ihcuekaT
ypocsnlC
:dnuorgkcaB
latceroloc
si eno
，
tub ti nac kolrevo
smalpoen
To etaulave
:evitcejbO
tnerapsnart
:gnitteS
・
yraitret
:stneitaP
eviF
ypocsnolc
gnisu
WLI
dernuh
tnerapsnart
thgiE
stsipocsonoloc
Main
outcme
:stluseR
・N
eoplasm
WLI tuohtiw
tnaerapsnart
;doh
etar
WLI
enola
puorg
nosirapmoc
desab
tnaerapsnart
smalpoen
gnisu
AFI
TH:
ypocsnolc
AFI tuohtiw
a
tnaerapsnart
noitceted
eht WLI enola
ni eht
dna
AFI+
.doh
etar
AFI+
evitaleR
TH puorg
noitceted
noiserger
model
(number
wasyltnacifingis
.1 )4 ，
P =320.0
soitar
(95%CI)
rof
wasyltnacifingis
，
]1O
fo
TH .spuorg
4. )3 sv .1 91 -39.0(
.1[ 96 .1( 50-2
desaercni
htiw
(WLI)
.dohtem
1[ 96. .1( 2-43 1.)2 ，
P<O.
wasyltnacifingis
gniam
gnisu
ni msalpoen
.])tset
on nosioP
hod
ypocsnolc
hcae detacola
(95%CI)
thgil
)2( 明+ILr
;doh
ypocsnolc
newtb
noitceted
smalpoen
gnituom
a
airt .l
)1( etihw
)3( AFI :enola
gnisu
elpitlum
diopylop
:spuorg
The ecnerefid
ni eht
htiw
delortnoc
tnaerapsnart
dna )4( AFI+TH:
(Tukey-Kram
rof talf
ot ruof
rep )tneitap
naht
)IFA(
，
dezimonar
detacola
:stnemrusa
smalpoen
gniam
fo
.stneitap
detagitsevni
detceted
rehgih
evitc，
epsorp
erw
;doh
rof noitceted
.smalpoen
dna eno-ytxis
gnisu
htiw
sdohtem
.retnec
stn・
eitaP
:enola
folatceroloc
dengised
recnac
:snoitnevretnI
foecnecseroulfotua
rof noitceted
a 2x2 lairotcaf
most elbailer
some .snoisel
eht ycacife
hod
:ngiseD
fo eht
.Y 1
desaercni
dna evitaler
by AFI noitavresbo
by
noitceted
38.1[
soitar
1( 2.)17.2-4
.]20.0
Lim，t i:α
snoit
Open lairt
AFI
:noisulcnoC
latceroloc
smalpoen
demrofep
ypocsnolc
nielgnis
htiw
naht
did lanoitnevnoc
tnearapsnart
recnac
larrefer
hod
WLI ypocsnolc
etnec
detceted
.r
yltnacifingis
tuohtiw
more
tnearapsnart
，
P =
ihcuekaT
.doh
(UMIN
lacinilC
slairT
yrtsigeR
number
，
UMIN0001473)
Y. 2
ihcuekaT
.Y 3
noitcudortnI
latceroloC
recnac
/ediwlro
dna
latceroloc
lavomer
ecnac
noitneverp
si eno
fo eht
folatceroloc
.r 2 ，3eroferhT
most
adenoms
noit，
ceted
folatceroloc
recnac
common
sesuac
secuder
fo recnac
eht ksir
folatceroloc
htaed
fo tneuqesbus
smalpoen
si yrev
tnatropmi
ni
.ytilatrom
Background
ypocsnlC
si eno
tub ti nac kolrevo
we tcepsus
some
two
them tluciffid
taht
snoisel
era nedih
htgnelevaw-trohs
.noitaticxeotohp
gniam
(WLI)
戸 On eht rehto
epocsnolc
nac pleh
noitceted
We detcudnoc
AFI
htiw
WLI tuohtiw
ot tceted
smalpoen
hod
tnaerapsnart
，
tub yeht
erw
taht
AFI
tnereffid
retteb
hod
eht cinoloc
sdlof
dna
makes
si
delortnoc
noitceted
sesu
ot
fo talf snoisel
naht
ton detaulave
nilatot
ot eht pit fo
by gninrut
tnearapsnart
yratnemlpoc
，
dezimonar
.doh
noitceted
tnearapsnart
，
gnisu
devihca
taht
by erusopxe
retteb
dniheb
，
The rehto
euqinhcet
stroper
snoisel
eavitcepsorp
tnaerapsnart
AFI delaever
，
gnituom
unknown
era talf ，
whic
.ypocsonloc
erohporoulf
，
we dezisehtopyh
eroferhT
folatceroloc
dnah
，
.sdlof
eht suoengd
did ni suoiverp
era
snoisel
si na cipocsodne
6
fo smalpoen
rof gnikolrevo
lanoitnevnoc
cinoloc
)IFA(
from
ypocsnolc
.sdlof
gnisu
dniheb
gniam
detime
rof noitceted
eht snosaer
sti ecnetsixe
snoisel
ecnecseroulfotua
cinoloc
戸 hguotlA
sdohtem
One sitaht dekolrevo
ot ezingocer
dekolrevo
thgil
most elbailer
rojam .seitilibissop
ecnecseroulfotuA
etihw
fo eht
revo
eht
nac
work
hod
.sminahce
lairt
fo smalpoen
9
ot enimretd
rehtw
naht lanoitnevnoc
rof
ihcuekaT
Y. 4
Methods
sihT
ypocsdne
yduts
tinu
was dengised
ni Osak
sa na nepo
lacideM
retneC
locotorp
was
devorpa
by eht hcraesR
yduts
dewolof
eht
CONSORT
senilediug
Network
lacinilC
slairT
lairt
rof recnaC
yduts
lacideM
dezimonar
yrtsigeR
demrofep
ta na
dna ralucsavoidraC
scihtE
dna
dna
.sesaesiD
Comite
The
.r sihT
ni ruo etnec
was deretsiger
ni eht ytisrevinU
latipsoH
，
UMINOOOI473.
(UMIN-CTR)
stnapicitraP
stneitaP
lacef
tluco
gniogrednu
dolb
gnitset
retfa cipocsodne-tsop
fi yeht
symptoms
suoicipsus
:dah
sisopylop
stneitap
sisonets
evag
netirw
demrofni
tnerapsnart
tonac
snoitacidni
:spuorg
TH:
ypocsnolc
gnisu
gnisu
WLI
htiw
ro )5( fi eht
.noitacolla
eht tcapmi
desab
erw
ypocsnolc
fo random
，
sesaesid
，
eruliaf
;ypareht
otetagitsevni
，
ehtstnapicitrap
)1( WLI :enola
)2(
llA
ni siht .yduts
retfA noitacifitarts
rof ypocsnolc
;yregrus
Masking
ngised
hod .ylsuoenatlumis
nagro
eht ecnatropmi
oetapicitrap
a 2x2 lairotcaf
erw
bowel
tnalugaocitna
and
stneitaP
)3( yrotamlfni
)4( ereves
ezilaer
，
Asignmet
ypocsnolc
，
wer .elbigile
gniogrednu
gninercs
rofecnalievrus
ro ;recnac
;recnac
tnesnoc
Design
We detpoda
yeht
derrefer
ro m 吋ro lanimodba
latceroloc
，
ro wer
taht
Study
WLI+
rof latceroloc
known
fo eavitisop
smalpoen
fo ymotcerolc
deguj
erw
folatceroloc
yhtapolugaoc
tsipocsonoloc
ruof
，
ro who
)1( ayrotsih
dna
elbatceroc-non
rofnoitagitsevni
(FOBT)
noitceser
deulcxe
lailimaf
ypocsnolc
tnearapsnart
dengisa
;doh
dna
onstsipocsonoloc
ylmodnar
WLI tuohtiw
fo AFI
a
dna
ot eht gniwolof
tnaerapsnart
)3( AFI :enola
;doh
ypocsnolc
)2(
ihcuekaT
gnisu
AFI tuohtiw
tnearapsnart
.doh
noitazimnim
was
ehtstnapicitrap
ehtstnapicitrap
wer
was
ni siht lairt
，
WA ，
USA).
The
.dengisa
ypocsnolc
by dynamic
elbat
ton devlovni
，
Redmond
spuorg
dna )4( AFI+TH:
Anoitazimodnar
who
noitaroproC
;doh
Wedetacola
.dohtem
rehcraeser
litnu
tnearapsnart
rof hcae
四
gnisu
lecxE
ecneuqes
208
AFI
gnisu
eht
mutarts
htiw
by a
rof Mac tfosorciM(
was delaecnoc
stsipocsonoloC
gnisu
gnicnalab
erp deredro
Y. 5
ot eht stsipocsonoloc
wer
ton dednilb
ot eht detacola
ni siht .lairt
Procedus
stneitaP
wer
eht
yad erofeb
:ypocsonoloc
Osak
，
)napaJ
retfa
lacituecamrahP
roirp
nevig
arebif-wol
061
yrev
，
Osak
locylg
otmnijA
Pharma
enimalopcS
Nihon
，
Tokyo
)napaJ
ro nogaculg
tsuj erofeb
02(
l( mg;
.ypocsonloc
)napaJ
was
rof eht tneitap
(EVIS
was
，
)napaJ
LUCERA
depiuqe
CV-260SL;
htiw
who
two delpuoc-egrahc
secruos
Olympus)
was
secived
ot naelc
eht
.l
，
Tokyo
，
Tokyo
Pharma
rednu
lacideM
rofnoitinifed-hgih
bowe
，
was deretsinimda
ypocsnolc
ni siht .yduts
(CDs)
desu
saletsA
Olympus)
desu
，
ro;celfiN
miehlegnI
Olympus
CLV-260SL;
gnirom
ro 731 1. 5 g
，
)napaJ
Dormicum;
CF-H260AZI;
erw
nI eht
regnirheoB
ot ogrednu
(EVIS
;P iroH
，
napJ
，
Tokyo
iasiE
detnaw
(EVIS
t，
hgil
Nipon
2( 5. mg;
，
ni 8.1 L retaw
ni 2 L retaw
G Nov;
lacituecamrahP
ta.thgin
，
Tokyo
;napocsuB
Glucagon
AFI sepocsonloc
Tokyo
tL .d ，
mg;
Midazolam
desu
devlosid
devlosid
gnirud
lorcgaM(
mL fo retaw
lacituecamrahP
，
)napaJ
edimorblytub
etartic
ni 081
etartic
noitacidem
;S F 吋otmi
ledoY(
devlosid
(Muben;
kot evitaraperp
34 g magnesium
，
68 g magnesium
enelyhteylop
dna
mg edisones
，
dna
laem
，
)napaJ
ot ypocsnolc
teid
.noitades
smetyS
dna
The
，
oediv
，
.oC ，
srosecorp
AFI epocsonloc
WLI
dna rof
ihcuekaT
.IFA
Each
notub
noitavresbo
mode
on eht epocs
WLI+
TH ro AFI+
was dehcata
yllaitrap
WLI
dluoc
eht
and
AFI
eb nes
image
ni eht
"se“
niart
eht
segami
AFI
gnidulcni
image
eht
retfA
eht esac
detimil
.sedom
100%
ot eht
AFI
stsipocsonoloc
ypocsnolc
ni eht
eht pit fo eht
hod
9
，
by rieht
“
more
ruof
more
naht
01
seipocsonoloc
wer
ecneirepxe
and
railimaf
aerutcel
htiw
tuoba
AFI
.smalpoen
otni
sa ylkciuq
eht
cecum
gnisu
sa elbisop
l，
lastsipocsonoloc
snoisel
eht
tuohtiw
detrats
de，
tceted
pek
noitaraperp
;)noitazilausiv
，
nev
noitazilausiv
AFI
mode
etairporpa
was
)2( god
enola
dna
AFI+
，
tub we wer
tlef taht
ton
latot
fo bowel
fo lasocum
eht
cecum
ylno
sa elbisop
lA eht stsipocsonoloc
demrofep
eht
hod
sa ped
，
os taht
was detresni
was
dehsup
done
folatceroloc
cecum
同
WLI
mode.
gnikol
rof
eht yduts .noitagitsevni
wer
osla
nI
derocer
ni eht
.aera
fo lasocum
detacola
a
(D ;30461-02
The tnerapsnart
had ylsuoiverp
，
eht epocsnolc
gnihcaer
devrsbo
by gnihsup
by thgie :stsipocsonoloc
smalpoen
fo etlpmocni
く( 90%
demrofep
segami
The ytilauq
dluoc
fo htob
folatceroloc
otni
.snoisel
gnisu
dleif
(< 1
0 .)seipocsonoloc
esac
sdnoces
hod
，
ti was
noitabutni
ぺwho
nI hcae
ni a few
AFI .epocsonloc
gnitrats
wer
evif lacipyt
noitresnI
，
tnaerapsnart
，
erofeb
stsipocsonoloc
and ruof
TH puorg
erof，
ereht
dleif
image
lA serudecorp
decneirepxe
ylisae
ot eht pit fo eht
debrutsid
hcae
eb dehctiws
.eldnah
nI eht
Olympus)
nac
.Y 6
AFI
dearg
注( 90%
retfa
folaudiser
.)diulf
WLI
mode
ni eht noitautis
mucosa
ro )3( rop
nI eht stneitap
was yllacisab
ot esu eht
ot eht
tsomla(
;)noitazilausiv
noit，
avresbo
was etairporpani
ecnatsid
fo lasocum
noitcus
TH spuorg
dewola
)1( tnelecxe
sa:swolof
rof AFI noitavresbo
demrofep
yliraropmet
taht
when
eht stsipocsonoloc
.g.e(
ta eht
eht
ihcuekaT
renroc
，
ni diomgis
fo eht nolc
，
ezis
The noitacol
fo lla detceted
dna
erw
ymotcepl
was
tuoba
dradnats
desongaid
lanitsetniortsag
Measured
latoT
yramirp
diopylop
lf/ ta s
malpoen
esrvdA
stneve
wer
sisylana
ton
olatcigolotsih
dradnats
nilyxotameh
sgnidnif
Viena
and
noitacifissalc
nilatceroloc
newtb
stneve
gnidroca
rof esrvdA
eht
htiw
fo
erw
noisrev
msalpoen
WLI
dna
sa yradnoces
recnaC
etar
AFI+
TH .spuorg
noit，
ceted
detaulave
.0.3
noitceted
enola
smalpoen
ot eht lanoitaN
stnevE
，
WLI tuohtiw
，
戸61 The
rep tneitap
ot tceted
Power
ot eht
，
dna stneitap
spylop
detaulave
seiduts
5. 4 adenomas
puorg
gnidroca
erw
etar
fo
.stniopdne
etutitsnI
Common
41
eziS
nI suoiverp
enola
ot eht cipocsodne
rep )tneitap
htiw
airetirC
tneiciffus
dednilb
eht ecnerefid
，
dna esrevda
Sample
0-62.0
was
smalpoen
fostneitap
ygolnimreT
gnisu
yeht
21. ，
1
tniopdne
fo detceted
number
detcejbus
，
deispoib
Outcomes
The
(number
aisalpoen
erw
01 ，
11
wer
esuaceb
was ygolohtapotsih
lla snemiceps
ipelaileht
snoisel
fnoitagitsevni
snemiceps
Twostsigolohtapotsih
spuorg
ot eht siraP noitacifissalc
l，
la detceted
ta eht emit
The dexif
dna nisoe .gniniats
gnidroca
ylacisaB
ton demrofep
The ecnerefer
detacola
epyt
.detnmucod
.ymotcepylop
.noitanimaxe
htiw.)sisolucitrevid
，
dna cipocsrcam
snoisel
demrofni
noloc
.Y 7
30%
more
smalpoen
03. 6 smalpoen
gnimusa(
detacidni
taht
tnaerapsnart
elpmas
ezis
fo siht lairt
ni eht
AFI+
TH puorg
，
htiw
rep tneitap
> 21 stneitap
hod
erw
den
detceted
adradnats
ni hcae
a mean
was detaluclac
compared
ot eb
htiw
WLI
fo 0)3.
noitaived
puorg
eht
，
gnimusa
61 ，
.71
a 5%
ihcuekaT
ecnacifingis
level
andlacitsitats
erofereht
detanritse
taht
ytilibigile
noitaived
and
lacitsitatS
;etar
noitavresbo
ton
(TH-
wer
detaluclac
spuorg
egakcp
was denifed
desesa
hcae
，
otetagitsevni
ni siht lairt
spuorg
gnisu
eht tcapnri
edonr
(WLI
evit，
aler
sv TH+)
gnisu
.ecnelaviuqe
eb den
，
gniraeb
We
ni dninr
nosioP
nriretni
sisylana
who
by eht atad
tnaerapsnart
dna /dedurtorp
Dat
.tnacifingis
ta eht ytisrevinU
tset ta
noitceted
hod
ro
日tasnrsalpoen
ot eht elpicnirp
wer
deredisnoc
sisylana
lA atad
fo ihsanraY
ytsialibigile
detcudnoc
P seulav
wer
fo
tuohtiw
was
lA
retnec
，
dna gnitnuonr
sastneitap
R 8.)2
/gro.tcejor1p-r.ww/:pth(
yllascaitsitats
eht nrsalpoen
gnidroca
retfa noitazinrodnar
ta.lla
nosirapnroc
taht detcefa
，
edanr
.l
edonr
pa st此
napici
wer
elpitlunr
rof llarevo
stnapicitrap
eht
otllorne
soitar
noiserger
snosirapnroc
renarK-yekuT
sv AFI )noitavresbo
lla detacola
and desufer
dna elpitlunr
fo two srotcaf
noitceted
，
gnidoc
taert-ot-noitnetni
ton nrofrep
would
deis-owt
.sesac
wer
We dezylan
sesac
gnisu
fo 50 stneitap
tuoprd
，
we derapnroc
srif .t Then
dezylan
alatot
fo 80%
siylanA
Four
erofereht
power
.Y 8
noitaived
yna .snoisel
gnisu
ehltacitsitats
wer deliat-owt
detceloc
ni ruo latipsoh
，
.napaJ
We did
，
and
P
and
<50.0
ihcuekaT
.Y 9
stluseR
Recruitmn
and tnapictraP
Betwn
November
deludehcs
ot ogrednu
deulcxe
from
erw
eht(
ylmodnar
Flow
208
dna
ypocsnolc
htiw
dengisa
dna dezylana
user tI s erw
tsomla
suoirav
same
)1
November
ni ruo
tnemlorne
erugiF(
209
ypocsdne
gnidroca
erw
tfel
fo 165 stneitap
who
sisylana
“
wer
fo 362 stneitap
alatot
ot eht elpicnirp
ni rep locotorp
stneitap
inu .t Alatot
，
whic
snosaer
，
329 elbigile
gnidulcxe
taert-ofto-noitnetni
ytilibigile
noitaived
.)sesac
newtb
enilesaB
Data
enilesaB
atad
eht spuorg
was detar
rof hcae
dna
puorg
wer
satnelecxe
era
shown
tonyltnacifingis
ro god
ni elbaT
.1 They
.tnereffid
ytilauQ
by eht stsipocsodne
ni tatsael
wer
dezylan
fo bowel
98%
noitaraperp
fo eht sesac
ni hcae
.puorg
Outcomes
& noitamitse
Alatot
deniatbo
from
fo 501
was elbaliava
serutaef
fo eht detceted
dna
The
wasyltnacifingis
-39.0(
erw
esuaceb
fso'tsipocsonoloc
31 snoisel
sisongaid
sa smalpoen
snoisel
detceted
217
yramirp
wer
desongaid
tniopdne
rehgih
.1 )4 ，
P =320.0
elbaT
thgiE
，
neoplasm
naht
(Tukey-Kram
ni eht
snemicpS
dernuh
2 seziramus
ehltacigolohtapocinilc
dna evif-ytneves
snoisel
sacitsalpoen-non
noitceted
WLI enola
mutIelpi
erw
ton
，
dna lacigolotsih
senselerac
rof .snoise12901
.snoisel
ni 380 .stneitap
wer
desongaid
.snoisel
etar
puorg
nosirapmoc
(95%CI)
ni eht
AFI+
.1[ 96 1( 5.)34.2-0
method
TH puorg
sv .1 91
，
serugiF
2 dna .])3
ihcuekaT
AFI
htiw
tnaerapsnart
.ypocsonloc
evitaleR
noiserger
neoplasm
oitar
more
smalpoen
etar
smalpoen
more
hod
The noitceted
setar
was
diopylop
neoplasm
by gnituom
noitceted
tnaerapsnart
hod
noitceted
oitar
noitceted
oitar
decneulfni
.C).I rof talf
rof talf
stnev
Mucosal
minor
and
smalpoen
2 ni eht
dna
decneulfni
yltn，
ednepdni
era
shown
fo
model
smalpoen
wasyltnacifingis
1. 2 ，
)lO.O<p
2-43.1(
The
desaercni
by gnituom
tnaerapsnart
desaercni
hand
，
)20.=p
1( 2.17.2-4
38.1
.C).I rof
(95%
On eht rehto
by gnituom
wasyltnacifingis
96.1
tnaci3fingis(
by AFI .noitavresbo
by AFI .noitavresbo
was
oitar
was
.1 12 ，
)89.0=p
neoplasm
ni elbaT
noitceted
.1 0 -28.0(
tnaerapsnart
Advers
hod
WLI noitavresbo
evitaleR
0( 5.1-9 4. 1，
p=O )76.
19.0
by mountig
spuorg
and
tub ton decneulfni
and
hod
did ，
AFI noitavresbo
mode
noiserger
rof diopylop
(95%
noitavresbo
eht .)spuorg
hod
oitar
tnaerapsnart
tnaerapsnart
lf/ ta s
malpoen
on nosioP
tnaerapsnart
did
on nosioP
ro .ton
newtb
desab
desab
by mountig
eht noitavresbo
naht
fo diopylop
ton nes
neoplasm
hguotlA
naht
yltneuqerf
tnaerapsnart
ecnerefid
more
naht lanoitnevnoc
.C).I rof llarevo
(95%
.1 45 .1( -81 .1 7 ，
)lO.O<p
was
noitceted
gnituom
enola
tceted
.1 36 ，
p=0 1. )3 by AFI .noitavresbo
detceted
evitaler
dluoc
noitceted
model
.1 41 -69.0(
eht
hod
Y. 01
evit，
aler
by AFI
.doh
The evitaler
by AFI noitavresbo
tub ton
.doh
gnidelb
was
AFI+
TH )puorg
nes
ni 4sesac
tub
no citatsomeh
1( hcae
ni eht
erudecorp
WLI+
TH and
was .deen
AFI
ihcuekaT
.Y 11
rof noitceted
fo
noisucsiD
We detartsnomed
latceroloc
，
compared
smalpoen
nretsew
9，
20
.teromehtruF
rieht
roloc .ecnereffid
ezilitu
chromendspy
cinoloc-nap
eyd
ot detacilpmoc
sah
tnaerapsnart
emit
by
dna ti was
adenoma
ysae
ot
nilacinilc
hand
，
，
esuaceb
ecitcarp
stsipoc，
sonoloc
taht
lla yeht
，
dna tiaw
eht notub
，
dna
noitceted
2 _1，2 However
stpmeta
eyd ;noitulos
，
hsup
elbazingocer
rof.seeniart
method
gniyarps
fo
ysllaitnatsbus
ni siht lairt
On eht rehto
den
fo
dna ecneserp
adenoma
eht latceroloc
adradnats
ot noitanimaxe
tisi
esu
den
si ot mount
rof a few
sdnoces
，
whic
sdeiifissalc
si eno
fo eht
AFI
a
eht .noitanimaxe
Anevitanretla
method
desab-tnempiuqe
decnah-egmi
desab-tnempiuqe
IE
rof eyd gniyarps
methods
2 _4ー26 yltnecR
chromendspy
ehtsenevitcefe
dezimonar
slairt
hguotlA
eht ycacife
NBI
do ton
roirp
neb
nI
number
foaisalpsyd
era ylisae
fo eht gnismorp
.gnimusnoc
hod
hod
ton
，
erged
nev
ot evorpmi
.doh
ot eht
folatceroloc
hod
si eno
yarps
ezis
oetapicitrap
made
tnaerapsnart
smalpoen
4seeniart
neb
hod
gnidroca
latce，
roloc
image
tnearapsnart
evah
dna
tnerapsnart
show
noitceted
htiw
stpmeta
cinoloc-nap
gnirud
et，
aruca
We detivni
AFI
Some
htiw
pylop
，
ni AFI
ylevitceffe
tnearapsnart
era deiced
ot eht detceted
eroferhT
natropmi
htiw
WLI tuohtiw
slavretni
ninoitida
.erutcetihcra
fo AFI
htiw lanoitnevnoc
，
eht ecnalievrus
seirtnuoc
adenomas/
suolliv
eht ycaciffe
sah citsongaid
sah
neb
ypocsdne
)EI(
2 _3 NBI
，
si detcepxe
otezilaer
，
hguohtla
fo NBI rof noitceted
gni，
dulcni
eno retnecitlum
fo NBI rof noitceted
ycaruca
rofgnihsiugnitsid
lareves
depolevd
，
whic
stilaitnetop
sacinortcele
srotagitsevni
evah
folatceroloc
lairt
folatceroloc
citsalpoen
shown
neb
，
most
adenomas
，
evah
sa
vitagen
adenoma
from citsalpoen-non
gniyrt
ot
fo eht
er 陀ses叩
tlu .臼s，
戸 凶16幻
， 929
刊
si tnoc laisre甘
vor
0，
3ピ
f
ihcuekaT
.snoisel
AFI
The
13 ，
32
ypocsdne
，
dna
metsy
sisongaid
smalpoen
dna
detcepxe
ot eveihca
retteb
eht tneserp
lairt
，
eht tcapmi
evah
sesu
neb
detartsnomed
si osla
regnorts
hod
neoplasm
detceted
ni eht tneserp
smalpoen
AFI noitavresbo
sievitceffe
sihT
yduts
，
whic
retnec
tsilaiceps
naisA
detacola
eht
detroper
dna
ni siht
gnirud
yduts
esuaceb
etar
ni eht
t1 show
taht
51 ，
38
61 ，
28 ，
enola
kot
rehto
ot tceted
and
ecalp
eht
ni arecnac
larrefer
edistuo
elbaliava
，
we dluoc
ylaniF
erw
we did ton mrofep
日
ta
fo talf .smalpoen
otstsipocsonoloc
puorg
fo
dna talf .smalpoen
eht stsipocsonoloc
WLI
depleh
number
hcae
nI
osla
fo eht /diopylop
hod
，
eht yduts
sihT lairt erofereht
37
seld，
rager
more
eht stluser
Kingdom.
.etabed
fo msalpoen
WLI noitavresbo
diopylop
si
，
AFI noitavresbo
si ylaicremoc
eht detinU
eht .erudecorp
noitceted
.atad
fo htob
hod
rof noitceted
complent
，
eht AFI epocsdneodiv
Second
puorg
neoplasm
dluoc
ot ylpa
folatceroloc
si rednu
tnearapsnart
tsriF
tluiciffid
seirtnuoc
tnempiuq
hod
a
tub ti seod
tnaerapsnart
detceted
dah.snoitatimilareves
.stinu
some
，
gnituom
rof noitceted
makes
naht
AFI noitavresbo
tnearapsnart
noitceted
ro no .t nI eht sisylana
lairt
htiw
.snoisel
However
etar
mounted
dna
dna
noitanibmoc
fo AFI .noitavresbo
was
ypocsnolc
hguotlA
hod
sa
ot eht lacitpo
，
71 ，
34-6
sti ycacife
taht
noitceted
tnaerapsnart
.EI
sa lew
WLI
rof retteb
htiw
tnaerapsnart
msalpoen
gnidroca
戸AFI
ecived
fo gnituom
NBI
naht lanoitnevnoc
fo adenoms
naht
htiw
rof eht detceted
agnismorp
mechanism
rehtw
diopylop
sisongaid
snoisel
noitceted
depiuqe
snoisel
sisongaid
tnaereffid
aretteb
more
lacigolotsih
more citsalpoen
hod
was
eht detceted
lacfiogolohtapotsih
Atnerapsnart
thgim
lamrof
nac tceted
eht tsoc
ni ruo lairt
dna dracsid
，
tuohtiw
NBI
hod
ton esaercni
desu
we nac tceser
gnisu
tnerapsnart
metsy
Y. 21
ylno
ton laecnoc
eraw
dah
ot eb na open
was
elbarpmoc
tnegilgen
fo
ni
eht
fo eht detacola
airt .l Howevr
，
htiw ylsuoiverp
noitavresbo
ni eht
WLI
ihcuekaT
enola
，
and eht neoplasm
puorg
rehgih
naht
ni eht
htiw
tanerapsnart
we detarsnomed
smalpoen
enola
eht stluser
hod
htiw
ni eht
tnaraw
sa adradnats
eht ycacife
，
compared
etar
AFI+
TH puorg
wasyltnacifingis
.puorg
，
hguohtla
nI noisulcnoc
AFI
WLI
noitceted
.Y 31
fo AFI
lanoitnevnoc
method
htiw
tnaerapsnart
WLI tuohtiw
arehtruf
esahp
rof noitceted
111 yduts
folatceroloc
hod
tanerapsnart
rof noitceted
othsilbatse
smalpoen
folatceroloc
.doh
，
ihcuekaT
Table
.1 enilesaB
atad
fodetacola
WLI enola
Sex
，
%)
elam(
Median
)egnar(
lacef
牢
co 1u tdolb
gnitset
AFI 1a en0
WLI+TH
39 1/ 3 (70%)
141/9
(70%)
AFI+TH
74101
(69%)
041/49
)%76(
ega
)y(
64 43(
noitacidnI
FOBT;
.spuorg
.Y 41
同
)48
・
)38
36 13(
36 53(
46 33(
・
)48
同
)38
fo
，
n (%)
ypocsnolc
FOBT+*
evruS
Bowel
11i ecna
47 (35%)
35 (38%)
35
(36%)
25 )%73(
68 (65%)
8 (62%)
94
(64%)
8 (63%)
13(85%)
)%98(521
，
noitaraperp
n(%)
tnelecxE
God
)%41(8
roP
)%28(51
81 1( 2%)
)%9(31
2(%)
2(1%)
2(16%)
2(1%)
3(2%)
，
n
tsipocsodnE
More
decneirepxe
seniarT
Mean
latot
126(8%)
(95%
87
68
08
5
36
16
06
)IC
erudecorp
iT me ).nim(
78
7.02
91 4.
1( 93.)0.2-
)9.02-8.71(
8.42
62-1.32(
9.2
)4.
42-6.12(
Cec 1anoitabutni
etar
，
n (%)
31/231
(9%)
141/631
(96%)
741/541
(9%)
31 81/ 40 (9%)
)2.
Table
l.aci2golohtapocinilC
serutaef
WLI
stneitaP
fo detceted
htiw
spylop
htiw
smalpoen
事ILT
enola
)n(
snoisel
n( ヲ%)
n( ，
%)
lA detceted
snoisel
citsalpoen-noN
Y. 51
AFI+TH
latoT
and .stneitap
+ TH
AFI
enola
141
31
ihcuekaT
741
38 (62%)
89 (70%)
59 (65%)
401
74 (56%)
48 (60%)
38 (56%)
8 (62%)
)n(
391
23
165
041
(74%)
25
38
(68%)
923
(59%)
501
38
spylop
)n(
40
Neoplasm
)n(
Adenoma
Low-grade
adenoma
High
6
49
217
62
251
248
20
572
578
641
24
791
269
458
41
237
981
257
728
edarg
田
adenoma
2
5
8
。
。
evisavni-noN
carcmoa
2
evisavnI
amonicra
3
4
6
3
3
dionicraC
27
21
21
2
3
Nolacigolotsih
noitanimaxe
)n(
Neoplasm
8
noitceted
(95%
)IC
1-39.0(
The
P seulav
TH:
02. 1，WLI
AFI :enola
.1 91
etar
rof suoirav
35.0
enola
，
WLI+TH
.1 72
4.)4
snoirapmoc
.sv AFI :enola
29.0
.sv AF +I TH:
noitceted
.1( 07- .1)56
1( 2-05.
;etar
enola
WLI
enola
.sv AF +I TH:
320.0
，
AFI enola
.sv AFI
TH: .01.0
，WLI
97.0
.1 96
.1 36
1( 2.)51.2-8
fo neoplasm
31
3
十
.1 57
4. )3 .1( 83 .，
1 )67
.sv WLI
，WL +I TH .sv
+
ihcuekaT
elbaT
.3noitceteD
cipocsrcaM
r創 出 (95%
)IC tafolfldiopylop
WLI enola
WLI+TH
.Y 61
.smsalpoen
AFI+TH
AFI enola
latoT
epyt
diopylop
msalpoen
noitceted
etar
(95%
14. 5
68.0
)IC
)70.1-46.0(
.1( 03- .1)78
59.0
.1 71
14. 4
.1)91 )58.1-40.1(
-07.0(
.1( 01- .1)43
talf msalpoen
noitceted
etar
(95%
The
13.0
)IC
P seulav
.sv WLI
必))93.0-71.0(
0-61.0(1
+ TH:
WL +I TH .sv
rof suoirav
snosirapmoc
370.0
，WLI enola
AFI :enola
51.0
rof suoirav
snosirapmoc
.1 0 ，WLI
enola
AFI :enola
36.0
04. 1
02. 8
msalpoen
noitceted
;etar
enola
.sv AFI
89.0
AF +I TH:
ラ
WLI
.1 0
ラ
AFI
4.))6
0-03.0(
)27.0-13.0(
.sv AFI :enola
.sv
83.0
0( 2. 7-0 )65.
fo diopylop
，WLI+TH
15.0
WLI
enola
TH:
570.0
十
，
enola
.sv
AF +I TH:
;etar
WLI
enola
.51.0
The
WLI
P seulav
+ TH:
WL +I TH .sv
.87.0
fo talf
.sv
ラ
WLI+TH
AFI :enola
.sv
msalpoen
noitceted
97.0
AF +I TH:
，WLI
51.0
enola
，AFI
.sv
enola
AF +I TH:
.sv
.sv
52.0
AF +I TH:
，
ihcuekaT
.Y 71
secnrefR
.1 lameJ
A，
legeiS
R ，Ward
.Bs'tnediserP
:sserdda
E，
te a.l recnaC
scitsitats
，.902
CA recnaC
J nilC
.942-52:95;902
.2 nosirM
Soc
JS ，rebuaZ
cipocsonoloc
.ymotcepylop
by kcab-ot-kcab
.6 Uedo
.lewob
corP
R
folatceroloc
yb
.1
sim
setar
ygoloretneortsaG
fo samoned
ー
.82
42:1;791
RE ，
te.laevitcepsorP
desim
recnac
yduts
fo eht ycneuqerf
by .ypocsonoloc
J ltaN
dna
recnaC
tsnI
.271-9671
N，
iIihs
H，
atustaT
dna ecnatcelfer
tsetniortsaG
metsy
ni eht egral
GT ，
te .al cipocsonloC
.seipocsonoloc
fo spylop
ecnecseroulfotua
.7 Matsud
ecneuqes
J Med 891-791:23;91
MB ，
renilpmaS
ezis noitubirtsid
:28;091
日
M N ，te a.l noitneverP
N lgnE
CS ，Lemel
ytreneF
LJ ，
.5 nosxiH
AG ，Ho
DK ，
reltuC
denimretd
recnac
-4 .75
Med 154:76;4791
.3 Winawer
.4 Rex
eht pylop
csodnE
M ，te a.l A levon
gniami
ypocsdneodiv
metsy
rof sisongaid
by gnisu
focirtsagogahpose
.srecnac
.825-125:26;502
otiaS
T，
Y ，Fu KI ，
te a.l Does ecnecseroulfotua
evorpmi
eht cipocsonoloc
pylop
noitceted
gniami
?etar
ypocsdneodiv
- atolip
.yduts
Am J
ihcuekaT
loretneortsaG
;802
.8 Uedo
:301
Y，
euonI
hod
:metsys
T，
Hanoka
.ypocsodne
ni eht siraP
citsalpoen
.11 cipocsdnE
:snoisel
csodnE
lpuS(91;802
Dig
csodnE
，
hcamots
3:)lpuS(85;302
snoisel
by new
:)1
lailehtipe
31-0
.1
.41 lanoitaN
recnaC
.etutitsnI
.puorG
RH ，otaK
tnearapsnart
.35-74S:)1lpuS(2;012
cipocsodne
noitacifissalc
noloc
lfaoicifrepus
- November
etadpU
30 ot Decmber
1，
Endoscpy
fo
.875-075:73;502
aneiV
noitacifissalc
fo
Gut .52-152:74;02
lailehtipe
Common
.tcart
on eht siraP noitacifissalc
Y ，te .al The
.aisalpoen
MF. lanitsetniortsaG
:15;202
gnisu
-4 .3
ni eht evitsegid
RJ ，
lediR
lanitsetniortsag
，
dna
Reviw
citsalpoen
csodnE
The siraP
sugahpose
tsetniortsaG
repmlhcS
Dixon
adenoms
ypocsonloc
Dig
.pohskrow
noitacifissalC
laicifrepus
.yduts
N，
te.laecnalievruS
dna decnahe-gami
.01stnapicitraP
.202
atolip
fo cinoloc
4- .831
.9 ihcuekaT
.31
R，
te .al sisongaiD
K ar，
ahihsI
gniami
S13
.21
.921-6291
N，
onihsagiH
ecnecseroulfotua
.Y 81
ygolnimreT
:aisalpoen
aneiV
airetirC
rof esrvdA
.detisiver
Gut
stnevE
.0.3v
ihcuekaT
Y. 91
:at
elbaliavA
h立旦/: /etc 03_ctc#mpt_h.，
ctc/snoi旦
tacilpa且
_cinortce盟
le/tnempoleveDlocotorp/vog.r
.51
.702
8，
Acesd
yraubeF
reldA
A ，lhoP
dnab-wor
seod
.61
euonI
H，
uoalkinapP
gniam
SI ，
te a.l A evitcepsorp
susrev
dnab-wor
gniam
T ，Murano
ypocsnloc
ecudni
rof
?tceffe
:spylop
yduts
adenoma
on
:noitceted
Gut .46-95:7;802
N ，te .al evitarpmoC
cinoloc-nap
cinoloc
ypocsnolc
agninael
M ，Murano
and
citsalpoen
lanoitnevnoc
dezimonar
yduts
dnab-woran
gniam
metsy
a dezimonar
，
delortnoc
fo lanoitnevnoc
ni eht noitceted
fo
airt .l JloretneortsaG
.05-4:3;802
.71
Kondo
Yam 吋i Y ，
Watbe
S，
senlufesu
fo atnerapsnart
Muto
T，
Busey
Cancer
.072-152:6;5791
.91 senilediuG
hod
dehcata
delortnoc
ot eht pit
lairt gnitaulave
eht
fo eht .epocsonloc
Am J
.1
8-57:201;7021oretnortsaG
.81
H，
te .al A dezimonar
HJ ，
Morson
rof ypocsnloc
BC.
ecnalievrus
The noitulove
retfa
fo recnac
:ymotcepylop
fo eht nolc
and .mutcer
A sunesoc
etadpu
by
ihcuekaT
eht
US yteicoS-itluM
ksaT
.yteicoS
ygoloretneortsaG
.02 snriaC
Sdleife，
lohcS
.HJ senilediuG
Gut .2-1:)51puS(15;202
2.1 rekorB
JC ，
srednuaS
fo evitunimid
dellortnoc
airt .tsetlniortsaG
eht
naciremA
recnaC
.ypocsmorhc
Gut 73:5;402
T，
Sano
etutitsnI
ypocsonloc
enituor
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