Contents Part I From Tissues to Cells Mechanical Behavior and Properties of Adipose Tissue . . . . . . . . . . . . Cees Oomens and Gerrit Peters 3 Mathematical Models of Adipose Tissue Dynamics . . . . . . . . . . . . . . . Junghyo Jo, Zeina Shreif, Jonathan R. Gaillard, Matilde Arroyo, Samuel W. Cushman and Vipul Periwal 11 Mechanical Stretching and Signaling Pathways in Adipogenesis. . . . . . Yoshiyuki Tanabe, Maki Tanji Saito and Koichi Nakayama 35 Role of Mechanical Stimulations in Directing Mesenchymal Stem Cell Adipogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Hillary Stoll and Jung Yul Lim 63 The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction . . . . . . . . . . . . . . . . . . . . . . . . . . . Naama Shoham, Natan T. Shaked, Dafna Benayahu and Amit Gefen 89 Extracellular Matrix Remodeling and Mechanical Stresses as Modulators of Adipose Tissue Metabolism and Inflammation . . . . . Kyongbum Lee and Catherine K. Kuo 105 Part II The Biomechanics and Mechanobiology in Comorbidities of Obesity The Impact of Obesity and Weight Loss on Gait in Adults . . . . . . . . . Tarja Lyytinen, Timo Bragge, Tuomas Liikavainio, Paavo Vartiainen, Pasi A. Karjalainen and Jari P. Arokoski 125 ix x Contents Excessive Weight Bearing Compromises Foot Structure and Function Across the Lifespan . . . . . . . . . . . . . . . . . . . . . . . . . . . Julie R. Steele, Diane L. Riddiford-Harland and Karen J. Mickle Obesity, Osteoarthritis and Aging: The Biomechanical Links. . . . . . . . Yao Fu and Timothy M. Griffin Impaired Neutrophil Mechanoregulation by Fluid Flow: A Potential Contributing Factor for Microvascular Dysfunction in Obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Michael L. Akenhead, Xiaoyan Zhang and Hainsworth Y. Shin 149 181 203 Mechanotransduction and the Myogenic Response in Diabetes. . . . . . . Sewon Lee, Srijita Dhar, Kwangseok Hong, Yan Yang and Michael A. Hill 233 Role of Adipose Cells in Tumor Microenvironment . . . . . . . . . . . . . . . Tao Zhang and Mikhail G. Kolonin 271 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 http://www.springer.com/978-3-319-09335-2
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