving our knowledge in the biology and in the clinic of infectious diseases and bone marrow
failure syndromes. We look forward to seeing you in Naples for this unique and exciting course from the EBMT
Infectious Diseases and Severe Aplastic Anemia Working Parties.
This meeting is dedicated to the memory of our friend Bruno Rotoli, who actively contributed to the field of PNH
and other marrow failures for more than 30 years, and pioneered hematology and bone marrow transplantation in
Naples.
Yours sincerely,
Simone Cesaro
ID WP Chair
Carlo Dufour
SAA WP Chair
Antonio Risitano
Local Organiser
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Day 1 - Monday 29th Sept
Infectious Diseases Controversies Day
8.30-8.45
Welcome and Introduction
Session I. Bacteria and Neutropenia
8.45-9.30
Lecture: How to manage infections caused by antibiotic resistant
Gram-negative bacteria
S. Cesaro
Chair: S. Cesaro
M. Mikulska
Controversy I: Granulocyte transfusion: it is time to revalue its use?
9.30-10.00
No
D. Averbuch
10.00-10.30
Yes
S. Cesaro
10.30-10.45
Debate and remarks
10.30-11.00
Coffee break
Session II. Fungal Infection
Chair: P. Donnelly
11.00-11.45
C. Cordonnier
Lecture: How to manage mould infections in SCT patients ?
Controversy II: Is empiric approach outdated for fungal infections?
11.45-12.15
Yes
C. Cordonnier
12.15-12.45
No
T. Rogers
12.45-13.00
Debate and remarks
13.00-14.00
Lunch
Session III. Viral Infection
Chair: R. De la Camara
14.00-14.45
P. Ljungman
Lecture: How to manage CMV infection
Controversy III: Is adoptive immunotherapy for CMV really needed?
14.45-15.15
Yes
H. Einsele
15.15-15.45
No
R. De la Camara
15.45-16.00
Debate and remarks
16.00-16.15
Coffee Break
Session IV. Prevention
Chair: C. Cordonnier
16.15-16.45
O. Penack
Lecture: How to prevent infection in SCT patients?
Controversy IV: Will a protective environment still be necessary in 2020?
16.45-17.15
Yes
A. Ullman
17.15-17.45
No... or perhaps
P. Donnelly
17.45-18.00
Debate and remarks
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Day 2 - Tuesday 30th Sept
Morning – Parallel Business Meetings
Severe Aplastic Anaemia WP Business Meeting
8:30 - 12:30
Sala Compagna, Castel dell’Ovo
Infectious Diseases WP Business meeting
8:30 - 12:30
Room to be confirmed, The Royal Continental Hotel
Afternoon – A special focus on PNH
Session I. Pathophysiology and clinical presentation
Chairs: A. Risitano
and R. Peffault De
Latour
13.30-14.00
The dual pathophysiology theory 25 years later
L. Luzzatto
14.00-14.20
The International PNH Registry
H. Schrezenmeier
14.20-14.40
Diagnosis of PNH
L. Del Vecchio
14.40-15.00
PNH from the prespective of the Pediatric Haematologists
F. Timeus
15.00-15.30
Clinical manifestations and natural history of PNH
G. Sociè
15.30-16.00
Coffee break
Session II: Therapeutic options
Chairs: L. Luzzatto
and G. Sociè
16.00-16.30
Clinical impact of PNH clone(s) on AA treatment
N. Young
16.30-17.00
Allogeneic SCT in PNH
R. Peffault De Latour
17.00-17.30
Eculizumab and PNH
R. Notaro
17.30-18.00
Thrombosis and PNH
P. Hillmen
18.00-18.30
The future of complement treatment
A. Risitano
18.30-18.45
Closing
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Day 3 - Wednesday 1st Oct
Severe Aplastic Anaemia Educational Day
Chairs: C. Dufour and
R. Peffault de Latour
Session I
8.00-8.15
Opening
8.15-8.45
Pathophysiology
N. Young
8.45-9.15
Differential diagnosis of Aplastic anemia
A. Rovo
9.15-9.45
Non SCT treatment: standard immunosuppression
H. Schrezenmeier
9.45-10.15
Alternative IST and eltrombopag
A. Risitano
10.15-10.45
Coffee break
Chairs: A. Risitano and
G. Sociè
Session II
10.45-11.15
Supportive care in AA and management of moderate Aplastic Anemia
B. Hochshman
11.15-11.45
MSD HSCT for AA, indications, conditioning, GVHD prophylaxis
A. Tichelli
11.45-12.15
MUD HSCT for AA. Indications, donor selection, conditioning, GVHD
prophylaxis
A.P. Iori
12.15-12.45
Experimental HSCT for AA: haplo and cord
F. Ciceri
12.45-13.45
Lunch
13.45-14.15
Architecture clone in AA. What we learnt from the NGS
Chairs: F. Ciceri and H.
Schrezenmeier
A. Kulesekararaj
14.15-14.45
Long-term outcome after IST
G. Sociè
14.45-15.15
Long-term outcome after HSCT
A. Tichelli
15.15-15.45
Is treatment for AA in children somehow different?
S. Samarasinghe
15.45-16.10
Coffee Break
Session III
16.10-16.35
Differential diagnosis of inherited AA
Chairs: A. Tichelli and
A. Rovo
C. Dufour
16.35-17.00
Diagnosis and treatment of telomeropaties
R. Calado
17.00-17.25
SCT in FA and other inherited AA
R. Peffault de Latour
17.25-17.50
HSCT in Severe Chronic Neutropenia
F. Fioredda
17.50-18.15
Risk of SCC and other tumours in FA
E. Velleuer
18.15-18.30
Closing remarks
C. Dufour
Session IV
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Course Faculty
Dina Averbuch (Jerusalem, Israel)
Peter Hillmen (Leeds, UK)
Antonio Risitano (Naples, Italy)
Rodrigo Calado (São Paulo, Brazil)
Britta Höchsmann (Ulm, Germany)
Thomas Rogers (Dublin, Ireland)
Simone Cesaro (Verona, Italy)
Anna Paola Iori (Rome, Italy)
Alicia Rovo (Basel, Switzerland)
Fabio Ciceri (Milan, Italy)
Austin Kulasekararaj (London, UK)
Sujith Samarasinghe (Newcastle, UK)
Catherine Cordonnier (Paris, France)
Per Ljungman (Stockholm, Sweden)
Hubert Schrezenmeier (Ulm, Germany)
Rafael de la Camara (Madrid, Spain)
Lucio Luzzatto (Florence, Italy)
Gérard Socié (Paris, France)
Luigi Del Vecchio (Naples, Italy)
Johan Maertens (Leuven, Belgium)
André Tichelli (Basel, Switzerland)
Peter Donnelly (Nijmegen, Netherlands)
Malgorzata Mikulska (Genoa, Italy)
Fabio Timeus (Turin, Italy)
Carlo Dufour (Genoa, Italy)
Rosario Notaro (Florence, Italy)
Andrew Ullman (Wurzburg, Germany)
Hermann Einsele (Wurzburg, Germany)
Regis Peffault de Latour (Paris, France)
Eunike Velleuer (Dusseldorf, Germany)
Francesca Fioredda (Genoa, Italy)
Olaf Penack (Berlin, Germany)
Neal Young (Bethesda, USA)
Registration
Registration for the course can be carried out at the following weblink:
ww.ebmt.org/naples2014
Registration for participants is €200 and includes course materials, catering during the course and an informal
dinner on Tuesday 30th September.
Participants are also cordially invited to share their opinions and expertise at the separate Working Party
Business Meetings that will take place on the morning of Tuesday 30 th September from 08.30 - 12.30.
Course venue
The course will be held in the Sala Compagna of the
Castel dell’Ovo . Entrance to the Castel dell’Ovo is from
Via Eldorado - the road on top of the port wall with
access from Via Partenope.
EBMT Severe Aplastic Anaemia and Infectious Diseases Working Parties
Bruno Rotoli Memorial Educational Course
29 Sept – 1 Oct 2014
Reccommended accommodation
The EBMT has reached an agreement with the following hotel:
Hotel Royal Continental
Via Partenope, 38/44
80121 Napoli, Italy
http://www.royalgroup.it/royalcontinental
Tel: +39 081 7644614 Fax: +39 081 7644616
A limited number of superior double rooms for single use will be available to participants at the very competitive
price of €139 per night (including sales taxes but excluding local city tax of €2.50). This price includes breakfast
and wifi. These rooms can be booked on a first-come, first-served basis.
In order to reserve your room please contact the hotel on [email protected] or using the contact details
above, and quote ‘EBMT’ to access the special reduced rate.
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