řŽŴũŮN;«Ł ƥƆƒÁóª+kđńESCs/iPSCsŅœźŮ¯kđŮn« °s+kđ °s Ishikura et al., Cell Reports, 17, 2789-2804, 2016 (h]«°º) ƥƆƒ PSCs EpiLCs mPGCLCs Morohaku et al., PNAS, 113, 9021-9026, 2016 (PGCsœźĬs) Hikabe et al., Nature, 539, 299-303, 2016 ńh]«ĬºŅ Þ©YsŭŹż¯kđŮĠë: Ĭs Nakaki et al., Nature, 501, 222-226, 2013 ¯kđE«ŭ/ģŝżƐƍƚƭ4]Ůę: Aramaki et al., Dev. Cell, 27, 516-529, 2013 PRDM14 ŮƚƅŃơDÁóª©Y4]Ůę: Yamaji et al., Cell Stem Cell, 12, 368-382, 2013 ¯kđE«Ùŭ/ģŝżƌƮƥƕƯ©Y4]Ůę: Kurimoto et al., Cell Stem Cell, 16, 517-532, 2015 ¯kđE«Ùŭ/ģŝżDNAƨƕƭƬƢƮƍƫƦƯƍ4]Ůę: Shirane et al., Dev. Cell, 39, 87-103, 2016 ƥƆƒÁóª+kđœźŮ¯kđŮn«Ł rR¯kđŪ°s+kđŮ ¯q°ºŭ °s «Ã°ºŭ ES/iPSkđ ŏ rR¯kđ °s °s+kđ °sE«ó ¯q°º °s wQ,î¼ó «Ã°º rR¯kđ °s+kđ °s+kđůľ«ÃŮ°ºîŭſŞœśœ¿mşŞľ¯!ŭſŢŻ°sƀpŝż kđũľ¯kđFķũĝ Ů+kđư 4 h]«ĬºŪh]«°º h]«Ĭº (3 wks) h]«°º (3 wks) SC AAG ĬČkđŮwQ,îö¯ °s+kđŮwQ,îö¯ (Hikabe et al., Nature, 2016; Ishikura et al., Cell Reports, 2016) ƞƙES/iPSkđœźŮ¯kđn«N;ŮU ńî(ą¯ĘijĮµĜÓfư110928Ņ ¯ÃîũŮ¯kđö¯Ùƀ~ğŭN;ũŕżƥƆƒŭŒŏŨŚőľŹŐŸŖ ES/iPSkđœźrR¯kđƀŎżÙâĹĮÚŭĠëũ࿏ŐŭŬťŢÍ ũŎŻľƞƙkđƀĦŏŢN;ůŚźŭĖŬÍŭŎżĿ ½ŤľƥƆƒŭŒŏŨ2śŢÕŻŁ řŽŴũĎcŚŽŨŕŢÁŖńŝųŨŅŮďĐũůľESkđƀƫƯƔƧŭĉŚşľŠŮÑũ û'ÚX3ŮrR¯kđƥŃƉŃƀöUŝżkđƀľwQ,îĠërR¯kđŪśľ ŠŽźƀŚźŭƫƯƔƧŭĉŚşŨľŏŖŦœŮƥŃƉŃƀöUŝżkđƀľ°sĥkđŪ VƁũŏżĿ ŠŮGŁ n«ZįŔÖŏ n«ŮhUªŔÒśŖēśŏ Ñ.pĈũŎżrR¯kđĥkđŮăĂŔ_ſŽŨŏŬŏ ipĈń°sĥŅŮăŔÒśŖ±ŭOőż ŪŏŐŮŔUũŎżĿ î(ą¯ĘijĮµĜÓfư161213 řŮ řŮŋò.ũƥƆƒŭŒŗżN;ů#ÍŮ¡Ýƀ¥ŘŢĿ Ůŋò.ũƥƆƒŭŒŗżN;ů#ÍŮ¡Ýƀ¥ŘŢĿ ŠŽŭčŏľƞƙŭŒŗżN;Ŕ:¾ŭ¡ÝśŦŦŎżĿ ŠŽ ŽŭčŏľƞƙŭŒŗżN;Ŕ:¾ŭ¡ÝśŦŦŎżĿ 5
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