Ongoing research projects funded by the DFG, BMBF,
EU, Industry of members of the AG THS
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Bochum: S. Skodda
Berlin: A. Kühn
Berlin: F. Klostermann
Dresden: C. Winter
Düsseldorf: A. Schnitzler, J.
Vesper
Freiburg: V. Coenen, S. Klebe
Hamburg: M. Poetter-Nerger, W.
Hamel
Hannover: J. Krauss, C. Schrader
Kassel/Göttingen: F. SixelDöring, C. Trenkwalder
Kiel: K. Witt, G. Deuschl, A. Falk
• Köln: A. Barbe, J. Kuhn
• Leipzig: J. Claßen
• Luxemburg: D. Hertel, R.
Krueger
• Mannheim: A. Sartorius
• Magdeburg: I. Galatzky, J.
Voges, A. Kupsch
• Marburg: L. Timmermann
• München: (LMU) K. Boetzel, J.
Merkens
• München (TU): B. Haslinger
• Tübingen: D. Weiß
• Würzburg: J. Volkmann
2 DFG Clinical research groups
• Clinical Research Group 219:
Basal-Ganglia-Cortex-Loops:
Mechanisms of Pathological
Interactions and therapeutic
Modulation
• Leader: J. Timmermann, G. Fink
• 13 projects
• > 7 Mio €
• Clinical Research Group 247:
Deep Brain Stimulation:
Mechanism of Action, CortexBasal Ganglia Physiology and
Therapy
• Leader: A. Kuehn
• 9 projects
• > 7 Mio €
Clinical Research Group 219: Basal-Ganglia-Cortex-Loops:
Mechanisms of Pathological Interactions and therapeutic
Modulation
Ongoing scientific workup in core cohort (PD/controls):
Main results
Development of ß-synchronisation, 6OHDA model
Beta-network
LEAD-DBS
toolbox
Beck et al., Exp. Neurol. 2016; Dvorzhak et al., J Physiol 2012;
Rea et al., Brain stim 2013; Haumesser et al., subm.
CG25-DBS for depression
Accola et al., Brain 2016; Hohlefeld et al., EJN 2012, Neurosci 2013;
Horn and Kühn, Neuroimage 2015
Characterization of physiomarker in depression
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Merkl et al., Exp Neurol 2013
Neumann et al., Mol Psy 2015; Merkl et al., Cerebral Cortex 2015; Hübl et al.,
SCAN 2016; Accola et al., J Affect Dis 2016
Arbeitsgemeinschaft ‚Tiefe Hirnstimulation‘ 2016
der
Deutschen Gesellschaft für Neurologie
Deutschen Gesellschaft für Neurochirurgie
Current officers
J. Voges, Sprecher
J. Volkmann, stellv. Sprecher
R. Hilker, Sekretär
J. Vesper, Schatzmeister
J. Kuhn, kooptiertes Mitglied
D. Gruler, Sekretariat
118 members
74 neurologists
35 neurosurgeons
10 Psychiatrists
3 Epileptologists
The future
• Basic mechanisms of DBS (animal research)
• New stimulation parameters, new hardware
• Large scale pivotal trials (Camptocormia,
impulse control disorders)
• Psychiatric indications for DBS
• Registry for DBS-patients
• DFG-Collaborative Research group