27th Annual Meeting of
the Society for Virology
DVV
Gesellschaft für Virologie e. V. (GfV)
und
Deutsche Vereinigung zur Bekämpfung
der Viruskrankheiten e. V. (DVV)
© 99173780 l Blackosaka • 90481797 l yurkaimmortal l fotolia.com
22–25 March 2017
Marburg • Germany
Philipps-Universität Marburg
www.virology-meeting.de
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Table of Contents
Welcome notes
Conference chair.................................................................................... 4
President of the Society for Virology (GfV)........................................... 5
Organisation and imprint........................................................................................ 7
Societies and meetings............................................................................................ 8
Keynote speakers, awards, poster prize committee and chair persons................ 9
Programme overviews............................................................................................ 10
Scientific programme
Wednesday, 22 March 2017.................................................................. 14
Thursday, 23 March 2017....................................................................... 22
Friday, 24 March 2017............................................................................ 30
Saturday, 25 March 2017....................................................................... 42
Poster sessions
Poster session overview......................................................................... 46
Poster session 1...................................................................................... 47
Poster session 2...................................................................................... 64
Poster session 3...................................................................................... 86
Sponsors.................................................................................................................. 113
Industrial exhibition................................................................................................. 114
Floor plan................................................................................................................. 115
Media cooperations and scientific sponsors.......................................................... 116
General information................................................................................................ 117
Social programme.................................................................................................... 119
Index of presenting authors and chair persons...................................................... 120
Upcoming conferences and meetings.................................................................... 126
p3
Welcome note • Conference chair
Dear colleagues,
© Markus Scholz/Leopoldina
It is a great pleasure to welcome you to the 27th Annual Meeting of the Society for Virology held from 22–25 March 2017 in Marburg, Germany.
The Philipps-Universität is not only a university steeped in tradition, it is also the oldest
university in the world that was founded as a Protestant institution in 1527. It has been
a place of research and teaching for nearly five centuries. Nowadays the nearly 25,700
students studying in Marburg shape the appearance of the city with 75,000 inhabitants.
The year 2017 is an important year for Marburg virologists since we commemorate the
anniversary of the Marburg virus outbreak 50 years ago, in 1967. The first outbreak of
an imported highly pathogenic tropical virus in Germany coined virological research in
Marburg which is focused on Marburg, Ebola, Lassa, Nipah and highly pathogenic influenza A viruses. Our interest in emerging viruses will also partially influence the plenary
sessions of the meeting.
As usual, the annual meeting of the German Society of Virology will cover a broad spectrum of topics in virology in workshops and poster sessions. Since a major aim of the
meeting is to provide a platform for young scientists to present their results and ideas, we
are really delighted that many “next generation`s researchers” will join us and we hope
very much the programme will be entertaining and enlightening across the generations.
The organising committee and I are pleased to welcoming you all in Marburg!
Prof. Dr. Stephan Becker
Conference Chair
p4
President of the Society for Virology (GfV)
Dear colleagues,
I warmly welcome you to our 2017 scientific meeting of the Society for Virology (GfV).
Our meetings cover the field of virology from basic research to medical virology, a field
of great scientific, epidemiological, medical and social impact. By nature, virology is also
a cross-sectional discipline and therefore contributes fruitfully to many interdisciplinary
research initiatives. So, we all permanently aim to keep Virology at the front of scientific
developments concerning both scientific concepts and methods.
Although I can assure you that the GfV is very active throughout the year concerning
multiple tasks, the most visible evidence of the vitality of our Society is our annual
meeting and again, this year we have an exciting program of high quality. For the future,
the Executive and Advisory Boards of the GfV decided not to have any meetings of GfVCommissions during our annual meetings so that everyone can attend poster sessions
to have good discussions especially with the young virologists.
This year, we shall award the Loeffler-Frosch-Prize to PhD Cesar Muñoz-Fontela, HPI
Hamburg, and we will honor Prof. Dr. phil. nat. Dr. h.c. Wolfram H. Gerlich, University of
Gießen, who will receive the Loeffler-Frosch-Medal. In our General Meeting I will hand
over the Presidency to Prof. Dr. Hartmut Hengel and I cordially invite you to participate.
I am convinced that we will have a very successful, challenging and scientifically stimulating meeting. At this point, I also want to welcome our international guests and deeply
feel the need to give my special thanks to Prof. Dr. Stephan Becker, all the organizers
and the many helpers for the work and responsibilities they have taken on to prepare
and to perform this year’s highlight in virology.
Prof. Dr. Thomas Mertens
President of the GfV
p5
General Information
Collaborative
Research Centre 1021
RNA Viruses:
RNA Metabolism, Host Response
and Pathogenesis
The Collaborative Research Center (CRC) 1021 was
established by the Deutsche Forschungsgemeinschaft
(DFG) in 2013 and is now, after a successful evaluation
in 2016, in its second funding period (2017 – 2020).
More than 60 scientists investigate medically impotant
RNA viruses from different families, and focus on (i)
synthesis and metabolism of viral RNA, (ii) viral
factors determining pathogenicity, and (iii)
cellular responses to RNA virus infections
and viral factors that counteract these
cellular responses.
© laackmann photostudios marburg
p6
www.sfb1021.de
Organisation and imprint
Venue
Philipps-Universität Marburg
Central Lecture Building
Biegenstraße 14
35037 Marburg (DE)
Organiser
Gesellschaft für Virologie e. V.
(GfV, Society for Virology)
www.g-f-v.org
Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.
(DVV, German Association for the Control of Virus Diseases)
www.dvv-ev.de
DVV
Conference chair
Prof. Dr. Stephan Becker
Philipps-Universität Marburg
Center for Hygiene and Infection Biology
Institute for Virology
Hans-Meerwein-Straße 2
35043 Marburg (DE)
Conference organisation
Conventus Congressmanagement & Marketing GmbH
Marlen Schiller/Ann-Kathrin Schulte
Carl-Pulfrich-Straße 1
07745 Jena (DE)
Tel. +49 3641 31 16-358/-363
Fax +49 3641 31 16-243
[email protected]
www.conventus.de
Design/Layout
Layout Print Circulation Editorial deadline krea.tif-studio UG (haftungsbeschränkt)
Siblog • Gesellschaft für Dialogmarketing,
Fulfillment & Lettershop mbH
1,000
07 March 2017
p7
Societies and meetings
Executive committee of the Society for Virology (GfV, Gesellschaft für Virologie)
President Thomas Mertens (Ulm/DE)
Secretary Sigrun Smola (Homburg a. d. S./DE)
Treasurer Detlev H. Krüger (Berlin/DE)
Vice presidents Hartmut Hengel (Freiburg/DE)
Franz X. Heinz (Vienna/AT)
Former presidents Nikolaus Müller-Lantzsch (Homburg a. d. S./DE)
Hans-Dieter Klenk (Marburg/DE)
Otto Haller (Freiburg/DE)
Bernhard Fleckenstein (Erlangen/DE)
Advisory board Ralph Bartenschlager (Heidelberg/DE)
Stephan Becker (Marburg/DE)
Wolfram Brune (Hamburg/DE)
Ulf Dittmer (Essen/DE)
Helmut Fickenscher (Kiel/DE)
Frank Kirchhoff (Ulm/DE)
Klaus Osterrieder (Berlin/DE)
Thomas Pietschmann (Hanover/DE)
Sibylle Schneider-Schaulies (Würzburg/DE)
Thomas Schulz (Hanover/DE)
Beate Sodeik (Hanover/DE)
For more information and for membership application, please visit our website
www.g-f-v.org.
German Association for the Control of Virus Diseases
(DVV, Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.)
Barbara Gärtner (Homburg/DE)
President Heinz Zeichhardt (Berlin/DE)
Vice president
Secretary Beate Ebel (Homburg a. d. S./DE)
Treasurer
Helmut Fickenscher (Kiel/DE)
Meetings of the Society for Virology
Wednesday, 22 March 2017, 09.00–12.00
GfV Board Meeting (Vorstands- und Beiratssitzung) Alter Senatssitzungssaal, Biegenstraße 10
GfV General Assembly (Mitgliederversammlung)
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Thursday, 23 March 2017, 19.00–20.00
Audimax
Keynote speakers, awards, poster prize committee and chair persons
Keynote speakers
M. Addo (Hamburg/DE)
J. Briggs (Cambridge/GB)
G. Gao (Beijing/CN)
J. Hauber (Hamburg/DE)
M. P. Kieny (Genf/CH)
K. Lang (Essen/DE)
U. Protzer (Munich/DE)
F. Rey (Paris/FR)
T. Stamminger (Erlangen/DE)
F. v. Kuppeveld (Utrecht/NL)
F. Weber (Giessen/DE)
S. Weaver (Galveston, TX/US)
Awards
Loeffler-Frosch-Award
C. Muñoz-Fontela (Hamburg/DE)
Loeffler-Frosch-Medal
W. H. Gerlich (Giessen/DE)
Poster prize committee
S. Pleschka (Giessen/DE)
B. Sodeik (Hanover/DE)
N. Tautz (Lübeck/DE)
Chair persons
R. Bartenschlager (Heidelberg/DE)
P. Becher (Hanover/DE)
M. Beer (Greifswald – Isle of Riems/DE)
A. A. Berger (Giessen/DE)
B. Biesinger (Erlangen/DE)
M. Brinkmann (Braunschweig/DE)
W. Brune (Hamburg/DE)
C. Buchholz (Langen/DE)
S. Ciesek (Essen/DE)
K.-K. Conzelmann (Munich/DE)
U. Dittmer (Essen/DE)
C. Drosten (Bonn/DE)
O. Fackler (Heidelberg/DE)
N. Fischer (Hamburg/DE)
H. Franz (Vienna/AT)
E. Friebertshäuser (Marburg/DE)
D. Glebe (Giessen/DE)
A. Groseth (Greifswald – Isle of Riems/DE)
A. Heim (Hanover/DE)
H. Hengel (Freiburg/DE)
S. Junglen (Bonn/DE)
C. Keller (Marburg/DE)
O. Keppler (Munich/DE)
F. Klein (Cologne/DE)
B. Klupp (Greifswald – Isle of Riems/DE)
G. Kochs (Freiburg/DE)
R. König (Langen/DE)
H.-G. Kräusslich (Heidelberg/DE)
T. Krey (Hanover/DE)
S. Ludwig (Münster/DE)
A. Mankertz (Berlin/DE)
T. Mettenleiter (Greifswald – Isle of Riems/DE)
C. Muñoz-Fontela (Hamburg/DE)
K. Osterrieder (Berlin/DE)
M. Panning (Freiburg/DE)
S. Pöhlmann (Göttingen/DE)
M. Schmidtke (Jena/DE)
J. Schneider-Schaulies (Würzburg/DE)
M. Schwemmle (Freiburg/DE)
B. Sodeik (Hanover/DE)
S. Stertz (Zurich/CH)
K. Stiasny (Vienna/AT)
T. Strecker (Marburg/DE)
G. Sutter (Munich/DE)
N. Tautz (Lübeck/DE)
G. Tekes (Giessen/DE)
V. v. Messling (Langen/DE)
M. Weber-Gerlach (Giessen/DE)
J. Ziebuhr (Giessen/DE)
G. Zimmer (Mittelhäusern/CH)
p9
Programme overview • Wednesday, 22 March 2017
Track I – The Virus
Track II – The Host
Track III – The Clinical View
Audimax - 2nd floor
Lecture hall 1 - ground floor
Lecture hall 2 - 1 floor
st
12.30–13.00
Opening Ceremony
p. 14
13.00–14.30
Plenary Session 1
Emerging Viruses - Emergency Responses
p. 14
Coffee Break within the Industrial Exhibition
15.15–15.30
Talk Zymo Research Europe GmbH
p. 14
Workshop 1
Virus Receptors and Entry
p. 15
Coffee Break within the Industrial Exhibition
Workshop 4
Viral Replication 1
p. 18
Get-Together within the Industrial Exhibition
Poster Session 1
Virus Receptors and Entry
Innate Immunity 1+2
Diagnostic Tools
Viral Replication 1+2
p 10
14.30–15.15
15.30–17.00
Workshop 2
Innate Immunity 1
17.00–17.45
Workshop 3
Diagnostic Tools
p. 16
p. 17
17.45–19.15
Workshop 5
Innate Immunity 2
19.15–21.30
19.30–21.30
p. 19
p. 119
p.47
Programme overview • Thursday, 23 March 2017
Track I – The Virus
Track II – The Host
Track III – The Clinical View
Audimax - 2nd floor
Lecture hall 1 - ground floor
Lecture hall 2 - 1 floor
Workshop 6
Viral Replication 2
08.30–10.00
Workshop 7
Adaptive Immunity
Workshop 8
Emerging Viruses
p. 22
Coffee Break within the Industrial Exhibition
10.45–12.15
Plenary Session 2
Structural Virology
10.00–10.45
st
p. 23
p. 24
p. 25
12.30–13.30
Lunch Symposium
QIAGEN GmbH
12.30–13.30
Lunch Symposium
Carl Zeiss Microscopy GmbH
p. 25
Workshop 9
Trafficking
p. 25
14.00–15.30
Workshop 10
Virus Vectors and Gene Therapy
p. 26
Coffee Break within the Industrial Exhibition
Poster Session 2
Adaptive Immunity
Emerging Viruses
Trafficking
Virus Vectors and Gene Therapy
Structure and Assembly
15.30–17.30
14.00-15.30
Workshop
Neue Formate in der virologischen Lehre
p. 27
p. 28
15.30–17.30
Tumor Viruses
Antiviral Therapy and Resistance
Evolution of Viruses – Viruses in Evolution
p. 64
17.30–18.45
Laudationes and Presentations
Loeffler Frosch Award and Medal
19.00–20.00
GfV General Assembly
Lunch Break within the Industrial Exhibition
p. 28
p. 28
p 11
Programme overview • Friday, 24 March 2017
Track I – The Virus
Track II – The Host
Track III – The Clinical View
Audimax - 2nd floor
Lecture hall 1 - ground floor
Lecture hall 2 - 1 floor
Workshop 11
Structure and Assembly
Workshop 12
Tumor Viruses
p. 30
Coffee Break within the Industrial Exhibition
10.45–12.15
Plenary Session 3
Novel Antiviral Concepts
st
08.30–10.00
10.00–10.45
Workshop 13
Antiviral Therapy and Resistance
p. 31
p. 32
p. 33
12.30–13.30
Lunch Symposium
Takara Bio Europe SAS
Lunch Break within the Industrial Exhibition
p. 33
Workshop 14
Evolution of Viruses – Viruses in
Evolution
15.00-15.30
DURC Workshop
15.45–16.15
DFG Funding
p. 35
15.00–15.45
p. 36 Coffee Break within the Industrial Exhibition
p. 36
p. 38
Social Evening
Workshop 15
Vaccines
p. 34
Workshop 16
Viral Pathogenesis and Persistence
Poster Session 3
Vaccines
Viral Pathogenesis and Persistence
Host Cell Factors and Modulation 1+2
Epidemiology and Public Health
Zoonoses
Clinical Virology
13.30–15.00
16.15–17.45
Workshop 17
Host Cell Factors and Modulation 1
17.45–19.45
20.00–01.00
Workshop 18
Epidemiology and Public Health
p. 39
p. 40
p. 86
p. 119
p 12
Programme overview • Saturday, 25 March 2017
Track I – The Virus
Track II – The Host
Track III – The Clinical View
Audimax - 2nd floor
Lecture hall 1 - ground floor
Lecture hall 2 - 1 floor
Workshop 19
Zoonoses
08.30–10.00
Workshop 20
Host Cell Factors and Modulation 2
Workshop 21
Clinical Virology
p. 42
Coffee Break within the Industrial Exhibition
10.30–12.00
Plenary Session 4
Innate Immunity
12.00–12.30
Poster Prizes and Farewell
10.00-10.30
st
p. 43
p. 44
p. 45
p. 45
p 13
Room
nn
on
Audimax – 2nd floor
Musical Interlude
Tango para tres
Welcome note by the President of the Society for Virology (GfV)
T. Mertens (Ulm/DE)
Welcome note by the Vice President of the Society for Virology (GfV)
H. Hengel (Freiburg/DE)
Welcome note by the Conference Chair
S. Becker (Marburg/DE)
Welcome note by the Vice President of the
Philipps-Universität Marburg
M. Bölker (Marburg/DE)
Musical Interlude
Tango para tres
Room
Chairs
n
ss on
n
s s
n
Audimax – 2nd floor
T. C. Mettenleiter (Greifswald – Isle of Riems/DE)
C. Drosten (Bonn/DE)
s ons s
13.00
Lessons learned from Ebola R&D during a public health emergency
M. P. Kieny (Geneva/CH)
13.30
Vaccines against emerging viruses - Insights from Ebola, MERS and beyond
M. Addo (Hamburg/DE)
14.00
Emergence of congenital Zika syndrome in the Americas
S. C. Weaver (Galveston, TX/US)
off
Room
n
n
o s
Audimax – 2nd floor
o
s
tion
From sample to insight – simplify your lab life with zymo
A. Martin (Freiburg/DE)
p 14
Scientific Programme • Wednesday, 22 March 2017
15.30–17.00
Room
Chairs
15.30
OP01
15.45
OP02
16.00
OP03
16.15
OP04
16.30
OP05
16.45
OP06
Workshop 1 – Virus Receptors and Entry
Audimax – 2nd floor
J. Schneider-Schaulies (Würzburg/DE), S. Pöhlmann (Göttingen/DE)
Proteomic analysis of the CD81-receptor complex reveals interactions
important for hepatitis C virus and plasmodium entry into
hepatocytes
J. Brüning, P. Banse, S. Kahl, D. Todt, F. Vondran (Hanover/DE)
L. Kaderali (Greifswald/DE), O. Silvie (Paris/FR)
T. Pietschmann (Hanover/DE), F. Meissner (Martinsried/DE)
G. Gerold (Hanover/DE)
A novel mechanism of antibody-induced enhancement of flavivirus
cell attachment and infection
D. Haslwanter, D. Blaas, J. Blazevic, F. X. Heinz, K. Stiasny (Vienna/AT)
Phosphoproteomic-based kinase profiling of influenza A virus
infected cells reveals GRK2 as a crucial host-factor for viral entry
E. Yangüez (Zurich/CH), M. P. Dobay (Lausanne/CH)
S. Stertz (Zurich/CH)
A conserved Eph receptor-binding motif and novel receptor
interactions of the gH/gL glycoprotein complexes of KSHV and
RRV – determinants of infectivity and tropism
A. Großkopf (Göttingen/DE), A. Ensser (Erlangen/DE)
S. Schlagowski (Göttingen/DE), R. Desrosiers (Miami, FL/US)
A. Hahn (Göttingen/DE)
A polymorphism within the internal fusion loop of the Ebola virus
glycoprotein modulates host cell entry efficiency
M. Hoffmann, L. Crone (Göttingen/DE), E. Dietzel (Marburg/DE)
J. Paijo (Hanover/DE), M. González Hernández (Göttingen/DE)
U. Kalinke (Hanover/DE), S. Becker (Marburg/DE)
S. Pöhlmann (Göttingen/DE)
ErbB2 as part of the secondary and entry receptor complex
S. Mikulicic, K. D. Scheffer, F. Boukhallouk, S. Tenzer (Mainz/DE)
K. Reiß (Kiel/DE), L. Florin (Mainz/DE)
p 15
Scientific Programme • Wednesday, 22 March 2017
15.30–17.00
Room
Chairs
15.30
OP07
15.45
OP08
16.00
OP09
16.15
OP10
16.30
OP11
16.45
OP12
p 16
Workshop 2 – Innate Immunity 1
Lecture hall 1 – ground floor
M. M. Brinkmann (Braunschweig/DE), G. Kochs (Freiburg/DE)
Nuclear RIG-I as an influenza A virus restriction factor
M. Gerlach (Giessen/DE; Kyoto/JP), W.-L. Yao, J. M. Cabrejas
A. Makino, K. Tomonaga, H. Kato (Kyoto/JP), F. Weber (Giessen/DE)
T. Fujita (Kyoto/JP)
The evolutionary stand-off between STAT2-mediated antiviral activity
and virus-encoded STAT2 antagonism determines host as well as
virus survival
V. T. K. Le-Trilling, K. Wohlgemuth, M. Rückborn, A. Jagnjic, L. Timmer
B. Katschinski, M. Trilling (Essen/DE)
Identification of potent restriction factors of HCV infection and their
contribution to viral species-tropism
R. Brown, C. Ginkel, M. Engelmann, A. Kusuma, J. Sheldon, T. Khera
K. Welsch, R. Weller, D. Todt, P. Perin, K. Hüging, G. Vieyres
G. Gerold, D. Bankwitz, E. Steinmann, Q. Yuan, M. Ott (Hanover/DE)
E. Michailidis, V. L. Dao Thi, M. Saeed (New York, NY/US), Q. Ding
B. Winer (Princeton, NJ/US), C. Rice (New York, NY/US)
A. Ploss (Princeton, NJ/US), T. Pietschmann (Hanover/DE)
Secretion of Hepatitis C virus replication intermediates in
extracellular vesicles reduces TLR3 response in hepatocytes
O. Grünvogel, V. Klöss, A. Reustle, K. Esser-Nobis, I.-K. Stöck, J.-Y. Lee
R. Bartenschlager, A. Dalpke, V. Lohmann (Heidelberg/DE)
Polarized innate immune response against enteric viruses reveals
novel mechanisms of immune tolerance in the human gut
M. Stanifer, D. Albrecht, K. Pervolakari (Heidelberg/DE)
S. Bartfeld (Würzburg/DE), S. Boulant (Heidelberg/DE)
LGP2 plays an essential role in HCV infection-induced interferon
responses
L. Hei, J. Zhong (Shanghai/CN)
Scientific Programme • Wednesday, 22 March 2017
15.30–17.00
Room
Chairs
15.30
OP13
15.45
OP14
16.00
OP15
16.15
OP16
16.30
OP17
16.45
OP18
Workshop 3 – Diagnostic Tools
Lecture hall 2 – 1st floor
C. Keller (Marburg/DE), M. Panning (Freiburg/DE)
Effective detection of porcine cytomegalovirus (PCMV) in piglets
using samples collected by non-invasive methods
V. Morozov (Berlin/DE), G. Heinrichs (Aachen/DE)
J. Denner (Berlin/DE)
Comparative characterization of hepatitis B virus surface antigen
derived from different hepatitis B virus genotypes
M. Hassemer, M. Finkernagel (Langen/DE)
K.-H. Peiffer (Frankfurt a. M./DE), D. Glebe (Giessen/DE), S. Akhras
A. Reutter, H. Scheiblauer (Langen/DE)
L. Sommer (Frankfurt a. M./DE), M. Chudy
C. M. Nuebling (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
Differentiation of flavivirus infections using a multi antigen ELISA
based on recombinant envelope proteins with mutations in the
conserved fusion loop domain
A. Rockstroh, B. Moges, F. von Daak (Leipzig/DE)
L. Barzon (Padova/IT), M. Niedrig (Berlin/DE), S. Ulbert (Leipzig/DE)
Development of a novel highly specific ZIKV immune complex binding
IgG ELISA
A. Rackow, C. Ehmen, A.-M. Mallmann, J. Sievertsen, H. Schmitz
J. Schmidt-Chanasit, C. Deschermeier, A. Mika (Hamburg/DE)
How to manage the change of measurement method for viral load in
an ISO 15189 accredited laboratory using the Panther platform?
H. Le Guillou-Guillemette, A. Pivert, C.-T. Tran, A. Ducancelle
F. Lunel-Fabiani (Angers/FR)
Deciphering the viral origin of acute febrile illnesses in Uganda using
a metagenomic next-generation sequencing approach.
H. Jerome (Glasgow/GB), T. Byaruhanga, B. Kigozi, H. Bukenya
J. Salazar-Gonzalez, M. Salazar, A. Nankya (Entebbe/UG), G. Kharod
S. Shadomy, D. Blaney, W. Bower (Atlanta, GA/US), J. Bwogi
R. Downing,J. Kayiwa, J. Lutwama, P. Kaleebu (Entebbe/UG)
E. Thomson (Glasgow/GB)
17.00–17.45Coffee break within the industrial exhibition
p 17
Scientific Programme • Wednesday, 22 March 2017
17.45–19.15
Room
Chairs
17.45
OP19
18.00
OP20
18.15
OP21
18.30
OP22
18.45
OP23
19.00
OP24
p 18
Workshop 4 – Viral Replication 1
Audimax – 2nd floor
N. Tautz (Lübeck/DE), J. Ziebuhr (Giessen/DE)
The 5’-terminal stem-loop 2 is a structurally and functionally
conserved cis-acting RNA element in coronavirus genomes
R. Madhugiri, N. Karl, D. Petersen (Giessen/DE), M. Fricke
M. Marz (Jena/DE), J. Ziebuhr (Giessen/DE)
Role of RNA secondary structures within the transcription start sites
of the Ebola virus (EBOV) genome
R. K. Hartmann, S. Bach, H. Huber, A. Grünweller, S. Becker
N. Biedenkopf (Marburg/DE)
Hepatitis E virus replication and interferon response in human
placental-derived cells
L. Knegendorf, S. A. Drave (Hanover/DE), Y. Debing (Leuven/BE)
M. Engelmann, D. Todt (Hanover/DE), J. Neyts (Leuven/BE)
P. Behrendt, E. Steinmann (Hanover/DE)
Mutational analysis suggests that coordinated acetylation of the
influenza A virus nucleoprotein is required for efficient budding of
viral particles and polymerase activity
S. Giese, K. Ciminski, H. Bolte, E. Moreira (Freiburg/DE)
S. Lakdawala (Pittsburgh, PA/US), Q. David (Freiburg/DE)
L. Kolesnikova (Marburg/DE), V. Götz (Freiburg/DE), Y. Zhao, E. Chin
K. Xu (Shanghai/CN), M. Schwemmle (Freiburg/DE)
Mechanistic studies of NS2-3 independent virion morphogenesis in
pestiviruses
F. Schlotthauer, D. Dubrau, N. Tautz (Lübeck/DE)
Membrane alterations induced by nonstructural proteins of human
Norovirus
S. Doerflinger, M. Cortese, I. Romero Brey, Z. Menne (Heidelberg/DE)
T. Tubiana (Gif-Sur-Yvette/FR), R. Bartenschlager (Heidelberg/DE)
S. Bressanelli (Gif-Sur-Yvette/FR)
G. S. Hansman (Gif-Sur-Yvette/FR; Heidelberg/DE)
V. Lohmann (Heidelberg/DE)
Scientific Programme • Wednesday, 22 March 2017
17.45–19.15 Workshop 5 – Innate Immunity 2
Room
Lecture hall 1 – ground floor
Chairs
K.-K. Conzelmann (Munich/DE), M. Gerlach (Giessen/DE)
17.45
SMARCA2, the ATPase subunit of the BAF chromatin remodeling
OP25
complex, is required for the antiviral activity of MxA
D. Dornfeld, A. Dudek (Freiburg/DE), T. Vausselin (New York, NY/US)
S. Günther (Freiburg/DE), J. Hultquist (San Francisco, CA/US)
A. Garcia-Sastre, M. Shaw (New York, NY/US)
M. Schwemmle (Freiburg/DE)
18.00
The interferon-γ-inducible protein 16 (IFI16) restricts HIV replication
OP26
by inhibiting LTR promoter-driven viral gene expression
D. Hotter (Ulm/DE), K. L. Jønsson (Aarhus/DK), D. Krnavek
K. Regensburger, M. Bosso, D. Sauter, F. Kirchhoff (Ulm/DE)
18.15
pH-optimum of hemagglutinin-mediated membrane fusion determines
OP27
influenza virus sensitivity to interferon-induced antiviral state
T. Gerlach, L. Hensen, T. Matrosovich, J. Wolf (Marburg/DE)
M. Winkler (Göttingen/DE), C. Peteranderl (Giessen/DE)
H.-D. Klenk (Marburg/DE), F. Weber, S. Herold (Giessen/DE)
S. Pöhlmann (Göttingen/DE), M. Matrosovich (Marburg/DE)
18.30
Effect of allelic variations in the human MxA protein on its antiviral
OP28
activity
L. Graf, F. Sendker (Freiburg/DE), A. Dick (Berlin/DE), E. Barth
M. Marz (Jena/DE), O. Daumke (Berlin/DE), G. Kochs (Freiburg/DE)
18.45
Exploitation of the immune-regulatory function of ADAR1 by measles
OP29virus
C. Pfaller, R. Donohue, R. Cattaneo (Rochester, NY/US)
19.00
The role of TRIM proteins in virus-induced autophagy
OP30
K. M. Sparrer, S. Gableske, F. Full, G. J. Baumgart (Chicago, IL/US)
J. Kato, G. Pacheco-Rodriguez (Bethesda, MD/US)
C. Liang (Los Angeles, CA/US), O. Pornillos (Charlottesville, VA/US)
J. Moss, M. Vaughan (Bethesda, MD/US), M. U. Gack (Chicago, IL/US)
p 19
Scientific Programme • Wednesday, 22 March 2017
19.15–21.30Get-Together within the industrial exhibition
(please refer to page 119)
19.30–21.30
Room
Poster Session 1
00/0080, Foyer 1st floor 1.1
(Virus Receptors and Entry, Innate Immunity 1+2, Diagnostic Tools,
Viral Replication 1+2)
3rd GERMAN PHARM-TOX SUMMIT
84. Jahrestagung
Deutschen Gesellschaft für experimentelle und klinische
Pharmakologie und Toxikologie (DGPT)
und 20. Jahrestagung des Verbundes Klinische Pharmakologie (VKliPha)
der
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in Zusammenarbeit mit der AGAH
26 February–01 March
p 20 GÖTTINGEN | 2018
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p 21
Scientific Programme • Thursday, 23 March 2017
08.30–10.00
Room
Chairs
08.30
OP31
08.45
OP32
09.00
OP33
09.15
OP34
09.30
OP35
09.45
OP36
p 22
Workshop 6 – Viral Replication 2
Audimax – 2nd floor
O. T. Fackler (Heidelberg/DE), W. Brune (Hamburg/DE)
Herpes Simplex Virus 1 induces antisense transcription from the host
cell genome
E. Wyler (Berlin/DE), J. Menegatti (Homburg/DE), V. Franke
C. Kocks (Berlin/DE), A. Rutkowski (Würzburg/DE)
L. Baer (Homburg/DE), L. Münster, A. Boltengagen
K. Theil (Berlin/DE), T. Hennig (Würzburg/DE), A. Akalin
N. Rajewsky (Berlin/DE), L. Dölken (Würzburg/DE)
M. Landthaler (Berlin/DE), F. Grässer (Homburg/DE)
Role of virus replication in Marek’s disease virus integration
R. Lopes Previdelli, L. D. Bertzbach, T. Faflíková, B. B. Kaufer (Berlin/DE)
Three-dimensional ultrastructural analysis reveals rate-determining
steps of HCMV egress
C. Villinger, G. Neusser, P. Walther, T. Mertens, J. von Einem (Ulm/DE)
Non-plaque-forming virions of Modified Vaccinia virus Ankara
express viral genes
A.-T. Lülf, A. Freudenstein, L. Marr, G. Sutter, A. Volz (Munich/DE)
Covalent SUMO attachment to HAdV E2A/DBP by host-cell cascades
is beneficial for productive virus replication
M. Terzic (Neuherberg, Munich/DE), J. Berscheminski (Hamburg/DE)
R. T. Hay (Dundee/GB), T. Dobner (Hamburg/DE)
S. Schreiner (Neuherberg, Munich/DE)
Refined characterization of Cowpox virus replication and virus-host
interaction using human skin equivalents as a 3D infection model
M. Neumann, R. Koban (Berlin/DE), F. Groeber
H. Walles (Würzburg/DE), H. Ellerbrok (Berlin/DE)
Scientific Programme • Thursday, 23 March 2017
08.30–10.00
Room
Chairs
08.30
OP37
08.45
OP38
09.00
OP39
09.15
OP40
09.30
OP41
09.45
OP42
Workshop 7 – Adaptive Immunity
Lecture hall 1 – ground floor
F. Klein (Cologne/DE), H. Hengel (Freiburg/DE)
Investigating into the “antibody bipolar bridging hypothesis” by the
HCMV-encoded Fc-gamma receptors gp34 and gp68
P. Kolb, D. Gütle, H. Hengel (Freiburg/DE)
Fas Ligand-mediated cytotoxicity of CD4+ T cells control chronic
Friend Retrovirus Infection
A. Malyshkina, U. Dittmer (Essen/DE)
NKG2Cpos NK cells associated with CMV infection inhibit expansion
of activated virus-specific CD8 T cells
C. Thöns, E. Bäcker, A. Zimmermann, M. Uhrberg, P. Lang
J. Timm (Düsseldorf/DE)
Down regulation of Matrix protein 2 levels is a novel immune escape
mechanism of influenza A virus
S. Xavier, S. Van den Hoecke, B. Vrancken, L. Deng, E. Job, K. Roose
B. Schepens, P. Lemey (Ghent/BE)
Molecular determinants of human neutralizing antibodies isolated
from a patient infected with Zika virus
Q. Wang* (Beijing, Shenzhen/CN), H. Yang* (Beijing, Hefei/CN)
X. Liu* (Nanchang/CN), L. Dai* (Beijing/CN), T. Ma (Beijing, Hefei/CN)
J. Qi (Beijing/CN), G. Wong (Shenzhen, Beijing/CN), R. Peng (Beijing/CN)
S. Liu (Beijing, Hefei/CN), J. Li, S. Li, J. Song, J. Liu (Beijing/CN)
J. He (Shanghai/CN), H. Yuan, Y. Xiong (Nanchang/CN)
Y. Liao, J. Yang (Ganzhou/CN), Z. Tong (Beijing, Shenzhen/CN)
B. D. Griffin (Winnipeg/CA), Y. Bi (Shenzhen, Beijing/CN)
M. Liang (Beijing/CN), X. Xu (Oxford/GB), C. Qin, G. Cheng
X. Zhang (Beijing/CN), P. Wang (Leeds/GB), X. Qiu
G. Kobinger (Winnipeg/CA), Y. Shi (Shenzhen, Beijing/CN)
J. Yan (Beijing, Shenzhen, Hefei/CN)
G. F. Gao (Shenzhen, Beijing, Hefei, Hangzhou/CN)
Antigen-dependent competition shapes the local repertoire of
tissue-resident memory CD8+ T cells
A. Muschaweckh, V. Bucholz (Munich/DE), A. Fellenzer
C. Hessel (Mainz/DE), P. A. König (Munich/DE), S. Tao
R. Tao (Düsseldorf/DE), M. Heikenwälder, D. Busch
T. Korn (Munich/DE), W. Kastenmüller (Bonn/DE)
G. Gasteiger (Mainz/DE), I. Drexler (Düsseldorf/DE)
p 23
scientific Programme • thursday, 23 march 2017
08.30–10.00 Workshop 8 – emerging Viruses
(organised in cooperation with “SFB 1021”)
Room
Lecture hall 2 – 1st floor
Chairs
A. Groseth (Greifswald – Isle of Riems/DE)
T. Strecker (Marburg/DE)
08.30
OP43
Uukuniemi virus as a tick-borne virus model
M. Mazelier, B. Brügger (Heidelberg/DE), L. Bell-Sakyi (Pirbright/GB)
P.-Y. Lozach (Heidelberg/DE)
08.45
OP44
Novel reassorted highly pathogenic H5N8 influenza A viruses cause
massive outbreaks in wild birds and poultry in Germany, 2016/2017
A. Pohlmann, E. Starick, T. C. Harder, C. Grund, D. Höper, A. Globig
C. Staubach, K. Dietze, G. Strebelow, R. G. Ulrich, J. Schinköthe
J. P. Teifke, F. Conraths, T. C. Mettenleiter
M. Beer (Greifswald – Isle of Riems/DE)
09.00
OP45
Zika virus NS2B-NS3 protease – Structures, cleavage specificity, and
inhibitors
R. Hilgenfeld, L. Zhang, Y. Gül, M. Onwuatuegwo (Lübeck/DE), W. Rut
M. Drag (Wroclaw/PL), J. Lei (Lübeck/DE)
09.15
OP46
Epidemic strains of Zika virus infect cytotrophoblasts and Hofbauer
cells modeled in explants of chorionic villi from early-gestation
human placentas
L. Pereira, T. Tabata, M. Petitt (San Francisco, CA/US)
H. Puerta-Gardo, D. Michlmayr, E. Harris (Berkeley, CA/US)
09.30
OP47
Structural biology of Zika virus – drug targets from NS1 and NS5
Y. Shi, G. F. Gao (Beijing/CN)
09.45
OP48
Several novel orthobunyaviruses detected in mosquitoes from
Central-American rainforests
M. Marklewitz (Bonn/DE; Panama City/PA), K. Hermanns (Bonn/DE)
J. Schmid, G. Eibner (Panama City/PA; Ulm/DE), F. Zirkel (Bonn/DE)
J. R. Loaiza (Panama City/PA), P. Trippner (Bonn/DE)
S. Sommer (Ulm/DE), C. Drosten, S. Junglen (Bonn/DE)
10.00–10.45 coffee break within the industrial exhibition
p 24
Scientific Programme • Thursday, 23 March 2017
10.45–12.15 Plenary Session 2 – Structural Virology
Room
Audimax – 2nd floor
Chairs
F. X. Heinz (Vienna/AT), H.-G. Kräusslich (Heidelberg/DE)
10.45
New views of virus structure from cryo-EM
J. Briggs (Cambridge/GB)
11.15
Enveloped virus entry and fusion
G. Gao (Beijing/CN)
11.45
Flavivirus structural heterogeneity – implications for antibody
neutralisation and vaccine design
F. Rey (Paris/FR)
12.15–14.00Lunch break within the industrial exhibition
12.30–13.30Lunch Symposium – Carl Zeiss Microscopy GmbH 3D imaging microscopy – From specific fluorescence to SEM
ultrastructure
Room
Audimax – 2nd floor
Your platform for automated live cell imaging – ZEISS
celldiscoverer 7
S. Alsheimer (Jena/DE)
Your new standard for fast and gentle confocal imaging – Airyscan
from ZEISS
E. Simbürger (Jena/DE)
New tools for 3D electron microscopy from ZEISS
J. Lindenau (Jena/DE)
12.30–13.30Lunch Symposium – QIAGEN GmbH
Room
Lecture hall 1 – ground floor
Chairs
N. N.
QIAGEN sample to insight solutions for Virology – A R&D update
N.N.
p 25
Scientific Programme • Thursday, 23 March 2017
14.00–15.30
Room
Chairs
14.00
OP49
14.15
OP50
14.30
OP51
14.45
OP52
15.00
OP53
15.15
OP54
p 26
Workshop 9 – Trafficking
Audimax – 2nd floor
B. Klupp (Greifswald – Isle of Riems/DE), B. Sodeik (Hanover/DE)
Identification of syntaxin 4 as an essential factor for the hepatitis C
virus life cycle
H. Ren, F. Elgner, K. Himmelsbach, S. Akhras, B. Jiang, R. Medvedev
D. Ploen (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
Cytomegalovirus pUL50, the multi-interacting determinant of the
core nuclear egress complex (NEC), is phosphorylated by viral and
cellular protein kinases
E. Sonntag, J. Milbradt, M. Marschall (Erlangen/DE)
A tyrosine-based trafficking motif of the tegument protein pUL71 is
crucial for human cytomegalovirus virion envelopment
A. Dietz, C. Villinger, S. Becker, L. Wettstein, M. Frick
J. von Einem (Ulm/DE)
The importins of nuclear targeting of herpes simplex virus in neurons
K. Döhner, A. Buch (Hanover/DE), S. Hügel (Lübeck/DE)
F. Rother (Berlin/DE), R. Lebbink, E. Wiertz (Utrecht/NL)
E. Hartmann (Lübeck/DE), M. Bader (Berlin/DE)
B. Sodeik (Hanover/DE)
A novel live-cell imaging system reveals essential viral factors for the
transport of Ebola virus nucleocapsids
Y. Takamatsu, S. Becker (Marburg/DE)
The CD63-syntenin-1 complex controls post-endocytic trafficking of
oncogenic human papillomaviruses
L. Fast, L. Gräßel, K. D. Scheffer, F. Boukhallouk, G. A. Spoden
S. Tenzer (Mainz/DE), K. Boller (Langen/DE), R. Bago
S. Rajesh (Birmingham/GB), M. Overduin (Edmonton/CA)
F. Berditchevski (Birmingham/GB), L. Florin (Mainz/DE)
Scientific Programme • Thursday, 23 March 2017
14.00–15.30 Workshop 10 – Virus Vectors and Gene Therapy
Room
Lecture hall 1 – ground floor
Chairs
C. Buchholz (Langen/DE), G. Zimmer (Mittelhäusern/CH)
14.00
Construction of large capacity gene transfer vectors based on murine
OP55cytomegalovirus
A. Riedl, D. Bojková, P. König, P. Zimmermann, S. Naumann
Z. Ruzsics (Freiburg/DE)
14.15
Oncolytic viruses retargeted to the tumor stem cell marker CD133
OP56
D. Kleinlützum (Langen, Heidelberg/DE), A. G. Muik, J. D. S. Hanauer
S.-K. Kays (Langen/DE), C. Ayala-Breton
K. W. Peng (Rochester, NY/US), C. J. Buchholz (Langen, Heidelberg/DE)
14.30
Measles virus-derived oncolytic tumor vaccines inhibit metastasis and
OP57
are effective during therapeutic treatment
B. Bodmer, S. Hutzler (Langen/DE), S. Erbar (Mainz/DE)
C. Nürnberger, J. Schnotz (Langen/DE), R. Jabulowsky
U. Sahin (Mainz/DE), M. Muehlebach (Langen/DE)
14.45
Foamy virus particles – Adaptable nucleic acid delivery vehicles to
OP58
provide tools for genetic engineering
F. Lindel, N. Weidner, C. Dodt, F. Bergemann, M. Hamann
D. Lindemann (Dresden/DE)
15.00
CD30-targeted oncolytic viruses as novel therapeutic approach
OP59
against Hodgkin Lymphoma
J. D. S. Hanauer (Langen/DE), B. Rengstl (Frankfurt a. M./DE)
T. Friedel, I. Schneider (Langen/DE), S. Newrzela (Frankfurt a. M./DE)
C. J. Buchholz, A. G. Muik (Langen/DE)
15.15
Efficient delivery of a multiplex CRISPR/Cas9 machinery for the
correction of mutations underlying Duchenne Muscular Dystrophy
OP60
(DMD) using one single high capacity adenoviral vector
E. Ehrke-Schulz, M. Gebbing (Witten/DE), R. A. Kley (Bochum/DE)
A. Ehrhardt (Witten/DE)
p 27
Scientific Programme • Thursday, 23 March 2017
14.00–15.30 Workshop – Neue Formate in der virologischen Lehre
Room
Lecture hall 2 – 1st floor
14.00
Die „Marphili-Simulation” – Ein Modellprojekt zur Erkennung und zum
Management einer neu auftretenden Viruserkrankung
A. Maisner (Marburg/DE)
14.30
MicroLabSkills – Praxis-orientierte Einführung in moderne
mikrobiologisch-virologische Untersuchungsverfahren
M. Panning (Freiburg/DE)
15.00
Das Fach Virologie in den Lernzielkatalogen für das Medizin-Studium
H. Fickenscher (Kiel/DE)
15.30–17.30Coffee break within the industrial exhibition
15.30–17.30 Poster Session 2
Room
01/0120, Foyer 2nd floor 2.6, 2.8
(Adaptive Immunity, Antiviral Therapy and Resistance, Emerging
Viruses, Evolution of Viruses – Viruses in Evolution, Structure and
Assembly, Trafficking, Tumor Viruses, Virus Vectors and Gene Therapy)
17.30–18.45Laudationes and Presentations for the Loeffler Frosch Award and
Medal
Room
Audimax – 2nd floor
19.00–20.00GfV General Assembly
Room
Audimax – 2nd floor
p 28
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p 29
Scientific Programme • Friday, 24 March 2017
08.30–10.00
Room
Chairs
08.30
OP61
08.48
OP62
09.06
OP63
09.24
OP64
09.42
OP65
p 30
Workshop 11 – Structure and Assembly
Audimax – 2nd floor
T. Krey (Hanover/DE), K. Stiasny (Vienna/AT)
Labeling of the HIV-1 envelope protein by genetic code expansion
and click chemistryfor live-cell imaging and super-resolution nanoscopy
V. Sakin, J. Hanne, M. Anders-Össwein, V. Laketa (Heidelberg/DE)
I. Nikić (Heidelberg, Tübingen/DE), H.-G. Kräusslich, E. A. Lemke
B. Müller (Heidelberg/DE)
Structural insights into arenavirus cap-snatching machinery
M. Rosenthal, N. Gogrefe (Hamburg/DE), J. Reguera (Marseille/FR)
D. Vogel, B. Rauschenberger (Hamburg/DE), S. Cusack (Grenoble/FR)
S. Günther, S. Reindl (Hamburg/DE)
RNA structure in Influenza A virus ribonucleoproteins
D. Ferhadian, V. Vivet-Boudou, G. Bec, P. Wolff
R. Marquet (Strasbourg/FR)
Crystal structure of the HCMV inner tegument protein pUL77 P. Naniima, E. Borst, B. Sodeik, M. Messerle, T. F. Schulz
T. Krey (Hanover/DE)
HCMV nuclear capsid motility is neither directed nor dependent on
nuclear F-actin
E. M. Borst (Hanover/DE), M. Holthaus, T. Günther, R. Reimer
C. Schneider (Hamburg/DE), M. Messerle (Hanover/DE)
A. Grundhoff, K. Grünewald, J. B. Bosse (Hamburg/DE)
Scientific Programme • Friday, 24 March 2017
08.30–10.00
Room
Chairs
08.30
OP66
08.45
OP67
09.00
OP68
09.15
OP69
09.30
OP70
09.45
OP71
Workshop 12 – Tumor Viruses
Lecture hall 1 – ground floor
B. Biesinger (Erlangen/DE), N. Fischer (Hamburg/DE)
Induction of dormancy in hypoxic human papillomavirus
(HPV)-positive cancer cells
K. Hoppe-Seyler, F. Bossler, C. Lohrey, J. Bulkescher
F. Rösl (Heidelberg/DE), L. Jansen (Jena/DE), A. Mayer
P. Vaupel (Mainz/DE), M. Dürst (Jena/DE)
F. Hoppe-Seyler (Heidelberg/DE)
Identification of the tumor suppressor C/EBPα, a novel target of the
HPV8 E6 protein, as a key regulator of the stemness-regulating
miR-203
A. Marthaler, A. Fingerle, E. Ebert, Y.-J. Kim, C. Müller
F. Grässer (Homburg/DE), S. Majewski (Warsaw/PL)
S. Smola (Homburg/DE)
Peripheral and mature B cells are dispensable for Marek’s disease
virus pathogenesis
L. D. Bertzbach (Berlin/DE), M. Laparidou, B. Kaspers
B. Schusser (Munich/DE), B. B. Kaufer (Berlin/DE)
Epstein-Barr virus particles induce centrosome amplification and
chromosomal instability
A. Shumilov, M.-H. Tsai, H.-J. Delecluse (Heidelberg/DE)
Characterization of the interaction of the host factor Kap1/TRIM28
and the Merkel cell polyomavirus encoded oncoproteins
S. Siebels, M. Czech-Sioli, J. Theiss, M. Spohn, C. Schmidt
A. Grundhoff, N. Fischer (Hamburg/DE)
BRD2/4-mediated chromatin association of LANA is important for
latent replication of KSHV
M. Weidner-Glunde, R. Lotke (Hanover/DE)
T. Günther (Hamburg/DE), J. Rückert (Hanover/DE)
A. Grundhoff (Hamburg/DE), T. F. Schulz (Hanover/DE)
p 31
Scientific Programme • Friday, 24 March 2017
08.30–10.00
Room
Chairs
08.30
OP72
08.45
OP73
09.00
OP74
09.15
OP75
p 32
Workshop 13 – Antiviral Therapy and Resistance
Lecture hall 2 – 1st floor
D. Glebe (Giessen/DE), M. Schmidtke (Jena/DE)
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs)
represent regulators of cytomegalovirus replication and putative
targets for anti-herpesviral drugs
C. Hutterer, J. Milbradt (Erlangen/DE), S. Hamilton (Sydney/AU)
M. Zaja, J. Leban, C. Henry (Martinsried/DE), M. Steingruber
E. Sonntag, I. Zeittraeger, H. Bahsi, T. Stamminger (Erlangen/DE)
W. Rawlinson (Sydney/AU), S. Strobl (Martinsried/DE)
M. Marschall (Erlangen/DE)
Tetrahalogenated benzimidazole D-ribonucleoside are active against
RCMV
I. Woskobojnik, A. Dittmer (Berlin/DE), J. C. Drach
L. B. Townsend (Ann Arbor, MI/US), S. Voigt, E. Bogner (Berlin/DE)
Virucidal activity of WHO-recommended formulations against
enveloped viruses including Zika, Ebola and emerging Coronaviruses
A. Siddharta (Hanover/DE), S. Pfaender, N. Jane Vielle
R. Dijkman (Bern/CH), M. Friesland (Hanover/DE)
B. Becker (Bremen/DE), J. Yang (Seoul/KR), M. Engelmann
D. Todt (Hanover/DE), M. Windisch (Seoul/KR), F. Brill (Bremen/DE)
J. Steinmann (Essen/DE), J. Steinmann (Bremen/DE)
S. Becker (Marburg/DE), M. Alves (Bern/CH)
T. Pietschmann (Hanover/DE), M. Eickmann (Marburg/DE)
V. Thiel (Bern/CH), E. Steinmann (Hanover/DE)
Labyrinthopeptin A1 and A2 efficiently inhibit cell entry of primary
human respiratory syncytial virus isolates
S. Blockus, S. Haid, S. M. Wiechert, M. Wetzke (Hanover/DE)
H. Prochnow (Braunschweig/DE), R. Dijkman (Bern/CH)
B. Wiegmann (Hanover/DE)
M.-A. Rameix-Welti (Boulogne-Billancourt/FR)
J.-F. Eléouet (Jouy-en-Josas/FR), P. Duprex (Boston, MA/US)
V. Thiel (Bern/CH), G. Hansen (Hanover/DE)
M. Brönstrup (Braunschweig/DE), T. Pietschmann (Hanover/DE)
Scientific Programme • Friday, 24 March 2017
09.30
HCV Resistance Profile Evolution in a GT1b, DAA-naïve Patient before,
OP76
on and after Failing Triple DAA Therapy
E. Knops, N. Schübel, E. Heger, M. Neumann-Fraune, R. Kaiser
S. Inden, P. Kalaghatgi, S. Sierra (Cologne/DE)
09.45
Risk of HIV-1 low level viremia to treatment failure in the AREVIR
OP77
cohort in Germany
N. Lübke (Düsseldorf/DE), A. Pironti (Saarbrücken/DE)
E. Knops (Cologne/DE), B. Jensen (Düsseldorf/DE)
M. Oette (Cologne/DE), S. Esser (Essen/DE)
T. Lengauer (Saarbrücken/DE), J. Timm (Düsseldorf/DE)
R. Kaiser (Cologne/DE)
10.00–10.45Coffee break within the industrial exhibition
10.45–12.15 Plenary Session 3 – Novel Antiviral Concepts
Room
Audimax – 2nd floor
Chairs
R. Bartenschlager (Heidelberg/DE), S. Ludwig (Münster/DE)
10.45
Antiviral therapy of persistent infection using genome editing
J. Hauber (Hamburg/DE)
11.15
Picornavirus replication – From basic insight to antiviral drug
development
F. v. Kuppeveld (Utrecht/NL)
11.45
HBV-Cure – Fact or fiction?
U. Protzer (Munich/DE)
12.15–13.30Lunch break within the industrial exhibition
12.30–13.30Lunch Symposium Takara Bio Europe SAS
Room
Audimax – 2nd floor
Next-Gen tools to clone and purify proteins: Discover In-Fusion®
and Capturem™!
F. X. Sicot (Saint-Germain-en-Laye/FR)
p 33
Scientific Programme • Friday, 24 March 2017
13.30–15.00
Room
Chairs
13.30
OP78
13.45
OP79
14.00
OP80
14.15
OP81
14.30
OP82
Workshop 14 – Evolution of Viruses – Viruses in Evolution
Audimax – 2nd floor
P. Becher (Hanover/DE), M. Beer (Greifswald – Isle of Riems/DE)
Molecular basis of cell culture adaptation of street rabies virus from
fox and dog
S. Nemitz, M. Christen, F. Pfaff, S. Finke (Greifswald – Isle of Riems/DE)
A novel alphaherpesvirus associated with fatal diseases in banded
penguin chicks (Spheniscus humboldti and S. demersus).
F. Pfaff (Greifswald – Isle of Riems/DE), C. Schulze (Frankfurt/DE)
P. König, K. Franzke (Greifswald – Isle of Riems/DE), S. Bock
A. Hlinak (Frankfurt/DE), J. Kämmerling (Cottbus/DE), A. Ochs
A. Schüle (Berlin/DE), T. C. Mettenleiter, D. Höper
M. Beer (Greifswald – Isle of Riems/DE)
Specific virulence determinants of H7 avian influenza viruses in
chickens – The hemagglutinin multibasic cleavage site and beyond E. M. Abdelwhab, J. Veits, J. Stech
T. C. Mettenleiter (Greifswald – Isle of Riems/DE)
Phylogenetic and functional analyses propose an avian precursor of
currently circulating mammalian bornaviruses
S. Runge, J. Müller, S. Kessler, P. Staeheli, D. Rubbenstroth (Freiburg/DE)
The genome of RNA viruses is highly constrained by the convergent
interplay between protein evolution and RNA structure
A. N. Lozada Chávez, M. Fricke, M. Marz (Jena/DE)
I. Lozada Chávez (Leipzig/DE)
14.45
Virus-virophage-host interactions in the marine protozoan Cafeteria
OP83roenbergensis
M. Fischer (Heidelberg/DE), T. Hackl (Cambridge, MA/US)
p 34
Scientific Programme • Friday, 24 March 2017
13.30–15.00
Room
Chairs
13.30
OP84
13.45
OP85
14.00
OP86
14.15
OP87
14.30
OP88
Workshop 15 – Vaccines
(organised in cooperation with DZIF)
Lecture hall 2 – 1st floor
G. Sutter (Munich/DE), V. von Messling (Langen/DE)
Tropism of attenuated RABV after oral administration in different
reservoir species
V. te Kamp (Greifswald – Isle of Riems/DE), T. Nolden (Innsbruck/AT)
S. Nemitz, C. Freuling, T. Müller (Greifswald – Isle of Riems/DE)
S. Ortmann, C. Kaiser, A. Vos, P. Schuster (Dessau-Rosslau/DE)
S. Finke (Greifswald – Isle of Riems/DE)
Attenuation mechanisms of the Junin virus vaccine strain, candid #1
S. Paessler (Galveston, TX/US)
Adeno-associated virus (AAV) vector as a vehicle for a broadly
protective influenza vaccine
D. Demminger, S. Norley, T. Wolff (Berlin/DE)
Efficacy testing of a newly developed MVA-based vaccine against
Ebola virus in a mouse model
A. Kupke (Marburg/DE), A. Volz (Munich/DE), E. Dietzel, J. Schmidt
H. Shams-Eldin, L. Sauerhering (Marburg/DE)
C. Herden (Giessen/DE), M. Eickmann, S. Becker (Marburg/DE)
G. Sutter (Munich/DE)
Priming with a potent HIV-1 DNA vaccine frames the quality of T cell
and antibody responses prior to a poxvirus and protein boost
B. Asbach, J. Köstler (Regensburg/DE), K. Kibler (Tempe, AZ/US)
B. Perdiguero, M. Esteban (Madrid/ES), B. L. Jacobs (Tempe, AZ/US)
D. C. Montefiori, C. C. LaBranche, N. L. Yates, G. D. Tomaras
G. Ferrari (Durham, NC/US), K. E. Foulds
M. Roederer (Bethesda, NY/US), G. Landucci
D. N. Forthal (Irvine, CA/US), M. S. Seaman (Boston, MA/US)
N. Hawkins, S. G. Self (Seattle, WA/US), S. Phogat
J. Tartaglia (Swiftwater, MS/US), S. W. Barnett
B. Burke (Cambridge, MA/US), A. D. Cristillo (Rockville, MD/US)
S. Ding (Lausanne/CH), J. L. Heeney (Cambridge/GB)
G. Pantaleo (Lausanne/CH), R. Wagner (Regensburg/DE)
p 35
Scientific Programme • Friday, 24 March 2017
14.45
OP89
Needle-free delivery of measles virus vaccine to the lower respiratory
tract of non-human primates elicits optimal immunity and protection
R. de Swart, R. de Vries (Rotterdam/NL), L. Rennick (Boston, MA/US)
G. van Amerongen (Rotterdam/NL), S. McQuaid (Belfast/GB)
J. Verburgh, S. Yüksel, A. de Jong (Rotterdam/NL)
K. Lemon (Boston, MA/US), T. Nguyen (Rotterdam/NL)
M. Ludlow (Boston, MA/US), A. Osterhaus (Rotterdam/NL)
P. Duprex (Boston, MA/US)
15.00–15.30DURC Workshop
Room
Audimax – 2nd floor
Update zum gemeinsamen Ausschuss zum Umgang mit
sicherheitsrelevanter Forschung
J. Fritsch (Halle a. d. Saale/DE)
Risk-Assessment von Forschung mit Dual Use-Potential
J. Bohne (Hanover/DE)
15.00–15.45Coffee break within the industrial exhibition
15.45–16.15DFG funding Room
Audimax – 2nd floor
DFG funding: Programme and criteria for successful applications
K. Hartmann (Bonn/DE)
p 36
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Visit the Luminex booth to
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For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/
regions. Please contact Luminex at [email protected] to obtain the appropriate product
information for your country of residence. Validation of the LIS compatibility must be performed by the
end user. Some features may not be available at launch. The ARIES System is a class 1 laser product.
©2017 Luminex Corporation. All rights reserved. Luminex and ARIES are trademarks of Luminex
Corporation, registered in the U.S. and other countries.
p 37
Scientific Programme • Friday, 24 March 2017
16.15–17.45
Room
Chairs
16.15
OP90
16.30
OP91
16.45
OP92
17.00
OP93
17.15
OP94
17.30
OP95
p 38
Workshop 16 – Viral Pathogenesis and Persistence
Audimax – 2nd floor
G. Tekes (Giessen/DE), C. Muñoz-Fontela (Hamburg/DE)
Cytomegalovirus infection promotes the development of allergic
airway disease
S. Reuter (Borstel/DE), J. Maxeiner, J. Podlech, K. Freitag, A. Heinz
C. Belz, R. Holtappels (Mainz/DE)
Differential interactions of a virus suppressor of RNA silencing with
miRNAs modulate plant gene expression and antiviral measures early
in infection
R. Pertermann, S. Tamilarasan, T. Gursinsky (Halle a. d. S./DE)
G. Gambino (Torino/IT), J. Schuck, L. Schwien, H. Lilie
R. Golbik (Halle a. d. S./DE), V. Pantaleo (Bari/IT)
S.-E. Behrens (Halle a. d. S./DE)
The role of infection and depletion of lymphocyte subsets in the
pathogenesis of measles-induced immune suppression
B. Laksono, C. Grosserichter-Wagener, S. Langeveld, R. de Vries
R. Huizinga, J. van Dongen, P. Katsikis, M. Koopmans, M. van Zelm
R. de Swart (Rotterdam/NL)
To cut or not to cut – RNA target selection of the KSHV host-shut-off
factor SOX
C. Vogt (Hanover/DE; Berkeley, CA/US)
M. M. Gaglia (Berkeley, CA, Boston, MA/US), J. Bohne (Hanover/DE)
B. A. Glaunsinger (Berkeley, CA/US)
Antiviral immunity, galectins and the interaction of hantavirus with
professional antigen presenting cells
M. Raftery, F. Weege, A. Karlas, T. Meyer (Berlin/DE)
R. G. Ulrich (Greifswald – Isle of Riems/DE), D. H. Krüger (Berlin/DE)
B. Klempa (Berlin/DE; Bratislava/SK), G. Schönrich (Berlin/DE)
Reverse genetics for a feline coronavirus field isolate to study the
molecular pathogenesis of FIP R. Ehmann, C. Kristen-Burmann, B. Bank-Wolf, M. König, T. Hain
J. Ziebuhr, G. Tekes (Giessen/DE)
Scientific Programme • Friday, 24 March 2017
16.15–17.45
Room
Chairs
16.15
OP96
16.30
OP97
16.45
OP98
17.00
OP99
17.15
OP100
17.30
OP101
Workshop 17 – Host Cell Factors and Modulation 1
Lecture hall 1 – ground floor
E. Friebertshäuser (Marburg/DE), S. Stertz (Zurich/CH)
Genetic manipulation of the IRE1-dependent ER stress pathway
reveals an unexpected role of XBP1u as a repressor of
cytomegalovirus replication
F. Hinte (Hamburg/DE), E. van Anken (Milano/IT)
B. Tirosh (Jerusalem/IL), W. Brune (Hamburg/DE)
Flavivirus infection uncouples translation suppression from cellular
stress responses
H. Roth, V. Magg, F. Uch, P. Mutz, P. Klein (Heidelberg/DE)
K. Haneke (Mannheim, Heidelberg/DE), V. Lohmann
R. Bartenschlager, O. T. Fackler (Heidelberg/DE)
N. Locker (Guildford/GB), G. Stoecklin (Mannheim, Heidelberg/DE)
A. Ruggieri (Heidelberg/DE)
Inhibition of cytosolic phospholipase 2α impairs coronavirus
replication by interfering with virus-induced replicative organelle
formation
C. Müller, M. Hardt (Giessen/DE), D. Schwudke (Borstel/DE)
B. W. Neuman (Texakarna, TX/US), S. Pleschka, J. Ziebuhr (Giessen/DE)
PI3K–Akt hyperactivation and metabolic changes upon alphavirus
infection
B. Thaa (Stockholm/SE; Leipzig/DE), L. Liu (Stockholm/SE)
M. Mazzon (London/GB), C. Castro (Cambridge/GB)
G. M. McInerney (Stockholm/SE)
Role of the endogenous protease testisin in combination with a
secreted Legionella pneumophila protease in activation of influenza
virus HA
A. Arendt, B. Schmeck (Marburg/DE), A. Flieger (Wernigerode/DE)
W. Garten, H.-D. Klenk, E. Böttcher-Friebertshäuser (Marburg/DE)
Hepatitis C Virus replication changes the host cell lipid profile and is
sensitive to manipulations of the lipid metabolism
S. Hofmann (Hamburg/DE), M. Krajewski (Borstel/DE), C. Scherer
V. Mordhorst (Hamburg/DE), V. Scholz (Borstel/DE), M. Klabes
M. Melling, P. Truschow, R. Reimer (Hamburg/DE)
D. Schwudke (Borstel/DE), E. Herker (Hamburg/DE)
p 39
Scientific Programme • Friday, 24 March 2017
16.15–17.45 Workshop 18 – Epidemiology and Public Health
Room
Lecture hall 2 – 1st floor
Chairs
A. Heim (Hanover/DE), A. Mankertz (Berlin/DE)
16.15
Genetic history of HIV-1 subtype A reveals two independent
OP102
introductions in Germany and increasing spread among German MSM
K. Hanke (Berlin/DE), N. R. Faria (Oxford/GB), D. Kühnert (Zurich/CH)
K. Yousef, A. Hauser, K. Meixenberger, A. Hofmann, V. Bremer
B. Bartmeyer (Berlin/DE), O. Pybus (Oxford/GB), C. Kücherer
M. von Kleist, N. Bannert (Berlin/DE)
16.30
Impact of rainfall events on the concentrations of human
OP103
adenoviruses, human noroviruses and bacteriophages in urban
surface waters
F. Kubek, B. Süßenbach, C. Arndt, C. Mekonnen, W. Seis, R. Szewzyk
H.-C. Selinka (Berlin/DE)
16.45
The Global Polio Eradication Program – A never ending story?
OP104
S. Böttcher (Berlin/DE), F. Feil (Hanover/DE), S. Diedrich (Berlin/DE)
17.00
Primary infection vs secondary infection of HCMV in pregnancy and
OP105
impact for the outcome in newborns – why the incoming data from
China do change the incomplete and even wrong view, based on
published data from Birmingham (Alabama) and Sao Paolo (Brazil)
G. Jahn, J. Yang, L. Ye, J. Xu (Tübingen/DE)
17.15
Steep rise of norovirus cases and emergence of a new recombinant
OP106
strain GII.P16-GII.2 in Germany in season 2016–2017
S. Niendorf, S. Jacobsen, M. Faber, T. Bock (Berlin/DE)
17.30
A four year survey of Adenovirus circulation in patients with acute
OP107
respiratory infections
A. Heim (Hanover/DE), S. Buda, B. Schweiger (Berlin/DE)
17.45–19.45 Poster Session 3
02/0110, Foyer 2nd floor 2.1 – 2.5, 2.7
Room
(Vaccines, Viral Pathogenesis and Persistence, Host Cell Factors and
Modulation 1+2, Epidemiology and Public Health, Zoonoses, Clinical Virology)
20.00–01.00Social Evening
(please refer to page 119)
p 40
General Information
p 41
Scientific Programme • Saturday, 25 March 2017
08.30–10.00
Room
Chairs
08.30
OP108
08.45
OP109
09.00
OP110
09.15
OP111
09.30
OP112
09.45
OP113
p 42
Workshop 19 – Zoonoses
Audimax – 2nd floor
M. Schwemmle (Freiburg/DE), S. Junglen (Bonn/DE)
A comparative analysis of Thogotoviruses to assess their zoonotic risk
J. Fuchs (Freiburg/DE), A. Dick, O. Daumke (Berlin/DE)
G. Kochs (Freiburg/DE)
Global assessment of protein de novo synthesis in response to
infection with avian and human influenza A virus
B. Bogdanow, K. Eichelbaum, A. Sadewasser, K. Paki, M. Flöttmann
X. Wang, J. Hou, W. Chen, E. Klipp, L. Wiebusch, T. Wolff
M. Selbach (Berlin/DE)
SARS coronavirus may have originated from frequent recombination
events between SL-CoVs in a single horseshoe bat habitat
B. Hu, X.-L. Yang, X.-Y. Ge, W. Zhang, B. Li, D.-S. Luo (Wuhan/CN)
Y.-Z. Zhang (Dali/CN), M.-N. Wang (Wuhan/CN)
P. Daszak (New York, NY/US), L. Wang (Singapore/SG), J. Cui
Z.-L. Shi (Wuhan/CN)
Hantavirus infection in human gut and hamster animal model
P. T. Witkowski (Berlin/DE), C. C. Perley, R. L. Brocato
J. W. Hooper (Ft. Detrick, MD/US), C. Jürgensen, J.-D. Schulzke
D. H. Krüger, R. Bücker (Berlin/DE)
HPAIV H5 evolution requires adaptation of the hemagglutinin by
elevation of the fusion competence activation pH
U. Wessels, E.-S. M. Abdelwhab, J. Veits, S. Mamerow, O. Stech
D. Hoffmann, M. Beer, T. C. Mettenleiter
J. Stech (Greifswald – Isle of Riems/DE)
Determinants of highly pathogenic H7N7 avian influenza virus
pathogenicity and transmission
C. Dreier (Hamburg/DE), P. Resa-Infante (Hamburg/DE; Grenoble/FR)
A. Otte (Hamburg, Kiel/DE), A. Preuß (Hamburg/DE)
D. van Riel (Hamburg/DE; Rotterdam/NL)
S. Bertram (Hamburg, Lübeck/DE), H.-D. Klenk (Marburg/DE)
G. Gabriel (Hamburg, Lübeck/DE)
Scientific Programme • Saturday, 25 March 2017
08.30–10.00
Room
Chairs
08.30
OP114
08.45
OP115
09.00
OP116
09.15
OP117
09.30
OP118
Workshop 20 – Host Cell Factors and Modulation 2
Lecture hall 1 – ground floor
K. Osterrieder (Berlin/DE), O. Keppler (Munich/DE)
09.45
OP119
Restriction of HIV-1 infectivity by SERINC5 is not mediated by
alterations of the lipid composition of viral particles
B. Trautz, H. Wiedemann, V. Pierini, R. Wombacher, B. Stolp
A. J. Chase (Heidelberg/DE), M. Pizzato (Trento/IT), B. Brügger
O. T. Fackler (Heidelberg/DE)
Varicella zoster virus glycoprotein C increases chemokine-mediated
leukocyte migration
V. Gonzalez-Motos, C. Jürgens, B. Ritter (Hanover/DE)
O. Larsen (Copenhagen/DK), T. L. Rovis, S. Jonjic (Rijeka/HR)
T. Krey, T. F. Schulz (Hanover/DE), B. B. Kaufer (Berlin/DE)
U. Kalinke (Hanover/DE), A. E. Proudfoot (Geneva/CH)
M. M. Rosenkilde (Copenhagen/DK), A. Viejo-Borbolla (Hanover/DE)
Macrophage-released TRAIL contributes to impaired alveolar fluid
clearance after influenza A virus infection
C. Peteranderl, B. Selvakumar (Giessen/DE), L. Morales-Nebreda
E. Lecuona (Chicago, IL/US), T. Wolff (Berlin/DE), R. Morty
W. Seeger (Giessen/DE), J. I. Sznajder, G. Mutlu
S. Budinger (Chicago, IL/US), S. Herold (Giessen/DE)
Inhibition of replication and pathogenesis of Coronaviruses by targeting
viral 2’-O-Methyltransferase
S. Wang, C. Zeng, Y. Wang, R. Pan, Y. Chen, D. Guo (Wuhan/CN)
Marburg virus Vp30 balances the XBP1-dependent unfolded protein response
C. Rohde, S. Becker, V. Krähling (Marburg/DE)
Comparative loss of function screens reveal common pathways
required by Paramyxoviridae and Pneumoviridae
K. Pfeffermann (Langen/DE), D. Anderson (Singapore/SG)
S. Y. Kim (Durham, NC/US), B. Sawatsky (Langen/DE)
P. Duprex (Boston, MA/US)
M. A. Garcia-Blanco (Singapore/SG; Durham, NC, Galveston, TX/US)
V. von Messling (Langen/DE; Singapore/SG; Laval/CA)
p 43
Scientific Programme • Saturday, 25 March 2017
08.30–10.00 Workshop 21 – Clinical Virology
Room
Lecture hall 2 – 1st floor
Chairs
S. Ciesek (Essen/DE), A. Berger (Frankfurt a. M./DE)
08.30
Hepatitis E virus infection is common in neuralgic amyotrophy
OP120
patients and associated with pathological CSF
M. Fritz, B. Berger, D. Endres, O. Stich, M. Panning (Freiburg/DE)
08.45
Effectiveness of rotavirus vaccination in preventing rotavirus-related
OP121
hospitalisations of under-five children, Germany
C. Pietsch, V. Schuster, U. G. Liebert (Leipzig/DE)
09.00
CMV particles mediate acute myeloid leukaemia cell death via soluble
OP122
factors irrespective of viral replication, gene expression, and entry
L. Rink, V. T. K. Le-Trilling (Essen/DE), S. Voigt (Berlin/DE)
M. Trilling (Essen/DE)
09.15
Are human parainfluenza viruses important pathogens in children
OP123
with influenza-like-illness?
B. Schweiger, B. Biere, J. Reiche (Berlin/DE)
09.30
what is required for a hpv test to be suitable for the upcoming
OP124
organized cervical cancer screening programme in germany?
T. Iftner, S. Brucker (Tübingen/DE), K. Neis (Saarbrücken/DE)
A. Staebler, M. Henes, J. Haedicke-Jarboui (Tübingen/DE)
G. Boehmer (Bad Münder/DE), P. Sasieni (London/GB)
09.45
Molecular characterization of influenza A viruses circulating in
OP125
Germany during 2014–2015 to 2016–2017
J. Naumann, M. Wedde, T. Wolff, B. Schweiger (Berlin/DE)
10.00–10.30Coffee break within the industrial exhibition
p 44
Scientific Programme • Saturday, 25 March 2017
10.30–12.00
Room
Chairs
10.30
11.00
11.30
12.00–12.30
Room
Plenary Session 4 – Innate Immunity
Audimax – 2nd floor
U. Dittmer (Essen/DE), R. König (Langen/DE)
Enforced viral replication determines outcome of disease
K. S. Lang (Essen/DE)
Induction and suppression of the interferon response by RNA viruses
F. Weber (Giessen/DE)
Innate antiviral defense by PML nuclear bodies
T. Stamminger (Erlangen/DE)
Poster Prizes & Farewell
Audimax – 2nd floor
Quality Control for Molecular Diagnostics
QCMD Head Office
Todd Campus, West of Scotland
Science Park, Glasgow, Scotland, UK
Qualitätskontrolle für die molekulare Diagnostik
QCMD – Ihr Partner in der Qualitätssicherung der molekularen Diagnostik
Blutübertragbare Viren
MPP
Zentrales Nervensystem
Kongenitale Infektionen
Tropenkrankheiten / “Emerging Diseases“
Multiparameterdiagnostik
Respiratorische Erkrankungen
Wirkstoffresistenz
SERO
Serologie
Sexuell übertragbare Infektionen
Tx-assoziierte Erkrankungen
Gastrointestinale Erkrankungen
Typisierung
Immunschwäche-assoziierte Erkrankungen
Tel: +44 (0) 141 945 6474
Fax: +44 (0) 141 945 5795
www.qcmd.org
p 45
POSTER SESSION OVERVIEW
Posters will be displayed during the whole duration of the conference. The following
topics will be included in the respective sessions:
Poster session 1
Date and time Wednesday, 22 March 2017 • 19.30–21.30
Topics
Virus Receptors and Entry
Innate Immunity 1+2
Diagnostic Tools
Viral Replication 1+2
Numbers
P01-P25
P26-P64
P65-P79
P80-P104
Poster session 2
Date and time
Thursday, 23 March 2017 • 15.30–17.30
Topics
Adaptive Immunity Emerging Viruses
Trafficking
Virus Vectors and Gene Therapy
Structure and Assembly
Tumor Viruses
Antiviral Therapy and Resistance
Evolution of Viruses – Viruses in Evolution
Numbers
P105–P133
P134–P165
P166–P170
P171–P177
P178–P185
P186–P193
P195–P227
P228–P242
Poster session 3
Date and time Friday, 24 March 2017 • 17.45–19.45
Topics
Vaccines
Viral Pathogenesis and Persistence
Host Cell Factors and Modulation 1+2
Epidemiology and Public Health
Zoonoses
Clinical Virology
Numbers
P243–P274
P275–P307
P308–P367
P368–P380
P381–P392
P393–P408
p 46
Poster Session 1
Virus Receptors and Entry
P01
Porcine amino peptidase N domain VII has critical role in binding and entry of
porcine epidemic diarrhea virus
H.-J. Shin (Taejon/KR)
P02
Binding of murine norovirus to histo-blood group antigen impacts infection in cell
culture
H. Wegener, A. Mallagaray, T. Schöne (Lübeck/DE), J. Lockhauserbäumer
C. Uetrecht (Hamburg/DE), T. Peters, S. Taube (Lübeck/DE)
P03
Flavivirus E protein stem interactions in virus entry
I. Medits, F. X. Heinz, K. Stiasny (Vienna/AT)
P04
Identification of candidate domains in the canine distemper virus attachment
protein crucial for infection
M. Herren, M. Wyss, P. Plattet (Bern/CH)
P05
Identification of functional determinants in the Chikungunya virus E2 protein
C. Weber, E. Berberich, C. von Rhein, L. Henss (Langen/DE)
E. Hildt (Langen, Braunschweig/DE), B. Schnierle (Langen/DE)
P06
Establishment of replication-deficient VSVeGFP∆G viruses pseudotyped with
Nipah virus glycoproteins
M. Elvert, O. Dolnik, L. Sauerhering, A. Maisner (Marburg/DE)
P07
Native mass spectrometry analysis of norovirus – glycan mimetics interaction
H. Yan (Hamburg/DE), K. Bücher, L. Hartmann (Düsseldorf/DE), R. Creutznacher
A. Mallagaray, T. Peters (Lübeck/DE), C. Uetrecht (Hamburg/DE)
P08
The autophagic pathway in Uukuniemi virus infection
A. Hoffmann, H. Fleckenstein, M. Simon, S. Blobner, V. Lang (Heidelberg/DE)
N. Brady (Baltimore, MD/US), P.-Y. Lozach (Heidelberg/DE)
p 47
Poster Session 1
Virus Receptors and Entry
P09
Monitoring Measles Virus transmission through a 3D tissue model of human
airway mucosa
S. Derakhshani, M. Steinke, E. Avota, S. Schneider-Schaulies (Würzburg/DE)
P10
Coding and non-coding SCARB1 variants modulate hepatitis C virus replication
cycle as well as the clinical features of hepatitis C
S. Westhaus (Essen, Hanover/DE), M. Deest, A. T. X. Nguyen, F. Stanke, D. Heckl
R. Costa, A. Schambach, M. P. Manns (Hanover/DE), T. Berg (Leipzig/DE)
F. Vondran (Hanover/DE), C. Sarrazin (Frankfurt a. M., Wiesbaden/DE)
S. Ciesek (Essen, Hanover/DE), T. von Hahn (Hanover/DE)
P11
Zika virus entry into permissive cells
K. Kosowicz, K. Pyrć (Krakow/PL)
P12
Identification of potential receptor binding sites on glycoprotein O of the human
cytomegalovirus (HCMV) by charge cluster to alanine scanning
C. Stegmann, F. Rothemund (Ulm/DE), B. Adler (Munich/DE), C. Sinzger (Ulm/DE)
P13
Characterization of SH-SY5Y, a non-lymphocytic cell line resistant to filovirus cell
entry
F. J. Zapatero Belinchon (Hanover/DE), E. Dietzel, O. Dolnik (Marburg/DE)
K. Döhner (Hanover/DE), R. Marques da Costa (Hanover, Essen/DE)
M. P. Manns (Hanover/DE), S. Ciesek (Essen/DE), B. Sodeik (Hanover/DE)
S. Becker (Marburg/DE), T. von Hahn (Hanover/DE)
P14
The cytoplasmic domain of the G protein of Kumasi virus, a novel member of the
genus Henipavirus, determines host species-specific functional activity of Kumasi
virus surface glycoproteins
K. Voigt (Hanover/DE), M. Hoffmann (Göttingen/DE), M. Müller, J. F. Drexler
C. Drosten (Bonn/DE), G. Herrler, N. Krüger (Hanover/DE)
P15
Analysis of herpes simplex virus type 1 glycoprotein L and D chimeras
A. Hofemeier, S. Imdahl, N. Kirschnick, M.-L. Romberg, W. Hafezi, J. Kühn (Münster/DE)
p 48
Poster Session 1
Virus Receptors and Entry
P16
Entry determinants of the human endogenous retrovirus HERV-K(HML-2)
J. Wamara, H. Al-Shehabi, A. Richter, N. Bannert (Berlin/DE)
P17
Functional relevance of the N-terminal domain of pseudorabies virus envelope
glycoprotein H and its interactions with glycoprotein L
M. Vallbracht, S. Rehwaldt, B. G. Klupp, T. C. Mettenleiter
W. Fuchs (Greifswald – Isle of Riems/DE)
P18
Epigallocatechin-3-gallate protects macaques from intrarectal simian/human
immunodeficiency virus infection
J.-B. Liu (Wuhan/CN), J.-L. Li (Philadelphia, PA/US), H. Liu (Wuhan/CN)
X. Wang (Philadelphia, PA/US), Q.-H. Xiao, Q.-Y. Xian, Y. Wang, X.-D. Li, K. Zhuang
L. Zhou, R.-H. Zhou, T.-C. Ma (Wuhan/CN), Y. Persidsky (Philadelphia, PA/US)
W.-Z. Ho (Philadelphia, PA/US; Wuhan/CN)
P19
Emerging bat hepatitis B viruses – evidence for co-factors restricting hepadnaviral
entry and species-specificity
A. König (Giessen/DE), A. Rasche (Bonn/DE), A. Geipel, S. Müller
J. Geyer (Giessen/DE), J. F. Drexler (Bonn/DE), D. Glebe (Giessen/DE)
P20
Receptor-targeted AAV – Improving cell selectivity and identification of cell
Surface receptors mediating cell entry
J. Hartmann, F. Höpfner (Langen/DE), J. E. Carette (Stanford, CA/US)
H. Büning (Hanover/DE), C. J. Buchholz (Langen/DE)
P21
Arenavirus trVLPs as tools to study antibody neutralization
A. Leske, K. Schnepel (Greifswald – Isle of Riems/DE), E. C. Dunham, K. Shifflett
A. Watt (Hamilton, MT/US), T. Hoenen
A. Groseth (Greifswald – Isle of Riems/DE; Hamilton, MT/US)
P22
Phenotypic characterization of substitutions in the hemagglutinin of the 1968
pandemic influenza virus
J. West, J. Baumann, J. Röder, J. Jansen, J. Doedt, N. Mounogou Kouassi
H.-D. Klenk, M. Matrosovich (Marburg/DE)
p 49
Poster Session 1
Virus Receptors and Entry
P23
The role of LAMP1 binding and pH sensing by the spike complex of Lassa virus
H. Cohen Dvashi, H. Israeli, O. Shani, A. Katz, R. Diskin (Rehovot/IL)
P24
Entry of merkel cell polyomavirus into A549 cells
M. Becker, M. Dominguez (Münster/DE), R. M. Schowalter
C. B. Buck (Bethesda, NY/US), M. Schelhaas (Münster/DE)
P25
Host cell tropism of Lassa virus in the human respiratory tract
H. Müller, S. K. Fehling, M. Matrosovich, T. Strecker (Marburg/DE)
Innate Immunity 1+2
P26
Pre-activation with TLR7 agonist accelerates hepatitis B virus clearance in the
mouse model
X. Huang (Essen/DE; Guangzhou/CN), G. Zhang (Guangzhou/CN), J. Liu
Y. Lin (Essen/DE), J. Hou, X. Zhang (Guangzhou/CN), M. Lu (Essen/DE)
P27
APOBEC3-mediated coronavirus restriction through editing and no-editing
mechanism
A. Milewska, K. Pyc (Kraków/PL)
P28
Expression pattern of individual IFN-α subtypes in chronic HIV infection
Y. Li, B. Sun (Wuhan/CN), S. Esser, H. Streeck (Essen/DE), R. Yang (Wuhan/CN)
U. Dittmer, K. Sutter (Essen/DE)
P29
Establishing robust induced pluripotent stem cell-derived model systems to study
hepatitis C virus–host interactions
A. Schoebel, K. Roesch, E. Herker (Hamburg/DE)
P30
Comparative study of human hepatoma cell lines and primary hepatocytes for
hepatotropic virus innate immunity studies
W. Nicolay, J. Brüning, S. Kahl, F. Vondran, T. Pietschmann, G. Gerold (Hanover/DE)
p 50
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p 51
Poster Session 1
Innate Immunity 1+2
P31
The chromatin remodeling factor SPOC1 – a novel player in the intrinsic defense
against human Cytomegalovirus
A. Reichel, M. Scherer, A.-C. Stilp, N. Reuter, S. Lukassen (Erlangen/DE)
S. Schreiner (Munich/DE), A. Winterpacht, T. Stamminger (Erlangen/DE)
P32
Infection of primary human hepatocytes with cell culture-derived Hepatitis B
virus in vitro is accompanied by toll-like receptor 2 activation
R. Broering, Z. Zhang, M. Trippler, C. Real, M. Werner, A. Paul
G. Gerken (Essen/DE), J. Schlaak (Essen, Duisburg/DE), M. Lu (Essen/DE)
P33
Exploitation of PKR as a selector for the identification of immunostimulating
influenza virus RNAs useful for antiviral therapy
M. Budt, C. Mache, M. Zickler, A. Beling, T. Wolff (Berlin/DE)
P34
Mass-spectrometry based profiling of PKR-interaction partners identifies KSRP as
a novel protein regulator of PKR
S. Sänger, T. Wolff (Berlin/DE)
P35
Cholesterol and IFITM3 in influenza A virus entry
A. Kühnl, A. Musiol, C. Ehrhardt, S. Ludwig (Münster/DE), T. Grewal (Sydney/AU)
V. Gerke, U. Rescher (Münster/DE)
P36
Effect of human APOBEC3C Cytidine deaminase on herpes simplex virus 1 (HS V-1)
N. Kirschnick, A. Hofemeier, M.-L. Romberg, W. Hafezi, J. Kühn (Münster/DE)
P37
A systematic approach to identify Interferon Stimulated Genes (ISGs) with
antiviral potential against Ebola virus
R. P. Galao, H. Wilson, K. L. Schierhorn, F. Debeljak (London/GB)
S. Wilson (Glasgow/GB), C. M. Swanson, S. Neil (London/GB)
p 52
Poster Session 1
Innate Immunity 1+2
P38
Stress granule proteins inhibit Ebola virus replication in a transcription- and
replication-competent virus-like particle system
K. L. Schierhorn, H. Wilson, R. P. Galao, F. Debeljak, S. Neil
C. M. Swanson (London/GB)
P39
The human cytomegalovirus ULb’ region codes for multilayered modulation of
TNFα and NFκB signaling
T. Becker (Essen/DE), S. Voigt (Berlin/DE), H. Hengel (Freiburg/DE), M. Trilling
V. T. K. Le-Trilling (Essen/DE)
P40
Regulation of interferon induction through sequestering IRF 7 into inclusion bodies
by nonstructual protein NSs in SFTS Bunyavirus infection
Y. Hong (Nanjing/CN), Z. Xing (Saint Paul, MN/US; Nanjing/CN)
P41
Modulation of DAF and CD59 by influenza A viruses
Z. Vaz da Silva, M. J. Amorim (Oeiras/PT)
P42
HIV-1-mediated downmodulation of HLA-C impacts target-cell recognition and
antiviral activity of NK cells
C. Körner (Hamburg/DE), C. R. Simoneau (Cambridge, MA/US)
P. Schommers (Cologne/DE), M. Granoff, B. Corleis (Cambridge, MA/US)
V. Naranbhai (Cambridge, MA, Frederick, MD/US)
D. S. Kwon (Cambridge, Boston, MA/US)
E. P. Scully (Cambridge, Boston, MA, Baltimore, MD/US)
S. Jost (Cambridge, Boston, MA/US)
M. Carrington (Cambridge, MA, Frederick, MD/US) M. Altfeld (Hamburg/DE)
P43
Inhibition of type I interferon induction by Sandfly Fever Sicilian Virus virulence
factor NSs
J. D. Wuerth (Giessen/DE), M. Habjan, A. Pichlmair (Martinsried/DE)
G. Superti-Furga (Vienna/AT), F. Weber (Giessen/DE)
p 53
Poster Session 1
Innate Immunity 1+2
P44
Gene expression of innate immunity receptors, type I interferons and IL-10 in equine
peripheral mononuclear blood cells in vitro after infection with different strains of
equine herpesvirus type 1 (EHV-1)
A. Golke, R. Jacek, J. Cymerys, T. Dzieciatkowski, A. Chmielewska, A. Tucholska
A. Cywinska, K. Posyniak, M. W. Banbura (Warsaw/PL)
P45
Functional characterization of the porcine ISG15 system regarding expression and
antiviral potential
M. Zickler, N. Althof, A. Beling (Berlin/DE)
P46
Interaction of the foot-and-mouth disease virus with the innate immune system
C. Luttermann, K. Schult, G. Meyers (Greifswald – Isle of Riems/DE)
P47
Reduction of HIV-1 particle infectivity by the interferon-inducible guanylate-binding
proteins 2 and 5 (GBP2 and 5) is evolutionary conserved
E. Reith, D. Hotter, F. Kirchhoff, D. Sauter (Ulm/DE)
P48
Unbiased mass spectrometry based approach to identify protein complexes in
interferon stimulated cells
L. Beatrice, S. Alexey, H. Nadine, G. Virginie, P. Andreas (Martinsried, Munich/DE)
P49
The role of inhibitory ligands expressed on myeloid cells for the regulation of
T cell responses
P. David, M. Drabczyk-Pluta, T. Werner, U. Dittmer, G. Zelinskyy (Essen/DE)
P50
HIV-1 infection leads to changes in the HLA class I-presented peptide repertoire of
primary human CD4+ T-cells
M. Ziegler (Hamburg/DE), A. Nelde, S. Stevanović (Tübingen/DE)
M. Altfeld (Hamburg/DE)
P51
MicroRNA expression profile in NK cells in children with severe and/or recurrent
infection with Herpes simplex virus
M. Lenart, A. Gruca, M. Rutkowska-Zapała, A. Szaflarska, M. Surmiak, K. Kobylarz
M. Majka, M. Sanak, M. Siedlar (Kracow/PL)
p 54
Poster Session 1
Innate Immunity 1+2
P52
SAMHD1-dependent retroviral restriction and sensing in mice
A. Herrmann (Erlangen/DE), R. Behrendt (Dresden/DE), S. Wittmann (Erlangen/DE)
A. Roers (Dresden/DE), T. Gramberg (Erlangen/DE)
P53
Modified Vaccinia virus Ankara induced CCL2 is mediated by type I IFN receptor
and recruits natural killer cells and T cells to the lung
M. H. Lehmann, L. E. Torres-Domínguez, P. J. R. Price, C. Brandmüller (Munich/DE)
C. J. Kirschning (Essen/DE), G. Sutter (Munich/DE)
P54
IFN -λs-induced human Mx2 protein inhibits Hantaan virus infection through the
JAK-STAT pathway
N. Li, Q.-z. Chen (Wuhan/CN), N. Zhu (Wuhan, Xianning/CN), H. Wang, L. Xie, F. Luo
H. Xiong, Y. Feng (Wuhan/CN), M. Yue, Y. Zhang (Nanjing/CN), W. Hou (Wuhan/CN)
P55
Suppression of chikungunya virus and differential innate responses of human
peripheral blood mononuclear cells during co-infection with dengue virus
J. A. Aguilar Briseño, M. Ruiz Silva, H. van der Ende-Metselaar, J. Smit
I. A. Rodenhuis-Zybert (Groningen/NL)
P56
Control of human cytomegalovirus infection by murine and human
monocyte-derived dendritic cells
B. Kasmapour, J. Holzki, T. Kubsch, U. Rand (Braunschweig/DE)
C. Sinzger (Ulm/DE), L. Cicin-Sain (Braunschweig/DE)
P57
Identification and molecular characterization of a novel inhibitory feedback loop
of RIG-I signaling mediated by DAPK1
J. Willemsen, O. Wicht, J. Wolanski, N. Baur, S. Bastian (Heidelberg/DE)
D. A. Haas (Munich/DE), P. Matula (Brno/CZ), B. Knapp (Heidelberg/DE)
L. Meyniel-Schicklin (Lyon/FR), C. Wang (Piscataway, NJ/US), R. Bartenschlager
V. Lohmann, K. Rohr, H. Erfle (Heidelberg/DE)
L. Kaderali (Heidelberg, Greifswald/DE), J. Marcotrigiano (Piscataway, NJ/US)
A. Pichlmair (Munich/DE), M. Binder (Heidelberg/DE)
p 55
Poster Session 1
Innate Immunity 1+2
P58
Kinetic characterization of the RIG-I signal transduction pathway
J. Frankish (Heidelberg/DE), D. Schweinoch, L. Kaderali (Greifswald/DE)
M. Binder (Heidelberg/DE)
P59
DAPK family members are negative regulators of RIG-I signalling
J. Wolanski, J. Willemsen, M. Binder (Heidelberg/DE)
P60
Dissecting molecular mechanisms of inhibition of HCV RNA replication by interferon
A. Pandey, C. Dächert (Heidelberg/DE), D. Schweinoch (Greifswald/DE)
J. Frankish (Heidelberg/DE), C. Zitzmann (Greifswald/DE), M. Schulze (Dresden/DE)
L. Kaderali (Greifswald/DE), M. Binder (Heidelberg/DE)
P61
In vitro evolution of persistent rabies virus – a role for pattern receptors?
M. Eizinger, A. A. Hennrich (Munich/DE), K. M. Sparrer (Munich/DE; Chicago, IL/US)
A. Ghanem, K.-K. Conzelmann (Munich/DE)
P62
IFN inhibition by rabies and other lyssaviruses – identification of critical residues
in the viral phosphoprotein P
M. Wachowius, T. Halbach, K.-K. Conzelmann (Munich/DE)
P63
Phenylalanines 75 and 78 of IFITM3 are dispensable for normal membrane
targeting and IFITM3-IFITM3 interactions
M. Winkler, F. Wrensch, P. Bosch, S. Gärtner, M. Knoth (Göttingen/DE)
M. Schindler (Tübingen/DE), S. Pöhlmann (Göttingen/DE)
P64
Rhesus macaque IFITM3 gene polymorphisms and SIV infection.
M. Winkler, S. Gärtner, F. Wrensch (Göttingen/DE), M. Krawczak (Kiel/DE)
U. Sauermann, S. Pöhlmann (Göttingen/DE)
p 56
70.
EINLADUNG
Jahrestagung der Deutschen
Gesellschaft für Hygiene und
Mikrobiologie (DGHM) e. V.
2018
18.–21. Februar 2018
Tagungspräsidenten:
Prof. Dr. med. Jan Buer
Universitätsklinikum Essen
Prof. Dr. med. Sören Gatermann
Ruhr-Universität Bochum
Prof. Dr. med. Frauke Mattner
Kliniken der Stadt Köln gGmbH
www.dghm-kongress.de
© 9919327 l Sebastian Kaulitzki • 39012914 l reeel l fotolia.com/Bill Branson l wikimedia org
Ruhr-Universität Bochum
p 57
Poster Session 1
Diagnostic Tools
P65
Rapid and sensitive detection of the coat protein gene of red seabream iridovirus
(RSIV) and nervous necrosis virus (NNV) by loop-mediated isothemal
amplification (LAMP)
J. Hwang, S. Y. Park, T.-K. Lee (Geoje/KR)
P66
Efficient detection of pathogen virus in sand dabs, Paralichthys olivaceus using
loop-mediated isothermal amplification (LAMP)
J. Hwang, S. Y. Park, T.-K. Lee (Geoje/KR)
P67
HIV drug resistance in 2 and 1% proportions with NGS in virologic relevant
quantities
R. Ehret, M. Schütze, M. Obermeier (Berlin/DE)
P68
Development of neutralization assay using an eGFP chikungunya virus based on a
newly isolated strain
S.-Q. Liu, C.-L. Deng, L.-L. Xu, B. Zhang (Wuhan/CN)
P69
CpG oligonucleotides increase HBV specific cytokine responses in whole blood
and enhance cytokine release assay sensitivity
W. Dammermann, J. Dornbrack, K. Bröker (Brandenburg a. d. H., Hamburg/DE)
S. Lüth (Brandenburg a. d. H./DE)
P70
Detection of viruses in environmental samples using NGS
A. Bogoyavlenskiy, M. Alexyuk, P. Alexyuk, A. Turmagambetova, V. Berezin (Almaty/KZ)
P71
Development and validation of an immunohistochemistry procedure for the
detection of a neurotropic bovine astrovirus
C. Boujon, S. Selimovic-Hamza, I. Bouzalas, T. Seuberlich (Bern/CH)
P72
Comparison of two imunoassays for simultaneous detection of HCV antigen and
antibodies among HCV/HIV Co-infected patients in dried serum spots
A. Eshetu, B. Bartmeyer, V. Bremer, D. Schmidt, C.-T. Bock, N. Bannert
A. Hauser (Berlin/DE)
p 58
Poster Session 1
Diagnostic Tools
P73
Elaboration of diagnostic tool for detection of antibodies to Newcastle disease virus
O. Blotska (Kyiv/UA)
P74
A cell-based ELISA testing for HIV-1 neutralizing antibodies
D. Ivanusic, J. Denner (Berlin/DE)
P75
Real-time PCR-based, sequencing-independent pathotyping of potentially
zoonotic avian influenza A viruses of the subtypes H5 and H7
A. Graaf, M. Naguib, M. Beer, T. C. Harder (Greifswald – Isle of Riems/DE)
P76
Development of multiplex real-time PCR method for cell-culture based testing of
antivirals with potential activity against human adenovirus C
M. Przybylski, R. Zahorska, T. Dzieciatkowski (Warsaw/PL)
A. Gorski (Warsaw, Wroclaw/PL)
P77
Can plasma free DNA levels be a diagnostic tool to rule out severe postpartal sepsis
G. O. Ajayi (Lagos/NG)
P78
Mechanism research for rion disease
Q. Shi (Beijing/CN)
P79
VAmpSeq – Ultrahigh multiplex PCRs for virus detection
A. Brinkmann, A. Radonic, A. Nitsche (Berlin/DE)
p 59
Poster Session 1
Viral Replication 1+2
P80
The “Y-domain” of hepatitis E virus (HEV) ORF1 – role in RNA replication and
Virion infectivity
M. Parvez (Riyadh/SA)
P81
Epstein-Barr Viruses (EBVs) deficient in EBV-encoded RNAs (EBERs) display reduce
lytic replication in EBV-transformed lymphoblastoid cell lines
Z. Li, M.-H. Tsai, R. Poirey, H.-J. Delecluse (Heidelberg/DE)
P82
Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute
2 complexes binding to the 5´untranslated region of Hepatitis C Virus RNA
A. Nieder-Röhrmann, N. Dünnes, G. Gerresheim, L. Shalamova, A. Herchenröther
M. Niepmann (Giessen/DE)
P83
RNA structure dynamics and sequence context influence microRNA-122 binding in
the NS5B coding region and the 3´untranslated region of Hepatitis C Virus RNA
G. Gerresheim, N. Dünnes, A. Nieder-Röhrmann, L. Shalamova (Giessen/DE)
M. Fricke (Jena/DE), I. Hofacker (Vienna/AT), C. Höner zu Siederdissen (Leipzig/DE)
M. Marz (Jena/DE), M. Niepmann (Giessen/DE)
P84
Dissecting the requirements for Hepatitis C virus RNA synthesis using a split
replication system
L. Shalamova, N. Dünnes, A. Nieder-Röhrmann, G. Gerresheim
D. Metzger (Giessen/DE), S. Mueller, Y. Yutong, E. Wimmer (Stony Brook, NY/US)
O. Rossbach, M. Niepmann (Giessen/DE)
P85
Specific NS1 residues enhance viral replication and pathogenicity of avian
influenza A virus in mammalian systems
P. Kanrai, A. Mostafa, R. Madhugiri (Giessen/DE), M. Lechner (Marburg/DE)
E. Wilk, K. Schughart (Braunschweig/DE), L. Ylösmäki, K. Saksela (Helsinki/FI)
J. Ziebuhr, S. Pleschka (Giessen/DE)
P86
PIAS2 and PIAS1, novel restriction factors of filoviruses?
M. Klüver, S. Becker (Marburg/DE)
p 60
Poster Session 1
Viral Replication 1+2
P87
Influence of bovine hepacivirusIRES domains on translation efficiency
A. L. Baron (Hanover/DE)
P88
Three-dimensional cultivation of primary human cells affects virus-host
interaction on transcriptome level (RNA-Seq)
R. Koban, M. Neumann, A. Daugs, O. Bloch, H. Ellerbrok (Berlin/DE)
P89
A seven-segment influenza A virus packages eight riboucleoprotein cmplexes
T. Noda (Kyoto/JP), S. Murakami, H. Imai, S. Nakatsu (Tokyo/JP), Y. Muramoto
K. Shindo (Kyoto/JP), H. Sagara, Y. Kawaoka (Tokyo/JP)
P90
Examining herpes simplex virus Type 1-induced host shutoff at the transcriptional
level
A. Whisnant, L. Dölken (Würzburg/DE)
P91
First characterization of the pestiviral replication factories
I. Romero Brey (Heidelberg/DE), O. Isken (Lübeck/DE)
R. Bartenschlager (Heidelberg/DE), N. Tautz (Lübeck/DE)
P92
The host factor AUF1 supports Flavivirus RNA replication by destabilizing
stem-loop structures in the 5” and 3” untranslated regions
S. Friedrich, S. Höpfner, T. Schmidt (Halle a. d. S./DE), G. Szczepankiewicz, S. Bergs
U. G. Liebert (Leipzig/DE), B. Kümmerer (Bonn/DE), R. Golbik
S.-E. Behrens (Halle a. d. S./DE)
P93
Human respiratory 3D-tissue models to study the pathogenesis of respiratory
syncytial virus
T. Kreuzahler, M. Steinke, B. Weißbrich, J. Liese, H. Walles, C. Krempl (Würzburg/DE)
P94
Phenotypic lentivirus screens to identify functional single domain antibodies to
interfere with virus replication
F. I. Schmidt (Bonn/DE; Cambridge, MA/US), L. Hanke (Cambridge, MA/US)
B. Morin (Boston, MA/US), R. Brewer (Cambridge, MA/US), V. Brusic
S. P. J. Whelan (Boston, MA/US), H. L. Ploegh (Cambridge, MA/US)
p 61
Poster Session 1
Viral Replication 1+2
P95
Sequence requirements for avian ANP32A to overcome influenza A virus
polymerase host restriction
P. Domingues, B. Hale (Zurich/CH)
P96
Virus-specific antibodies allow viral replication in the marginal zone, thereby
promoting CD8+ T-cell priming and viral control
V. Duhan, V. Khairnar, K. S. Lang (Essen/DE)
P97
Establishment and functional characterization of a fully infectious Hepatitis Delta
Virus genotype 3 clone
F. Lempp, Z. Zhang, S. Urban (Heidelberg/DE)
P98
HI V-1 Vpr increases HCV replication through VprBP in cell culture
Y. Yan, F. Huang, T. Yuan, B. Sun, R. Yang (Wuhan/CN)
P99
Dynamic Phosphorylation of VP30 is essential for Ebola virus life cycle
C. Lier, S. Becker, N. Biedenkopf (Marburg/DE)
P100
Identification of NS3 Surface residues that are critical for HCV replicase assembly
or virion morphogenesis
H. Schwanke, N. Tautz, O. Isken, C. Erfurth (Lübeck/DE)
P101
Role of M1 tyrosine 132 phosphorylation in the influenza A virus life cycle
A. Mecate-Zambrano, Y. Börgeling, D. Anhlan (Münster/DE), T. Shi (Basel/CH)
S. Ludwig (Münster/DE)
P102
The role of the PB2 627-domain in influenza virus polymerase function
B. Nilsson, A. te Velthuis, E. Fodor (Oxford/GB)
p 62
tion
P103
sti
non s
o n
s ti
n
on o o n s s
D. Dubrau, A. E. Kiss, J. Janz, N. Tautz (Lübeck/DE)
n o
n
P104
n tion n
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tion o no o
s nons
Z. Menne, P. Schult, S. Doerflinger, A. Koromyslova, G. S. Hansman
V. Lohmann (Heidelberg/DE)
tion
o
n
SAVE THE DATE
47th Annual Meeting of the German Society for Immunology
© Selby/Janericloebe l wikimedia.org
CELEBRATING
12–15 September 2017 l ERLANGEN
Abstract deadline: 7 May 2017
www.immunology-conference.de
p 63
Poster Session 2
Adaptive Immunity
P105
Improved effector functions of CD8+ T cells by IFNα subtypes are mediated by
antigen-specific DCs
J. Dickow, U. Dittmer, K. Sutter (Essen/DE)
P106
Mesenchymal stem cells induce immune response and protect against lethal
Herpes Simplex Virus Type 1 infection in an animal model
E. Momotyuk, R. Klimova, A. Kushch (Moscow/RU)
P107
Naïve T cells are activated by autologous HCMV-infected endothelial cells through
NKG2D and can control HCMV transmission in vitro
N. Subramanian, Z. Wu, F. Reister, K. Laib Sampaio, G. Frascaroli (Ulm/DE)
L. Cicin-Sain (Braunschweig/DE), T. Mertens (Ulm/DE)
P108
HBV-mediated Nrf2 activation in host cells and its implication for CTL-mediated
immune response
M. Biehl (Langen/DE), K. Wisskirchen, U. Protzer (Munich/DE)
E. Hildt (Langen, Braunschweig/DE)
P109
Zika virus cross-neutralization by polyclonal sera after dengue virus infection
S. Malafa, J. Aberle, S. Aberle, F. X. Heinz, K. Stiasny (Vienna/AT)
P110
Characterization of endogenous MHC Class II presentation pathways from
modified Vaccinia Virus Ankara infected dendritic cells
S. Tao (Düsseldorf/DE), F. Thiele, Y. Zhang, A. Muschaweckh (Munich/DE)
T. Zollmann (Frankfurt a. M./DE), U. Protzer (Munich/DE)
R. Abele (Frankfurt a. M./DE), I. Drexler (Düsseldorf/DE)
P111
Quantification of the TBEV neutralising antibody response to antibody subsets in
human and mouse sera after depletion
V. Bradt, S. Malafa, G. Tsouchnikas, J. Zlatkovic, K. Stiasny, F. X. Heinz (Vienna/AT)
p 64
Poster Session 2
Adaptive Immunity
P112
Identification of blood donors with exceptional neutralizing responses against the
human cytomegalovirus
F. Jessica, S. Dagmar, S. Christian, W. Martina, L. Ramin (Ulm/DE), A. Krawczyk
A. Mira (Essen/DE)
P113
Regulation of antiviral CD8 T cell response by CD100 and its soluble form in HBV
infection
L. Wang, S. Yang (Wuhan/CN), W. Bayer, M. Lu, U. Dittmer (Essen/DE)
J. Timm (Düsseldorf/DE), D. Yang, J. Liu (Wuhan/CN)
P114
Presentation of a conserved adenoviral epitope on HLA-C*0702 allows evasion of
NK but not T-cell responses
A. Keib, P. Günther (Tübingen/DE), B. Faist (Munich/DE), A. Halenius (Freiburg/DE)
D. Busch, M. Neuenhahn (Munich/DE), G. Jahn, K. Dennehy (Tübingen/DE)
P115
Genetic background shapes the fine-specificity and individual variation of
antibody responses to a tick-borne encephalitis virus vaccine
G. Tsouchnikas, V. Bradt, J. Zlatkovic, K. Stiasny, F. X. Heinz (Vienna/AT)
P116
Genome-wide analysis of T cell responses in patients with ongoing and resolved
hepatitis E
J. Al-Ayoubi, P. Behrend, B. Bremer, A. Gisa, F. Rinker, M. P. Manns, M. Cornberg
H. Wedemeyer, A. Kraft (Hanover/DE)
P117
Antibody-mediated virus control in “tolerant” congenitally infected virus carriers
P. Reuther, K. Martin, Y. I. Ertuna, D. Pinschewer (Basel/CH)
P118
Analysis of the adaptive immune response to Nipah virus infection in mice and pigs
E. Stroh (Greifswald – Isle of Riems/DE), L. Sauerhering, A. Maisner (Marburg/DE)
U. Blohm, M. Groschup, S. Diederich (Greifswald – Isle of Riems/DE)
p 65
Poster Session 2
Adaptive Immunity
P119
IL-1β as mucosal vaccine adjuvant – Specific induction of tissue-resident memory
T cells and enhanced protection against heterologous IAV
D. Lapuente, A. Maaske, V. Stab (Bochum/DE), W. Bayer (Essen/DE)
C. Ehrhardt (Münster/DE), M. Tenbusch (Bochum/DE)
P120
In vivo imaging of the interplay between regulatory and effector T cells during
retroviral infection
L. Otto, A. Hasenberg, G. Zelinskyy, W. Bayer, U. Dittmer, M. Gunzer (Essen/DE)
P121
Cross-reactivity profiles of CD8+ T cells targeting an immunodominant epitope in
the core protein of HBV
J. Brinkmann, T. Schwarz (Düsseldorf/DE), H. Kefalakes (Essen/DE)
A. Walker (Düsseldorf/DE), G. Gerken (Essen/DE), J. Timm (Düsseldorf/DE)
P122
Immune evasion strategies of human cytomegalovirus – functional
characterization of the novel HCMV-encoded Fcγ receptor gp95/RL12
K. Hoffmann (Freiburg/DE), E. Mercé-Maldonado, H. Reinhard (Düsseldorf/DE)
E. Corrales-Aguilar (Düsseldorf/DE; San José/CR)
V. T. K. Le-Trilling (Düsseldorf, Essen/DE), P. Lacher (Düsseldorf/DE)
H. Hengel (Freiburg/DE)
P124
B cell-dependent protection during acute pneumovirus infection i immunodeficient
mice
L. Prager, C. Krempl (Würzburg/DE)
P125
The human Cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell
IL-10 secretion
J. Zischke, P. Mamareli, R. Jacobs, C. Falk, T. Sparwasser, T. F. Schulz
P. Kay-Fedorov (Hanover/DE)
p 66
Poster Session 2
Adaptive Immunity
P126
The HSV-1 encoded immunoevasin ICP47 makes use of a highly conserved
ProLeuLeu motif to arrest the conformation of the transporter associated with
antigen processing (TAP)
T. Matschulla (Freiburg/DE), R. Berry (Clayton/AU), C. Gerke (Freiburg/DE)
M. Döring (Hanover/DE), J. Busch (Düsseldorf/DE), U. Kalinke (Hanover/DE)
F. Momburg (Heidelberg/DE), H. Hengel, A. Halenius (Freiburg/DE)
P127
A green fluorescent BAC-cloned human cytomegalovirus with an intact US-gene
region and a self-excisable BAC cassette for use in immunological research
K. Laib Sampaio (Ulm/DE), Z. Wu (New York, NY/US), N. Subramanian, A. Weyell
C. Sinzger (Ulm/DE)
P128
Human cytomegalovirus-infected macrophages are refractory to immunoevasion
mediated by the US2-11 genes and elicit memory CD4+ and CD8+ T responses
C. Bayer, C. Setz (Ulm/DE), S. Varani (Bologna/IT), J. van der Merwe, Z. Wu
J. Hegler, T. Mertens, G. Frascaroli (Ulm/DE)
P129
Decreased immunocompetence in day-old chicks hampers effective immunization
against highly pathogenic avian influenza (HPAI)
J. Schmiedeke, D. Hoffmann, B. Hoffmann, U. Blohm (Greifswald/DE)
P130
Canonical and non-canonical expression of a murine cytomegalovirus early
protein CD8 T-cell epitope drives memory inflation.
A. Fink, A. Renzaho, R. Holtappels, M. J. Reddehase, N. Lemmermann (Mainz/DE)
P131
Ephemeral immune control of CMV infection in TCR transgenic mice recognizing a
single viral epitope
L. Borkner, F. Mbui, Z. Chaudhry, L. Cicin-Sain (Braunschweig/DE)
P132
Fcγ receptor type I (CD64)-mediated abrogation of the capacity of dendritic cells
to activate specific CD8 T cells by IgG-opsonized Friend virus
Z. Banki, D. Bichler, R. Werner, V. Oberhauser (Innsbruck/AT)
S. Verbeek (Leiden/NL), D. von Laer (Innsbruck/AT), U. Dittmer (Essen/DE)
H. Stoiber (Innsbruck/AT)
p 67
Poster Session 2
Adaptive Immunity
P133
Combination of oncolytic virotherapy and DC-based immunotherapy for the
treatment of melanoma
I. Koske, Z. Banki, I. Barnstorf, C. Tripp, P. Stoitzner, N. Romani, G. Wollmann
J. Kimpel, D. von Laer (Innsbruck/AT)
Emerging Viruses
P134
Stratify and rescue Ebola in silico patients
G. Zhao, S. Binder (Braunschweig/DE), G. Pongratz (Düsseldorf/DE)
M. Meyer-Hermann (Braunschweig/DE)
P135
Genetically divergent Filoviruses in Chinese Rousettus and Eonycteris bats
X.-L. Yang (Wuhan/CN), Y.-Z. Zhang (Dali/CN), R.-D. Jiang, Z.-L. Shi (Wuhan/CN)
P136
Zika virus production in different cellular systems
K. Himmelsbach, D. Ploen (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
P137
Screening of new potential inhibitors for ZIKV infection
F. Elgner, D. Ploen, K. Himmelsbach (Langen/DE), T. Schirmeister (Mainz/DE)
A. Grünweller, K. Lange-Grünweller, W. Diederich (Marburg/DE)
E. Hildt (Langen, Braunschweig/DE)
P138
Severe fever with thrombocytopenia syndrome – Transmission of SFTSV and migratory
bird routes in East Asia and SFTS in patients suspected of having scrub Typhus
K. H. Lee (Jeju/KR)
P139
Bafilomycin A1efficiently inhibits infection by ZIKV
C. Sabino, D. Ploen, K. Himmelsbach, S. Akhras, F. Elgner (Langen/DE)
E. Hildt (Langen, Braunschweig/DE)
P140
Isolation and characterization of Zika virus imported to China and development of
SYBR green one-step real-time RT-PCR for virus detection
C. Deng, S. Liu, M. Xu, B. Zhang (Wuhan/CN)
p 68
Poster Session 2
Emerging Viruses
P141
Investigating the host tropism of bovine hepaciviruses
C. Baechlein (Hanover, Braunschweig/DE), D. Meyer, A. L. Baron (Hanover/DE)
S. Peine (Hamburg/DE)
N. Fischer (Hamburg, Lübeck, Borstel, Greifswald – Isle of Riems/DE)
P. Becher (Hanover, Braunschweig/DE)
P142
Transmission of Rift Valley fever virus from viremic lambs to Culex pipiens
mosquitoes native to The Netherlands
R. Vloet, C. Vogels, C. Koenraadt, G. Pijlman, L. Van Keulen, P. Wichgers Schreur
J. Kortekaas (Lelystad/NL)
P143
The Zika virus toolbox-development of an animal model and molecular assays for
an emerging Flavivirus
D. Anderson, O. Sessions, S. Mani, T. Chawla, B. Ho Wenkae, J. H. Tan, X. M. Ong
U. Sangumathi Kamaraj, L.-F. Wang (Singapore/SG)
V. von Messling (Singapore/SG; Langen/DE)
P144
Porcine Epidemic Diarrhea – on the hunt for its molecular pathogenesis
C. Kristen-Burmann, R. Ehmann (Giessen/DE), M. Ackermann (Zurich/CH)
V. Thiel (Bern/CH), G. Tekes (Giessen/DE)
P145
Recent emergence of a novel porcine pestivirus – Interference with classical
swine fever diagnosis?
A. Postel, D. Meyer, A. Petrov, M. Wendt, P. Becher (Hanover/DE)
P146
First outbreak and co-circulation of three different Usutu virus strains in Eastern
Germany
M. Sieg, V. Schmidt (Leipzig/DE), U. Ziegler, M. Keller
D. Höper (Greifswald – Isle of Riems/DE), K. Heenemann, A. Rückner (Leipzig/DE)
H. Nieper, A. Muluneh (Dresden/DE), M. Groschup (Greifswald – Isle of Riems/DE)
T. Vahlenkamp (Leipzig/DE)
P147
Polyanions as the backbone for broad-spectrum antiviral agents
F. Schandock, C. Frich Riber, A. Röcker, P. Gajda, K. Borup Løvchall, F. Kreppel
A. N. Zelikin, J. Münch (Ulm/DE)
p 69
Poster Session 2
Emerging Viruses
P148
Occurrence of Shrew- and Mole-Borne Hantaviruses in Germany
B. Klempa (Berlin/DE; Bratislava/SK), L. Radosa, P. T. Witkowski
P. Köppen-Rung (Berlin/DE), M. Ličková (Bratislava/SK), A. Stang (Bochum/DE)
L. Striešková, T. Szemeš (Bratislava/SK), S. Essbauer (Munich/DE)
R. G. Ulrich (Greifswald – Isle of Riems/DE), D. H. Krüger (Berlin/DE)
P149
The molecular tweezer CLR01 inhibits Zika and other sexually transmitted viruses
A. Röcker, J. Müller, M. Harms, J. Münch, F. Schandock (Ulm/DE)
E. Sanchez-Garcia, K. Bravo-Rodriguez (Mülheim a. d. R./DE), E. Dietzel, A. Kupke
S. Becker (Marburg/DE), J. Schmidt-Chanasit (Hamburg/DE), O. Vapalahti (Helsinki/FI)
T. Schrader (Essen/DE)
P150
Semen inhibits Zika Virus infection
M. Harms, J. Müller, S. Joas, M. Hayn, A. Dietz, J. von Einem, A. Schubert
D. Michel (Ulm/DE), O. Vapalahti (Helsinki/FI), J. Shorter (Philadelphia, PA/US)
J. Schmidt-Chanasit (Hamburg/DE), F. Ebner, J. Münch (Ulm/DE)
P151
VrAP – Full length de novo genome assembly of unknown RNA viruses
M. Fricke (Jena/DE), F. Zirkel, C. Drosten, S. Junglen (Bonn/DE), M. Marz (Jena/DE)
P152
Encephalitis and ganglionitis in domestic sheep caused by astroviruses.
F. Pfaff, K. Schlottau (Greifswald – Isle of Riems/DE), S. Scholes (Penicuik/GB)
A. Courtenay (Neston/GB), B. Hoffmann, D. Höper
M. Beer (Greifswald – Isle of Riems/DE)
P153
If you seek thou shalt find – Optimised sampling efforts and screening assays to
assess the diversity and ecology of coronaviruses in South African bats
W. Preiser, N. L. Ithete, N. Cronjé, T. Suliman (Cape Town/ZA)
P154
Transmission of Zika virus by mosquitoes from Central Europe
A. Heitmann, J. Stephanie, R. Lühken, M. Leggewie, M. Badusche (Hamburg/DE)
B. Pluskota, N. Becker (Speyer/DE), O. Vapalahti (Helsinki/FI), J. Schmidt-Chanasit
E. Tannich (Hamburg/DE)
p 70
Poster Session 2
Emerging Viruses
P155
Phylogeny of TBE virus in Austria and Central Europe
M. Bestehorn (Stuttgart/DE), G. Dobler, L. Chitimia-Dobler (Munich/DE), K. Stiasny
F. X. Heinz (Vienna/AT)
P156
First detection and phylogenetic characterization of a TBE virus strain isolated
from Dermacentor reticulatus in Northern Saxony, Germany
M. Bestehorn (Stuttgart/DE), L. Chitimia-Dobler (Munich/DE)
M. Pfeffer (Leipzig/DE), G. Dobler (Munich/DE)
P157
Molecular epidemiology of the Dengue virus involved in Dengue disease cases
registered in Mozambique between 2014–2015
I. Mahumane Gundane (Maputo/MZ), F. Barreto dos Santos
F. de Bruycker Nogueir (Rio de Janeiro/BR), E. Samo Gudo (Maputo/MZ)
P158
Development of a high-throughput colorimetric Zika virus infection assay
J. Müller, M. Harms, A. Schubert, B. Mayer (Ulm/DE), S. Jansen (Hamburg/DE)
J.-P. Herbeuval (Paris/FR), D. Michel, T. Mertens (Ulm/DE)
O. Vapalahti (Helsinki/FI), J. Schmidt-Chanasit (Hamburg/DE), J. Münch (Ulm/DE)
P159
Prevalence of recently discovered human polyomaviruses (HPyVs) in children
with gastroenteritis in Accra, Ghana
S. Silling (Cologne/DE), B. Mensah, J. Bonney (Accra/GH), H. Pfister
U. Wieland (Cologne/DE), J. Fobil (Accra/GH)
P160
Discovery and isolation of a novel pestivirus species in pigs in Austria
B. Lamp, L. Schwarz, S. Högler, C. Riedel, L. Sinn, H. Weissenböck, A. Ladinig
T. Rümenapf (Vienna/AT)
P161
Find the right sample – Using non-invasive samples for the diagnosis of the
emerging and reemerging viruses
M. Niedrig, P. Patel (Berlin/DE), A. Abd El Wahed (Göttingen/DE)
R. Schädler (Berlin/DE), S. Yactayo (Geneva/CH)
p 71
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P162
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T. Plegge, H. Hofmann-Winkler, M. Spiegel, S. Pöhlmann (Göttingen/DE)
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P163
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T. Plegge, M. González Hernández, M. Spiegel, S. Pöhlmann (Göttingen/DE)
P164
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C. Brinkmann, I. Nehlmeier, K. Walendy-Gnirß (Göttingen/DE)
J. Nehls (Tübingen/DE), M. González Hernández, M. Hoffmann (Göttingen/DE)
X. Qiu (Winnipeg/CA), A. Takada (Sapporo/JP), S. Pöhlmann (Göttingen/DE)
P165
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C. Hahn, S. K. Fehling, V. Krähling (Marburg/DE), R. Thom, Y. Hall (Salisbury/GB)
O. Dolnik (Marburg/DE), M. W. Carroll (Salisbury/GB), S. Becker
T. Strecker (Marburg/DE)
p 72
tion o
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Trademarks: QIAGEN®, Sample to Insight®, QuantiNova® (QIAGEN Group).
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Sample to Insight
p 73
Poster Session 2
Trafficking
P166
Cell-to-cell spread of dengue viral RNA via C189-bound vacuoles between
mosquito cells
C.-C. Cheng, W.-J. Chen, C.-F. Yang (Taoyuan City/TW)
P167
The intra-cellular cholesterol transport inhibitor U18666A blocks the release of
HCV particles
F. Elgner, R. Medvedev, H. Ren, D. Ploen, K. Boller (Langen/DE)
E. Hildt (Langen, Braunschweig/DE)
P168
Murine cytomegalovirus recruits the retromer complex to promote NEMO
degradation by autophagy
E. Muscolino, R. Brost, M. Rizzato, E. Krause (Hamburg/DE)
S. Loroch (Dortmund/DE), V. Juranic Lisnic (Rijeka/HR), W. Brune (Hamburg/DE)
P169
Intracellular transport of the marburg virus glycoprotein
S. Halwe, S. Becker, O. Dolnik (Marburg/DE)
P170
Composition of a “transport of p8 complex” (TOPC) to understand transfer of the
HTLV-1 p8 protein to target cells
N. Donhauser, S. Millen, M. Jeninga, E. Socher, J. Hofmann, H. Sticht
A. K. Thoma-Kress (Erlangen/DE)
Virus Vectors and Gene Therapy
P171
Establishment of a highly efficient virus-inducible CRISPR/Cas9 system in insect cells
Z. Dong, M. Pan (Chongqing/CN)
P172
Specific and stable repression of HIV provirus expression in vitro by chimeric DNA
methyltransferase
H. Zhu, J. Liu (Shanghai/CN)
P173
Development of novel cornaviral vector.
A. Naskalska, A. Dąbrowska, P. Nowak, K. Pyrć (Krakow/PL)
p 74
Poster Session 2
Virus Vectors and Gene Therapy
P174
Generation of recombinant Newcastle disease virus expressing surface glycoproteins
of Peste des petits ruminants virus
M. Murr, B. Hoffmann, T. C. Mettenleiter
A. Römer-Oberdörfer (Greifswald – Isle of Riems/DE)
P175
Expression of viral immunogens by novel pestivirus replicons
A. Dalmann, I. Reimann, M. Beer (Greifswald/DE)
P176
Fibrils that enhance virus infection interact with cell membrane protrusions
S. Rode, M. Hayn, A. Röcker (Ulm/DE), S. Sieste (Ulm, Mainz/DE), C. Meier
D. Markx, F. Kirchhoff, P. Walther, M. Fändrich (Ulm/DE), T. Weil (Ulm, Mainz/DE)
J. Münch (Ulm/DE)
P177
LCMV-GP pseudotyped oncolytic vesicular Stomatitis virus for the treatment of
solid tumors
L.-M. Schreiber, C. Rodriguez Urbiola, J. Kimpel, P. Erlmann, H. Zwierzina
D. von Laer, G. Wollmann (Innsbruck/AT)
Structure and Assembly
P178
Influence of a newly identified late domain motif in the Ebola virus matrix protein
on particle release
L. Wendt (Marburg, Greifswald – Isle of Riems/DE), L. Kämper, M. L. Schmidt
T. Hoenen (Greifswald – Isle of Riems/DE)
P179
African henipavirus G protein contains a functional endocytosis motif
L. Behner, A. Maisner (Marburg/DE)
P180
Characterization of interaction domains in the large tegument protein pUL36 of
herpes simplex virus
D. Otoo, A. Pholman, L. Ivanova, K. Döhner, T. Krey, B. Sodeik (Hanover/DE)
p 75
Poster Session 2
Structure and Assembly
P181
Mapping of disulfide bonds in the small hepatitis B virus envelope protein S
N. Gerstenberg, F. Zörndlein, S. Suffner, V. Bruss (Neuherberg/DE)
P182
Dimerization efficiency of the canine distemper virus matrix protein dictates
membrane budding activity
F. Bringolf, M. Herren (Bern/CH), J. P. Langedijk (Leiden/NL), A. Zurbriggen
P. Plattet (Bern/CH)
P183
Regulation of vesicle-mediated nuclear egress of herpesvirus capsids
B. Klupp, T. Hellberg, S. Rönfeldt, W. Fuchs
T. C. Mettenleiter (Greifswald – Isle of Riems/DE)
P184
Analyzing self-assembly of Ebola virus nucleoprotein with native mass
spectrometry
J. Kopicki, J. Heidemann, C. Muñoz-Fontela (Hamburg/DE)
C. Uetrecht (Hamburg, Schenefeld/DE)
P185
Filamentous/chained morphology of enveloped virus particles – Defects of
budding or electron microscopy artefacts?
L. Kordyukova, R. Mintaev, S. Abramchuk, S. Markushin (Moscow/RU)
Tumor Viruses
P186
HPV8 increases the spare respiratory capacity of keratinocyte through ATP5B
S. Heuser, J. Seeger, G. P. Marcuzzi (Cologne/DE), S. Majewski (Warsaw/PL)
H. Kashkar, B. Akgül (Cologne/DE)
P187
Host telomerease RNA can complement the functions of viral telomerase RNA in
Marek”s disease virus induced transformation
A. Kheimar, B. B. Kaufer (Berlin/DE)
p 76
Poster Session 2
Did you
Know?
Conventus is the professional
Congress Organiser for the GfV 2017*
*Gesellschaft für Virologie e. V.
p 77
Poster Session 2
Tumor Viruses
P188
IL-6 signaling induces a unique STAT3/IRF1 pathway in HPV-transformed cells
sensitizing them to chemotherapeutic drugs
B. Walch-Rückheim (Homburg/DE), J. Pahne-Zeppenfeld (Cologne/DE), K. Bastuck
J. Fischbach (Homburg/DE), C. Wickenhauser (Halle a. d. S./DE)
L. C. Horn (Leipzig/DE), R. Büttner, P. Mallmann (Cologne/DE), R. M. Bohle
R. Ströder, E.-F. Solomayer, S. Smola (Homburg/DE)
P189
The ORF012 gene of the oncogenic Marek’s disease virus Type 1 encodes a novel
SR-like phosphoprotein essential for virus growth
T. Schippers, N. Osterrieder (Berlin/DE)
P190
Spotting the effect on HTLV-1 transmission – COL4A1 and COL4A2 are novel
targets of the Tax-1 oncoprotein
S. Millen, C. Gross, M. Mann, K. Überla, A. K. Thoma-Kress (Erlangen/DE)
P191
Establishment of an outbred latency model with the cottontail rabbit
papillomavirus in New Zealand White rabbits allows measuring the effect of UV
and immunosuppression on latent skin infections
J. Xi, M. Schneider, J. Haedicke-Jarboui, A. Iftner, F. Stubenrauch
T. Iftner (Tübingen/DE)
P192
Identification and characterization of phosphorylation sites of the human
papillomavirus 31 E2 and E8^E2 proteins
T. Iftner, S. van der Poel, M. Dreer, A. Velic, B. Macek, F. Stubenrauch (Tübingen/DE)
P193
A role for the KSHV non-structural membrane protein K15 in virus reactivation
B. Abere, N. Samarina, E. Hage, T. F. Schulz (Hanover, Braunschweig/DE)
p 78
Poster Session 2
Antiviral Therapy and Resistance
P195
Evaluating the significance of serum chemokines as prognostic biomarkers in
Pegylated IFN-α-2a /ribavirin-treated chronic hepatitis C patients using Luminex
xMAP technology
M. H. Hamed, P. Pushparaj, S. Bazarah, S. Karim, K. Alghamdy, I. Qadri (Jeddah/SA)
P196
Polyvalent 2D entry inhibitors for Pseudorabies Virus and African Swine Fever
Virus
J. Rahn (Greifswald – Isle of Riems/DE), B. Ziem, I. Donskyi (Berlin/DE), K. Silberreis
L. Cuellar (Berlin/DE), J. Dernedde, G. Keil
T. C. Mettenleiter (Greifswald – Isle of Riems/DE), R. Haag (Berlin/DE)
P197
A new antiviral approach – Inhibition of the RNA helicase eIF4A by the natural
compound Silvestrol
A. Grünweller, F. W. Schulte, N. Biedenkopf, K. Lange-Grünweller (Marburg/DE)
C. Müller (Giessen/DE), M. Schlitzer (Marburg/DE), J. Ziebuhr (Giessen/DE)
S. Becker, R. K. Hartmann (Marburg/DE)
P198
Neuraminidase inhibitor effectivity varies with influenza virus subtype
S. Duwe, J. Milde (Berlin/DE), T. C. Harder (Greifswald – Isle of Riems/DE)
B. Schweiger (Berlin/DE)
P199
Influence of the hormone vitamin D3 (Cholecalciferol) and its metabolites on the
in vitro replication of Hepatitis B virus infection
K. Singethan (Munich/DE), W. Dammermann (Brandenburg, Hamburg/DE)
M. Feuerherd (Munich/DE), C. Kühne, J. Schulze zur Wiesch (Hamburg/DE)
U. Protzer (Munich/DE), S. Lüth (Brandenburg, Hamburg/DE)
P200
Generation and Characterization of HCMV mutants with point mutations in the
UL27 gene with regard to antiviral drug resistance
M. Lippmann, T. Weitbrecht, M. Widmann, E. Imrich, K. Hamprecht, G. Jahn
K. Göhring (Tübingen/DE)
p 79
Poster Session 2
Antiviral Therapy and Resistance
P201
Generation and characterization of newly detected mutations in respiratory
syncytial virus fusion protein F concerning resistance to palivizumab
T. Weitbrecht, K. Hamprecht, G. Jahn, K. Göhring (Tübingen/DE)
P202
HIV-1 drug resistance development in women following Option B+ for PMTCT
P. Machnowska, A. Hauser, K. Meixenberger, B. Altmann, N. Bannert (Berlin/DE)
P. Busingye, J. Rubaihayo (Fort Portal/UG), G. Harms-Zwingenberger
S. Theuring (Berlin/DE)
P203
Resistance testing of clinical varicella-zoster virus isolates collected over three
decades
A. Hoffmann, K. Döring, N. T. Seeger, M. Bühler, A. Sauerbrei (Jena/DE)
P204
A derivative of platelet-derived growth factor receptor alpha binds to the trimer
of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells
C. Stegmann, D. Hochdorfer, D. Lieber, N. Subramanian, D. Stöhr, K. Laib Sampaio
C. Sinzger (Ulm/DE)
P205
Cationically modified dextrans inhibit HSV-1 infection at early stages
M. Pachota, K. Pyrć (Kraków/PL)
P206
Generation and characterization of newly detected combined HCMV polymerase
(UL54)-and phosphotransferase (UL97)-mutations associated with drug resistance
M. Widmann, G. Jahn, K. Hamprecht, K. Göhring (Tübingen/DE)
P207
Only half of the oseltamivir dose is needed to treat acute influenza viral infections
G. Montaseri (Braunschweig/DE), A. Boianelli
E. A. Hernadez-Vargas (Braunschweig/DE), M. Meyer-Hermann (Braunschweig/DE)
P208
Resistance to antiviral therapies – answers form the endophyitic fungi Curvularia
papendorfii
H. Jacob (Dublin/IE), S. Philippot, R. Spina, M. Varbanov (Nancy/FR)
p 80
Poster Session 2
Antiviral Therapy and Resistance
P209
A high-throughput screening system for antivirals targeting the human
cytomegalovirus alkaline nuclease
T. Potgieter, A. Caceres-Nuñez, E. Ostermann, W. Brune (Hamburg/DE)
P210
Rapid acquisition of a known HSV-1 TK frameshift mutation leading to Acyclovir
resistance in a patient with HSV/EBVEncephalitis and chronic lymphocytic Leukemia
M. Karrasch, H. Axer, A. Kunze, S. Wagner, A. Sauerbrei (Jena/DE)
P211
Polypores as a new source for anti-influenza agents
M. Schmidtke, M. Richter (Jena/DE), C. Mair (Vienna/AT), U. Peintner (Innsbruck/AT)
J. M. Rollinger, U. Grienke (Vienna/AT)
P212
Antiviral activity of two N-N”-(bis-5-nitropyrimidyl) dispirotripiperazine (DSTP)
derivatives against human cytomegalovirus
R. Adfeldt (Berlin/DE), M. Schmidtke (Jena/DE), E. Novoselova
V. Makarov (Moscow/RU), E. Bogner (Berlin/DE)
P213
LNAs vs. HIV-1 RNA expression – an alternative approach to knock-down viral
replication
F. Hillebrand, H. Schaal (Düsseldorf/DE), S. Erkelenz (Cologne/DE)
M. Widera (Essen/DE), A.-L. Brillen, D. Degrandi, K. Pfeffer (Düsseldorf/DE)
P214
Functional analysis of Gag-p6 deletions accumulating in PI resistant HIV-1
M.-M. Langer, B. Bleekmann, M. Dirks (Essen/DE), N. Pfeiffer (Saarbrücken/DE)
E. Schülter (Cologne/DE), S. Esser (Essen/DE), G. Fätkenheuer (Cologne/DE)
B. Jensen (Düsseldorf/DE), R. Kaiser (Cologne/DE), J. Verheyen, M. Widera (Essen/DE)
P215
Passive antibody transfer reduces canine distemper virus mortality in ferrets
M. Dörr, S.-K. Kays, V. von Messling (Langen/DE)
P216
High throughput reporter screen to identify inhibitors of clinically relevant human
polyomavirus infections
E. Kraus, N. Fischer, A. Grundhoff (Hamburg, Borstel, Lübeck, Riems/DE)
p 81
Poster Session 2
Antiviral Therapy and Resistance
P217
Dimerization inhibitiors for ZikV, EboV, Alzheimer Aß?
H. J. Schramm (Oettingen/DE), W. Schramm (Munich/DE)
P218
Humanized camelid heavy chain antibody that interfered RNA-binding function ofHCV core protein
M. Chulanetra (Bangkok/TH), J. Thanongsaksrikul (Pathumthani/TH)
K. Thueng-in (Nakhon Ratchasima/TH), W. Chaicumpa (Bangkok/TH)
P219
An aspirin derivative impairs replication of coronavirus and other respiratory
viruses
C. Müller (Giessen, Marburg, Langen/DE), N. Karl (Giessen/DE)
J. Ziebuhr, S. Pleschka (Giessen, Marburg, Langen/DE)
P220
Antiviral activity of theaflavins from black tea against hepatitis C virus entry
P. Chowdhury (Jorhat/IN; Lille/FR), M.-E. Sahuc (Lille/FR), M. Goswami
T. Bandyopadhyay (Jorhat/IN), J. Dubuisson, K. Séron (Lille/FR)
P221
The NEDD8-activating enzyme inhibitor MLN4924 potently inhibits HBV
transcription in an HBx-dependent manner
B. Qu, M. Leuthold, S. Urban (Heidelberg/DE)
P222
Cyclophilin A antagonists as Coronavirus inhibitors
A. von Brunn, J. Carbajo-Lozoya, B. von Brunn, D. R. Bairad, Y. Ma-Lauer (Munich/DE)
P223
Computer aided design of novel nucleoside analogs inhibiting dengue virus
RNA polymerase
J. J. Bugert, C. Cima, A. Brancale (Munich/DE)
P224
In search of sCAR-Fc resistant Coxsackie B viruses; so far no mutants in sight
S. Pinkert, V. Brückner, B. Dieringer, J. Kurreck, H. Fechner (Berlin/DE)
p 82
Poster Session 2
Antiviral Therapy and Resistance
P225
Antiviral efficacy of rupintrivir and oseltamivir in human in vitro nasal epithelia
P. Alouani, b. Boda (Plan les Ouates/CH)
P226
Screening and identification of inhibitors against Japanese Encephalitis Virus from
an FDA-approved drug library
S. Wang (Wuhan/CN)
P227
Nafamostat is a new potent inhibitor of trypsin-independent influenza A viruses
spread
P. Zmora (Magdeburg, Göttingen/DE), A.-S. Moldenhauer, S. Erdelt (Göttingen/DE)
F. Dahlmann, K. Sewald (Hanover/DE), Y. Zhao, C. Bruns (Magdeburg/DE)
S. Pöhlmann (Göttingen/DE)
Evolution of Viruses – Viruses in Evolution
P228
Comparative study of in vivo evolution of hepaciviral glycoproteins in their
natural hosts
D. Todt, B. Richard J. P., S. Walter, J. Doerrbecker (Hanover/DE)
S. Pfaender (Hanover/DE; Bern/CH), H. Wedemeyer, T. Pietschmann
E. Steinmann (Hanover/DE)
P229
Identification of novel polyomaviruses in mammals from multiple orders and
experimental analysis of large T antigen mRNA splicing
B. Ehlers, C. Walter, S. Liebmann, N. Ben Salem, D. Fischer, H. Preugschas
N. Buchwald, S. Broll, T. Teichmann, M. Pauly, C. A. Szentiks (Berlin/DE)
M. Martin, B. Pérez de Val (Barcelona/ES), D. Richter (Braunschweig/DE)
A. Gedvilaite (Vilnius/LT), R. G. Ulrich (Greifswald – Isle of Riems/DE)
F. H. Leendertz, S. Calvignac-Spencer (Berlin/DE)
P230
Puumala virus prevalence and S-segment sequence evolution in the bank vole
(Myodes glareolus)
F. Binder, S. Jadgmann, U. M. Rosenfeld, R. Ryll (Greifswald – Isle of Riems/DE)
D. Reil, C. Imholt (Münster/DE), G. Heckel (Bern, Lausanne/CH)
J. Jacob (Münster/DE), R. G. Ulrich (Greifswald – Isle of Riems/DE)
p 83
Poster Session 2
Evolution of Viruses – Viruses in Evolution
P231
Molecular characterization of avian influenza H9N2 isolates from recent
outbreaks in poultry of Bangladesh
R. Parvin (Mymensingh/BD), J. A. Begum (Mymensingh/BD; Leipzig/DE)
K. Heenemann, T. Vahlenkamp (Leipzig/DE), E. H. Chowdhury
M. R. Islam (Mymensingh/BD)
P232
PoSeiDon – a web server for the detection of evolutionary recombination events
and positive selection
M. Hölzer, M. Marz (Jena/DE)
P233
Whole genome sequencing of eleven herpes simplex virus type 2 isolates
K. Döring, M. Groth, R. Zell, A. Sauerbrei (Jena/DE)
P234
Evolutionary dynamics and endemic co-circulation of avian influenza H5N1 and
H9N2 in Egypt provoke diagnostic challenges
M. Naguib, M. Beer, T. C. Harder (Greifswald – Isle of Riems/DE)
P235
V-table© The virosphere structured in one comprehensive table
V. Novitska (Kiev/UA)
P236
Ancient recombination events between human herpes simplex viruses
S. Burrel, D. Boutolleau (Paris/FR), D. Ryu (Berlin/DE), H. Agut (Paris/FR)
K. Merkel, F. H. Leendertz, S. Calvignac-Spencer (Berlin/DE)
P237
In silico analyses of evolutionary dynamics of N-linked glycosylation sites within
the influenza A virus hemagglutinin (HA) protein
D. Anhlan, W. Hafezi, J. Kühn (Münster/DE), P. Nymadawa (Ulaanbaatar/MN)
S. Ludwig, E.-R. Hrincius (Münster/DE)
P238
Virulence determinants of a recent H7N7 avian influenza virus in chickens
D. Scheibner, J. Veits, T. C. Mettenleiter, E. M. Abdelwhab (Greifswald – Isle of Riems/DE)
p 84
Poster Session 2
Evolution of Viruses – Viruses in Evolution
P239
Functional characterization of adaptive mutations during the West African Ebola
virus outbreak
E. Dietzel, G. Schudt, V. Krähling, M. Matrosovich, S. Becker (Marburg/DE)
P240
Genome-based host prediction in RNA-viruses
A. Viehweger, M. Fricke, M. Marz (Jena/DE)
P241
Electrostatics plays important role in transcription regulation in viral genomes
A. Osypov (Pushchino MR, Moscow/RU), G. Krutinin, E. Krutinina
S. Kamzolova (Pushchino MR/RU)
P242
Genesis, evolution and prevalence of H5N6 avian influenza viruses causing
sporadic human infections
Y. Bi, Q. Chen, Q. Wang, J. Chen, T. Jin, G. Wong, J. Liu, W. Liu, Y. Liu, W. Shi, D. Liu
G. F. Gao (Beijing/CN)
One source. Multiple solutions.
Next generation sequencing
E-procurement & E-commerce
GMP
Genes & gene fragments
qPCR
OEM
CRISPR genome editing
Custom formulation
Functional genomics
www.idtdna.com
Custom oligos
Custom packaging
p 85
Poster Session 3
Vaccines
P243
Cell-permeable capsids as universal antigen carrier platform for the induction of
an antigen-specific CD8+ T-cell response
S. Akhras, M. Toda, K. Boller, K. Himmelsbach, F. Elgner, S. Scheurer, M. Gratz
S. Vieths (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
P244
Development of a new approach for therapeutic vaccination against chronic HBV
infection
T. Zahn, S. Akhras (Langen/DE), E. Hildt (Braunschweig/DE)
P245
Immunization with DNA plasmids coding for Crimean Congo hemorrhagic fever
viral capsid and envelope proteins and/or virus like particles induce protection
and survival in challenged mice
J. Hinkula (Linköping, Solna/SE), S. Devignot (Giessen, Marburg/DE)
S. Åkerström (Uppsala/SE), H. Karlberg (Solna/SE), E. Wattrang (Uppsala/SE)
S. Bereczky, M. Mousavi-Jazi (Solna/SE), C. Risinger (Frederiksberg/DK)
G. Lindegren (Solna/SE), C. Vernersson (Uppsala/SE), J. Paweska
P. Jansen van Vuren (Sandringham/ZA), O. Blixt (Frederiksberg/DK)
A. Brun (Madrid/ES), F. Weber (Giessen, Marburg/DE)
A. Mirazimi (Solna, Uppsala/SE)
P246
Induction of complex immune responses and strong protection against retrovirus
challenge by adenovirus-based immunization depends on the order of vaccine
delivery
M. Kaulfuß, I. Wensing, S. Windmann, C. Hrycak, W. Bayer (Essen/DE)
P247
An mRNA-based vaccine technology for next generation prophylactic vaccines
B. Petsch, J. Lutz, S. Lazzaro, K. Schmidt, P. Baumhof, R. Heidenreich
M. Fotin-Mleczek (Tübingen/DE)
P248
Heterologous prime-boost therapeutic vaccination stimulates strong cellular
immune and breaks immune tolerance in HBV transgenic mice
A. Kosinska, K. Schulze (Braunschweig/DE), C. Jäger, N. Röder, J. Su
T. Bauer (Munich/DE), C. Guzman (Munich, Braunschweig/DE)
U. Protzer (Munich/DE)
p 86
Poster Session 3
Vaccines
P249
Increasing the antigenic spectrum of EBV virus-like particles
D. van Zyl (Heidelberg/DE), J. Mautner (Munich/DE), H.-J. Delecluse (Heidelberg/DE)
P250
Development of vaccination strategies for vector-based prophylactic immunization
in the Friend retrovirus model
N. Bongard, U. Dittmer, M. Trilling, V. T. K. Le-Trilling, M. Rückborn
W. Bayer (Essen/DE)
P251
Development of an HIV-Vaccine based on the VSV-GP vector
C. A. Bresk, R. Tober, M. Krismer, T. Hofer, S. Wilmschen (Innsbruck/AT)
G. Effantin (Grenoble/FR), H.-X. Liao, B. F. Haynes (Durham, NC/US), G. Schoehn
W. Weissenhorn (Grenoble/FR), Z. Banki, L. Egerer, D. von Laer
J. Kimpel (Innsbruck/AT)
P252
Novel influenza vaccine candidates based on Modified Vaccinia virus Ankara
expressing different neuraminidase consensus sequences
L. Marr (Munich/DE), K. Roose (Ghent/BE), A.-T. Lülf, A. Freudenstein (Munich/DE)
X. Saelens (Ghent/BE), G. Sutter, A. Volz (Munich/DE)
P253
Combination adjuvants as a source of vaccines effectivity increase
A. Bogoyavlenskiy, A. Turmagambetova, P. Alexyuk, M. Alexyuk, I. Zaitceva
E. Omirtaeva, V. Berezin (Almaty/KZ)
P254
Selection of nanobodies with broad neutralizing activity against primary HIV-1
strains of different subtypes using soluble subtype C gp140 immunogens
U. Dietrich, K. Koch, S. Kalusche (Frankfurt a. M./DE), J. Torres
R. Stanfield (La Jolla, CA/US), W. Danquah (Hamburg/DE), H. von Briesen (Sulzbach/DE)
I. Wilson (La Jolla, CA/US), U. Wernery (Dubai/AE), F. Koch-Nolte (Hamburg/DE)
A. Ward (La Jolla, CA/US)
p 87
Poster Session 3
Vaccines
P255
Inactivation of Influenza A Virus and RSV via low-energy electron irradiation
provides a versatile method for efficacious vaccine production
L. Bayer, J. Fertey (Leipzig/DE), E. Hiller, S. Bailer, S. Rupp (Stuttgart/DE), A. Pohl
C. Wetzel (Dresden/DE), S. Ulbert, T. Grunwald (Leipzig/DE)
P256
Immunogenicity and protective capacity of recombinant vaccinia virus MVA
delivering influenza A virus M2 protein ectodomain (M2e) antigens
A. Volz, K. Roose (Munich/DE; Ghent/BE), A. Freudenstein (Munich/DE)
G. Rimmelzwaan (Rotterdam/NL), X. Saelens (Ghent/BE), G. Sutter (Munich/DE)
P257
Potent humoral and cellular immunity induced by a measles virus-derived Zika
virus vaccine
C. Nürnberger, A. Fiedler, B. Bodmer, M. Muehlebach (Langen/DE)
P258
Neuraminidase-expressing vesicular stomatitis virus replicons induce
subtype-specific protection against influenza A virus
L. Walz, S.-K. Kays (Langen/DE), G. Zimmer (Mittelhäusern/CH)
V. von Messling (Langen/DE)
P259
Biodistribution of the recombinant vaccine MVA-MERS-S following single dose
intramuscular inoculation in mice
M. Langenmayer, S. Adam-Neumair, G. Sutter, A. Volz (Munich/DE)
P260
Novel recombinant DNA vaccine candidates for human respiratory syncytial virus:
Preclinical evaluation of immunogenicity and protection efficiency
F. Almajhdi, H. Amer, M. Farrag, M. Hamad (Riyadh/SA), P. Öhlschläger (Juelich/DE)
P261
Low genetic stability of recombinant influenza A viruses carrying a foreign gene in
the neuraminidase segment
V. Czudai-Matwich (Giessen, Marburg, Langen/DE), C. Paul, S. Thoma
L. Enns (Marburg/DE), S. Becker
M. Matrosovich (Giessen, Marburg, Langen/DE)
p 88
Poster Session 3
Vaccines
P262
Naked DNA immunization with full-length attachment gene of human respiratory
syncytial virus induces safe and protective immune response
H. Amer, F. Almajhdi, M. Hamad, M. Farrag (Riyadh/SA)
P263
A new RNA-based adjuvant enhances virus-specific vaccine responses by locally
activating DC and inducing type I IFN responses
A. Ziegler, C. Soldner, S. Lienenklaus, J. Spanier (Hanover/DE), S. Trittel
P. Riese (Braunschweig/DE), T. Kramps (Ingelheim/DE), S. Weiss (Braunschweig/DE)
R. Heidenreich (Tübingen/DE), C. A. Guzmán (Braunschweig, Tübingen/DE)
K.-J. Kallen (Niel/BE), M. Fotin-Mleczek (Tübingen/DE), U. Kalinke (Hanover/DE)
P264
Cross-protection induced by Japanese encephalitis vaccines against different
serotypes of Dengue viruses in mice
J. Li, N. Gao, D. Fan, H. Chen, Z. Sheng, S. Fu, G. Liang, J. An (Beijing/CN)
P265
Immunization with electroporation enhances the protective effect of a DANN
vaccine candidate expressing prME antigen against dengue virus serotype 2 infection
H. Chen, X. Zheng, R. Wang, N. Gao, Z. Sheng, D. Fan, K. Feng, X. Liao, J. An (Beijing/CN)
P266
Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles
M. Schweneker (Martinsried/DE), A. S. Laimbacher (Zurich/CH)
G. Zimmer (Mittelhäusern/CH), S. Wagner (Martinsried/DE)
E. M. Schraner (Zurich/CH), M. Wolferstätter, M. Klingenberg, U. Dirmeier
R. Steigerwald, H. Lauterbach, H. Hochrein, P. Chaplin (Martinsried/DE)
M. Suter (Zurich/CH), J. Hausmann (Martinsried/DE)
P267
Validation of MST to determine binding affinities of HIV-1 Env to bNAbs in solution:
Benchmarking against ELISA, SPR-Spectroscopy and Flow Cytometry
B. Zimmer, K. Kuttenberger, T. Fischer, S. Schmidt, A. Gabele, T.-H. Bruun
T. Schubert, R. Wagner (Regensburg/DE)
p 89
Poster Session 3
Vaccines
P268
A novel recombinant Orf virus (ORFV) vector system as a therapeutic strategy
against CRPV-induced tumors
T. Iftner, M. Schneider, R. Amann, T. Feger, H.-G. Rammensee
F. Stubenrauch (Tübingen/DE)
P269
Development of an Enzyme-Linked-Lectin-Assay to measure influenza A virus
neuraminidase specific antibodies
H. Sediri (Langen/DE), S. Ho, J. Waldock, K. Hoschler, O. G. Engelhardt (London/GB)
R. Wagner (Langen/DE)
P270
Impact of HCMV pentameric complex-specific depletion on neutralizing capacity
of immunoglobulin preparations in vitro
M. S. Schampera, J. Arellano-Galindo, G. Jahn, K. Hamprecht (Tübingen/DE)
P271
Generation and characterization of recombinant Vesicular stomatitis viruses
coding for several filovirus proteins
J. Westmeier, S. Becker, O. Dolnik (Marburg/DE)
P272
Generation and biochemical characterization of HIV-1 envelope immunogens
with increased stability and affinity to broadly neutralizing antibodies
C. Schmalzl, V. Graßmann, H. Hierl, M. Glögl, A. Kliche, D. Peterhoff
R. Wagner (Regensburg/DE)
P273
Cytomegalovirus mutants lacking interferon antagonists as candidates for a live
attenuated vaccine
A. Jagnjic, K. Wohlgemuth, W. Bayer (Essen/DE), K. Hoffmann
H. Hengel (Freiburg/DE), V. T. K. Le-Trilling, M. Trilling (Essen/DE)
P274
Vaccinia virus MVA vector expressing a novel synthetic HCMV pp65-IE1 fusion
antigen efficiently induces IE1- and pp65-specific CD8 T cells in HLA-A0201
transgenic mice
E. Link, C. Brandmüller, A. Volz, G. Sutter, M. H. Lehmann (Munich/DE)
p 90
Poster Session 3
28 Annual Meeting of
the Society for Virology
th
DVV
Gesellschaft für Virologie e. V. (GfV)
und
Deutsche Vereinigung zur Bekämpfung
der Viruskrankheiten e. V. (DVV)
SAVE THE DATE
© Congress-Tourismus-Wirtschaft Würzburg l Fotograf A. Bestle
14–17 March 2018
Würzburg • Germany
University Würzburg
www.virology-meeting.de
© 88649465 l JiSign l Fotolia.com
p 91
Poster Session 3
Viral Pathogenesis and Persistence
P275
Characterization of Feline Coronavirus 7b Accessory Protein
D. Florek, J. Ziebuhr, H.-J. Thiel, G. Tekes (Giessen/DE)
P276
Transmission of low-pathogenic avian influenza viruses in chickens – Role of the
hemagglutinin in organ tropism and cloacal shedding
G. Zimmer, T. Ludersdorfer, M. Tippenhauer, S. Locher (Mittelhäusern/CH)
P277
Immunosuppressive properties of a trimeric recombinant transmembrane
envelope protein gp41 of HIV-1
M. Mühle (Berlin/DE), M. Lehmann (Friesoythe/DE), K. Hoffmann, D. Stern
T. Kroniger (Berlin/DE), W. Luttmann (Friesoythe/DE), J. Denner (Berlin/DE)
P278
Characterization of cowpox virus proteins based on protein interaction studies
I. Schlenther, L. Schrick, J. Döllinger, A. Nitsche (Berlin/DE)
P279
Newcastle disease virus W protein – investigation of its role during infection
J. Karsunke, A. Karger, K. Franzke, A. Groseth, T. C. Mettenleiter
A. Römer-Oberdörfer (Greifswald – Isle of Riems/DE)
P280
Seminal plasma inhibits human Cytomegalovirus infection
S. Lippold, J. Müller, J. Münch, J. von Einem (Ulm/DE)
P281
Construction of Chimeric Dengue Virus Type 2 to explore the determinant of
pathogenicity in mice
P. Dhole, A. Saito, E. Nakayama, T. Shioda, T. Kawagishi, T. Kobayashi (Osaka/JP)
K. Limkittikul (Bangkok/TH), T. Kurosu (Tokyo/JP)
P282
Role of the protein m139 in murine cytomegalovirus replication in macrophages
O. Puhach, E. Ostermann, W. Brune (Hamburg/DE)
p 92
Poster Session 3
Viral Pathogenesis and Persistence
P283
Merkel cell polyomavirus encoded small viral tumor antigen contributes to
metastasis formation in a xenograft mouse model
M. Czech-Sioli, J. Knips, M. Spohn, I. Moll, M. Heiland, A. Grundhoff
U. Schumacher, N. Fischer (Hamburg/DE)
P284
Impact of vius-induced ERK signaling on the expression of Na,K-ATPase and ENaC
during influenza A virus infection
I. Kuznetsova, C. Peteranderl (Giessen/DE), J. Schulze (Berlin/DE)
S. Herold (Giessen/DE), T. Wolff (Berlin/DE), S. Pleschka (Giessen/DE)
P285
Importance of the ciliary activity of the airway epithelium in preventing influenza
virus infection
Y. Fu, F. Meng, G. Herrler (Hanover/DE)
P286
Prepackaged nonstructural protein 1 of Influenza A virus supports
ribonucleoprotein import into the nucleus
T. W. Sha (Kyoto/JP), M. Gerlach (Giessen/DE)
P287
Pathogenesis and transmission of the novel highly pathogenic avian influenza
H5N8 2016 virus in ferrets and mice
D. Hoffmann, M. Naguib, T. C. Harder, C. Grund, M. Beer (Greifswald – Isle of Riems/DE)
P288
Characterization of the ORF4-encoded accessory protein of human coronavirus 229E
A. Friedrich, G. Tekes, J. Ziebuhr (Giessen/DE)
P289
Barrier function of the differentiated airway epithelium retains after infection by
influenza viruses
N.-H. Wu, D.-L. Shin, W. Yang, F. Meng (Hanover/DE), R. Dijkman (Bern/CH)
M. Matrosovich (Marburg/DE), V. Thiel (Bern/CH), P. Valentin-Weigand
G. Herrler (Hanover/DE)
p 93
Poster Session 3
Viral Pathogenesis and Persistence
P290
Human Endogenous RetroViruses (HERVs), the missing link between exogenous
pathogens and mis-understood auto-immune diseases
B. Charvet, J. Medina, S. Levet, H. Perron (Plan les Ouates/CH; Lyon/FR)
P291
HHV-6A infection induces the expression of Human Endogenous RetroViral
elements (HERV-W-Env) in human cells – link to the neuroinflammation
B. Charvet (Plan les Ouates/CH; Lyon/FR), J. Reynaud (Lyon/FR), G. Ragenez
H.-L. Reynaud-Dougier (Grenoble/FR), H. Perron (Plan les Ouates/CH; Lyon/FR)
P. Marche (Grenoble/FR), B. Horvat (Lyon/FR)
P292
Illuminating the in vivo tropism of Modified Vaccinia virus Ankara in infected
chicken embryos
A.-T. Lülf, M. Langenmayer, K. Müller, S. Adam-Neumair, G. Sutter, A. Volz (Munich/DE)
P293
Elucidation of the cowpox virus mature virion ubiquitinome using mass
spectrometry
M. Grossegesse, J. Döllinger, A. Fritsch, J. Piesker, G. Holland, A. Nitsche (Berlin/DE)
P294
Novel bat influenza virus NS1 proteins – usual and unusual features
H. Turkington (Zurich/CH), M. Juozapaitis, M. Schwemmle (Freiburg/DE)
B. Hale (Zurich/CH)
P295
Novel mutations in the avian influenza H5N1 neuraminidase that modulate
sialidase activity and virulence in mice with minimal impact on virus replication in
cell culture and virulence or transmission in chickens A. Salaheldin, D. Hoffmann, M. Gischke, J. Veits, H. Hafez, T. C. Mettenleiter
E.-S. M. Abdelwhab (Greifswald – Isle of Riems/DE)
P296
Targeted attenuation of CSFV – the crucial role of Erns homodimer formation for
CSFV virulence
A. Tucakov (Greifswald/DE), S. Wirtz (Ulm/DE), G. Meyers (Greifswald/DE)
p 94
Poster Session 3
Viral Pathogenesis and Persistence
P297
Varicella zoster virus modulates the expression of genes involved in neuronal
activity and pain in human peripheral neurons
S. Zhu, P. Yu, N. Stanslowsky, B. Ritter (Hanover/DE), B. B. Kaufer (Berlin/DE)
G. Verjans (Rotterdam/NL; Hanover/DE), A. Leffler, B. Sodeik, F. Wegner, D. Mzinza
R. Förster, A. Grundhoff (Hamburg/DE), A. Viejo-Borbolla (Hanover/DE)
P298
Occult hepatitis B virus infection among blood donors in blood bank, Central
hospital of Maputo
A. Zicai (Maputo/MZ), L. Lewis (Rio de Janeiro/BR), N. Mabunda, N. Bhatt
P299
Dependence of viral replication on B-Myb is crucial for successful antiviral
immunity
P. Sharma, A. Pandyra, H. Kalkavan, K. Lang (Essen/DE)
P300
Comparison of differentially expressed genes in two human cell lines infected
with Zaire and Reston Ebolaviruses
N. F. Mostajo Berrospi (Jena, Marburg/DE), M. Hölzer (Jena/DE), N. Biedenkopf
S. Becker (Marburg/DE), M. Marz (Jena/DE)
P301
Measles virus infection of B- and T-lymphocyte subsets sorted from human
peripheral blood mononuclear cells
S. Langeveld, B. Laksono, P. Katsikis, R. de Swart (Rotterdam/NL)
P302
Characterization of respiratory syncytial virus replication and dissemination in
immortalized cell lines and primary cells
A. de Jong, S. Yüksel, T. Nguyen, S. Nieuwkoop, B. van den Hoogen (Rotterdam/NL)
P. Duprex (Boston, MA/US), R. de Swart (Rotterdam/NL)
P303
Impact of virus infection on targeted differentiation of induced pluripotent stem
cells (iPSCs)
D. Hübner (Leipzig/DE), M. Jung (Halle a. d. S./DE), U. G. Liebert, C. Claus (Leipzig/DE)
p 95
Poster Session 3
Viral Pathogenesis and Persistence
P304
Characterization of two clones derived from a non-neurotropic measles virus in
cultured cells and neuronal tissue
J. Busch, U. Brinckmann, S. Chey, M. Hönemann, U. G. Liebert (Leipzig/DE)
P305
Mechanism research for prion disease
X. Dong (Beijing/CN)
P306
Labeling of deformed wing virus (DWV)
K. Seitz, B. Lamp, D. Fink, A. Url, T. Rümenapf (Vienna/AT)
P307
Modelling of virus-induced alterations during early human embryonic development
through induced pluripotent stem cells (iPSCs)
D. Hübner, K. Jahn (Leipzig/DE), S. Pinkert (Berlin/DE), M. Jung (Halle a. d. S./DE)
H. Fechner (Berlin/DE), U. G. Liebert, C. Claus (Leipzig/DE)
p 96
Poster Session 3
9th International Filovirus Symposium
13–16 SEPTEMBER 2017
MARBURG/DE
© pkproject - #93622169/yurkaimmortal - #90481833 - fotolia.com
www.filovirus-meeting.com
ABSTRACT DEADLINE: 28 MAY 2017
EARLY BIRD REGISTRATION: 05 JUNE 2017
p 97
Poster Session 3
Host Cell Factors and Modulation 1+2
P308
Comprehensively annotating the HSV-1 genome by the combined power of
high-throughput techniques and computational methods
F. Erhard (Würzburg, Munich/DE), T. Hennig, A. Whisnant (Würzburg/DE)
A. Rutkowski (Cambridge/GB), E. Wyler (Berlin/DE), A. L’Hernault (Cambridge/GB)
M. Landthaler (Berlin/DE), C. Friedel, R. Zimmer (Munich/DE)
F. Grässer (Homburg/DE), L. Dölken (Würzburg/DE; Cambridge/GB)
P309
Primate lentiviruses use three alternative strategies to suppress NF‑κB-mediated
immune activation
D. Hotter, T. Krabbe, A. Gawanbacht (Ulm/DE), N. Rahm (Montpellier/FR)
F. Kirchhoff, D. Sauter (Ulm/DE)
P310
p53 regulates SARS-CoV replication via interaction of SUD and PLpro with E3
ubiquitin ligase RCHY1
Y. Ma-Lauer, J. Carbajo-Lozoya (Munich/DE), M. Müller (Bonn/DE), D. R. Bairad
B. von Brunn (Munich/DE), J. Lei (Lübeck/DE), C. Drosten (Bonn/DE)
R. Hilgenfeld (Lübeck/DE), A. von Brunn (Munich/DE)
P311
Time-resolved quantitative proteomic analysis of Zika virus-infected cells
P. Scaturro (Martinsried/DE), A. Plaszczyca (Heidelberg/DE)
K. Draganova (Munich/DE), A. Stukalov (Martinsried/DE), M. Götz (Munich/DE)
R. Bartenschlager (Heidelberg/DE), A. Pichlmair (Martinsried/DE)
P312
Disarming the chromatin remodeling ATPases SMARCA2 and SMARCA4 by
Caspase-mediated cleavage in virus-infected cells
A. Dudek, M. Schwemmle (Freiburg/DE)
P313
The novel immune modulator KSHV ORF20 interacts with the interferon-stimulated
gene oligoadenylate synthetase-like protein OASL
K. A. Bussey, L. Osbelt, U. Lau, C. Steffens, J. Wissing, L. Jänsch (Braunschweig/DE)
H. H. Gad, R. Hartmann (Aarhus/DK), M. M. Brinkmann (Braunschweig/DE)
p 98
Poster Session 3
Host Cell Factors and Modulation 1+2
P314
Perilipin-2 regulates lipid droplet turnover and is a host factor for the Hepatitis C Virus
S. Lassen, C. Grüttner, E. Herker (Hamburg/DE)
P315
HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors
release of viral particles
R. Medvedev, D. Ploen, C. Spengler (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
P316
Functional analysis of the influenza A virus M2 protein interaction with Na,K-ATPase
in influenza pneumonia
J. Schulze (Berlin/DE), C. Peteranderl, S. Pleschka, S. Herold (Giessen/DE)
T. Wolff (Berlin/DE)
P317
Hepatitis B virus production is enhanced through early autophagic flux but
degraded through autophagosome-lysosome fusion
Y. Lin, T. Kemper, X. Wang, A. Squire, M. Günzer, M. Lu (Essen/DE)
P318
Schistosome-induced IFN-γ suppresses HBV replication and induces virus-specific
T-cells
E. Loffredo-Verde, S. Bhattacharjee, A. Malo, F. Reisinger M. Ringelhan (Munich/DE)
M. Heikenwälder (Heidelberg/DE), U. Protzer
C. Prazeres da Costa (Munich/DE)
P319
XBP1-mediated BiP/GRP78 upregulation copes with the oxidative stress in mosquito
cells with dengue 2 virus infection
W.-J. Chen, T.-H. Chen, Y.-H. Chiang (Kwei-San, Tao-Yuan/TW)
P320
PERK-regulated protein translation benefits for the survival of mosquito cells with
dengue 2 virus infection
J.-N. Hou, T.-H. Yang, T.-H. Chen, C.-Y. Perng, W.-J. Chen (Taoyuan City/TW)
p 99
Poster Session 3
Host Cell Factors and Modulation 1+2
P321
Mammalian haploid cell screen to identify host factors essential for Rift Valley
fever virus
S. Devignot, P. Schmerer (Giessen/DE), A. Leibbrandt, T. Burkhard, U. Elling
J. Penninger (Vienna/AT), F. Weber (Giessen/DE)
P322
Highly pathogenic avian influenza virus induced phosphorylation of Tripartite
Motif containing 28 (TRIM28) occurs via the stress-activated protein kinase
Pathway p38-MSK1/MK2
T. Krischuns, S. Ludwig, L. Brunotte (Münster/DE)
P323
Identification of a p53 homologue which is involved in regulating antioxidant
defense of C6/36 cells in response to dengue virus infection
T.-H. Chen, Y.-J. Wu, J.-N. Hou, Y.-H. Chiang, T.-H. Yang, C.-C. Cheng
W.-J. Chen (Taoyuan City/TW)
P324
Tegument-derived VP1-2 protein targets IFN-induced intrinsic defence mechanisms
and facilitates lytic HSV-1 infection
J. Mohnke, T. Hennig (Würzburg/DE), P. O‘Hare (London/GB), L. Dölken (Würzburg/DE)
P325
Modulation of dendritic cell adhesion and migration by Herpes Simplex Virus Type 1
and human Cytomegalovirus
L. Grosche, C. Draßner, A. Steinkasserer, C. Heilingloh (Erlangen/DE)
P326
L particles transmit viral proteins from Herpes Simplex Virus 1-Infected mature
dendritic cells to uninfected bystander cells, inducing CD83 downmodulation
C. Heilingloh, M. Kummer, P. Mühl-Zürbes, C. Draßner, C. Daniel, M. Klewer
A. Steinkasserer (Erlangen/DE)
P327
Cellular peptidyl-prolyl isomerases Pin1 and Cyclophilin A as novel, multifunctional
regulators of cytomegalovirus replication
S. Wagner, M. Marschall, J. Milbradt (Erlangen/DE)
p 100
Poster Session 3
Host Cell Factors and Modulation 1+2
P328
Relevance and molecular determinants of SERINC5 antagonism by primate
lentiviral Nef proteins
D. Kmiec, A. Heigele, S. Wildum, D. Sauter, F. Kirchhoff (Ulm/DE)
P329
Comparison of retroviral restriction factors blocking LINE-1 retrotransposition
B. Volkmann, A. Herrmann, S. Wittmann, J. J. Ross, T. Gramberg (Erlangen/DE)
P330
The human cytomegalovirus IE1 protein antagonizes PML nuclear body mediated
intrinsic immunity via the inhibition of PML de novo SUMOylation
E.-M. Schilling, M. Scherer, N. Reuter, J. Schweininger, Y. A. Muller
T. Stamminger (Erlangen/DE)
P331
Species-specific differences in the interplay between PML nuclear bodies and the
Cytomegalovirus IE1 Protein
M. Scherer, V. Strauch, E.-M. Schilling, R. Müller, J. Schweininger
Y. A. Muller, T. Stamminger (Erlangen/DE)
P332
Characterization of influenza A virus-dependent phosphoproteome changes
reveals modification of virus proteins as an independent anti-viral signaling
mechanism and novel host cell signaling networks
S. Dam, A. Weber, V. Saul, I. Kuznetsova, C. Müller, S. Pleschka (Giessen/DE)
K. Fritz-Wolf (Heidelberg/DE), K. Becker (Giessen/DE)
J. C. Silva (Massachusetts, MA/US), M. Kracht, M. L. Schmitz (Giessen/DE)
P333
Interaction of matrix proteins with nuclear ANP32B is conserved among Henipa- and
Avulaviruses
M. Günther, A. Bauer, L. Zaeck, A. Römer-Oberdörfer
S. Finke (Greifswald – Isle of Riems/DE)
P334
A comparative molecular analysis of viral DDB1 interacting proteins
C. Landsberg, V. T. K. Le-Trilling (Essen/DE), D. A. Megger, B. Sitek (Bochum/DE)
M. Trilling (Essen/DE)
p 101
Poster Session 3
Host Cell Factors and Modulation 1+2
P335
A comprehensive overview of microRNAs in RNA viruses
K. Lamkiewicz, M. Marz (Jena/DE)
P336
External citrate cycle substrates promote hepatitis B virus replication by upregulation
of lipogenesis-related genes
J. Wu, X. Wang, Y. Lin, M. Lu (Essen/DE)
P337
Interaction of the MuHV-8-encoded γ-chemokine vXCL1 with XCR1+ rat DC
A. Bauer, S. Gurka, H. W. Mages, R. Kroczek, E. Popova, M. Bader, S. Voigt (Berlin/DE)
P338
Induction of the unfolded protein response by Henipavirus glycoproteins
J. Hüther, L. Behner, C. Rohde, V. Krähling, M. Ringel, A. Maisner (Marburg/DE)
P339
Protease specificity of influenza A virus hemagglutinin with monobasic cleavage
site in human and murine airway epithelial cells
H. Limburg, D. Bestle, M. R. Heindl (Marburg/DE), H. Moulton
D. A. Stein (Corvallis, OR/US), E. Böttcher-Friebertshäuser (Marburg/DE)
P340
Rift Valley fever virus NSs virulence factor blocks the nuclear export of host mRNAs
S. Lau (Giessen/DE), M. Habjan (Martinsried, Munich/DE)
G. Superti-Furga (Vienna/AT), A. Pichlmair (Martinsried, Munich/DE)
F. Weber (Giessen/DE)
P341
Rubella virus infection leads to an upregulation of prostaglandin E2 synthesis
in human fetal endothelial cells
J. C. Madela, N. Friedrich, H. Geyer, P. Rennert, A. Mankertz (Berlin/DE)
P342
Differential regulation of MAPK signalling pathways after rubella virus infection
in immortalized and primary cells
P. Rennert, N. Friedrich, H. Geyer, A. Mankertz (Berlin/DE)
p 102
Poster Session 3
Host Cell Factors and Modulation 1+2
P343
TLR7/8 agonists induce a post-entry SAMHD1-independent restriction to HIV-1
infection of monocytes
H. Hofmann (Berlin/DE; New York, NY/US), K. Tolubaev, H. Al-Shehabi (Berlin/DE)
B. Vanwalscappel (New York, NY/US), N. Bannert (Berlin/DE)
N. Landau (New York, NY/US)
P344
Analysis of the protease repertoire of murine airways to identify new influenza A
virus activating proteases
A. Harbig, N. Lange, M. Sebastiani, M. Mernberger, A. Nist, T. Steinmetzer
E. Böttcher-Friebertshäuser (Marburg/DE)
P345
The nuclear protein complex ND10 plays an important role in the decision between
lytic replication and latency of Human Herpesvirus 6
A. Sanyal, D. J. Wight, N. Wallaschek, B. B. Kaufer (Berlin/DE)
P346
Env-mediated tetherin antagonism is conserved among different groups of HIV-2
E. Heusinger, K. Deppe, D. Sauter, F. Kirchhoff (Ulm/DE)
P347
Characterisation of HSV gG mutant viruses in vitro and in neuronal tissue explants
K. A. Kropp, B. Ritter, B. Sodeik (Hanover/DE), A. Alcami (Madrid/ES)
A. Viejo-Borbolla (Hanover/DE)
P348
HIV-1 interferes with the cellular NMD machinery
L. Walotka, N. Diehl, F. Hillebrand, H. Schaal (Düsseldorf/DE)
P349
Low oxygen levels in the human gut influences the barrier and immune functions
of the intestinal mucosa
S. Muenchau, M. Stanifer, C. Martinez, B. Niesler, S. Boulant (Heidelberg/DE)
p 103
Poster Session 3
Host Cell Factors and Modulation 1+2
P350
IRE-1 signaling as putative therapeutic target to dampen lung injury in influenza
virus-induced pneumonia
C. Schmoldt, C. Peteranderl, I. Shalashova, A.-I. Vazquez-Armendariz, S. Pleschka
A. Günther, S. Herold (Giessen/DE)
P351
Human genetic susceptibility/resistance to tick-borne encephalitis virus – role of
variability in chemokine and interleukin genes
A. Barkhash, A. Romaschenko (Novosibirsk/RU)
P352
Human cytomegalovirus attracts non-classical monocytes by selective AP1-dependent
induction of CXCL14
J. Noffke, M. Maywald, M. Fiedler, F. Hillebrand (Düsseldorf/DE)
M. Nevels (St. Andrews/GB), H. Hengel (Freiburg/DE), B. Homey
A. Zimmermann (Düsseldorf/DE)
P353
Impact of the variation of putative host factor SEC14L2 in Hepatitis C Virus (HCV)
replication in vitro
R. Costa, M. Ruckert (Hanover/DE), S. Westhaus (Essen/DE), B. Hertel
M. P. Manns, E. Steinmann, T. von Hahn (Hanover/DE), S. Ciesek (Essen/DE)
P354
The viral FGARAT homologs of Rhadinoviruses effect proteasomal degradation of
ND10 component
A. Hahn, A. Großkopf (Göttingen/DE), F. Full, B. Scholz, D. Jungnickl
A. Ensser (Erlangen/DE)
P355
Broad-spectrum antiviral activity of potent furin inhibitors
K. Hardes, T. Ivanova, Y. Lu (Marburg/DE), B. Thaa (Stockholm/SE, Leipzig/DE)
L. Walz, V. von Messling (Langen/DE), W. Garten, T. Steinmetzer (Marburg/DE)
P356
A novel, small linear interaction motif in HCMV-pUL21a is required for destabilization
of APC/C subunits
I. Husic, I. Gruska, B. Vetter, C. Hagemeier, L. Wiebusch (Berlin/DE)
p 104
Poster Session 3
Host Cell Factors and Modulation 1+2
P357
Beta-herpesviral kinase M97 controls cell cycle progression via a bifunctional
cyclin A binding and nuclear localization element
B. Bogdanow, M. Schmidt, H. Weisbach, I. Gruska, B. Vetter, K. Imami, M. Selbach
C. Hagemeier, L. Wiebusch (Berlin/DE)
P358
Establishment of a novel vRNP reconstitution assay to study the role of importin-α
isoforms on influenza A virus polymerase activity in vitro
S. Beck, G. Gabriel, S. Bertram (Hamburg/DE)
P359
Roles of host lncRNA4 in the regulation of influenza virus replication
J. Wang, X. Li, S. Cen (Beijing/CN)
P360
IFN-β response dynamics upon Cytomegalovirus infection of endothelial cells
U. Rand, T. Kubsch, B. Kasmapour, L. Cicin-Sain (Braunschweig/DE)
P361
Ebola virus glycoprotein (EBOV GP) shedding is suppressed by the antiviral host
cell restriction factor tetherin
J. Nehls (Tübingen, Oberschleißheim/DE), C. Brinkmann, S. Pöhlmann (Göttingen/DE)
M. Schindler (Tübingen, Oberschleißheim/DE)
P362
SamHD1 restricts human cytomegalovirus (HCMV)
R. Businger (Tübingen/DE), T. Gramberg (Erlangen/DE), M. Schindler (Tübingen/DE)
P363
RNF4 STUbL promotes HAdV gene expression by supporting E1B-55K-dependent
Daxx restriction
S. Müncheberg (Neuherberg, Munich, Hamburg/DE), R. T. Hay (Dundee/GB)
W. H. Ip, T. Dobner (Hamburg/DE), S. Schreiner (Neuherberg, Munich/DE)
P364
Rabies virus modulates the cellular localization of neurotrophins receptors
C. Scordel, M. Eizinger, K.-K. Conzelmann (Munich/DE)
p 105
Poster Session 3
Host Cell Factors and Modulation 1+2
P366
Regulated TRIM5α expression as tool to prevent HIV infection
C. Elsner, J. Bohne (Hanover/DE)
P367
A potential role of miR-122 in HCV IRES formation
P. Schult, V. Lohmann (Heidelberg/DE)
Epidemiology and Public Health
P368
Seroprevalence of Hepatitis B, C and associated risk factors in Hemodialysis units in
Baghdad
B. Alabdali (Baghdad/IQ)
P370
An outbreak of cowpox in prairie dogs in a zoological garden – molecular and
virological investigations
A. Muluneh, K. Hoffmann (Dresden/DE)
P371
Clinical and epidemiological particularities of acute viral respiratory infections
during the 2015–2016 season
C. Spinu, P. Scoferta, I. Spinu, I. Gostev, O. Pirvu, A. Donos, L. Suveica
A. Druc (Chisinau/MD)
P372
The consequences of geopolitical upheavals on the dynamics and epidemiology of
rabies in the Central African Republic
S. M. C. Garba-Ouangole (Bangui/CF)
p 106
Poster Session 3
Epidemiology and Public Health
P373
Hospital-based assessment of rotavirus infection in children with gastroenteritis
in Ogun State, Nigeria
K. Arowolo, C. Ayolabi (Lagos/NG)
P374
No significant HTLV seroprevalence in german people who inject drugs
O. Hohn, S. Norley, C. Kücherer (Berlin/DE), A. Bazarbachi, H. El Hajj (Beirut/LB)
U. Marcus, R. Zimmermann, N. Bannert (Berlin/DE)
P375
Two different mechanisms of emergence of tick-borne encephalitis virus in Eastern
Bavaria
G. Dobler, L. Chitimia-Dobler (Munich/DE), U. Mackenstedt, M. Bestehorn (Stuttgart/DE)
P376
Hepatitis G virus and its prevalence in patients with hepatitis B and C i pre-pregnancy population in Lagos
G. O. Ajayi (Lagos/NG)
P377
Seroprevalence of Parvovirus B19 from Lagos pre-pregnancy class population:
a retrospective analysis
G. O. Ajayi (Lagos/NG)
P378
Micro organism co- infections in Nigeria women with HPV DNA soul type positivity
G. O. Ajayi (Lagos/NG)
P379
Epidemiological aspects of rotavirus and adenovirus in hospitalized children with
diarrhea – a 5-year survey in Beijing
L. Liu, Q. Yuan, Z. You, Z. Linqing, J. Liping, D. Huijing (Beijing/CN)
P380
Epidemiological analysis and genetic diversity of human metapneumovirus in
children with acute respiratory tract infections during a 4-year study in Beijing
R.-n. Zhu, C.-y. Guo, Y. Qian, L.-q. Zhao, J. Deng, Y. Sun, F. Wang, R. Tian (Beijing/CN)
p 107
Poster Session 3
Zoonoses
P381
Recombinant mumps viruses expressing the surface glycoproteins of a bat-derived
mumps virus are highly fusion active and neurovirulent
N. Krüger (Hanover/DE), C. Sauder (Silver Spring, MD/US), M. Hoffmann (Göttingen/DE)
C. Örvell (Stockholm/SE), J. F. Drexler (Bonn/DE), S. Rubin (Silver Spring, MD/US)
G. Herrler (Hanover/DE)
P382
Bushmeat hunting and zoonotic transmission of Simian T-lymphotropic virus 1 in
tropical West and Central Africa
G. Schubert (Berlin/DE), A. Mossoun, S. Calvignac-Spencer (Berlin/DE), C. Akoua-Koffi
E. Couacy-Hymann, J.-J. Muyembe-Tamfum, S. Karhemere (Kinshasa/CG)
R. M. Wittig (Leipzig/DE), F. H. Leendertz (Berlin/DE)
P383
Molecular mechanisms of the cytomegalovirus species specificity – the role of the
MCMV M28 protein
K. Pawletko, E. Ostermann (Hamburg/DE), S. Loroch (Dortmund/DE)
D. Indenbirken, W. Brune (Hamburg/DE)
P384
Monitoring and characterization of swine influenza viruses (SIV) in Europe since 2015
D. Henritzi (Greifswald – Isle of Riems/DE), S. Wacheck (Dessau-Rosslau/DE)
M. Beer, T. C. Harder (Greifswald – Isle of Riems/DE)
P385
Hepatitis E Virus – The underestimated Issue?
K. Himmelsbach, K. Funke, K. Friedrich (Langen/DE), E. Hildt (Langen, Braunschweig/DE)
P386
Virus safety of xenotransplantation
E. Plotzki, V. Morozov, M. Keller, U. Fiebig, D. Ivanusic, J. Heinze, J. Denner (Berlin/DE)
P387
Development and optimization of a GFP-expressing tetracistronic trVLP system
for ebolaviruses
M. L. Schmidt, B. A. Tews, A. Groseth, T. Hoenen (Greifswald – Isle of Riems/DE)
p 108
Poster Session 3
Zoonoses
P388
Landscaping of cytomegaloviruses from wild African ape populations indicates
high species-specificity with occasional cross-species transmission
S. Murthy, F. H. Leendertz, S. Calvignac-Spencer (Berlin/DE), M. A. Jarvis (Plymouth/GB)
B. Ehlers (Berlin/DE)
P389
Development of an in-solution capture strategy to study respiratory viral pathogens
at the great ape-human interface
L. V. Patrono, S. Calvignac-Spencer, F. H. Leendertz (Berlin/DE)
P390
A bench approach to paleovirology – Using hybridization capture to search for
filoviral integrations in potential Ebolavirus hosts’ genomes
A. Düx (Berlin/DE), J. F. Gogarten (Berlin/DE; Montreal/CA), L. Müller
F. H. Leendertz, S. Calvignac-Spencer (Berlin/DE)
P391
New biological system for the isolation of human and animal viruses
Z. Klestova, I. Savinova (Kyiv-151/UA)
P392
The sialic acid binding preference determines the differential interaction between
influenza A viruses and streptococci.
J. Tong, F. Meng, N.-h. Wu, P. Valentin-Weigand, G. Herrler (Hanover/DE)
p 109
Poster Session 3
Clinical Virology
P393
Absence of the porcine endogenous retrovirus (PERV) transmission in a clinical
pig islet cell xenotransplantation trial performed in Argentina
V. Morozov (Berlin/DE), S. Wynyard, D. Nathu, R. Elliott (Manukau/NZ)
J. Denner (Berlin/DE)
P394
Virological Surveillance of Influenza B in Germany – Season 2014/2015 and Season
2015/2016
A. Heider, M. Wedde, T. Wolff, B. Schweiger (Berlin/DE)
P395
Sus scrofa papillomavirus 2 – a novel suid papillomavirus isolated from wild boar
in Germany
E. Link (Munich/DE), M. Hoferer (Fellbach/DE), K. Rigbers, B. Strobel (Karlsruhe/DE)
G. Sutter, R. Fux (Munich/DE)
P396
The impact of perfusion solutions on the infectivity of different viruses
V. Wanders, S. Swoboda, V. T. K. Le-Trilling, F. Helfritz, A. Paul, M. Trilling
S. Ciesek (Essen/DE)
P397
A Case of Parvovirus B19-induced Intracerebral Bleeding after allogeneic
hematopoietic stem cell transplantation
M. Karrasch (Jena/DE), A. Plentz, S. Modrow (Regensburg/DE)
P398
Clinical course and core variability in HBV infected patients without detectable
anti-HBc antibodies
O. E. Anastasiou, J. Verheyen, M. Widera, J. Korth, G. Gerken, A. Canbay (Essen/DE)
H. Wedermeyer (Hanover/DE), S. Ciesek (Essen, Hanover/DE)
P399
Impact of mTOR inhibition on BK-Polyomavirus Non Coding Control Region
(NCCR) activity
J. Korth, J. Verheyen, S. Ciesek, O. Anastasiou, A. Brinkhoff, A. Kribben, B. Wilde
U. Dittmer, O. Witzke, M. Widera (Essen/DE)
p 110
Poster Session 3
Clinical Virology
P400
The relationship between viral infection and the development of acute
graft-versus-host disease on adult recipients of allogeneic haematopoietic stem cells
T. Dzieciatkowski, M. Przybylski, J. Bilinski, A. Waszczuk-Gajda, W. W. Jedrzejczak
G. W. Basak, M. Wroblewska, G. Mlynarczyk (Warsaw/PL)
P401
Sequence typing of human adenoviruses isolated from Polish allogeneic
haematopoietic stem cell transplant recipients
M. Przybylski, S. Rynans, A. Waszczuk-Gajda, J. Bilinski, W. W. Jedrzejczak
G. W. Basak, G. Mlynarczyk, T. Dzieciatkowski (Warsaw/PL)
P402
Anogenital warts of HIV-positive men frequently harbour high-grade dysplasia
U. Wieland (Cologne/DE), C. Siorokos (Oberhausen/DE)
F. Oellig (Mülheim a. d. R./DE), S. Silling, H. Pfister (Cologne/DE)
A. Kreuter (Oberhausen/DE)
P403
Human Polyomavirus JC – Sequencing and analysis of the VP1 – and NCCR-region
from PML patients
O. Adams, C. Gkioule, I. Ramminger, C. Warnke (Düsseldorf/DE)
P404
Cytomegalovirus reactivation in pediatric acute leukemia after stem cell transplantation
has an effect on relapse and survival in AML but not in B-precursor ALL
L. Sparkuhl, J.-S. Kühl, S. Voigt (Berlin/DE)
P405
Characterization of human milk cells and the role of CD14+ monocytes in HCMV
cell-associated transmission during lactation
T. Kussmann, K. Wistuba-Hamprecht, R. Goelz, G. Pawelec, G. Jahn
K. Hamprecht (Tübingen/DE)
P406
INSTAND External Quality Assessment (EQA) Schemes for Zika Virus Diagnostics:
Schemes for detection of Virus Specific IgG and IgM and Virus Genome
H. Zeichhardt, M. Kammel (Berlin, Düsseldorf/DE), V. Lindig (Berlin/DE)
P. Emmerich, J. Schmidt-Chanasit, S. Günther (Hamburg/DE)
H. F. Rabenau (Frankfurt a. M./DE), H.-P. Grunert (Berlin/DE)
p 111
n
oo
P407
o
no
n sso
n
no
o n
o o ti s
ns
A. Dhingra, E. Hage, A. Heim (Hanover/DE)
ss
s
s
o
o
P408
n
o n n n
s s
o
s n tion
A. Osterman, M. Münchhoff, S. Böhm (Munich/DE), S. Niendorf
A. Mas Marques (Berlin/DE), M. Graw, R. Penning (Munich/DE)
ÜBERTRAGEN SIE PROBEN ZWISCHEN
UNTERSCHIEDLICHEN LABORGEFÄSSEN?
VOYAGER II
Pipetten mit einstellbarem Spitzenabstand
Der elektronisch einstellbare Spitzenabstand ermöglicht die simultane
Übertragung von mehreren Proben zwischen Laborgefäßen unterschiedlicher Größen und Formate. Der Spitzenabstand lässt sich durch
einen einfachen Knopfdruck einstellen und erfordert keinerlei manuelles
Nachstellen oder Zweihandbedienung.
p
EVOLVE
112VIAFLO II
ASSIST
VIAFLO 96 I 384
www.integra-biosciences.com
We would like to give our sincere thanks to the following sponsors:
Platin sponsor
Zymo Research Europe GmbH (Freiburg/DE)
Gold sponsor
Takara Bio Europe SAS (St-Germain-en-Laye/FR)
Silver sponsors
Abbott GmbH & Co. KG (Wiesbaden/DE)
Epithelix Sàrl(Plan les Ouates/CH)
GlaxoSmithKline GmbH & Co. KG (Munich/DE)
Luminex (‘s-Hertogenbosch/NL)
QIAGEN GmbH (Hilden/DE)
Bronze sponsors
BIOMOL GmbH (Hamburg/DE)
INTEGRA Biosciences Deutschland GmbH (Biebertal/DE)
Integrated DNA Technologies Germany GmbH (Munich/DE)
QCMD (Glasgow/GB)
Further sponsors
CAISTER ACADEMIC PRESS (Poole/GB)
Siemens Healthcare Diagnostics GmbH (Eschborn/DE)
State at printing.
p 113
Industrial exhibition
The following exhibitors are looking forward to welcoming you at their booth:
Company
Abbott GmbH & Co. KG (Wiesbaden/DE)
AID GmbH (Strassberg/DE)
altona Diagnostics GmbH (Hamburg/DE)
BIO-SYS GmbH (Karben/DE)
bioMérieux Deutschland GmbH (Nürtingen/DE)
BIOMOL GmbH (Hamburg/DE)
BIOZOL Diagnostica Vertrieb GmbH (Eching/DE)/
BioLegend (San Diego, CA/US)
Carl Zeiss Microscopy GmbH (Jena/DE)
Cepheid GmbH (Frankfurt a. M./DE)
Epithelix Sàrl (Plan les Ouates/CH)
Gen Mark Diagnostics Germany GmbH (Frankfurt a.M./DE) Geman Center for Infection Research – DZIF (Braunschweig/DE)
Gilson International BV Germany (Limburg/DE)
GlaxoSmithKline GmbH & Co. KG (Munich/DE) Greiner Bio-One GmbH (Frickenhausen/DE)
Hologic Deutschland GmbH (Wiesbaden/DE)
Implen GmbH (Munich/DE)
INTEGRA Biosciences Deutschland GmbH (Biebertal/DE)
Integrated DNA Technologies Germany GmbH (Munich/DE)
Lehmanns Media GmbH (Marburg/DE)
Li-COR Biosciences GmbH (Bad Homburg/DE)
Luminex B.V. (MV`s-Hertogenbosch/NL)
Oxford Immunotec Ltd. (Oxfordshire/GB) New England BioLabs GmbH (Frankfurt a. M./DE)
Pantec Biosolutions AG (Ruggell/LIE)
Promega GmbH (Mannheim/DE)
QCMD (Glasgow/GB)
Qiagen GmbH (Hilden/DE)
Roche Diagnostics Deutschland GmbH (Mannheim/DE)
Takara Bio Europe SAS (St-Germain-en-Laye/FR)
Zymo Research Europe GmbH (Freiburg/DE)
Booth Nr.
12
11
13
26
21
9
15
18
16
4
6a
25
10
24a
17
6
2
14
4a
27
19
3
6b
20
24
5
23
8
22
7
1
The member companies of the „Voluntary Self-Regulation of the Pharmaceutical Industry (FSA) e. V.“ have
more narrowly defined the FSA code to ensure more transparency. Congress organisers are obliged to inform
potential congress participants in advance about the scope and terms of the support of the pharmaceutical
industry. We fulfil this obligation and inform you about the amount of the sponsorship of companies involved:
Abbott GmbH & Co. KG (Wiesbaden/DE) • Silver Sponsor • 3.500 EUR
GlaxoSmithKline GmbH & Co. KG (Munich/DE) • Silver Sponsor • 3.500 EUR
Roche Diagnostics Deutschland GmbH (Mannheim/DE) • Industrial Exhibition • 1.950 EUR
State at printing.
p 114
Floor plan
2nd floor
Posters
Posters
Posters
Audimax
Posters
Posters
Speakers ready room/
internet point
Posters
Posters
1st floor
Display
desk
Conference
bags
10 9
8
Posters
7
11
6b 6a
12
6
13
5
Catering
Lecture hall
4a
4
reserviert
3
2
1
Posters
Posters
Ground floor
Posters
Lecture hall
25
26
24a
24
21
22
23
20
19
17
18
16
15
27
Catering
14
Check-In
Standing table
State at printing.
p 115
media cooPerations and scientific sPonsors
We would like to thank the following media partners and scientific sponsors for their
great support:
Media cooperations
Bundesverband der Hygieneinspektoren (Hanover/DE)
Der Hygieneinspektor
Büro-, Verlags- und Tagungsservice (Berlin/DE)
Der Mikrobiologe
S. Karger AG (Basel/CH)
Intervirology
Trillium GmbH (Grafrath/DE)
Trilliumdiagnostik
Shanghai Springer Information Consulting Services Co., Ltd. (Beijing/CN)
Virologica Sinica
Scientific sponsors
Gesellschaft für Virologie e. V.
(GfV, Society for Virology)
Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.
(DVV, German Association for the Control of Virus Diseases)
Philipps-Universität Marburg, SFB 1021
Deutsches Zentrum für Infektionsforschung e. V.
(DZIF, Geman Center for Infection Research)
State at printing.
p 116
General Information
@
Conference website
You will find current information on our website at www.virology-meeting.de.
Language
The conference language is English.
Registration fees Regular (GfV-Member) Regular (Non-Member) Day ticket Student*(GfV-Member) Student* (Non-Member)
on-site
220 EUR
280 EUR
130 EUR
100 EUR
170 EUR
Conference dinner (24 March 2017)
Regular Student* Accompanying Person 40 EUR
20 EUR
40 EUR
* Confirmation of status is required.
AGB
General terms and conditions
Please find all details on our website at www.virology-meeting.de.
Opening hours Wednesday ThursdayFridaySaturday
Industrial Exhibition 11.30–21.30 08.00–17.30 08.00–19.45 08.00–10.30
Poster Exhibition
19.00–21.30 08.30–19.00 08.30–19.45 –
Registration Desk 10.00–19.15 07.30–19.00 07.30–17.30 07.30–13.00
Speakers Ready Room/Internet station
Catering and lunch
Tea, coffee, refreshments and snacks will be provided during the official programme
breaks and poster sessions within the industrial exhibition areas (please refer to
page 115). Free lunch boxes will be offered on Thursday and Friday during the
industrial symposia as well as within the industrial exhibition areas.
Internet
Wifi cannot be provided, but internet stations are available in the speakers ready
room as well as Eduroam. You will receive detailed information at the registration desk.
p 117
General Information
Education credits and certification
The certification of the conference for scientists is applied by the “Medical Chamber of Hessen” (Landesärztekammer Hessen) and especially for veterinarians by
the “Medical Chamber of Veterinary” (Bundestierärztekammer, Akademie für
tierärztliche Fortbildung):
Credit points “Medical Chamber of Hessen”:
22 March 2017
Category B 3 Points
23 March 2017
Category B 6 Points
24 March 2017
Category B 6 Points
25 March 2017
Category B 3 Points
Credit hours “Medical Chamber of Veterinary”: 22–25 March 2017 – 21 hours
For certification all attendants are required to sign the certification list near
the registration desk daily. Certificates of attendance may be picked up upon
leaving the conference at the registration desk. The content of the meeting is
product-neutral.
Poster prizes
All posters will be rated according to scientific basis and visual appearance. The
three best posters will be awarded.
Abstracts
All abstracts will be provided as a pdf-file on a memory stick. You will receive one
at the booth from Hologic Deutschland GmbH, booth number 6.
The pdf-file will also be available on the website at www.virology-meeting.de.
p 118
Social programme
Get-Together • Wednesday, 22 March 2017
“In the end it is always our relationships with people that
make our lives worth living.” (Wilhelm von Humboldt).
After the first conference day we would like to invite you
to our Get-Together with some drinks and snacks within
the industrial exhibition area.
© 111745888 l Rawpixel.com l Fotolia.com
The Get-Together is included in the registration fee.
At the same time, you can visit the Poster session 1 and meet the presenting authors
at their posters for inspiring discussions.
Date
Time Location
Wednesday, 22 March 2017
19.15–21.30
Philipps-Universität Marburg
Central lecture building
Biegenstraße 14 • 35037 Marburg (DE)
Social evening • Friday, 24 March 2017
At the conference dinner, a charming atmosphere in the
“Mensa“ of the Philipps-Universität Marburg will welcome
and enchant you. During the evening you are invited to
exchange and discuss current work and research findings
with your colleagues and friends while you enjoy the buffet. The musical highlight of the evening is the party band
“Daniel Ligges & Band”, which will certainly set the tone.
After their performance in Münster 2016 they return to
give you anew the best songs from current chart hits to
classics of rock and pop music.
Date
Time
Location
© Daniel Ligges & Band
Friday, 24 March 2017
20.00–01.00
Mensa Erlenring
Erlenring 5 • 35037 Marburg (DE)
p 119
Index of Presenting Authors and Chair Persons
A
Abdelwhab, E.-S. M.34, 94
Adams, O.
111
Addo, M.
14
Adfeldt, R.
81
Aguilar Briseño, J. A. 55
Ajayi, G. O. 59, 107
Akgül, B.
76
Akhras, S.
86
Alabdali, B. 106
Almajhdi, F.
88
Alouani, P.
83
Alsheimer, S. 25
Amer, H.
89
An, J.
89
Anderson, D.
69
Anhlan, D.
84
Arendt, A.
39
Arowolo, K.
107
Asbach, B.
35
Ayolabi, C.
107
B
Baechlein, C.
69
Banki, Z.
67
Bannert, N.
40
Barkhash, A.
104
Baron, A. L. 61
Bartenschlager, R.
33
Bastuck, K.
78
Bauer, A.
102
Bayer, L.
88
Bayer, W.
86
Becher, P.
34
Beck, S.
105
Becker, M.
50
Becker, S. 14
Becker, T.
53
Beer, M.
24, 34
Begum, J. A.
84
Behner, L.
75
Berger, A. 44
Bertzbach, L. D.
31
p 120
Bestehorn, M.
71
Bi, Y.
85
Biedenkopf, N.
62
Biehl, M.
64
Biesinger, B. 31
Binder, F.
83
Binder, M.
55
Blockus, S.
32
Blotska, O. 59
Boda, B.
83
Bodmer B.
27
Bogdanow, B.
42, 105
Bogner, E.
32
Bogoyavlenskiy, A. 58, 87
Bohne, J. 36
Bölker, M. 14
Böttcher, S.
40
Böttcher-Friebertshäuser, E.
39
Bongard, N.
87
Bosse, J. B.
30
Bossler, F.
31
Bosso, M.
19
Boujon, C.
58
Bradt, V.
64
Bresk, C. A.
87
Briggs, J. 25
Bringolf, F.
76
Brinkmann, A.
59
Brinkmann, J.
66
Brinkmann, M. M. 16
Broering, R.
52
Brown, R.
16
Brune, W. 22
Brüning, J.
15
Buchholz, C. J. 27
Budt, M.
52
Bugert, J. J.
82
Busch, J.
96
Businger, R.
105
Bussey, K. A.
98
C
Calvignac-Spencer, S. 84
Cen, S.
105
Charvet, B.
94
Chen, H.
89
Chen, T.-H.
100
Chen, W.-J.
99
Cheng, C.-C.
74
Chowdhury, P.
82
Chulanetra, M.
82
Ciesek, S. 44
Claus, C.
96
Cohen Dvashi, H.
50
Conzelmann, K.-K. 19, 56
Costa, R.
104
Czudai-Matwich, V.
88
D
Dalmann, A.
75
Dam, S.
101
Dammermann, W.
58
David, P.
54
de Jong, A.
95
de Swart, R.
36
Demminger, D.
35
Deng, C.
68
Dennehy, K.
65
Denner, J.
92, 108
Derakhshani, S.
48
Devignot, S.
86
Dhingra, A.
112
Dhole, P.
92
Dickow, J.
64
Dietrich, U.
87
Dietz, A.
26
Dietzel, E.
85
Dittmer, U. 45
Dobler, G.
107
Döhner, K.
26
Döring, K.
84
Dörr, M.
81
Domingues, P.
62
Dong, X. 96
Index of Presenting Authors and Chair Persons
Dong, Z.
74
Donhauser, N.
74
Dornfeld, D.
19
Dreier, C.
42
Drexler, I. 23
Drosten, C. 14
Dubrau, D.
63
Dudek, A.
98
Duhan, V.
62
Duwe, S.
79
Düx, A.
109
Dzieciatkowski, T.
54
59, 111
E
Ehlers, B.
Ehmann, R.
Ehrke-Schulz, E.
Elgner, F.
Elsner, C.
Elvert, M.
Ensser, A.
Erhard, F.
Eshetu, A.
83
38
27
68, 74
106
47
104
98
58 F
Fackler, O. T.
Fast, L.
Ferhadian, D.
Fickenscher, H. Fischer, M.
Fischer, N.
Florek, D.
Frankish, J.
Frascaroli, G.
Fricke, M.
Friedrich, A.
Friedrich, S.
Fritsch, J. Fu, Y.
Fuchs, J.
22
26
30
28
34
31, 93
92
56
67
70
93
61
36
93
42
G
Gao, G. F. 25
Garba-Ouangole, S. M. C. 106
Gerlach, M.
16, 19
Gerlach, T.
19
Gerold, G.
50
Gerresheim, G.
60
Gerstenberg, N.
76
Giese, S.
18
Glebe, D.
32, 49
Göhring, K.
79
Gonzalez-Motos, V.
43
Graaf, A.
59
Graf, L.
19
Grosche, L.
100
Groseth, A.
24, 49
Großkopf, A.
15
Grossegesse, M.
94
Grünvogel, O.
16
Grünweller, A.
79
Günther, M.
101
Guo, D.
43
Gursinsky, T.
38
H
Hackl, T. Hahn, C.
Halenius, A.
Halwe, S.
Hamed, M. H.
Hanauer, J. D. S.
Hanke, K.
Harbig, A.
Hardes, K.
Harms, M.
Hartmann, J.
Hartmann, K.
Hartmann, R. K.
Haslwanter, D.
Hauber, J. Hausmann, J.
Heider, A.
34
72
67
74
79
27
40
103
104
70
49
36
18
15
33
89
110
Heilingloh, C.
Heim, A.
Heinz, F. X. Heitmann, A.
Hengel, H. Henritzi, D.
Herchenröther, A.
Herold, S.
Herren, M.
Herrmann, A.
Heusinger, E.
Hildt, E.
Hilgenfeld, R.
Hillebrand, F.
Himmelsbach, K.
Hinte, F.
Ho, W.-Z.
Hoenen, T.
Hofemeier, A.
Hoffmann, A.
Hoffmann, A. Hoffmann, D.
Hoffmann, K.
Hoffmann, M.
Hofmann, H.
Hofmann, S.
Hohn, O.
Holtappels, R.
Hölzer, M.
Hou, J.-N.
Hou, W.
Huang, X.
Hübner, D.
Hüther, J.
Hwang, J.
I
Iftner, T.
Ivanusic, D.
J
Jagnjic, A.
100
40
25
70
14, 23
108
60
104
47
55
103
17, 26
24
81
68, 108
39
49
75, 108
48
80
47
93
66
15
103
39
107
38
84
99
55
50
95
102
58
44, 78, 90
59
90
p 121
Index of Presenting Authors and Chair Persons
Jahn, G.
Jerome, H.
Jessica, F.
Junglen, S. 40
17
65
42
K
Karrasch, M.
81, 110
Karsunke, J.
92
Kasmapour, B.
55
Kay-Fedorov, P.
66
Keller, C. 17
Keppler, O. 43
Kheimar, A.
76
Kieny, M. P. 14
Kirschnick, N.
52
Klein, F. 23
Kleinlützum, D.
27
Klempa, B.
70
Klestova, Z.
109
Klupp, B. G. 26, 76
Klüver, M.
60
Kmiec, D.
101
Knegendorf, L.
18
61
Koban, R.
Kochs, G. 16
Kolb, P.
23
Kopicki, J.
76
Kordyukova, L.
76
König, R. 45
Körner, C.
53
Kortekaas, J.
69
Korth, J.
110
Kosinska, A.
86
Koske, I.
68
Kosowicz, K.
48
Kraft, A.
65
Kraus, E.
81
Kräusslich, H.-G. 25
Krempl, C.
61
Krey, T.
30
Krischuns, T.
100
p 122
Kristen-Burmann, C. 69
Kropp, K. A.
103
Krüger, N.
108
Kubek, F.
40
Kühnl, A.
52
Kupke, A.
35
Kussmann, T.
111
Kuznetsova, I.
93
L
Laib Sampaio, K.
67
Laksono, B.
38
Lamkiewicz, K.
102
Lamp, B.
71
Landsberg, C.
101
Lang, K.
45
Langenmayer, M.
88
Langeveld, S.
95
Lapuente, D.
66
Lassen, S.
99
Lau, S.
102
Le Guillou-Guillemette, H.
17
16
Le-Trilling, V. T. K.
Lee, K. H. 68
Lehmann, M. H.
55
Lemmermann, N.
67
Lempp, F.
62
Lenart, M.
54
Li, Z.
60
Limburg, H.
102
Lin, Y.
99
Lindemann, D.
27
Lindenau, J. 25
Link, E.
90, 110
Lippold, S.
92
Liu, J.
65
Liu, L.
107
Liu, S.-Q.
58
Loffredo-Verde, E.
99
Lopes Previdelli, R.
22
Lozada Chávez, A. N.
Lu, M.
Lübke, N.
Ludwig, S. Lülf, A.-T.
Luttermann, C.
34
102
33
33
22
54
M
Machnowska, P.
80
Madela, J. C.
102
Madhugiri, R.
18
Mahumane Gundane, I.
71
Maisner, A. 28
Malafa, S.
64
Malyshkina, A.
23
Mankertz, A. 40
Marklewitz, M.
24
Marr, L.
87
Marschall, M.
32
Marthaler, A.
31
Martin, A. 14
Mazelier, M.
24
67
Mbui, F.
Mecate-Zambrano, A. 62
Medits, I.
47
Menne, Z.
18, 63
Mertens, T. 14
Mettenleiter, T. C. 14
Mika, A.
17
Mikulicic, S.
15
Milbradt, J.
100
Milewska, A.
50
Millen, S.
78
Mohnke, J.
100
Momotyuk, E.
64
Montaseri, G.
80
Morozov, V.
17, 110
Mostajo Berrospi, N. F.95
Muenchau, S.
103
Müller, C.
39, 82
Index of Presenting Authors and Chair Persons
Müller, H.
Müller, J.
Müller, K.
Muluneh, A.
Muñoz-Fontela, C. Murr, M.
Murthy, S.
Muscolino, E.
50
71
94
106
38
75
109
74
N
Naguib, M.
Naskalska, A.
Nehls, J.
Neil, S.
Nemitz, S.
Neumann, M.
Niedrig, M.
Niendorf, S.
Nilsson, B.
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Bist Du fit für
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ohne böse Überraschungen! Fit for Travel macht Dich reisemedizinisch
fit für über 300 Reiseziele rund um den Globus.
Weitere Infos unter www.fit-for-travel.de
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p 125
Upcoming conferences and meetings
Novel Concepts in Innate Immunity
27–29 March 2017 • Tübingen (DE)
www.innate-immunity-conference.de 20th International Workshop on Kaposi ́s Sarcoma Herpes Virus (KSHV) and Related
Agents
25–28 July 2017 • Berlin (DE)
Abstract deadline 04 May 2017
www.kshv-2017.de 47th Annual Meeting of the German Society for Immunology
12–15 September 2017 • Erlangen (DE)
Abstract deadline 07 May 2017
www.immunology-conference.de 9th International Symposium on Filoviruses
13–16 September 2017 • Marburg (DE)
Abstract deadline 28 May 2017
www.filovirus-meeting.com 5th Translational DZIF-School - Klausurtagung
22–24 November 2017 • Lübeck (DE)
www.dzif-autumn-school.de
3rd German Pharm-Tox Summit
26 February–01 March 2018 • Göttingen (DE)
Abstract deadline 26 October 2017
www.gpts-kongress.de
p 126
PIPETTIEREN
IN MULTIWELLPLATTEN
EINFACH UND
PREISWERT
VIAFLO 96 I 384
Die elektronische Handpipette
Zahlreiche Betriebsmodi wie Mehrfachdispensieren, Verdünnungsreihen und kundespezifische Programme
vereinfachen Ihre Pipettierungen mit 96 und 384 Kanälen und sorgen für gesteigerte Produktivität.
Austauschbare Pipettierköpfe ermöglichen präzises Pipettieren in Volumenbereichen von 0,5 bis 1250 µl.
EVOLVE
VIAFLO II
VOYAGER II
ASSIST
www.integra-biosciences.com

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