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Bias against disconfirmatory evidence in the ’at-risk mental state’ and during psychosis.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3726629
Author(s) Eisenacher, Sarah; Rausch, Franziska; Mier, Daniela; Fenske, Sabrina; Veckenstedt, Ruth;
Englisch, Susanne; Becker, Anna; Andreou, Christina; Moritz, Steffen; Meyer-Lindenberg, Andreas;
Kirsch, Peter; Zink, Mathias
Author(s) at UniBasel Andreou, Christina ;
Year 2016
Title Bias against disconfirmatory evidence in the ’at-risk mental state’ and during psychosis.
Journal Psychiatry research
Volume 238
Pages / Article-Number 242-50
Prior studies have confirmed a bias against disconfirmatory evidence (BADE) in schizophrenia which
has been associated with delusions. However, its role in the pathogenesis of psychosis is yet unclear. The objective was to investigate BADE for the first time in subjects with an at-risk-mental-state for
psychosis (ARMS), patients with a first episode of psychosis without antipsychotic treatment (FEP) and
healthy controls (HC). A standard BADE test presenting written scenarios was employed. In addition,
psychometric rating scales and a neuropsychological test battery were applied. A three-staged image
was revealed. FEP-patients showed a significant BADE compared to the other groups. The performance
of ARMS-patients lay in between HC and FEP-patients. A trend towards significance became evident
for a bias against confirmatory evidence (BACE) in FEP-patients. Results were not attributable to antipsychotic or other medication or depressive symptoms. Correlations with delusions reached medium
effect sizes but failed significance after Bonferroni-corrections. These results provide evidence for aberrations in evidence integration in the pathogenesis of psychosis and contribute to our knowledge of
metacognitive functioning which can be used for (meta-)cognitive intervention in psychosis.
ISSN/ISBN 1872-7123
Full Text on edoc ;
Digital Object Identifier DOI 10.1016/j.psychres.2016.02.028
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27086240

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