भੰෲपঢ়ॎॊ ଁੑ৓ऩਖ਻ ॔क़ॺছॖথ হ୻दभଁੑੰෲभ੶ൗ

2
ফা঩
ূপள୅੶୛൥ൡ
ਸ਼৚&63+25ফভ
َ42/௬੼भਈ৐଍ ‫ع‬ফभஷॉନॉध০৏भன஦‫ُع‬
4$/<4XDOLW\$GMXVWHG/LIH<HDU
z
৽ৎ஍৷கभශ଍৲એ஋
‡ েோফਯ॑42/஍৷கद੎ातऐ
4$/<भੰෲपঢ়ॎॊ
ଁੑ৓ऩਖ਻
ຠ⏝್
1
ূ਎প৾প৾੹ ୢ৾௺ଢ଼஢ఐ
௏೨ఐ৾‫่؞‬૧৾௧వ ে੟ଁੑ৾ী৙
༖ਉ೨೗
᏶඲䛺೺ᗣ
᭤⥺໬㠃✚
䠙QALY
0
েோফਯध42/॑
৊ৎपઅൟ
⏕Ꮡᖺᩘ
3
4
5&7ॹ‫॑ॱش‬৷ःञ4$/<भଁੑੰෲ
z
ষअधऌ
‡ ಏ෫ଢ଼஢भ௏೨ঢ়৴42/॔क़ॺढ़঒धखथ
¾ ୻ਤষ᷈ቅदभ*(67૥ୡ 8HQRHWDO-&2
‡ ા৷஍ટীෲभ஍ટधखथ
¾ ୻ৣ⍴ንᯂदभ9HQ86
¾ হ୻धखथງஂ
z
,,૥ୡ 6RDUHV HWDO%0-
z […], median QALY were 0.401 in the
gemcitabine group, […]
z The QALY value in the GS group was
significantly better than that in the
gemcitabine group (P<.001).
ম঩भਵ਻
‡ ૥ୡ਋৑भીവऩन॑৶૓पखञઊठજॉ
‡ ঋ‫ش‬५ছॖথ஍৷கदभ৹ତ
5
হ୻‫ৣ؟‬⍴ንᯂपৌघॊ
ঐ०ॵॺ௜১क़४དभા৷஍ટীෲ
॔क़ॺছॖথ
z
6
হ୻ງஂ
‡ 9HQ86
,,૥ୡॹ‫॑ॱش‬৷ःञા৷஍ટীෲ
‡ ଁੑੰෲभ੶ൗ
z
ଁੑ৓ୖ਻
‡ ઊठજॉॹ‫ॱش‬ध4$/<भଁੑੰෲ
‡ ঋ‫ش‬५ছॖথ஍৷கदभ৹ତ
z
হ୻दभ੥ટधऽधी
7
হ୻‫ৣ؟‬⍴ንᯂपৌघॊ
ঐ०ॵॺ௜১क़४དभા৷஍ટীෲ
z
হ୻दभଁੑੰෲभ੶ൗ
9HQ86 ,,ছথॲ঒৲૥ୡ
‡ ঐ०ॵॺ௜১੡
‡ ୯඄਋৑‫؟‬ਈপऊা
YVঁॖॻট।ঝ੡
¾ ીೕपఃஈऔोञ೩঻म‫ع‬ऊাभ୯඄਋৑
¾ ‫ع‬ऊাभँःटप୯඄ીവऋ৅ে
¾ ଈಝमऺऻऩख
‡ ஍৷கभ೾৒
Dumville et al. BMJ 2009.
Soares et al. BMJ 2009.
¾ (4'द‫ؚؚؚؚ‬ऊা৯
z
8
ऊাऽदभ4$/<॑ଁੑੰෲ
‡ ા৷஍ટীෲभ஍ટधखथ
z We used inverse probability weighting to
estimate the mean […] QALYs, accounting for
the censored nature of these data.
z The weights were evaluated as the inverse of
Kaplan Meier estimator of censoring probability.
z For QALYs […], we partitioned the study time
horizon in homogenous subintervals (quarterly
intervals) […]
z Linear regression was used […]. We included
baseline EQ-5D scores as a covariate in the
estimation of QALYs.
9
๕஑৓ऩ5&7भॹ‫ॱش‬ଡୗ
ᝈ⪅ID
ほᐹ
⏕Ꮡᖺᩘ
⩌
0䛛᭶䛾
ຠ⏝್
Ṛஸ
䛒䜚
3䛛᭶䛾
ຠ⏝್
4$/<ੰෲपउऐॊ୯඄ીവधઊठજॉ
z
6䛛᭶䛾 …
ຠ⏝್
HOR-001
1
0.4
YES
0.8
0.7
Ṛஸᚋ
HOR-002
2
1.2
YES
0.7
0.8
0.4
…
HOR-003
2
0.6
YES
0.8
Ḟ 0.7
…
HOR-004
1
1.5
NO
0.9
0.8
1.0
…
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2
1.1
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0.7
0.7
0.9
…
HOR-006
1
2.3
NO
0.7
0.8
0.4
…
HOR-007
1
0.3
YES
0.5
0.6
Ṛஸᚋ
…
䞉䞉䞉
䞉䞉䞉
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䞉䞉䞉
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䞉䞉䞉
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10
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ຠ⏝್
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᭤⥺໬㠃✚
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ऒभॹ‫ॱش‬ऊै೩঻ओधप4$/<॑ੑ઴खथ
ණ৑ૻຎ॑खञः
ઌभেோফਯऋ୯඄ીവৎਡ
भফਯेॉশःऒधमॎऊॊ
‡
ණ‫௴ؚ‬௄েோফਯ‫ؚ‬ଈಝથ૮‫৽ؚ‬ৎ஍৷க
z
ଈಝ৐ऽञमঢ়ੱभँॊৎਡ৐प୯඄ऋીവघॊ
धઌभ4$/<मਂ৥
েோফਯभઊठજॉ
ઌभ4$/<ऋ୯඄ીവৎਡऽ
दभ4$/<ेॉপऌःऒधम
ॎऊॊ
‡
0
4$/<भઊठજॉ
ᡴ䛱ษ䜚ᚋ䛾ຠ⏝್
䛿0௨ୖ䛸௬ᐃ
⏕Ꮡᖺᩘ
11
12
๕஑৓ऩॹ‫ॱش‬भেோফਯप
.DSODQ0HLHU১॑ి৷
ઊठજॉॹ‫ॱش‬भଁੑੰෲ
z
েோৎ৑ੰෲधखथ৅ன
㻝㻚㻜
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ঽேऩૢ৷
‡ েோৎ৑ੰෲু১दઊठજॉ4$/<॑ੰෲ
¾ .DSODQ0HLHU১ऩन॑ి৷
"
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13
14
๕஑৓ऩॹ‫ॱش‬भ4$/<प
.DSODQ0HLHU১॑ి৷
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¾ YV
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㻞㻚㻡
㻟㻚㻜
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ᝈ⪅ID
⩌
┿䛾
ほᐹ
⏕Ꮡᖺᩘ ⏕Ꮡᖺᩘ
Ṛஸ
䛒䜚
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┿䛾
QALY
ほᐹ
QALY
1.8
A 䛥䜣
1
3
2
NO
0.9
2.7
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1
3
2
NO
0.5
1.5
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1
3
3
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1
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1
3
3
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0.6
0.6
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15
ऩछ.DSODQ0HLHU১द4$/<भীഘ॑
ਫखऎ௓೾दऌऩःभऊ
z
ਖ਻मઊठજैोञ೩঻भඞः্
z
⩌
┿䛾
⏕Ꮡᖺᩘ
ほᐹ
⏕Ꮡᖺᩘ
Ṛஸ
䛒䜚
ຠ⏝್
┿䛾
QALY
ほᐹ
QALY
A 䛥䜣
1
3
2
NO
0.9
2.7
1.8
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1
3
2
NO
0.5
1.5
1.0
C 䛥䜣
1
3
2
NO
0.2
0.6
0.4
z
௴௄4$/<मઌभ4$/<॑੒೾⋈
‡ 4$/<दमੲਾभँॊઊठજॉ
.DSODQ0HLHU১मੲਾभऩःઊठજॉ॑ෘ৒
‡ ஍৷கऋঢ়બघॊ4$/<भଁੑੰෲदमਛॉয়ञऩः
Cox et al. JRSS A 1992.
z
௓೾भෙॉ఻়ংॖ॔५भপऌऔ
‡ ઊठજॉभ୤ऋ੗ःऺन‫ؚ‬পऌः
‡ ೩঻৑द஍৷கप୷ऋँॊऺन‫ؚ‬পऌः
䐠
௴௄েோফਯमઌभেோফਯ॑੒೾खऩः⋇
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ऩछ.DSODQ0HLHU১द4$/<भীഘ॑
ਫखऎ௓೾दऌऩःभऊ
z
ᝈ⪅ID
䐟
16
¾ ৢଞ‫ؚ‬4$/<॑পऌऎৄ஋ुॊ্਱भংॖ॔५
z
્पିਔघसऌ૾ய
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¾ ණ৑ૻຎभ੠पংॖ॔५ऋৼ௨औोऩः
17
18
ৌ૪১‫؟‬,3&:১
ઊठજैोऩःન૨भ௓৒
,QYHUVH3UREDELOLW\RI&HQVRULQJ:HLJKWHG১
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z
$‫)ع‬औ॒भॹ‫ॱش‬भઊठજैोऩःન૨
‡ ‫ع‬ফ‫؟‬
‡ ‫ع‬ফ‫؟‬
¾ '‫)ع‬औ॒मযী
ੰෲष๾൴
ᝈ⪅ID
⩌
┿䛾
⏕Ꮡᖺᩘ
ほᐹ
⏕Ꮡᖺᩘ
Ṛஸ
䛒䜚
A 䛥䜣
1
3
2
NO
B 䛥䜣
1
3
2
NO
C 䛥䜣
1
3
2
NO
D 䛥䜣
1
3
3
YES
E 䛥䜣
1
3
3
YES
F 䛥䜣
1
3
3
YES
েோফਯदੲਾभऩःઊठજॉभৃ়
z
ઊठજैोऩःન૨भಗਯदઊठજैोथःऩः
ॹ‫॑ॱش‬੎ातऐघॊ্১ Zhao et al. Biometrika 1997.
‡ ઊठજॉ॑ॖঋথॺधखञ.DSODQ0HLHU১द௓৒
ᡴ䛱ษ䜙䜜䛺䛔☜⋡
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ফ‫؟‬
¾ ফ‫؟‬ফ‫؟‬
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19
20
๕஑৓ऩॹ‫ॱش‬प,3&:১॑ి৷
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z We used inverse probability weighting to
estimate the mean […] QALYs, accounting for
the censored nature of these data.
z The weights were evaluated as the inverse of
Kaplan Meier estimator of censoring probability.
z For QALYs […], we partitioned the study time
horizon in homogenous subintervals (quarterly
intervals) […]
z Linear regression was used […]. We included
baseline EQ-5D scores as a covariate in the
estimation of QALYs.
,3&:১मઌभ4$/<भী
ഘपปअ
‡ ೩঻ਯऋ੗ऐोय঳ಱ
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21
ଢ଼஢਋৑॑ীસखथ,3&:১॑ి৷
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ຠ⏝್
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਴಑4$/< 4भ਴಑4भ਴಑
4भ਴಑4भ਴಑
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‡ ௓৒ಖ২भ਱঱ऋ਋ୄऔोॊ
22
ණ৑द॔থংছথ५ऩऊা৯भ஍৷க
z
਴಑(4'५॥॔भ௓୎
0䛛᭶
3䛛᭶
6䛛᭶
9䛛᭶
12䛛᭶
䝬䝂䝑䝖⒪ἲ⩌
0.485
0.556
0.592
0.585
0.595
䝝䜲䝗䝻䝀䝹⩌
0.539
0.559
0.566
0.628
0.625
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‡ ছথॲ঒৲मखथःॊऋ‫ؚ‬4$/<षभ୶஭প
Manca et al. Health Econ 2005.
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Q2
Q1
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6䛛᭶
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9䛛᭶
ঋ‫ش‬५ছॖথ஍৷கदभ৹ତ
‡ ௓৒ಖ২‫؞‬ਫ਼লৡभ਱঱
12䛛᭶
Ramsey et al. Value Health 2015.
¾ फ़ॖॻছॖথदम৹ତ॑ਘऎਏ੷
⏕Ꮡᖺᩘ
23
24
ৌ૪১‫؟‬4$/<भ৚షীෲ
z
,3&:১॑৷ःञ੎ाહऌ৚ష
‡
௞
ଵ
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হ୻दभ4$/<भੰෲ੥ટ
z
12䛛᭶䜎䛷䛾ᖹᆒQALY
(95% ಙ㢗༊㛫)
௞ଶ ଶ
Żঋ‫ش‬५ছॖথ஍৷க
䝬䝂䝑䝖⒪ἲ⩌
൅ ߚଶଵ ൅ ߚଷଵ ൅ ߚସଵ
¾ ऊাऽदभ਴಑4$/<भ৹ତੋाණ৑୷
‡ ఻৬৓पमਰৣभ௓৒୤॑ੑ઴
෡௞
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ൌ σ௡௜ୀଵ
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σ௡௜ୀଵ
ऊাऽदभ4$/<पණ৑୷मऩः
䝝䜲䝗䝻䝀䝹⩌
⩌㛫ᕪ
Willan et al. Stat Med 2005.
0.540 (0.489, 0.589)
0.011 (í0.067, 0.071)
‡ ઊठજॉ‫ؚ‬ঋ‫ش‬५ছॖথ஍৷கदभ৹ତੋा
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